JP4694963B2 - ケモカインレセプター活性のモジュレーターとしてのピリミジン誘導体 - Google Patents

ケモカインレセプター活性のモジュレーターとしてのピリミジン誘導体 Download PDF

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Publication number
JP4694963B2
JP4694963B2 JP2005501216A JP2005501216A JP4694963B2 JP 4694963 B2 JP4694963 B2 JP 4694963B2 JP 2005501216 A JP2005501216 A JP 2005501216A JP 2005501216 A JP2005501216 A JP 2005501216A JP 4694963 B2 JP4694963 B2 JP 4694963B2
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hydroxy
thio
amino
methylethyl
alkyl
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Expired - Fee Related
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Japanese (ja)
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JP2006503906A5 (enExample
JP2006503906A (ja
Inventor
マーク・リチャード・エブデン
プレムジ・メガニ
アントニー・ロナルド・クック
ジョン・スティール
ラル・ラシュカール・シン・チーマ
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AstraZeneca AB
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AstraZeneca AB
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Priority claimed from GB0219819A external-priority patent/GB0219819D0/en
Priority claimed from GB0223287A external-priority patent/GB0223287D0/en
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Publication of JP2006503906A publication Critical patent/JP2006503906A/ja
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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
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    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Otolaryngology (AREA)
  • Obesity (AREA)
JP2005501216A 2002-08-24 2003-08-20 ケモカインレセプター活性のモジュレーターとしてのピリミジン誘導体 Expired - Fee Related JP4694963B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0219819.0 2002-08-24
GB0219819A GB0219819D0 (en) 2002-08-24 2002-08-24 Novel compound
GB0223287A GB0223287D0 (en) 2002-10-08 2002-10-08 Novel compound
GB0223287.4 2002-10-08
PCT/GB2003/003632 WO2004018435A1 (en) 2002-08-24 2003-08-20 Pyrimidine derivatives as modulators of chemokine receptor activity

Related Child Applications (1)

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JP2010282057A Division JP2011052025A (ja) 2002-08-24 2010-12-17 ケモカインレセプター活性のモジュレーターとしてのピリミジン誘導体

Publications (3)

Publication Number Publication Date
JP2006503906A JP2006503906A (ja) 2006-02-02
JP2006503906A5 JP2006503906A5 (enExample) 2006-10-05
JP4694963B2 true JP4694963B2 (ja) 2011-06-08

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JP2005501216A Expired - Fee Related JP4694963B2 (ja) 2002-08-24 2003-08-20 ケモカインレセプター活性のモジュレーターとしてのピリミジン誘導体
JP2010282057A Withdrawn JP2011052025A (ja) 2002-08-24 2010-12-17 ケモカインレセプター活性のモジュレーターとしてのピリミジン誘導体

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JP2010282057A Withdrawn JP2011052025A (ja) 2002-08-24 2010-12-17 ケモカインレセプター活性のモジュレーターとしてのピリミジン誘導体

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Country Link
US (1) US7482355B2 (enExample)
EP (1) EP1539713B1 (enExample)
JP (2) JP4694963B2 (enExample)
AT (1) ATE381546T1 (enExample)
AU (1) AU2003255819A1 (enExample)
DE (1) DE60318219T2 (enExample)
ES (1) ES2295685T3 (enExample)
WO (1) WO2004018435A1 (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7037916B2 (en) 1999-07-15 2006-05-02 Pharmacopeia Drug Discovery, Inc. Pyrimidine derivatives as IL-8 receptor antagonists
GB0217431D0 (en) 2002-07-27 2002-09-04 Astrazeneca Ab Novel compounds
US8529625B2 (en) 2003-08-22 2013-09-10 Smith & Nephew, Inc. Tissue repair and replacement
EP2311827A1 (en) * 2004-08-28 2011-04-20 AstraZeneca AB Thiopyrimidine derivative, useful as an intermediate for chemokine receptor modulators.
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US7482355B2 (en) 2009-01-27
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US20060004030A1 (en) 2006-01-05
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