JP4686634B2 - 肝細胞成長因子（ｈｇｆ）結合蛋白質 - Google Patents

肝細胞成長因子（ｈｇｆ）結合蛋白質 Download PDF

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Publication number
JP4686634B2
JP4686634B2 JP2009513295A JP2009513295A JP4686634B2 JP 4686634 B2 JP4686634 B2 JP 4686634B2 JP 2009513295 A JP2009513295 A JP 2009513295A JP 2009513295 A JP2009513295 A JP 2009513295A JP 4686634 B2 JP4686634 B2 JP 4686634B2
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seq
sequence
variable region
antibody
hgf
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JP2009539347A (ja
JP2009539347A5 (https=
Inventor
ウィリアム エム． ウィンストン，
エス． カーク ライト，
メイ ハン，
リン ブレオー，
チエ リン，
ビジャン エテマド−ギルバートソン，
クリスティン クヌーエル，
ジェノ ギュリス，
アーノルド ホーウィッツ，
Original Assignee
アベオ ファーマシューティカルズ， インコーポレイテッド
ゾーマ テクノロジー リミテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
JP2009513295A 2006-06-02 2007-06-01 肝細胞成長因子（ｈｇｆ）結合蛋白質 Active JP4686634B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US81071406P 2006-06-02 2006-06-02
US60/810,714 2006-06-02
US86050906P 2006-11-21 2006-11-21
US60/860,509 2006-11-21
PCT/US2007/012939 WO2007143090A2 (en) 2006-06-02 2007-06-01 Hepatocyte growth factor (hgf) binding proteins

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010294222A Division JP2011072318A (ja) 2006-06-02 2010-12-28 肝細胞成長因子（ｈｇｆ）結合蛋白質

Publications (3)

Publication Number Publication Date
JP2009539347A JP2009539347A (ja) 2009-11-19
JP2009539347A5 JP2009539347A5 (https=) 2011-02-24
JP4686634B2 true JP4686634B2 (ja) 2011-05-25

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JP2009513295A Active JP4686634B2 (ja) 2006-06-02 2007-06-01 肝細胞成長因子（ｈｇｆ）結合蛋白質
JP2010294222A Withdrawn JP2011072318A (ja) 2006-06-02 2010-12-28 肝細胞成長因子（ｈｇｆ）結合蛋白質
JP2012269474A Active JP5735476B2 (ja) 2006-06-02 2012-12-10 肝細胞成長因子（ｈｇｆ）結合蛋白質

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JP2010294222A Withdrawn JP2011072318A (ja) 2006-06-02 2010-12-28 肝細胞成長因子（ｈｇｆ）結合蛋白質
JP2012269474A Active JP5735476B2 (ja) 2006-06-02 2012-12-10 肝細胞成長因子（ｈｇｆ）結合蛋白質

Country Status (20)

Country Link
US (5) US7649083B2 (https=)
EP (2) EP2027156B9 (https=)
JP (3) JP4686634B2 (https=)
KR (1) KR101196060B1 (https=)
AR (1) AR061171A1 (https=)
AT (1) ATE495195T1 (https=)
AU (1) AU2007254942B2 (https=)
BR (1) BRPI0712222B1 (https=)
CA (1) CA2654025C (https=)
CY (1) CY1111714T1 (https=)
DE (1) DE602007011923D1 (https=)
DK (1) DK2027156T3 (https=)
IL (2) IL195037A (https=)
MX (1) MX2008014829A (https=)
NO (1) NO345476B1 (https=)
NZ (1) NZ573818A (https=)
PL (1) PL2027156T3 (https=)
PT (1) PT2027156E (https=)
SG (1) SG158112A1 (https=)
WO (1) WO2007143090A2 (https=)

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AU2007254942A1 (en) 2007-12-13
CA2654025C (en) 2016-08-02
BRPI0712222B1 (pt) 2021-10-13
US20100173362A1 (en) 2010-07-08
JP2009539347A (ja) 2009-11-19
DE602007011923D1 (de) 2011-02-24
IL195037A0 (en) 2011-08-01
PT2027156E (pt) 2011-04-18
HK1129395A1 (en) 2009-11-27
BRPI0712222A2 (pt) 2012-01-10
IL195037A (en) 2015-08-31
AR061171A1 (es) 2008-08-06
AU2007254942A2 (en) 2009-05-28
US20080108565A1 (en) 2008-05-08
DK2027156T3 (da) 2011-04-26
JP2011072318A (ja) 2011-04-14
IL219654A0 (en) 2012-06-28
ATE495195T1 (de) 2011-01-15
US7649083B2 (en) 2010-01-19
NO345476B1 (no) 2021-02-22
US8580930B2 (en) 2013-11-12
US20130203963A1 (en) 2013-08-08
EP2027156B9 (en) 2011-03-30
NZ573818A (en) 2011-09-30
JP2013090632A (ja) 2013-05-16
CY1111714T1 (el) 2015-10-07
PL2027156T3 (pl) 2011-06-30
AU2007254942B2 (en) 2011-10-27
US7943344B2 (en) 2011-05-17
US20140178935A1 (en) 2014-06-26
KR20090027226A (ko) 2009-03-16
JP5735476B2 (ja) 2015-06-17
EP2027156A2 (en) 2009-02-25
EP2361934A3 (en) 2011-11-02
CA2654025A1 (en) 2007-12-13
NO20085421L (no) 2009-02-27
EP2027156B1 (en) 2011-01-12
MX2008014829A (es) 2009-01-29
AU2007254942A8 (en) 2009-02-05
WO2007143090A3 (en) 2008-03-13
KR101196060B1 (ko) 2012-11-01
US8273355B2 (en) 2012-09-25
US20110229462A1 (en) 2011-09-22
EP2361934A2 (en) 2011-08-31
US9096664B2 (en) 2015-08-04
WO2007143090A2 (en) 2007-12-13
SG158112A1 (en) 2010-01-29

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