AU3438897A - Stable drug form for oral administration and process for the preparation thereof - Google Patents

Stable drug form for oral administration and process for the preparation thereof

Info

Publication number
AU3438897A
AU3438897A AU34388/97A AU3438897A AU3438897A AU 3438897 A AU3438897 A AU 3438897A AU 34388/97 A AU34388/97 A AU 34388/97A AU 3438897 A AU3438897 A AU 3438897A AU 3438897 A AU3438897 A AU 3438897A
Authority
AU
Australia
Prior art keywords
drug form
stable drug
preparation
oral administration
resistant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU34388/97A
Inventor
Gerd-Ulfert Heese
Herbert Junger
Arnim Laicher
Claudio Lorck
Thomas Profitlich
Gerd Weiss
Peter Wolfegg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Deutschland GmbH
Original Assignee
Klinge Pharma GmbH and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Klinge Pharma GmbH and Co filed Critical Klinge Pharma GmbH and Co
Publication of AU3438897A publication Critical patent/AU3438897A/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The invention relates to a stable drug form which is for oral administration and comprises: (a) a core comprising one or more active ingredients which are not to be released until after they have passed through the stomach, together with conventional pharmaceutical adjuvants, (b) an intermediate layer applied to the core, and (c) an external layer which is resistant to gastric juice. The intermediate layer in (b) is in the form of a reactive layer comprising a polymeric layered material which is partly neutralised with alkalis, is resistant to gastric juice and has cation-exchanger capacity. A process for the preparation of the stable drug form is also disclosed.
AU34388/97A 1996-06-28 1997-06-27 Stable drug form for oral administration and process for the preparation thereof Abandoned AU3438897A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19626045 1996-06-28
DE19626045A DE19626045C2 (en) 1996-06-28 1996-06-28 A stable dosage form for oral administration containing omeprazole as the active ingredient and methods of making the same
PCT/EP1997/003388 WO1998000115A2 (en) 1996-06-28 1997-06-27 Stable drug form for oral administration and process for the preparation thereof

Publications (1)

Publication Number Publication Date
AU3438897A true AU3438897A (en) 1998-01-21

Family

ID=7798347

Family Applications (2)

Application Number Title Priority Date Filing Date
AU34388/97A Abandoned AU3438897A (en) 1996-06-28 1997-06-27 Stable drug form for oral administration and process for the preparation thereof
AU33451/97A Abandoned AU3345197A (en) 1996-06-28 1997-06-27 Stable drug form for oral administration with benzimidazole derivatives as active ingredient and process for the preparation thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU33451/97A Abandoned AU3345197A (en) 1996-06-28 1997-06-27 Stable drug form for oral administration with benzimidazole derivatives as active ingredient and process for the preparation thereof

Country Status (11)

Country Link
EP (1) EP0934058B1 (en)
JP (1) JP4641075B2 (en)
AT (1) ATE247457T1 (en)
AU (2) AU3438897A (en)
CA (1) CA2258918C (en)
DE (2) DE19626045C2 (en)
DK (1) DK0934058T3 (en)
ES (1) ES2205243T3 (en)
PT (1) PT934058E (en)
WO (2) WO1998000115A2 (en)
ZA (2) ZA975828B (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
SE9704869D0 (en) * 1997-12-22 1997-12-22 Astra Ab New pharmaceutical formulaton II
UA73092C2 (en) 1998-07-17 2005-06-15 Брістол-Майерс Сквібб Компані Tablets with enteric coating and method for their manufacture
US7041313B1 (en) 1998-08-12 2006-05-09 Altana Pharma Ag Oral administration form for pyridin-2-ylmethylsulfinyl-1H-benzimidazoles
DE19845358A1 (en) * 1998-10-02 2000-04-06 Roehm Gmbh Coated drug forms with controlled drug delivery
IL130602A0 (en) 1999-06-22 2000-06-01 Dexcel Ltd Stable benzimidazole formulation
US6420473B1 (en) * 2000-02-10 2002-07-16 Bpsi Holdings, Inc. Acrylic enteric coating compositions
AR030557A1 (en) 2000-04-14 2003-08-27 Jagotec Ag A TABLET IN MULTI-MAP OF CONTROLLED RELEASE AND TREATMENT METHOD
US7316819B2 (en) * 2001-03-08 2008-01-08 Unigene Laboratories, Inc. Oral peptide pharmaceutical dosage form and method of production
KR100479637B1 (en) * 2002-02-01 2005-03-31 한국화학연구원 Oral dosage form comprising Lansoprazole and preparation method for the same
DE10235475B4 (en) * 2002-08-02 2006-04-27 Ratiopharm Gmbh Medicaments containing a benzimidazole compound in admixture with microcrystalline cellulose and process for their preparation
BR0313173A (en) 2002-08-02 2007-07-17 Ratiopharm Gmbh pharmaceutical preparation containing a microcrystalline cellulose mixed benzimidazole compound, method for its preparation as well as use of said microcrystalline cellulose
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
AR045068A1 (en) * 2003-07-23 2005-10-12 Univ Missouri FORMULATION OF IMMEDIATE RELEASE OF PHARMACEUTICAL COMPOSITIONS
AU2004259006B2 (en) * 2003-07-24 2010-10-07 Glaxosmithkline Llc Orally dissolving films
US20070141137A1 (en) * 2004-03-04 2007-06-21 Naoki Nagahara Stable capsule preparation
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
AU2006213439A1 (en) * 2005-01-03 2006-08-17 Lupin Limited Pharmaceutical composition of acid labile substances
DE102005032806A1 (en) * 2005-07-12 2007-01-18 Röhm Gmbh Use of a partially neutralized, anionic (meth) acrylate copolymer as a coating for the preparation of a dosage form with a release of active ingredient at reduced pH values
DE102006006532B4 (en) 2006-02-10 2007-11-08 Biogenerics Pharma Gmbh Pharmaceutical preparation
BRPI0721654B8 (en) 2007-05-07 2022-07-05 Evonik Roehm Gmbh solid dosage forms comprising an enteric coating with accelerated drug release, their method of manufacture and use
DE102008056312A1 (en) 2008-11-07 2010-05-12 Biogenerics Pharma Gmbh Use of micro-tablets as food and feed additive
DE102010052847A1 (en) * 2010-11-29 2012-05-31 Temmler Werke Gmbh Process for the preparation of a PPI-containing pharmaceutical preparation
US8951996B2 (en) * 2011-07-28 2015-02-10 Lipocine Inc. 17-hydroxyprogesterone ester-containing oral compositions and related methods
JP5934835B2 (en) * 2013-03-08 2016-06-15 富士フイルム株式会社 Enteric granules and pharmaceutical compositions
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
EP3773513A4 (en) * 2018-04-12 2022-05-18 BPSI Holdings LLC Acidifying coatings and disintegration-resistant substrates coated therewith

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57171428A (en) * 1981-04-13 1982-10-22 Sankyo Co Ltd Preparation of coated solid preparation
JPS584730A (en) * 1981-06-29 1983-01-11 Shin Etsu Chem Co Ltd Enteric coating composition and its preparation
GB2189698A (en) * 1986-04-30 1987-11-04 Haessle Ab Coated omeprazole tablets
DE3822095A1 (en) * 1988-06-30 1990-01-04 Klinge Co Chem Pharm Fab NEW MEDICAMENT FORMULATION AND METHOD FOR THE PRODUCTION THEREOF
IT1230576B (en) * 1988-10-20 1991-10-28 Angeli Inst Spa ORAL PHARMACEUTICAL FORMULATIONS WITH SELECTIVE LIBERATION IN THE COLON
US5225202A (en) * 1991-09-30 1993-07-06 E. R. Squibb & Sons, Inc. Enteric coated pharmaceutical compositions
JPH0733659A (en) * 1992-07-17 1995-02-03 Yoshitomi Pharmaceut Ind Ltd Antiulcer agent-containing pharmaceutical preparation
WO1994002140A1 (en) * 1992-07-17 1994-02-03 Astra Aktiebolag Pharmaceutical composition containing antiulcer agent
SE9302395D0 (en) * 1993-07-09 1993-07-09 Ab Astra NEW PHARMACEUTICAL FORMULATION

Also Published As

Publication number Publication date
WO1998000115A3 (en) 1998-02-26
DE19626045C2 (en) 1998-12-03
DE59710629D1 (en) 2003-09-25
ZA975828B (en) 1998-01-30
ZA975827B (en) 1998-01-30
JP4641075B2 (en) 2011-03-02
EP0934058A2 (en) 1999-08-11
WO1998000114A3 (en) 1998-02-26
WO1998000114A2 (en) 1998-01-08
WO1998000115A2 (en) 1998-01-08
CA2258918A1 (en) 1998-01-08
CA2258918C (en) 2005-11-22
DE19626045A1 (en) 1998-01-08
AU3345197A (en) 1998-01-21
PT934058E (en) 2004-01-30
ATE247457T1 (en) 2003-09-15
EP0934058B1 (en) 2003-08-20
JP2000514051A (en) 2000-10-24
ES2205243T3 (en) 2004-05-01
DK0934058T3 (en) 2003-12-01

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