JP4607875B2 - 生理活性分子間の結合を決定するための磁性粒子の使用 - Google Patents

生理活性分子間の結合を決定するための磁性粒子の使用 Download PDF

Info

Publication number
JP4607875B2
JP4607875B2 JP2006521713A JP2006521713A JP4607875B2 JP 4607875 B2 JP4607875 B2 JP 4607875B2 JP 2006521713 A JP2006521713 A JP 2006521713A JP 2006521713 A JP2006521713 A JP 2006521713A JP 4607875 B2 JP4607875 B2 JP 4607875B2
Authority
JP
Japan
Prior art keywords
magnetic
beads
bead
particles
bound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2006521713A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007500346A5 (enExample
JP2007500346A (ja
Inventor
メッノ ダヴリュ ジェイ プリンス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Philips NV
Original Assignee
Koninklijke Philips NV
Koninklijke Philips Electronics NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips NV, Koninklijke Philips Electronics NV filed Critical Koninklijke Philips NV
Publication of JP2007500346A publication Critical patent/JP2007500346A/ja
Publication of JP2007500346A5 publication Critical patent/JP2007500346A5/ja
Application granted granted Critical
Publication of JP4607875B2 publication Critical patent/JP4607875B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2006521713A 2003-07-30 2004-07-14 生理活性分子間の結合を決定するための磁性粒子の使用 Expired - Fee Related JP4607875B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03102352 2003-07-30
PCT/IB2004/051213 WO2005010527A1 (en) 2003-07-30 2004-07-14 Use of magnetic particles for determining binding between bioactive molecules

Publications (3)

Publication Number Publication Date
JP2007500346A JP2007500346A (ja) 2007-01-11
JP2007500346A5 JP2007500346A5 (enExample) 2007-08-30
JP4607875B2 true JP4607875B2 (ja) 2011-01-05

Family

ID=34089715

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006521713A Expired - Fee Related JP4607875B2 (ja) 2003-07-30 2004-07-14 生理活性分子間の結合を決定するための磁性粒子の使用

Country Status (6)

Country Link
US (1) US20060205093A1 (enExample)
EP (1) EP1651960A1 (enExample)
JP (1) JP4607875B2 (enExample)
KR (1) KR20060052889A (enExample)
CN (1) CN1829916B (enExample)
WO (1) WO2005010527A1 (enExample)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007538252A (ja) * 2004-05-18 2007-12-27 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 生体検知において信号対バックグランド比を向上する磁気的な回転
US9494581B2 (en) * 2004-08-24 2016-11-15 University Of Wyoming System and method for Raman spectroscopy assay using paramagnetic particles
JP2008543279A (ja) 2005-06-09 2008-12-04 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 磁気検出を伴った核酸の増幅
EP1801594A1 (en) * 2005-12-23 2007-06-27 Koninklijke Philips Electronics N.V. Sensing device and method for determination of the amount of target molecule in an analyte
EP2030019A2 (en) * 2006-06-02 2009-03-04 Koninklijke Philips Electronics N.V. Microelectronic sensor device with washing means
EP2044402B2 (en) * 2006-07-24 2016-11-30 Becton Dickinson and Company Apparatus and method for performing an assay using magnetic particles
RU2009109185A (ru) 2006-08-14 2010-09-27 Конинклейке Филипс Электроникс Н.В. (Nl) Мониторинг ферментативных процессов с использованием намагничиваемых или магнитных объектов в качестве меток
WO2008020380A1 (en) * 2006-08-15 2008-02-21 Koninklijke Philips Electronics N.V. Magnetic field generation device
EP2092309A2 (en) * 2006-10-27 2009-08-26 Ramot, at Tel Aviv University Ltd. Method and system for detecting a target within a population of molecules
US9589686B2 (en) 2006-11-16 2017-03-07 General Electric Company Apparatus for detecting contaminants in a liquid and a system for use thereof
US20100134286A1 (en) * 2008-12-01 2010-06-03 General Electric Company Radio frequency based sensors employing analyte recognition element
US9538657B2 (en) 2012-06-29 2017-01-03 General Electric Company Resonant sensor and an associated sensing method
US9658178B2 (en) 2012-09-28 2017-05-23 General Electric Company Sensor systems for measuring an interface level in a multi-phase fluid composition
US10914698B2 (en) 2006-11-16 2021-02-09 General Electric Company Sensing method and system
US9536122B2 (en) 2014-11-04 2017-01-03 General Electric Company Disposable multivariable sensing devices having radio frequency based sensors
EP2102664A2 (en) * 2006-12-12 2009-09-23 Koninklijke Philips Electronics N.V. A system for applying magnetic forces to a biosensor surface by mechanically moving at least one magnet
WO2009012372A1 (en) * 2007-07-18 2009-01-22 Advantageous Systems, Llc Methods and apparatuses for detecting analytes in biological fluid of an animal
EP2220496A1 (en) * 2007-12-07 2010-08-25 Koninklijke Philips Electronics N.V. Magnetic washing for biosensor
US20100277160A1 (en) * 2007-12-18 2010-11-04 Koninklijke Philips Electronics N.V. Magnetic sensor device
CN101903760A (zh) * 2007-12-20 2010-12-01 皇家飞利浦电子股份有限公司 磁性线圈在传感器装置中的定位
EP2073016A1 (en) * 2007-12-20 2009-06-24 Koninklijke Philips Electronics N.V. Magnetic label based detection
US8070928B2 (en) * 2007-12-31 2011-12-06 Intel Corporation Nanofabricated structures for electric field-assisted nucleic acid extraction
CN101971015A (zh) 2008-01-17 2011-02-09 加利福尼亚大学董事会 集成的磁场产生和检测平台
EP2240776B1 (en) * 2008-02-06 2014-12-24 Koninklijke Philips N.V. Magnetic bead actuation using feedback for ftir biosensor
US8053250B2 (en) * 2008-06-27 2011-11-08 Rex Chin-Yih Hong Method and system for suppressing bindings on magnetic particles
GB0815212D0 (en) * 2008-08-20 2008-09-24 Roar Particles Ltd Identification of sample components
US20110206560A1 (en) * 2008-10-31 2011-08-25 Koninklijke Philips Electronics N.V. Biosensor with multi-chamber cartridge
CN102216780A (zh) * 2008-11-19 2011-10-12 皇家飞利浦电子股份有限公司 用于致动磁性粒子的生物传感器系统
WO2011021142A1 (en) * 2009-08-19 2011-02-24 Koninklijke Philips Electronics N.V. Detection of different target components by cluster formation
DE102010013900B4 (de) * 2010-04-01 2013-01-03 Hochschule Für Angewandte Wissenschaften Fachhochschule Würzburg-Schweinfurt Verfahren zur Bildgebung mittels magnetischer Kleinstpartikel sowie Vorrichtung hierfür
US8542023B2 (en) 2010-11-09 2013-09-24 General Electric Company Highly selective chemical and biological sensors
US9518984B2 (en) * 2011-02-22 2016-12-13 Chrome Red Technologies, Llc Separation, washing and determination of analytes tagged with magnetic particles
US20140127713A1 (en) * 2011-06-28 2014-05-08 Femke Karina de Theije Means for the examination of body fluids
US9746452B2 (en) 2012-08-22 2017-08-29 General Electric Company Wireless system and method for measuring an operative condition of a machine
US10598650B2 (en) 2012-08-22 2020-03-24 General Electric Company System and method for measuring an operative condition of a machine
US10684268B2 (en) 2012-09-28 2020-06-16 Bl Technologies, Inc. Sensor systems for measuring an interface level in a multi-phase fluid composition
JP2016510872A (ja) * 2013-03-01 2016-04-11 スピノミックス エス．ア．Ｓｐｉｎｏｍｉｘ Ｓ．Ａ． 磁気粒子をベースとする分離および分析方法
CN105980581B (zh) 2013-12-12 2021-03-26 阿尔查技术有限公司 电容传感器及使用方法
WO2015086652A1 (en) 2013-12-12 2015-06-18 Altra Tech Limited A sample preparation method and apparatus
EP2883961B8 (en) * 2013-12-12 2017-09-27 Altratech Limited A nucleic acid analysis method and apparatus
AU2015310976B2 (en) * 2014-09-07 2020-09-24 Selexis S.A. Microfluidic methods and cartridges for cell separation
CN109804235B (zh) * 2016-11-30 2022-05-13 国立研究开发法人产业技术综合研究所 目标物质检测装置及目标物质检测方法
CN107356758B (zh) * 2017-08-25 2019-11-22 李红俊 一种肺癌检测试剂盒及其使用方法
EP4219751A1 (en) 2017-09-20 2023-08-02 Altratech Limited Diagnostic device and system
JP7158015B2 (ja) * 2017-11-09 2022-10-21 国立研究開発法人産業技術総合研究所 ポリペプチドの凝集化抑制方法
CN108192007A (zh) * 2017-12-28 2018-06-22 苏州英芮诚生化科技有限公司 一种羧基官能化的聚氨酯包覆磁性微球及其制备方法
CN111693691B (zh) * 2019-03-14 2023-09-05 天津华科泰生物技术有限公司 一种基于卟啉结构的聚合物标签
FR3100338B1 (fr) * 2019-08-30 2022-09-02 Centre Nat Rech Scient Kit et méthode de capture d’une molécule
JP2021115493A (ja) * 2020-01-22 2021-08-10 株式会社島津製作所 磁性体粒子の操作方法
AU2021232687B2 (en) * 2020-05-25 2023-11-23 Quantum Ip Holdings Pty Limited Use of magnetic nanoparticles for the detection and quantitation of analyte(S)
CN114088680B (zh) * 2021-10-14 2023-06-27 安徽中科赛飞尔科技有限公司 一种染发样品中痕量毒品的快速检测方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU530410B2 (en) * 1978-02-21 1983-07-14 Sintef Preparing aqueous emulsions
NO155316C (no) * 1982-04-23 1987-03-11 Sintef Fremgangsmaate for fremstilling av magnetiske polymerpartikler.
EP0242773B1 (de) * 1986-04-21 1990-08-22 Siemens Aktiengesellschaft Verfahren zur kontinuierlichen Separation magnetisierbarer Partikel und Einrichtung zu seiner Durchführung
CN1030139A (zh) * 1986-05-22 1989-01-04 尤尼利弗公司 一种新的免疫测定方法
DE69333569T2 (de) * 1992-03-20 2005-08-04 Abbott Laboratories, Abbott Park Magnetisch assistierte bindungsassays unter verwendung von magnetisch markierten bindungspartnern.
DE69332267D1 (de) 1992-03-20 2002-10-10 Abbott Lab Bestimmung von bindungsaffinität mittels magnetisch markierter bindungspartner
US5445971A (en) * 1992-03-20 1995-08-29 Abbott Laboratories Magnetically assisted binding assays using magnetically labeled binding members
DE19503664C2 (de) * 1995-01-27 1998-04-02 Schering Ag Magnetorelaxometrische Detektion von Analyten
US6984491B2 (en) * 1996-07-29 2006-01-10 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6060246A (en) * 1996-11-15 2000-05-09 Avi Biopharma, Inc. Reagent and method for isolation and detection of selected nucleic acid sequences
US6337215B1 (en) * 1997-12-01 2002-01-08 International Business Machines Corporation Magnetic particles having two antiparallel ferromagnetic layers and attached affinity recognition molecules
US6180418B1 (en) * 1998-01-20 2001-01-30 The United States Of America As Represented By The Secretary Of The Navy Force discrimination assay
US6086821A (en) * 1999-03-29 2000-07-11 The United States Of America As Represented By The Secretary Of The Navy Ultrasonic force differentiation assay
US20020001855A1 (en) * 2000-03-22 2002-01-03 Prentiss Mara G. Methods and apparatus for parallel magnetic biological analysis and manipulation
WO2002090565A2 (en) 2001-05-07 2002-11-14 Gamida Volcano Ltd. Magnetic beads and uses thereof

Also Published As

Publication number Publication date
CN1829916B (zh) 2010-09-29
CN1829916A (zh) 2006-09-06
WO2005010527A1 (en) 2005-02-03
EP1651960A1 (en) 2006-05-03
JP2007500346A (ja) 2007-01-11
KR20060052889A (ko) 2006-05-19
US20060205093A1 (en) 2006-09-14

Similar Documents

Publication Publication Date Title
JP4607875B2 (ja) 生理活性分子間の結合を決定するための磁性粒子の使用
US7214427B2 (en) Composite beads comprising magnetizable substance and electro-conductive substance
JP5311445B2 (ja) 高速かつ高感度バイオセンシング
EP2018537B1 (en) Rapid magnetic biosensor
Gijs Magnetic bead handling on-chip: new opportunities for analytical applications
US7015047B2 (en) Microdevices having a preferential axis of magnetization and uses thereof
US9863857B2 (en) Device and method for particle complex handling
CN101849044B (zh) 通过磁性组装形成的微型设备阵列
US9689842B2 (en) Method and device for biomolecule preparation and detection using magnetic array
US20100279887A1 (en) Nonlinear magnetophoretic separation of biological substances
Jun et al. Protein separation and identification using magnetic beads encoded with surface-enhanced Raman spectroscopy
US20080241964A1 (en) Material for improving sensitivity of magnetic sensor and method thereof
EP2208531A1 (en) Distribution of particles in capillary channel by application of magnetic field
EP1751534A1 (en) Magnetic rotation to improve signal-over-background in biosensing
CN101490528A (zh) 将可磁化对象磁吸引到传感器表面和磁排斥离开传感器表面
US20090309588A1 (en) System and methods for actuation on magnetoresistive sensors
WO2003046507A2 (en) Apparatus used in identification, sorting and collection methods using magnetic microspheres and magnetic microsphere kits
WO2009083856A2 (en) Concentrated unbound magnetic particle assay for biosensors
De Palma et al. Magnetic particles as labels in bioassays: interactions between a biotinylated gold substrate and streptavidin magnetic particles
WO2009081336A1 (en) Magnetic label based detection
WO2008091364A2 (en) Nanoparticles as tags for bioanalyte detection by nuclear magnetic resonance or electron spin resonance
Gijs Magnetic Beads in Microfluidic Systems–Towards New Analytical Applications
Hoshino Magnetic Separation in Integrated Micro-Analytical Systems
Elaissari et al. Latexes: Magnetic
Ferreira Magnetoresistive biochips

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070713

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20070713

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20091022

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100121

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100706

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100806

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20100909

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20101007

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20131015

Year of fee payment: 3

LAPS Cancellation because of no payment of annual fees