JP4694963B2 - ケモカインレセプター活性のモジュレーターとしてのピリミジン誘導体 - Google Patents

ケモカインレセプター活性のモジュレーターとしてのピリミジン誘導体 Download PDF

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Publication number
JP4694963B2
JP4694963B2 JP2005501216A JP2005501216A JP4694963B2 JP 4694963 B2 JP4694963 B2 JP 4694963B2 JP 2005501216 A JP2005501216 A JP 2005501216A JP 2005501216 A JP2005501216 A JP 2005501216A JP 4694963 B2 JP4694963 B2 JP 4694963B2
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hydroxy
thio
amino
methylethyl
alkyl
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Japanese (ja)
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JP2006503906A5 (cg-RX-API-DMAC10.html
JP2006503906A (ja
Inventor
マーク・リチャード・エブデン
プレムジ・メガニ
アントニー・ロナルド・クック
ジョン・スティール
ラル・ラシュカール・シン・チーマ
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AstraZeneca AB
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AstraZeneca AB
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Priority claimed from GB0219819A external-priority patent/GB0219819D0/en
Priority claimed from GB0223287A external-priority patent/GB0223287D0/en
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Publication of JP2006503906A publication Critical patent/JP2006503906A/ja
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
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JP2005501216A 2002-08-24 2003-08-20 ケモカインレセプター活性のモジュレーターとしてのピリミジン誘導体 Expired - Fee Related JP4694963B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0219819.0 2002-08-24
GB0219819A GB0219819D0 (en) 2002-08-24 2002-08-24 Novel compound
GB0223287.4 2002-10-08
GB0223287A GB0223287D0 (en) 2002-10-08 2002-10-08 Novel compound
PCT/GB2003/003632 WO2004018435A1 (en) 2002-08-24 2003-08-20 Pyrimidine derivatives as modulators of chemokine receptor activity

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JP2010282057A Division JP2011052025A (ja) 2002-08-24 2010-12-17 ケモカインレセプター活性のモジュレーターとしてのピリミジン誘導体

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JP2006503906A JP2006503906A (ja) 2006-02-02
JP2006503906A5 JP2006503906A5 (cg-RX-API-DMAC10.html) 2006-10-05
JP4694963B2 true JP4694963B2 (ja) 2011-06-08

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JP2005501216A Expired - Fee Related JP4694963B2 (ja) 2002-08-24 2003-08-20 ケモカインレセプター活性のモジュレーターとしてのピリミジン誘導体
JP2010282057A Withdrawn JP2011052025A (ja) 2002-08-24 2010-12-17 ケモカインレセプター活性のモジュレーターとしてのピリミジン誘導体

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US (1) US7482355B2 (cg-RX-API-DMAC10.html)
EP (1) EP1539713B1 (cg-RX-API-DMAC10.html)
JP (2) JP4694963B2 (cg-RX-API-DMAC10.html)
AT (1) ATE381546T1 (cg-RX-API-DMAC10.html)
AU (1) AU2003255819A1 (cg-RX-API-DMAC10.html)
DE (1) DE60318219T2 (cg-RX-API-DMAC10.html)
ES (1) ES2295685T3 (cg-RX-API-DMAC10.html)
WO (1) WO2004018435A1 (cg-RX-API-DMAC10.html)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7037916B2 (en) 1999-07-15 2006-05-02 Pharmacopeia Drug Discovery, Inc. Pyrimidine derivatives as IL-8 receptor antagonists
GB0217431D0 (en) 2002-07-27 2002-09-04 Astrazeneca Ab Novel compounds
US8529625B2 (en) 2003-08-22 2013-09-10 Smith & Nephew, Inc. Tissue repair and replacement
EP2311827A1 (en) * 2004-08-28 2011-04-20 AstraZeneca AB Thiopyrimidine derivative, useful as an intermediate for chemokine receptor modulators.
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