JP4641075B2 - ベンズイミダゾール誘導体を活性成分とする経口投与用の安定な薬剤形およびその製造方法 - Google Patents

ベンズイミダゾール誘導体を活性成分とする経口投与用の安定な薬剤形およびその製造方法 Download PDF

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JP4641075B2
JP4641075B2 JP50383698A JP50383698A JP4641075B2 JP 4641075 B2 JP4641075 B2 JP 4641075B2 JP 50383698 A JP50383698 A JP 50383698A JP 50383698 A JP50383698 A JP 50383698A JP 4641075 B2 JP4641075 B2 JP 4641075B2
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gastric juice
drug
resistant
intermediate layer
layer
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JP2000514051A5 (enExample
JP2000514051A (ja
Inventor
ゲルド―ウルファート ヘッセ
ヘルベルト ヤンガー
アルニム ライハー
クラウディオ ローク
トーマス プロフィリッチ
ゲルド バイス
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AstraZeneca AB
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AstraZeneca AB
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

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  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP50383698A 1996-06-28 1997-06-27 ベンズイミダゾール誘導体を活性成分とする経口投与用の安定な薬剤形およびその製造方法 Expired - Fee Related JP4641075B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19626045A DE19626045C2 (de) 1996-06-28 1996-06-28 Stabile Arzneiform zur oralen Verabreichung, welche Omeprazol als aktiven Wirkstoff enthält, sowie Verfahren zur Herstellung derselben
DE19626045.0 1996-06-28
PCT/EP1997/003387 WO1998000114A2 (de) 1996-06-28 1997-06-27 Stabile arzneiform mit benzimidazolderivaten als wirkstoff zur oralen verabreichung und verfahren zu ihrer herstellung

Publications (3)

Publication Number Publication Date
JP2000514051A JP2000514051A (ja) 2000-10-24
JP2000514051A5 JP2000514051A5 (enExample) 2005-04-07
JP4641075B2 true JP4641075B2 (ja) 2011-03-02

Family

ID=7798347

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50383698A Expired - Fee Related JP4641075B2 (ja) 1996-06-28 1997-06-27 ベンズイミダゾール誘導体を活性成分とする経口投与用の安定な薬剤形およびその製造方法

Country Status (11)

Country Link
EP (1) EP0934058B1 (enExample)
JP (1) JP4641075B2 (enExample)
AT (1) ATE247457T1 (enExample)
AU (2) AU3438897A (enExample)
CA (1) CA2258918C (enExample)
DE (2) DE19626045C2 (enExample)
DK (1) DK0934058T3 (enExample)
ES (1) ES2205243T3 (enExample)
PT (1) PT934058E (enExample)
WO (2) WO1998000114A2 (enExample)
ZA (2) ZA975828B (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
SE9704869D0 (sv) * 1997-12-22 1997-12-22 Astra Ab New pharmaceutical formulaton II
UA73092C2 (uk) 1998-07-17 2005-06-15 Брістол-Майерс Сквібб Компані Таблетка з ентеросолюбільним покриттям і спосіб її приготування
ATE321538T1 (de) 1998-08-12 2006-04-15 Altana Pharma Ag Orale darreichungsform für pyridin-2- ylmethylsulfinyl-1h-benzimidazole
DE19845358A1 (de) * 1998-10-02 2000-04-06 Roehm Gmbh Überzogene Arzneiformen mit kontrollierter Wirkstoffabgabe
IL130602A0 (en) 1999-06-22 2000-06-01 Dexcel Ltd Stable benzimidazole formulation
US6420473B1 (en) * 2000-02-10 2002-07-16 Bpsi Holdings, Inc. Acrylic enteric coating compositions
AR030557A1 (es) 2000-04-14 2003-08-27 Jagotec Ag Una tableta en multicapa de liberacion controlada y metodo de tratamiento
US7316819B2 (en) * 2001-03-08 2008-01-08 Unigene Laboratories, Inc. Oral peptide pharmaceutical dosage form and method of production
KR100479637B1 (ko) * 2002-02-01 2005-03-31 한국화학연구원 란소프라졸을 함유하는 경구제제 및 그의 제조방법
RU2332237C2 (ru) 2002-08-02 2008-08-27 Рациофарм Гмбх Фармацевтический препарат, содержащий производное бензимидазола, смешанное с микрокристаллической целлюлозой, и способ его изготовления
DE10235475B4 (de) * 2002-08-02 2006-04-27 Ratiopharm Gmbh Arzneimittel mit einer Benzimidazolverbindung im Gemisch mit mikrokristalliner Cellulose und Verfahren zu deren Herstellung
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
AR045068A1 (es) * 2003-07-23 2005-10-12 Univ Missouri Formulacion de liberacion inmediata de composiciones farmaceuticas
BRPI0412752B8 (pt) * 2003-07-24 2021-05-25 Glaxosmithkline Llc composição de filme de dissolução oral
TWI372066B (en) 2003-10-01 2012-09-11 Wyeth Corp Pantoprazole multiparticulate formulations
EP1721604A4 (en) * 2004-03-04 2008-04-30 Takeda Pharmaceutical STABLE CAPSULE PREPARATION
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
EP1833469A2 (en) * 2005-01-03 2007-09-19 Lupin Ltd. Pharmaceutical composition of acid labile substances
DE102005032806A1 (de) * 2005-07-12 2007-01-18 Röhm Gmbh Verwendung eines teilneutralisierten, anionischen (Meth)acrylat-Copolymers als Überzug für die Herstellung einer Arzneiform mit einer Wirkstofffreisetzung bei erniedrigten pH-Werten
DE102006006532B4 (de) 2006-02-10 2007-11-08 Biogenerics Pharma Gmbh Pharmazeutische Zubereitung
DK2152250T3 (da) * 2007-05-07 2019-12-09 Evonik Degussa Gmbh Faste doseringsformer, der omfatter et enterisk overtræk, med accelereret lægemiddelfrigivelse
EP2293782B1 (en) 2008-05-06 2015-08-12 Dexcel Pharma Technologies Ltd. Stable benzimidazole formulation
DE102008056312A1 (de) 2008-11-07 2010-05-12 Biogenerics Pharma Gmbh Verwendung von Mikrotabletten als Lebens-und Futtermittelzusatz
DE102010052847A1 (de) * 2010-11-29 2012-05-31 Temmler Werke Gmbh Verfahren zur Herstellung einer PPI-haltigen pharmazeutischen Zubereitung
US8951996B2 (en) * 2011-07-28 2015-02-10 Lipocine Inc. 17-hydroxyprogesterone ester-containing oral compositions and related methods
WO2014136494A1 (ja) * 2013-03-08 2014-09-12 富士フイルム株式会社 腸溶性細粒及び医薬組成物
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
US10758489B2 (en) * 2018-04-12 2020-09-01 Bpsi Holdings Llc Acidifying coatings and disintegration-resistant substrates coated therewith
IL293653B1 (en) * 2019-12-11 2026-01-01 Evonik Operations Gmbh A dosage form for use in therapy comprising a core, an intermediate layer, and an enteric coating in a defined ratio

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57171428A (en) * 1981-04-13 1982-10-22 Sankyo Co Ltd Preparation of coated solid preparation
JPS584730A (ja) * 1981-06-29 1983-01-11 Shin Etsu Chem Co Ltd 腸溶性コ−テイング組成物およびその製造方法
GB2189698A (en) * 1986-04-30 1987-11-04 Haessle Ab Coated omeprazole tablets
DE3822095A1 (de) * 1988-06-30 1990-01-04 Klinge Co Chem Pharm Fab Neue arzneimittelformulierung sowie verfahren zu deren herstellung
IT1230576B (it) * 1988-10-20 1991-10-28 Angeli Inst Spa Formulazioni farmaceutiche per via orale a liberazione selettiva nel colon
US5225202A (en) * 1991-09-30 1993-07-06 E. R. Squibb & Sons, Inc. Enteric coated pharmaceutical compositions
AU4513393A (en) * 1992-07-17 1994-02-14 Astra Aktiebolag Pharmaceutical composition containing antiulcer agent
JPH0733659A (ja) * 1992-07-17 1995-02-03 Yoshitomi Pharmaceut Ind Ltd 抗潰瘍剤含有製剤
SE9302395D0 (sv) * 1993-07-09 1993-07-09 Ab Astra New pharmaceutical formulation

Also Published As

Publication number Publication date
AU3438897A (en) 1998-01-21
DE19626045C2 (de) 1998-12-03
WO1998000114A2 (de) 1998-01-08
ES2205243T3 (es) 2004-05-01
CA2258918A1 (en) 1998-01-08
ZA975827B (en) 1998-01-30
ATE247457T1 (de) 2003-09-15
WO1998000114A3 (de) 1998-02-26
DE19626045A1 (de) 1998-01-08
JP2000514051A (ja) 2000-10-24
AU3345197A (en) 1998-01-21
ZA975828B (en) 1998-01-30
CA2258918C (en) 2005-11-22
EP0934058B1 (de) 2003-08-20
PT934058E (pt) 2004-01-30
WO1998000115A3 (de) 1998-02-26
DE59710629D1 (de) 2003-09-25
DK0934058T3 (da) 2003-12-01
EP0934058A2 (de) 1999-08-11
WO1998000115A2 (de) 1998-01-08

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