JP4684509B2 - カプセルをシールする方法及び装置ならびに前記方法及び装置における使用に適したカプセル - Google Patents
カプセルをシールする方法及び装置ならびに前記方法及び装置における使用に適したカプセル Download PDFInfo
- Publication number
- JP4684509B2 JP4684509B2 JP2001513364A JP2001513364A JP4684509B2 JP 4684509 B2 JP4684509 B2 JP 4684509B2 JP 2001513364 A JP2001513364 A JP 2001513364A JP 2001513364 A JP2001513364 A JP 2001513364A JP 4684509 B2 JP4684509 B2 JP 4684509B2
- Authority
- JP
- Japan
- Prior art keywords
- capsule
- gap
- solvent
- sealing
- drying
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000002775 capsule Substances 0.000 title claims abstract description 175
- 238000007789 sealing Methods 0.000 title claims abstract description 53
- 238000000034 method Methods 0.000 title claims abstract description 32
- 239000002904 solvent Substances 0.000 claims abstract description 80
- 238000001035 drying Methods 0.000 claims abstract description 62
- 239000007788 liquid Substances 0.000 claims abstract description 38
- 239000007887 hard shell capsule Substances 0.000 claims abstract 3
- 239000007921 spray Substances 0.000 claims description 24
- 239000007787 solid Substances 0.000 claims description 2
- 239000003570 air Substances 0.000 description 41
- 238000013461 design Methods 0.000 description 20
- 239000000463 material Substances 0.000 description 19
- 230000007246 mechanism Effects 0.000 description 19
- 239000012530 fluid Substances 0.000 description 15
- 230000009471 action Effects 0.000 description 7
- 238000011049 filling Methods 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- 239000000203 mixture Substances 0.000 description 5
- 229910001220 stainless steel Inorganic materials 0.000 description 5
- 238000001816 cooling Methods 0.000 description 4
- 239000010935 stainless steel Substances 0.000 description 4
- 238000009792 diffusion process Methods 0.000 description 3
- 239000007903 gelatin capsule Substances 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 3
- 210000000281 joint capsule Anatomy 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 239000013557 residual solvent Substances 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 230000007723 transport mechanism Effects 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 239000012080 ambient air Substances 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000009956 central mechanism Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000003749 cleanliness Effects 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000008646 thermal stress Effects 0.000 description 1
- -1 time Substances 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
- A61J3/072—Sealing capsules, e.g. rendering them tamper-proof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Closing Of Containers (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99401949A EP1072245A1 (en) | 1999-07-30 | 1999-07-30 | Method and apparatus for sealing capsules and capsules suitable for use in said method and apparatus |
EP99401949.5 | 1999-07-30 | ||
PCT/EP2000/006098 WO2001008631A1 (en) | 1999-07-30 | 2000-06-30 | Method and apparatus for sealing capsules and capsules suitable for use in said method and apparatus |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2003505204A JP2003505204A (ja) | 2003-02-12 |
JP4684509B2 true JP4684509B2 (ja) | 2011-05-18 |
Family
ID=8242076
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2001513364A Expired - Fee Related JP4684509B2 (ja) | 1999-07-30 | 2000-06-30 | カプセルをシールする方法及び装置ならびに前記方法及び装置における使用に適したカプセル |
Country Status (12)
Country | Link |
---|---|
EP (2) | EP1072245A1 (ko) |
JP (1) | JP4684509B2 (ko) |
KR (1) | KR100789431B1 (ko) |
CN (1) | CN1213714C (ko) |
AT (1) | ATE310487T1 (ko) |
CA (1) | CA2379276C (ko) |
DE (1) | DE60024272T2 (ko) |
DK (1) | DK1202699T3 (ko) |
EA (1) | EA003124B1 (ko) |
ES (1) | ES2250152T3 (ko) |
MX (1) | MXPA02001062A (ko) |
WO (1) | WO2001008631A1 (ko) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1459725B1 (en) * | 2003-03-21 | 2007-10-17 | Warner-Lambert Company LLC | Apparatus for and method of sealing capsules |
US8377471B2 (en) * | 2005-08-09 | 2013-02-19 | Capsugel Belgium Nv | Container |
EP1752140A1 (en) * | 2005-08-12 | 2007-02-14 | Warner-Lambert Company LLC | Method for banding hard capsules using hydroxypropylmethyl cellulose (HPMC) as a base |
EP1886657A1 (en) * | 2006-08-11 | 2008-02-13 | Pfizer Products Inc. | Method and apparatus for sealing capsules |
EP2083787B1 (en) | 2006-10-24 | 2012-12-12 | Capsugel Belgium NV | Transfer line |
CN106619128B (zh) * | 2015-11-04 | 2019-12-06 | 曹荣华 | 胶囊的封存组合物及其封存方法 |
EP3219300B1 (en) | 2016-03-15 | 2019-06-19 | Capsugel Belgium NV | Aseptic hard capsule sealing apparatus and methods |
CN108451016B (zh) * | 2018-05-29 | 2021-01-29 | 云南中烟工业有限责任公司 | 一种预成型烟用包水爆珠的制备方法 |
CN113647674B (zh) * | 2021-07-27 | 2023-08-29 | 常德市雄鹰科技有限责任公司 | 一种控制香烟爆珠大小的装置及方法 |
CN113995677B (zh) * | 2021-11-23 | 2023-09-26 | 河北睿济堂中药股份有限公司 | 一种中药饮片润药机 |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4823890B1 (ko) * | 1970-12-26 | 1973-07-17 | ||
JPS53145907A (en) * | 1977-05-20 | 1978-12-19 | Capsugel Ag | Production of combined capsule filled with viscous substance |
JPS53145911A (en) * | 1977-05-20 | 1978-12-19 | Capsugel Ag | Production of combined capsule |
JPS60176656A (ja) * | 1984-02-22 | 1985-09-10 | ワ−ナ−・ランバ−ト・カンパニ− | カプセルを封止するための装置および方法 |
JPS61168357A (ja) * | 1984-10-25 | 1986-07-30 | ワ−ナ−・ランバ−ト・カンパニ− | カプセルを密封する方法 |
DE3543956A1 (de) * | 1985-12-12 | 1987-06-19 | Scherer R P Hartkapsel Gmbh | Zweiteilige steckkapsel und verfahren zum versiegeln einer solchen steckkapsel |
US4734149A (en) * | 1987-03-20 | 1988-03-29 | Warner-Lambert Company | Apparatus for heatsealing gelatin capsules containing a medicament |
JPS63249562A (ja) * | 1987-03-20 | 1988-10-17 | ワーナー・ランバート・カンパニー | 薬剤を含むカプセルを封止する方法及び装置 |
JPH0312160A (ja) * | 1989-06-12 | 1991-01-21 | Nippon Eranko Kk | カプセルの封緘機 |
JPH03113276A (ja) * | 1989-09-26 | 1991-05-14 | Nippon Eranko Kk | 固型製剤乾燥装置 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0116744A1 (en) | 1982-12-20 | 1984-08-29 | Warner-Lambert Company | Apparatus for and method of sealing capsules |
US4539060A (en) | 1983-02-18 | 1985-09-03 | Warner-Lambert Company | Apparatus and method of sealing capsules |
-
1999
- 1999-07-30 EP EP99401949A patent/EP1072245A1/en not_active Withdrawn
-
2000
- 2000-06-30 AT AT00943950T patent/ATE310487T1/de active
- 2000-06-30 ES ES00943950T patent/ES2250152T3/es not_active Expired - Lifetime
- 2000-06-30 CA CA002379276A patent/CA2379276C/en not_active Expired - Fee Related
- 2000-06-30 JP JP2001513364A patent/JP4684509B2/ja not_active Expired - Fee Related
- 2000-06-30 DK DK00943950T patent/DK1202699T3/da active
- 2000-06-30 EA EA200200195A patent/EA003124B1/ru not_active IP Right Cessation
- 2000-06-30 MX MXPA02001062A patent/MXPA02001062A/es active IP Right Grant
- 2000-06-30 DE DE60024272T patent/DE60024272T2/de not_active Expired - Lifetime
- 2000-06-30 CN CNB008110476A patent/CN1213714C/zh not_active Expired - Fee Related
- 2000-06-30 EP EP00943950A patent/EP1202699B1/en not_active Expired - Lifetime
- 2000-06-30 KR KR1020027001347A patent/KR100789431B1/ko not_active IP Right Cessation
- 2000-06-30 WO PCT/EP2000/006098 patent/WO2001008631A1/en active IP Right Grant
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4823890B1 (ko) * | 1970-12-26 | 1973-07-17 | ||
JPS53145907A (en) * | 1977-05-20 | 1978-12-19 | Capsugel Ag | Production of combined capsule filled with viscous substance |
JPS53145911A (en) * | 1977-05-20 | 1978-12-19 | Capsugel Ag | Production of combined capsule |
JPS60176656A (ja) * | 1984-02-22 | 1985-09-10 | ワ−ナ−・ランバ−ト・カンパニ− | カプセルを封止するための装置および方法 |
JPS61168357A (ja) * | 1984-10-25 | 1986-07-30 | ワ−ナ−・ランバ−ト・カンパニ− | カプセルを密封する方法 |
DE3543956A1 (de) * | 1985-12-12 | 1987-06-19 | Scherer R P Hartkapsel Gmbh | Zweiteilige steckkapsel und verfahren zum versiegeln einer solchen steckkapsel |
US4734149A (en) * | 1987-03-20 | 1988-03-29 | Warner-Lambert Company | Apparatus for heatsealing gelatin capsules containing a medicament |
JPS63249562A (ja) * | 1987-03-20 | 1988-10-17 | ワーナー・ランバート・カンパニー | 薬剤を含むカプセルを封止する方法及び装置 |
JPH0312160A (ja) * | 1989-06-12 | 1991-01-21 | Nippon Eranko Kk | カプセルの封緘機 |
JPH03113276A (ja) * | 1989-09-26 | 1991-05-14 | Nippon Eranko Kk | 固型製剤乾燥装置 |
Also Published As
Publication number | Publication date |
---|---|
KR20020035844A (ko) | 2002-05-15 |
EP1202699A1 (en) | 2002-05-08 |
WO2001008631A1 (en) | 2001-02-08 |
EA003124B1 (ru) | 2003-02-27 |
ATE310487T1 (de) | 2005-12-15 |
MXPA02001062A (es) | 2003-04-10 |
DE60024272D1 (de) | 2005-12-29 |
EP1072245A1 (en) | 2001-01-31 |
ES2250152T3 (es) | 2006-04-16 |
CN1365268A (zh) | 2002-08-21 |
EP1202699B1 (en) | 2005-11-23 |
CA2379276A1 (en) | 2001-02-08 |
KR100789431B1 (ko) | 2007-12-28 |
JP2003505204A (ja) | 2003-02-12 |
DE60024272T2 (de) | 2006-06-14 |
EA200200195A1 (ru) | 2002-06-27 |
CA2379276C (en) | 2008-09-30 |
DK1202699T3 (da) | 2006-04-03 |
CN1213714C (zh) | 2005-08-10 |
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