JP4677095B2 - エキセンジンおよびｇｌｐ−１の変力および利尿効果 - Google Patents
エキセンジンおよびｇｌｐ−１の変力および利尿効果 Download PDFInfo
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- JP4677095B2 JP4677095B2 JP2000531064A JP2000531064A JP4677095B2 JP 4677095 B2 JP4677095 B2 JP 4677095B2 JP 2000531064 A JP2000531064 A JP 2000531064A JP 2000531064 A JP2000531064 A JP 2000531064A JP 4677095 B2 JP4677095 B2 JP 4677095B2
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| PCT/US1999/002554 WO1999040788A1 (en) | 1998-02-13 | 1999-02-05 | Inotropic and diuretic effects of exendin and glp-1 |
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| JP2002509078A JP2002509078A (ja) | 2002-03-26 |
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| FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| US6852690B1 (en) | 1995-08-22 | 2005-02-08 | Amylin Pharmaceuticals, Inc. | Method and composition for enhanced parenteral nutrition |
| ES2278589T3 (es) | 1999-01-14 | 2007-08-16 | Amylin Pharmaceuticals, Inc. | Excendinas destinadas a la inhibicion de glucagon. |
| US7399489B2 (en) | 1999-01-14 | 2008-07-15 | Amylin Pharmaceuticals, Inc. | Exendin analog formulations |
| US6902744B1 (en) | 1999-01-14 | 2005-06-07 | Amylin Pharmaceuticals, Inc. | Exendin agonist formulations and methods of administration thereof |
| US6506724B1 (en) | 1999-06-01 | 2003-01-14 | Amylin Pharmaceuticals, Inc. | Use of exendins and agonists thereof for the treatment of gestational diabetes mellitus |
| EP1076066A1 (en) | 1999-07-12 | 2001-02-14 | Zealand Pharmaceuticals A/S | Peptides for lowering blood glucose levels |
| US6528486B1 (en) | 1999-07-12 | 2003-03-04 | Zealand Pharma A/S | Peptide agonists of GLP-1 activity |
| EP2213743A1 (en) | 2000-04-12 | 2010-08-04 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| NZ519752A (en) * | 2000-10-20 | 2005-04-29 | Amylin Pharmaceuticals Inc | Treatment of hibernating myocardium and diabetic cardiomyopathy with a GLP-1 peptide |
| IL155812A0 (en) | 2000-12-07 | 2003-12-23 | Lilly Co Eli | Glp-1 fusion proteins |
| ATE408414T1 (de) | 2001-07-31 | 2008-10-15 | Us Gov Health & Human Serv | Glp 1 exendin 4 peptidanaloga und deren verwendungen |
| KR20040054729A (ko) * | 2001-10-18 | 2004-06-25 | 브리스톨-마이어스 스큅 컴퍼니 | 인간 글루카곤-유사-펩티드-1 모방체, 및 당뇨병 및 이와관련된 증상의 치료에 있어서 이의 용도 |
| AU2002364586A1 (en) | 2001-12-21 | 2003-07-30 | Delta Biotechnology Limited | Albumin fusion proteins |
| WO2005003296A2 (en) | 2003-01-22 | 2005-01-13 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| PL209734B1 (pl) | 2002-02-20 | 2011-10-31 | Emisphere Tech Inc | Preparat farmaceutyczny zawierający związek GLP-1 i czynnik dostarczający oraz jego zastosowanie |
| BR0314996A (pt) | 2002-10-02 | 2005-08-09 | Zealand Pharma As | Composição, composição farmaceuticamente aceitável, método para produzir a composição, métodos para estabilizar a exendina-4 (1-39) ou uma sua variante, derivado ou análogo contra a degradação, antes, durante ou após o uso pretendido, para tratar doenças, para tratar de estados de doenças associados com nìveis elevados de glicose do sangue, para a regulação dos nìveis de glicose do sangue, para a regulação do esvaziamento gástrico, para estimular a liberação de insulina em um mamìfero para reduzir o nìvel de glicose do sangue em um mamìfero, para reduzir o nìvel de lipìdeos plasmáticos em um mamìfero, para reduzir a mortalidade e a morbidez após o infarto miocárdico em um mamìfero, para estimular a liberação de insulina em um mamìfero, e para produzir uma exendina (1-39) estabilizada, e, exendina (1-39) estabilizada |
| EP1610811A4 (en) * | 2002-12-17 | 2008-03-26 | Amylin Pharmaceuticals Inc | PREVENTION AND TREATMENT OF CARDIAC ARRHYTHMIAS |
| US7790681B2 (en) | 2002-12-17 | 2010-09-07 | Amylin Pharmaceuticals, Inc. | Treatment of cardiac arrhythmias with GLP-1 receptor ligands |
| US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
| ATE549028T1 (de) | 2003-05-15 | 2012-03-15 | Tufts College | Stabile analoga von glp-1 |
| EP1631308B1 (en) * | 2003-05-30 | 2013-07-31 | Amylin Pharmaceuticals, LLC | Novel methods and compositions for enhanced transmucosal delivery of peptides and proteins |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5424286A (en) * | 1993-05-24 | 1995-06-13 | Eng; John | Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same |
| US5512549A (en) * | 1994-10-18 | 1996-04-30 | Eli Lilly And Company | Glucagon-like insulinotropic peptide analogs, compositions, and methods of use |
| ATE493998T1 (de) * | 1996-08-08 | 2011-01-15 | Amylin Pharmaceuticals Inc | Pharmazeutische zusammensetzung mit einem exendin-4-peptid |
| ES2293688T5 (es) * | 1997-08-08 | 2011-05-04 | Amylin Pharmaceuticals, Inc. | Nuevos compuestos análogos de la exendina. |
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- 1999-02-05 WO PCT/US1999/002554 patent/WO1999040788A1/en not_active Ceased
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- 1999-02-05 DE DE69936446T patent/DE69936446T2/de not_active Expired - Lifetime
- 1999-02-05 AU AU26596/99A patent/AU759058C/en not_active Ceased
- 1999-02-05 AT AT99906762T patent/ATE366115T1/de not_active IP Right Cessation
- 1999-02-05 ES ES99906762T patent/ES2291017T3/es not_active Expired - Lifetime
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| EP1054594B1 (en) | 2007-07-04 |
| CA2320371A1 (en) | 1999-08-19 |
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| CA2320371C (en) | 2012-01-17 |
| DE69936446D1 (de) | 2007-08-16 |
| JP2002509078A (ja) | 2002-03-26 |
| WO1999040788A1 (en) | 1999-08-19 |
| EP1054594A4 (en) | 2002-04-17 |
| EP1054594A1 (en) | 2000-11-29 |
| AU759058C (en) | 2005-09-15 |
| AU2659699A (en) | 1999-08-30 |
| AU759058B2 (en) | 2003-04-03 |
| ES2291017T3 (es) | 2008-02-16 |
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