JP4630518B2 - アモナフィド塩 - Google Patents

アモナフィド塩 Download PDF

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Publication number
JP4630518B2
JP4630518B2 JP2002197809A JP2002197809A JP4630518B2 JP 4630518 B2 JP4630518 B2 JP 4630518B2 JP 2002197809 A JP2002197809 A JP 2002197809A JP 2002197809 A JP2002197809 A JP 2002197809A JP 4630518 B2 JP4630518 B2 JP 4630518B2
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JP
Japan
Prior art keywords
acid
sup
sub
amonafide
compound
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Expired - Fee Related
Application number
JP2002197809A
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English (en)
Japanese (ja)
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JP2003321452A (ja
Inventor
エム． アジャミ アルフレッド
オー． バーロウ デイビッド
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Antisoma Research Ltd
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Antisoma Research Ltd
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Publication date
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Publication of JP2003321452A publication Critical patent/JP2003321452A/ja
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Publication of JP4630518B2 publication Critical patent/JP4630518B2/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Lubricants (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
JP2002197809A 2002-04-22 2002-07-05 アモナフィド塩 Expired - Fee Related JP4630518B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/128,129 2002-04-22
US10/128,129 US6693198B2 (en) 2002-04-22 2002-04-22 Amonafide salts

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009197462A Division JP2010006831A (ja) 2002-04-22 2009-08-27 アモナフィド塩

Publications (2)

Publication Number Publication Date
JP2003321452A JP2003321452A (ja) 2003-11-11
JP4630518B2 true JP4630518B2 (ja) 2011-02-09

Family

ID=29248438

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002197809A Expired - Fee Related JP4630518B2 (ja) 2002-04-22 2002-07-05 アモナフィド塩
JP2009197462A Pending JP2010006831A (ja) 2002-04-22 2009-08-27 アモナフィド塩

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2009197462A Pending JP2010006831A (ja) 2002-04-22 2009-08-27 アモナフィド塩

Country Status (9)

Country Link
US (2) US6693198B2 (https=)
EP (1) EP1499595B1 (https=)
JP (2) JP4630518B2 (https=)
AT (1) ATE359273T1 (https=)
AU (1) AU2003221771B2 (https=)
CA (1) CA2482445A1 (https=)
DE (1) DE60313156T2 (https=)
ES (1) ES2287463T3 (https=)
WO (1) WO2003089415A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050239816A1 (en) * 2002-04-22 2005-10-27 Xanthus Life Sciences, Inc. Amonafide salts
US6693198B2 (en) 2002-04-22 2004-02-17 Xanthus Life Sciences, Inc. Amonafide salts
WO2004004716A1 (en) * 2002-07-08 2004-01-15 Chemgenex Pharmaceuticals Limited Naphthalimide synthesis including amonafide synthesis and pharmaceutical preparations thereof
AU2005209845A1 (en) * 2004-01-30 2005-08-18 Chemgenex Pharmaceuticals, Inc. Naphthalimide dosing by N-acetyl transferase genotyping
BRPI0510719A (pt) * 2004-05-05 2007-11-20 Unibioscreen Sa derivados de naftalimida, composição farmacêutica, uso e método de preparação dos mesmos
WO2005117893A2 (en) * 2004-06-04 2005-12-15 Chemgenex Pharmaceuticals, Inc. Methods of treating cellular proliferative disease using naphthalimide and parp-1 inhibitors
FR2898902B1 (fr) * 2006-03-24 2010-09-10 Oreal Colorants particuliers de type naphtalimide, composition tinctoriale comprenant au moins un tel colorant, procede de mise en oeuvre et utilisations
ES2338193B8 (es) * 2008-02-25 2011-07-19 Centro Atlantico Del Medicamento, S.A. Nuevas sales de amonafide.
NZ779754A (en) 2009-01-16 2023-04-28 Exelixis Inc Malate salt of n-(4-{ [6,7-bis(methyloxy)quinolin-4-yl] oxy} phenyl)-n’-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and crystalline forms thereof for the treatment of cancer
CN102718709A (zh) * 2011-03-30 2012-10-10 北京德众万全药物技术开发有限公司 一种制备氨萘非特的新方法
CN109490291B (zh) * 2018-11-20 2021-05-11 上海应用技术大学 基于吸电子基取代的1,8-萘酰亚胺类化合物作为氟离子的显色试剂的用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES459497A1 (es) * 1977-06-04 1978-04-16 Made Labor Sa Un metodo para la preparacion industrial de naftalimidas y sus derivados.
US4614820A (en) * 1983-04-01 1986-09-30 Warner-Lambert Co. 3,6-disubstituted-1,8-naphthalimides
US4499266A (en) * 1983-04-01 1985-02-12 Warner-Lambert Company 3,6-Dinitro-1,8-naphthalimides
US5183821A (en) 1983-09-19 1993-02-02 Laboratories Knoll, S.A. Method for treating leukemias using N-(2-dimethylaminoethyl)-3-amino-1,8-naphthalimide for treating leukemias and solid tumors
US4665071A (en) 1984-02-21 1987-05-12 Warner-Lambert Company 3,6-disubstituted-1,8-naphthalimides and methods for their production and use
DE3614414A1 (de) * 1986-04-29 1987-11-05 Knoll Ag Neue benzo(de)isochinolin-1,3-dione, ihre herstellung und verwendung
DE3635711A1 (de) * 1986-10-21 1988-04-28 Knoll Ag 5-nitrobenzo(de)isochinolin-1,3-dione, ihre herstellung und verwendung
DE3922771A1 (de) * 1989-07-11 1991-01-24 Knoll Ag Amonafide-salze
US5420137A (en) 1989-07-11 1995-05-30 Knoll Ag Amonafide salts
DE4106122A1 (de) * 1991-02-27 1992-09-03 Bayer Ag Neue naphthalimide, diese enthaltende toner und die verwendung der neuen naphthalimide als additive fuer toner
CN1330638A (zh) * 1998-11-25 2002-01-09 默克专利股份公司 取代的苯并[de]异哇啉－1,3－二酮
EP1274458B1 (en) 2000-04-12 2005-09-28 ChemGenex Pharmaceuticals, Inc. Compositions containing a naphthalmide and an antiproliferative agent
US6693198B2 (en) 2002-04-22 2004-02-17 Xanthus Life Sciences, Inc. Amonafide salts

Also Published As

Publication number Publication date
EP1499595B1 (en) 2007-04-11
JP2003321452A (ja) 2003-11-11
AU2003221771A1 (en) 2003-11-03
JP2010006831A (ja) 2010-01-14
ES2287463T3 (es) 2007-12-16
WO2003089415A1 (en) 2003-10-30
CA2482445A1 (en) 2003-10-30
US6693198B2 (en) 2004-02-17
AU2003221771B2 (en) 2007-02-15
DE60313156T2 (de) 2007-12-13
US20030203932A1 (en) 2003-10-30
US20040132763A1 (en) 2004-07-08
DE60313156D1 (de) 2007-05-24
US6989390B2 (en) 2006-01-24
ATE359273T1 (de) 2007-05-15
EP1499595A1 (en) 2005-01-26

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