JP4607859B2 - 蛍光分析物と連動して作動するインビボ蛍光センサ、システム及び関連方法 - Google Patents
蛍光分析物と連動して作動するインビボ蛍光センサ、システム及び関連方法 Download PDFInfo
- Publication number
- JP4607859B2 JP4607859B2 JP2006503890A JP2006503890A JP4607859B2 JP 4607859 B2 JP4607859 B2 JP 4607859B2 JP 2006503890 A JP2006503890 A JP 2006503890A JP 2006503890 A JP2006503890 A JP 2006503890A JP 4607859 B2 JP4607859 B2 JP 4607859B2
- Authority
- JP
- Japan
- Prior art keywords
- sensor
- fluorescence
- analyte
- fluorescent
- excitation light
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000012491 analyte Substances 0.000 title claims description 106
- 238000001727 in vivo Methods 0.000 title claims description 71
- 238000000034 method Methods 0.000 title claims description 52
- 230000005284 excitation Effects 0.000 claims description 80
- 206010028980 Neoplasm Diseases 0.000 claims description 75
- 210000004027 cell Anatomy 0.000 claims description 49
- 238000011282 treatment Methods 0.000 claims description 48
- 238000012544 monitoring process Methods 0.000 claims description 46
- 230000004044 response Effects 0.000 claims description 44
- 238000004590 computer program Methods 0.000 claims description 27
- 230000000694 effects Effects 0.000 claims description 24
- 230000003287 optical effect Effects 0.000 claims description 23
- 230000001225 therapeutic effect Effects 0.000 claims description 23
- 238000002560 therapeutic procedure Methods 0.000 claims description 22
- 230000014509 gene expression Effects 0.000 claims description 21
- 108090000623 proteins and genes Proteins 0.000 claims description 19
- 239000002775 capsule Substances 0.000 claims description 18
- 238000001514 detection method Methods 0.000 claims description 17
- 102000004169 proteins and genes Human genes 0.000 claims description 16
- 238000001415 gene therapy Methods 0.000 claims description 14
- 230000003285 pharmacodynamic effect Effects 0.000 claims description 14
- 201000011510 cancer Diseases 0.000 claims description 10
- 230000001413 cellular effect Effects 0.000 claims description 9
- 239000011521 glass Substances 0.000 claims description 8
- 230000008859 change Effects 0.000 claims description 7
- 230000035945 sensitivity Effects 0.000 claims description 7
- 239000002131 composite material Substances 0.000 claims description 6
- 239000000693 micelle Substances 0.000 claims description 5
- 239000003053 toxin Substances 0.000 claims description 5
- 231100000765 toxin Toxicity 0.000 claims description 5
- 230000006798 recombination Effects 0.000 claims description 4
- 238000005215 recombination Methods 0.000 claims description 4
- 238000012790 confirmation Methods 0.000 claims description 3
- 230000004936 stimulating effect Effects 0.000 claims description 3
- 239000004593 Epoxy Substances 0.000 claims description 2
- 230000004071 biological effect Effects 0.000 claims description 2
- 210000002950 fibroblast Anatomy 0.000 claims description 2
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 230000009120 phenotypic response Effects 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 description 71
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 53
- 239000000523 sample Substances 0.000 description 36
- 238000005259 measurement Methods 0.000 description 31
- 239000003814 drug Substances 0.000 description 28
- 238000012360 testing method Methods 0.000 description 25
- 229940022353 herceptin Drugs 0.000 description 24
- 230000006870 function Effects 0.000 description 19
- 239000000427 antigen Substances 0.000 description 18
- 108091007433 antigens Proteins 0.000 description 18
- 102000036639 antigens Human genes 0.000 description 18
- 229940079593 drug Drugs 0.000 description 18
- 239000000126 substance Substances 0.000 description 17
- 238000006243 chemical reaction Methods 0.000 description 16
- 238000002474 experimental method Methods 0.000 description 16
- 238000012545 processing Methods 0.000 description 16
- 238000010586 diagram Methods 0.000 description 15
- 238000003860 storage Methods 0.000 description 15
- 150000001875 compounds Chemical class 0.000 description 14
- 230000000875 corresponding effect Effects 0.000 description 14
- 239000000835 fiber Substances 0.000 description 14
- 238000002372 labelling Methods 0.000 description 12
- 238000002347 injection Methods 0.000 description 11
- 239000007924 injection Substances 0.000 description 11
- 101500025419 Homo sapiens Epidermal growth factor Proteins 0.000 description 10
- 238000011156 evaluation Methods 0.000 description 10
- 229940116978 human epidermal growth factor Drugs 0.000 description 10
- GVUGOAYIVIDWIO-UFWWTJHBSA-N nepidermin Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C(C)C)C(C)C)C1=CC=C(O)C=C1 GVUGOAYIVIDWIO-UFWWTJHBSA-N 0.000 description 10
- 206010006187 Breast cancer Diseases 0.000 description 9
- 241001465754 Metazoa Species 0.000 description 9
- 230000005855 radiation Effects 0.000 description 9
- 241000699660 Mus musculus Species 0.000 description 8
- 238000000338 in vitro Methods 0.000 description 8
- 239000003068 molecular probe Substances 0.000 description 8
- 238000011580 nude mouse model Methods 0.000 description 8
- 230000036962 time dependent Effects 0.000 description 8
- 210000004881 tumor cell Anatomy 0.000 description 8
- 208000026310 Breast neoplasm Diseases 0.000 description 7
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 7
- 241000699670 Mus sp. Species 0.000 description 7
- 238000011319 anticancer therapy Methods 0.000 description 7
- 239000007850 fluorescent dye Substances 0.000 description 7
- 238000002513 implantation Methods 0.000 description 7
- 230000007774 longterm Effects 0.000 description 7
- 230000002503 metabolic effect Effects 0.000 description 7
- 229960004641 rituximab Drugs 0.000 description 7
- 229940124597 therapeutic agent Drugs 0.000 description 7
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 6
- 101150029707 ERBB2 gene Proteins 0.000 description 6
- 239000002246 antineoplastic agent Substances 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 241000700159 Rattus Species 0.000 description 5
- 230000009471 action Effects 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- 238000004364 calculation method Methods 0.000 description 5
- 238000000576 coating method Methods 0.000 description 5
- 238000004891 communication Methods 0.000 description 5
- 231100000433 cytotoxic Toxicity 0.000 description 5
- 230000001472 cytotoxic effect Effects 0.000 description 5
- 230000007423 decrease Effects 0.000 description 5
- 230000002349 favourable effect Effects 0.000 description 5
- 230000010354 integration Effects 0.000 description 5
- 238000011160 research Methods 0.000 description 5
- 210000002966 serum Anatomy 0.000 description 5
- 238000010186 staining Methods 0.000 description 5
- 210000003462 vein Anatomy 0.000 description 5
- RTQWWZBSTRGEAV-PKHIMPSTSA-N 2-[[(2s)-2-[bis(carboxymethyl)amino]-3-[4-(methylcarbamoylamino)phenyl]propyl]-[2-[bis(carboxymethyl)amino]propyl]amino]acetic acid Chemical compound CNC(=O)NC1=CC=C(C[C@@H](CN(CC(C)N(CC(O)=O)CC(O)=O)CC(O)=O)N(CC(O)=O)CC(O)=O)C=C1 RTQWWZBSTRGEAV-PKHIMPSTSA-N 0.000 description 4
- 239000012110 Alexa Fluor 594 Substances 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 description 4
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 description 4
- 230000004913 activation Effects 0.000 description 4
- 230000005540 biological transmission Effects 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 229960001001 ibritumomab tiuxetan Drugs 0.000 description 4
- 239000003550 marker Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 210000003205 muscle Anatomy 0.000 description 4
- 239000013307 optical fiber Substances 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- 108700012359 toxins Proteins 0.000 description 4
- 239000012114 Alexa Fluor 647 Substances 0.000 description 3
- 241000283707 Capra Species 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 108010043121 Green Fluorescent Proteins Proteins 0.000 description 3
- 102000004144 Green Fluorescent Proteins Human genes 0.000 description 3
- 206010025323 Lymphomas Diseases 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 230000006907 apoptotic process Effects 0.000 description 3
- 239000012620 biological material Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 description 3
- 210000000170 cell membrane Anatomy 0.000 description 3
- 229940044683 chemotherapy drug Drugs 0.000 description 3
- 230000007012 clinical effect Effects 0.000 description 3
- 238000002591 computed tomography Methods 0.000 description 3
- 238000013480 data collection Methods 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- -1 doxorubicin Chemical class 0.000 description 3
- 238000000295 emission spectrum Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 229940088598 enzyme Drugs 0.000 description 3
- 239000000262 estrogen Substances 0.000 description 3
- 229940011871 estrogen Drugs 0.000 description 3
- 239000005090 green fluorescent protein Substances 0.000 description 3
- 201000010536 head and neck cancer Diseases 0.000 description 3
- 208000014829 head and neck neoplasm Diseases 0.000 description 3
- 238000003384 imaging method Methods 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 210000004379 membrane Anatomy 0.000 description 3
- 239000002207 metabolite Substances 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 108020004707 nucleic acids Proteins 0.000 description 3
- 238000011002 quantification Methods 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- 230000003595 spectral effect Effects 0.000 description 3
- 238000004611 spectroscopical analysis Methods 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- 238000011287 therapeutic dose Methods 0.000 description 3
- VRBFTYUMFJWSJY-UHFFFAOYSA-N 28804-46-8 Chemical compound ClC1CC(C=C2)=CC=C2C(Cl)CC2=CC=C1C=C2 VRBFTYUMFJWSJY-UHFFFAOYSA-N 0.000 description 2
- 208000000461 Esophageal Neoplasms Diseases 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 206010030155 Oesophageal carcinoma Diseases 0.000 description 2
- 240000005578 Rivina humilis Species 0.000 description 2
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 description 2
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 2
- 208000021096 adenomatous colon polyp Diseases 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 229940124650 anti-cancer therapies Drugs 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 210000003719 b-lymphocyte Anatomy 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 201000008274 breast adenocarcinoma Diseases 0.000 description 2
- 230000033077 cellular process Effects 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 229960004679 doxorubicin Drugs 0.000 description 2
- 238000007877 drug screening Methods 0.000 description 2
- 230000009977 dual effect Effects 0.000 description 2
- 238000005538 encapsulation Methods 0.000 description 2
- 238000011846 endoscopic investigation Methods 0.000 description 2
- 201000004101 esophageal cancer Diseases 0.000 description 2
- 210000003722 extracellular fluid Anatomy 0.000 description 2
- 238000000799 fluorescence microscopy Methods 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 238000005286 illumination Methods 0.000 description 2
- 238000009169 immunotherapy Methods 0.000 description 2
- 239000007943 implant Substances 0.000 description 2
- 238000011065 in-situ storage Methods 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 238000012933 kinetic analysis Methods 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 230000004807 localization Effects 0.000 description 2
- 230000033001 locomotion Effects 0.000 description 2
- 210000002751 lymph Anatomy 0.000 description 2
- 230000003211 malignant effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 238000001000 micrograph Methods 0.000 description 2
- 229940126619 mouse monoclonal antibody Drugs 0.000 description 2
- 239000005445 natural material Substances 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- 229960005419 nitrogen Drugs 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 230000002688 persistence Effects 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 208000014081 polyp of colon Diseases 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 238000010791 quenching Methods 0.000 description 2
- 230000000171 quenching effect Effects 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000004797 therapeutic response Effects 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 102100026802 72 kDa type IV collagenase Human genes 0.000 description 1
- 101710151806 72 kDa type IV collagenase Proteins 0.000 description 1
- 102100035526 B melanoma antigen 1 Human genes 0.000 description 1
- 208000028564 B-cell non-Hodgkin lymphoma Diseases 0.000 description 1
- 206010005003 Bladder cancer Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 208000011691 Burkitt lymphomas Diseases 0.000 description 1
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 102000003952 Caspase 3 Human genes 0.000 description 1
- 108090000397 Caspase 3 Proteins 0.000 description 1
- 102000004225 Cathepsin B Human genes 0.000 description 1
- 108090000712 Cathepsin B Proteins 0.000 description 1
- 102000003908 Cathepsin D Human genes 0.000 description 1
- 108090000258 Cathepsin D Proteins 0.000 description 1
- 102000004171 Cathepsin K Human genes 0.000 description 1
- 108090000625 Cathepsin K Proteins 0.000 description 1
- 208000035984 Colonic Polyps Diseases 0.000 description 1
- 101800003838 Epidermal growth factor Proteins 0.000 description 1
- 102400001368 Epidermal growth factor Human genes 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 208000005422 Foreign-Body reaction Diseases 0.000 description 1
- 102100039717 G antigen 1 Human genes 0.000 description 1
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 description 1
- 101000874316 Homo sapiens B melanoma antigen 1 Proteins 0.000 description 1
- 101000886137 Homo sapiens G antigen 1 Proteins 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010020843 Hyperthermia Diseases 0.000 description 1
- 238000012404 In vitro experiment Methods 0.000 description 1
- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 description 1
- 208000008839 Kidney Neoplasms Diseases 0.000 description 1
- 206010051589 Large intestine polyp Diseases 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 206010038389 Renal cancer Diseases 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 108090000190 Thrombin Proteins 0.000 description 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 241000021375 Xenogenes Species 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 229940009456 adriamycin Drugs 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 229940100198 alkylating agent Drugs 0.000 description 1
- 239000002168 alkylating agent Substances 0.000 description 1
- 239000003098 androgen Substances 0.000 description 1
- 229940030486 androgens Drugs 0.000 description 1
- 239000002870 angiogenesis inducing agent Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000002280 anti-androgenic effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 229940046836 anti-estrogen Drugs 0.000 description 1
- 230000001833 anti-estrogenic effect Effects 0.000 description 1
- 230000003667 anti-reflective effect Effects 0.000 description 1
- 239000000051 antiandrogen Substances 0.000 description 1
- 229940030495 antiandrogen sex hormone and modulator of the genital system Drugs 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 238000009175 antibody therapy Methods 0.000 description 1
- 229940045719 antineoplastic alkylating agent nitrosoureas Drugs 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 230000001640 apoptogenic effect Effects 0.000 description 1
- 238000003782 apoptosis assay Methods 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000004323 axial length Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005250 beta ray Effects 0.000 description 1
- 230000002457 bidirectional effect Effects 0.000 description 1
- 239000000560 biocompatible material Substances 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 239000002981 blocking agent Substances 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000000746 body region Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 229940127093 camptothecin Drugs 0.000 description 1
- 239000003560 cancer drug Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000022131 cell cycle Effects 0.000 description 1
- 238000003570 cell viability assay Methods 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000004624 confocal microscopy Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000001461 cytolytic effect Effects 0.000 description 1
- 230000001085 cytostatic effect Effects 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000013500 data storage Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 239000003398 denaturant Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000007435 diagnostic evaluation Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 description 1
- 238000009509 drug development Methods 0.000 description 1
- 229940126534 drug product Drugs 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000013399 early diagnosis Methods 0.000 description 1
- 229940116977 epidermal growth factor Drugs 0.000 description 1
- 239000003822 epoxy resin Substances 0.000 description 1
- 239000000328 estrogen antagonist Substances 0.000 description 1
- 239000010408 film Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000010304 firing Methods 0.000 description 1
- 238000009093 first-line therapy Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000001506 fluorescence spectroscopy Methods 0.000 description 1
- 238000002189 fluorescence spectrum Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 description 1
- 229940035638 gonadotropin-releasing hormone Drugs 0.000 description 1
- 230000036433 growing body Effects 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 239000003667 hormone antagonist Substances 0.000 description 1
- 150000004678 hydrides Chemical class 0.000 description 1
- 230000036031 hyperthermia Effects 0.000 description 1
- 239000002955 immunomodulating agent Substances 0.000 description 1
- 229940121354 immunomodulator Drugs 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000099 in vitro assay Methods 0.000 description 1
- 238000011337 individualized treatment Methods 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000013383 initial experiment Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000002601 intratumoral effect Effects 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 229960003299 ketamine Drugs 0.000 description 1
- 201000010982 kidney cancer Diseases 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 238000002595 magnetic resonance imaging Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000011326 mechanical measurement Methods 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 238000012634 optical imaging Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 210000003463 organelle Anatomy 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229920000647 polyepoxide Polymers 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000005522 programmed cell death Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 238000011363 radioimmunotherapy Methods 0.000 description 1
- 239000000985 reactive dye Substances 0.000 description 1
- 238000010223 real-time analysis Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000001055 reflectance spectroscopy Methods 0.000 description 1
- 208000037922 refractory disease Diseases 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229960001603 tamoxifen Drugs 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 108091005703 transmembrane proteins Proteins 0.000 description 1
- 102000035160 transmembrane proteins Human genes 0.000 description 1
- 229960000575 trastuzumab Drugs 0.000 description 1
- 230000005909 tumor killing Effects 0.000 description 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
- 229960001600 xylazine Drugs 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
- A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
- A61B5/417—Evaluating particular organs or parts of the immune or lymphatic systems the bone marrow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0058—Antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44834903P | 2003-02-19 | 2003-02-19 | |
| US47170603P | 2003-05-19 | 2003-05-19 | |
| PCT/US2004/005785 WO2004075032A2 (en) | 2003-02-19 | 2004-02-17 | In vivo fluorescence sensors, systems, and related methods operating in conjunction with fluorescent analytes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006520216A JP2006520216A (ja) | 2006-09-07 |
| JP2006520216A5 JP2006520216A5 (enExample) | 2007-04-05 |
| JP4607859B2 true JP4607859B2 (ja) | 2011-01-05 |
Family
ID=32912293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006503890A Expired - Fee Related JP4607859B2 (ja) | 2003-02-19 | 2004-02-17 | 蛍光分析物と連動して作動するインビボ蛍光センサ、システム及び関連方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US7510699B2 (enExample) |
| EP (1) | EP1594551A2 (enExample) |
| JP (1) | JP4607859B2 (enExample) |
| AU (1) | AU2004214420A1 (enExample) |
| CA (1) | CA2516497A1 (enExample) |
| WO (1) | WO2004075032A2 (enExample) |
Families Citing this family (121)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8263375B2 (en) | 2002-12-20 | 2012-09-11 | Acea Biosciences | Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology |
| US10551371B2 (en) | 2003-11-10 | 2020-02-04 | Acea Biosciences, Inc. | System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function |
| US11346797B2 (en) | 2002-12-20 | 2022-05-31 | Agilent Technologies, Inc. | System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties |
| US10539523B2 (en) | 2002-12-20 | 2020-01-21 | Acea Biosciences, Inc. | System and method for monitoring cardiomyocyte beating, viability, morphology, and electrophysiological properties |
| US10215748B2 (en) | 2002-12-20 | 2019-02-26 | Acea Biosciences, Inc. | Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways |
| CA2550274A1 (en) | 2003-11-12 | 2005-05-26 | Acea Biosciences, Inc. | Real time electronic cell sensing systems and applications for cell-based assays |
| US9011329B2 (en) * | 2004-04-19 | 2015-04-21 | Searete Llc | Lumenally-active device |
| US8512219B2 (en) | 2004-04-19 | 2013-08-20 | The Invention Science Fund I, Llc | Bioelectromagnetic interface system |
| US8353896B2 (en) * | 2004-04-19 | 2013-01-15 | The Invention Science Fund I, Llc | Controllable release nasal system |
| US8024036B2 (en) | 2007-03-19 | 2011-09-20 | The Invention Science Fund I, Llc | Lumen-traveling biological interface device and method of use |
| US7375347B2 (en) * | 2004-04-26 | 2008-05-20 | Sensors For Medicine And Science, Inc. | Systems and methods for extending the useful life of optical sensors |
| JP4619803B2 (ja) * | 2005-01-26 | 2011-01-26 | 富士フイルム株式会社 | 蛍光断層画像取得装置 |
| US8912908B2 (en) | 2005-04-28 | 2014-12-16 | Proteus Digital Health, Inc. | Communication system with remote activation |
| US8802183B2 (en) | 2005-04-28 | 2014-08-12 | Proteus Digital Health, Inc. | Communication system with enhanced partial power source and method of manufacturing same |
| EP2671508B1 (en) | 2005-04-28 | 2020-09-16 | Proteus Digital Health, Inc. | Pharma-informatics system |
| WO2006124648A2 (en) * | 2005-05-13 | 2006-11-23 | The University Of North Carolina At Chapel Hill | Capsule imaging devices, systems and methods for in vivo imaging applications |
| US7485875B2 (en) * | 2005-07-22 | 2009-02-03 | Carl Zeiss Microimaging Gmbh | Resolution-enhanced luminescence microscopy |
| MX2008002201A (es) * | 2005-08-16 | 2008-10-21 | Skin Cancer Scanning Ltd | Tecnologias infrarrojas pasivas y visuales-opticas combinadas y el sistema correspondiente para la deteccion e identificacion de precursores de cancer de piel, lunares y tumores para el diagnostico temprano. |
| DE102005041054A1 (de) * | 2005-08-30 | 2007-03-01 | Giesecke & Devrient Gmbh | Verfahren und Vorrichtung zur Echtheitsprüfung von Banknoten |
| EP1956966A2 (en) * | 2005-11-25 | 2008-08-20 | Philips Intellectual Property & Standards GmbH | Optical fluorescence tomography |
| US8095198B2 (en) * | 2006-01-31 | 2012-01-10 | Warsaw Orthopedic. Inc. | Methods for detecting osteolytic conditions in the body |
| US7918796B2 (en) | 2006-04-11 | 2011-04-05 | Warsaw Orthopedic, Inc. | Volumetric measurement and visual feedback of tissues |
| US20120035438A1 (en) | 2006-04-12 | 2012-02-09 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Path selection by a lumen traveling device in a body tub tree based on previous path |
| US20080058786A1 (en) * | 2006-04-12 | 2008-03-06 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Autofluorescent imaging and target ablation |
| US8180436B2 (en) * | 2006-04-12 | 2012-05-15 | The Invention Science Fund I, Llc | Systems for autofluorescent imaging and target ablation |
| HRP20060149B1 (en) * | 2006-04-19 | 2008-11-30 | Institut "Ruđer Bošković" | Intelligent sequential illuminator photodynamic therapy |
| DE102006050886B4 (de) * | 2006-10-27 | 2016-12-22 | Siemens Healthcare Gmbh | Medizinisches Instrument und Einrichtung zur Erzeugung von Gewebeschnittbildern |
| WO2008066054A1 (en) * | 2006-11-28 | 2008-06-05 | Nippon Sheet Glass Company, Limited | Detection system and its probe |
| US8110816B2 (en) | 2007-02-28 | 2012-02-07 | Nippon Sheet Glass Company, Limited | Fluorescence detection system |
| US9270025B2 (en) | 2007-03-09 | 2016-02-23 | Proteus Digital Health, Inc. | In-body device having deployable antenna |
| EP2148702A2 (en) * | 2007-05-16 | 2010-02-03 | GE Healthcare AS | Pentamethine cyanine dyes carrying at least three sulfonic acid groups |
| JP2010526859A (ja) * | 2007-05-16 | 2010-08-05 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | ペプチドイメージング剤 |
| WO2009002866A1 (en) * | 2007-06-22 | 2008-12-31 | The Trustees Of The University Of Pennsylvania | Fluorescent labeling of transfer rna and study of protein synthesis |
| GB0712109D0 (en) * | 2007-06-22 | 2007-08-01 | Edinburgh Instr | Fluorescence lifetime and fluorescence assays |
| US20090018403A1 (en) | 2007-07-12 | 2009-01-15 | Sicel Technologies, Inc. | Trackable implantable sensor devices, systems, and related methods of operation |
| EP2194847A1 (en) | 2007-09-14 | 2010-06-16 | Corventis, Inc. | Adherent device with multiple physiological sensors |
| WO2009036348A1 (en) | 2007-09-14 | 2009-03-19 | Corventis, Inc. | Medical device automatic start-up upon contact to patient tissue |
| WO2009036306A1 (en) | 2007-09-14 | 2009-03-19 | Corventis, Inc. | Adherent cardiac monitor with advanced sensing capabilities |
| WO2009036316A1 (en) | 2007-09-14 | 2009-03-19 | Corventis, Inc. | Energy management, tracking and security for adherent patient monitor |
| US8374688B2 (en) | 2007-09-14 | 2013-02-12 | Corventis, Inc. | System and methods for wireless body fluid monitoring |
| US8684925B2 (en) | 2007-09-14 | 2014-04-01 | Corventis, Inc. | Injectable device for physiological monitoring |
| US8275432B2 (en) * | 2007-12-12 | 2012-09-25 | Medtronic, Inc. | Implantable optical sensor and method for manufacture |
| US8529441B2 (en) | 2008-02-12 | 2013-09-10 | Innurvation, Inc. | Ingestible endoscopic optical scanning device |
| WO2009102445A2 (en) * | 2008-02-12 | 2009-08-20 | Innurvation, Inc. | Radial scanner imaging system |
| JP5405500B2 (ja) | 2008-03-12 | 2014-02-05 | コーヴェンティス，インク． | 心調律に基づく心代償不全予測 |
| US8412317B2 (en) | 2008-04-18 | 2013-04-02 | Corventis, Inc. | Method and apparatus to measure bioelectric impedance of patient tissue |
| CA2723223C (en) | 2008-05-05 | 2017-06-06 | Acea Biosciences, Inc. | Label-free monitoring of excitation-contraction coupling and excitable cells using impedance based systems with millisecond time resolution |
| CA2724973C (en) | 2008-05-20 | 2015-08-11 | University Health Network | Device and method for fluorescence-based imaging and monitoring |
| US8540633B2 (en) | 2008-08-13 | 2013-09-24 | Proteus Digital Health, Inc. | Identifier circuits for generating unique identifiable indicators and techniques for producing same |
| DK2317911T3 (en) * | 2008-08-22 | 2019-01-28 | Medibeacon Inc | TRANSCUTAN ORGAN FUNCTION MEASUREMENT |
| US8540664B2 (en) * | 2009-03-25 | 2013-09-24 | Proteus Digital Health, Inc. | Probablistic pharmacokinetic and pharmacodynamic modeling |
| SG10201810784SA (en) | 2009-04-28 | 2018-12-28 | Proteus Digital Health Inc | Highly Reliable Ingestible Event Markers And Methods For Using The Same |
| CA2760783C (en) * | 2009-05-05 | 2018-06-19 | Lumito Ab | A system, method, and luminescent marker for improved diffuse luminescent imaging or tomography in scattering media |
| US20110071403A1 (en) * | 2009-09-21 | 2011-03-24 | Board Of Regents Of The University Of Texas System | Functional near-infrared fluorescence lymphatic mapping for diagnosing, accessing, monitoring and directing therapy of lymphatic disorders |
| CN102549445B (zh) | 2009-09-28 | 2015-04-08 | 皇家飞利浦电子股份有限公司 | 用于单个颗粒检测的生物传感器系统 |
| JP2011131002A (ja) * | 2009-12-25 | 2011-07-07 | Fujifilm Corp | 蛍光画像撮像装置 |
| WO2011082314A2 (en) * | 2009-12-30 | 2011-07-07 | Brockman Holdings Llc | System, device, and method for determination of intraocular pressure |
| WO2011093914A1 (en) * | 2010-01-29 | 2011-08-04 | Medtronic, Inc. | Optical sensor for medical device |
| MX2012011693A (es) | 2010-04-07 | 2013-02-15 | Proteus Digital Health Inc | Dispositivo ingerible miniatura. |
| CA2803827C (en) | 2010-07-07 | 2014-04-08 | University Health Network | Fiber optic radiochromic dosimeter probe and method to make the same |
| WO2012071280A2 (en) | 2010-11-22 | 2012-05-31 | Proteus Biomedical, Inc. | Ingestible device with pharmaceutical product |
| JP5139602B2 (ja) * | 2010-12-13 | 2013-02-06 | オリンパスメディカルシステムズ株式会社 | 医療装置 |
| WO2012120004A1 (en) * | 2011-03-07 | 2012-09-13 | F. Hoffmann-La Roche Ag | In vivo selection of therapeutically active antibodies |
| US9756874B2 (en) | 2011-07-11 | 2017-09-12 | Proteus Digital Health, Inc. | Masticable ingestible product and communication system therefor |
| WO2015112603A1 (en) | 2014-01-21 | 2015-07-30 | Proteus Digital Health, Inc. | Masticable ingestible product and communication system therefor |
| EP2806784A1 (en) * | 2012-01-24 | 2014-12-03 | Niedre, Mark | Systems and methods for sensing, enumerating and imaging rare cells with diffuse light |
| WO2013177539A1 (en) | 2012-05-24 | 2013-11-28 | University Of Utah Research Foundation | Compounds, sensors, methods, and systems for detecting gamma radiation |
| KR20150038038A (ko) | 2012-07-23 | 2015-04-08 | 프로테우스 디지털 헬스, 인코포레이티드 | 섭취 가능한 부품을 포함하는 섭취 가능한 이벤트 마커를 제조하기 위한 기술 |
| DK2910013T3 (en) | 2012-10-18 | 2018-08-06 | Proteus Digital Health Inc | Apparatus, system and method for adaptive optimization for power output and transmit power in a power source for a communication device |
| JP5712337B2 (ja) | 2012-12-27 | 2015-05-07 | パナソニック株式会社 | 被検物質を検出する方法、および、検出システム |
| TWI659994B (zh) | 2013-01-29 | 2019-05-21 | 美商普羅托斯數位健康公司 | 高度可膨脹之聚合型薄膜及包含彼之組成物 |
| WO2014144738A1 (en) | 2013-03-15 | 2014-09-18 | Proteus Digital Health, Inc. | Metal detector apparatus, system, and method |
| US9796576B2 (en) | 2013-08-30 | 2017-10-24 | Proteus Digital Health, Inc. | Container with electronically controlled interlock |
| US10084880B2 (en) | 2013-11-04 | 2018-09-25 | Proteus Digital Health, Inc. | Social media networking based on physiologic information |
| DE102013226777B4 (de) * | 2013-12-19 | 2023-01-12 | Sirona Dental Systems Gmbh | Beobachtungseinheit zur Erkennung von Fluoreszenz und eine Vorrichtung zur Erkennung von Karies |
| WO2016011534A1 (en) | 2014-07-24 | 2016-01-28 | University Health Network | Collection and analysis of data for diagnostic purposes |
| WO2016149701A1 (en) * | 2015-03-19 | 2016-09-22 | The Regents Of The University Of Michigan | System for analyzing tissue |
| JP6467275B2 (ja) * | 2015-04-13 | 2019-02-06 | 富士フイルム株式会社 | 内視鏡用光源装置及び内視鏡システム |
| CN104970806B (zh) * | 2015-07-12 | 2017-08-04 | 北京泱深生物信息技术有限公司 | 一种用于癌症复发实时动态监测的智能设备 |
| US11051543B2 (en) | 2015-07-21 | 2021-07-06 | Otsuka Pharmaceutical Co. Ltd. | Alginate on adhesive bilayer laminate film |
| US10579891B2 (en) * | 2015-08-10 | 2020-03-03 | AI Biomed Corp | Optical overlay device |
| HK1258798A1 (zh) * | 2015-11-20 | 2019-11-22 | 安捷伦科技有限公司 | 癌细胞的细胞基质阻抗监测 |
| US12066428B2 (en) | 2015-11-20 | 2024-08-20 | Agilent Technologies, Inc. | Cell-substrate impedance monitoring of cancer cells |
| CN109843149B (zh) | 2016-07-22 | 2020-07-07 | 普罗秋斯数字健康公司 | 可摄入事件标记的电磁感测和检测 |
| KR102605670B1 (ko) | 2016-10-26 | 2023-11-24 | 오츠카 세이야쿠 가부시키가이샤 | 섭취 가능한 이벤트 마커를 갖는 캡슐을 제조하는 방법 |
| SG11201906938WA (en) | 2017-01-30 | 2019-08-27 | Medibeacon Inc | Method for non-invasive monitoring of fluorescent tracer agent with diffuse reflection corrections |
| EP3589299B1 (en) | 2017-03-03 | 2025-04-09 | Agilent Technologies, Inc. | METHODS AND SYSTEMS FOR FUNCTIONAL MATURATION OF iPSC AND ESC DERIVED CARDIOMYOCYTES |
| US11013436B2 (en) | 2017-09-06 | 2021-05-25 | Medtronic, Inc. | Marker monitoring via a medical device |
| EP3684463B1 (en) | 2017-09-19 | 2025-05-14 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement |
| US11717686B2 (en) | 2017-12-04 | 2023-08-08 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to facilitate learning and performance |
| US11318277B2 (en) | 2017-12-31 | 2022-05-03 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to enhance emotional response |
| US12280219B2 (en) | 2017-12-31 | 2025-04-22 | NeuroLight, Inc. | Method and apparatus for neuroenhancement to enhance emotional response |
| US11364361B2 (en) | 2018-04-20 | 2022-06-21 | Neuroenhancement Lab, LLC | System and method for inducing sleep by transplanting mental states |
| US11452839B2 (en) | 2018-09-14 | 2022-09-27 | Neuroenhancement Lab, LLC | System and method of improving sleep |
| CN113164386A (zh) * | 2018-11-21 | 2021-07-23 | 亮点医疗有限责任公司 | 纳米复合聚(i:c)制剂及其用途 |
| US11656369B2 (en) | 2018-12-21 | 2023-05-23 | The Royal Institution For The Advancement Of Learning/Mcgill University | Radiation dosimeter |
| WO2020176906A1 (en) | 2019-02-26 | 2020-09-03 | Ai Biomed Corp. | Tissue detection system and methods for use thereof |
| US11786694B2 (en) | 2019-05-24 | 2023-10-17 | NeuroLight, Inc. | Device, method, and app for facilitating sleep |
| US11759166B2 (en) | 2019-09-20 | 2023-09-19 | Bard Access Systems, Inc. | Automatic vessel detection tools and methods |
| USD941488S1 (en) | 2020-02-07 | 2022-01-18 | Agilent Technologies, Inc. | Instrument for analyzing biological cells |
| US20210301245A1 (en) | 2020-03-29 | 2021-09-30 | Agilent Technologies, Inc. | Systems and methods for electronically and optically monitoring biological samples |
| WO2022055887A1 (en) | 2020-09-08 | 2022-03-17 | Bard Access Systems, Inc. | Dynamically adjusting ultrasound-imaging systems and methods thereof |
| CN114159098B (zh) | 2020-09-10 | 2026-01-02 | 巴德阿克塞斯系统股份有限公司 | 具有压力测量能力的超声探测器 |
| CN116249504B (zh) * | 2020-09-29 | 2025-11-28 | 奥林巴斯株式会社 | 辅助装置、内窥镜系统、辅助方法以及存储介质 |
| WO2022070007A1 (en) * | 2020-09-30 | 2022-04-07 | Jdrf Electromag Engineering Inc. | Autonomous light power density detectors |
| EP4247267A1 (en) * | 2020-11-24 | 2023-09-27 | Bard Access Systems, Inc. | Ultrasound system with target and medical instrument awareness |
| EP4251062A1 (en) | 2020-12-01 | 2023-10-04 | Bard Access Systems, Inc. | Ultrasound system with pressure and flow determination capability |
| US12048491B2 (en) | 2020-12-01 | 2024-07-30 | Bard Access Systems, Inc. | Ultrasound probe with target tracking capability |
| US12287403B2 (en) | 2021-04-15 | 2025-04-29 | Bard Access Systems, Inc. | Ultrasound imaging system having near-infrared/infrared detection |
| EP4362027A4 (en) * | 2021-06-25 | 2025-11-12 | Portrai Inc | EXPLORATION APPARATUS, SYSTEM AND COMPUTER PROGRAM FOR EXPLORING MOLECULAR MARKER OR PHYSIOLOGICAL ACTIVITY INFORMATION IN TISSUE RELATING TO A DISTRIBUTION OR PHYSIOLOGICAL ACTIVITY OF MATERIAL UNDER EXPLORATION |
| CN113633261A (zh) * | 2021-08-11 | 2021-11-12 | 南京航空航天大学 | 一种基于荧光监测的多通道在体药代分析系统 |
| US11974726B2 (en) | 2021-09-27 | 2024-05-07 | Ai Biomed Corp. | Tissue detection systems and methods |
| US12279758B2 (en) | 2021-09-27 | 2025-04-22 | Ai Biomed Corp. | Tissue detection systems and methods |
| CN116058873A (zh) | 2021-11-03 | 2023-05-05 | 巴德阿克塞斯系统股份有限公司 | 通过基于多普勒和图像的脉管区分的互操作优化功能 |
| US12514533B2 (en) | 2022-03-01 | 2026-01-06 | Bard Access Systems, Inc. | Ultrasound imaging system |
| US12514532B2 (en) | 2022-03-01 | 2026-01-06 | Bard Access Systems, Inc. | Ultrasound imaging system |
| EP4489661B1 (en) | 2022-03-16 | 2025-10-29 | Bard Access Systems, Inc. | Ultrasound imaging system |
| WO2024035903A1 (en) * | 2022-08-10 | 2024-02-15 | University Of Cincinnati | Biosensor system for drug efficacy monitoring |
| USD1051738S1 (en) | 2023-01-06 | 2024-11-19 | Medibeacon Inc. | Sensor ring |
| USD1052412S1 (en) | 2023-01-06 | 2024-11-26 | Medibeacon Inc. | Sensor |
| WO2025019535A1 (en) * | 2023-07-20 | 2025-01-23 | The Johns Hopkins University | Methods and related aspects of biosensors |
Family Cites Families (185)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US32361A (en) * | 1861-05-21 | Portable filter | ||
| US424453A (en) * | 1890-04-01 | William f | ||
| DE332075C (de) | 1919-08-19 | 1921-01-21 | Walther Lenke | Ellipsenzirkel |
| JPS36022343B1 (enExample) | 1959-12-24 | 1961-11-18 | Univ Tokyo | |
| US3638640A (en) | 1967-11-01 | 1972-02-01 | Robert F Shaw | Oximeter and method for in vivo determination of oxygen saturation in blood using three or more different wavelengths |
| US3980075A (en) * | 1973-02-08 | 1976-09-14 | Audronics, Inc. | Photoelectric physiological measuring apparatus |
| US3972320A (en) | 1974-08-12 | 1976-08-03 | Gabor Ujhelyi Kalman | Patient monitoring system |
| US4163380A (en) | 1977-10-11 | 1979-08-07 | Lockheed Corporation | Forming of preconsolidated metal matrix composites |
| USRE32361E (en) | 1979-05-14 | 1987-02-24 | Medtronic, Inc. | Implantable telemetry transmission system for analog and digital data |
| US4326535A (en) | 1980-05-13 | 1982-04-27 | Akron City Hospital | Circuit and method for the radiotelemetry of esophageal pH in an ECG radiotelemetry system |
| US4361153A (en) | 1980-05-27 | 1982-11-30 | Cordis Corporation | Implant telemetry system |
| US4494545A (en) | 1980-05-27 | 1985-01-22 | Cordis Corporation | Implant telemetry system |
| US4556063A (en) | 1980-10-07 | 1985-12-03 | Medtronic, Inc. | Telemetry system for a medical device |
| US4523279A (en) | 1980-11-24 | 1985-06-11 | Oximetrix, Inc. | Apparatus for determining oxygen saturation levels in blood |
| US4397313A (en) | 1981-08-03 | 1983-08-09 | Clini-Therm Corporation | Multiple microwave applicator system and method for microwave hyperthermia treatment |
| US4397314A (en) | 1981-08-03 | 1983-08-09 | Clini-Therm Corporation | Method and apparatus for controlling and optimizing the heating pattern for a hyperthermia system |
| US4416283A (en) | 1981-08-31 | 1983-11-22 | Cordis Corporation | Programming and telemetry system for biomedical implantable device |
| CA1188431A (en) | 1981-10-02 | 1985-06-04 | Canadian Astronautics Limited | Direct reading dosimeter |
| US4431004A (en) | 1981-10-27 | 1984-02-14 | Bessman Samuel P | Implantable glucose sensor |
| DE3150052C2 (de) * | 1981-12-17 | 1985-02-21 | Sterimed Gesellschaft für medizinischen Bedarf mbH, 6600 Saarbrücken | Katheter zur Katheterung zentraler Venen |
| US5186172A (en) | 1982-03-22 | 1993-02-16 | Mountpelier Investments, S.A. | Remote sensing tonometric catheter apparatus |
| DE3219558C2 (de) | 1982-05-25 | 1986-10-23 | Norbert H.L. Dr.-Ing. 5173 Aldenhoven Koster | Vorrichtung zur Bestimmung der lokalen Temperatur in lebendem Gewebe |
| US4571292A (en) | 1982-08-12 | 1986-02-18 | Case Western Reserve University | Apparatus for electrochemical measurements |
| CH658729A5 (de) | 1982-09-17 | 1986-11-28 | Lehner Max & Co Ag | Vorrichtung zur registrierung der strahlenbelastung von mit strahlung umgehenden personen. |
| US4571589A (en) | 1982-11-22 | 1986-02-18 | Cordis Corporation | Biomedical implant with high speed, low power two-way telemetry |
| DE3490016T1 (de) | 1983-01-21 | 1985-02-07 | Ramm Associates, Creve Coeur, Mo. | Implantierbare Hyperthermie-Einrichtung und -System |
| US4961422A (en) | 1983-01-21 | 1990-10-09 | Marchosky J Alexander | Method and apparatus for volumetric interstitial conductive hyperthermia |
| US4575676A (en) | 1983-04-04 | 1986-03-11 | Advanced Research And Applications Corporation | Method and apparatus for radiation testing of electron devices |
| GB2140563B (en) | 1983-04-27 | 1987-03-04 | Critikon Inc | Method and apparatus for zero calibration of oxygen-sensing polarographic devices |
| US4543953A (en) | 1983-07-18 | 1985-10-01 | Cordis Corporation | Analog telemetry system for biomedical implant |
| US4655880A (en) | 1983-08-01 | 1987-04-07 | Case Western Reserve University | Apparatus and method for sensing species, substances and substrates using oxidase |
| US4519401A (en) | 1983-09-20 | 1985-05-28 | Case Western Reserve University | Pressure telemetry implant |
| FI68734C (fi) | 1983-11-11 | 1985-10-10 | Seppo Saeynaejaekangas | Foerfarande och anordning foer telemetrisk maetning av hjaertslag och ekg-signal med anvaendande av ett magnetiskt naerfaelt |
| GB8422876D0 (en) | 1984-09-11 | 1984-10-17 | Secr Defence | Silicon implant devices |
| US4638436A (en) | 1984-09-24 | 1987-01-20 | Labthermics Technologies, Inc. | Temperature control and analysis system for hyperthermia treatment |
| US4681111A (en) | 1985-04-05 | 1987-07-21 | Siemens-Pacesetter, Inc. | Analog and digital telemetry system for an implantable device |
| US4651741A (en) | 1985-05-30 | 1987-03-24 | Baxter Travenol Laboratories, Inc. | Method and apparatus for determining oxygen saturation in vivo |
| US5012411A (en) | 1985-07-23 | 1991-04-30 | Charles J. Policastro | Apparatus for monitoring, storing and transmitting detected physiological information |
| CA1204885A (en) | 1985-09-18 | 1986-05-20 | Thomson & Nielson Electronics Ltd. | Dosimeter |
| US4703756A (en) | 1986-05-06 | 1987-11-03 | The Regents Of The University Of California | Complete glucose monitoring system with an implantable, telemetered sensor module |
| AU585162B2 (en) | 1986-07-01 | 1989-06-08 | Terumo Kabushiki Kaisha | Biological information measurement apparatus |
| US4976266A (en) | 1986-08-29 | 1990-12-11 | United States Department Of Energy | Methods of in vivo radiation measurement |
| DE3700119A1 (de) | 1987-01-03 | 1988-07-14 | Inst Diabetestechnologie Gemei | Implantierbarer elektrochemischer sensor |
| US4769547A (en) | 1987-01-27 | 1988-09-06 | Medrad, Inc. | Personal dosimeter having a volume of gas atop an integrated circuit |
| US4804847A (en) | 1987-01-27 | 1989-02-14 | Medrad, Inc. | Radiation detector with an ionizable gas atop an integrated circuit |
| US4970391A (en) | 1987-01-27 | 1990-11-13 | Medrad, Inc. | Radiation detector with an ionizable gas atop an integrated circuit |
| US4935345A (en) | 1987-04-07 | 1990-06-19 | Arizona Board Of Regents | Implantable microelectronic biochemical sensor incorporating thin film thermopile |
| US4750495A (en) | 1987-06-05 | 1988-06-14 | Medtronic, Inc. | Oxygen sensing pacemaker |
| US4796641A (en) | 1987-07-06 | 1989-01-10 | Data Sciences, Inc. | Device and method for chronic in-vivo measurement of internal body pressure |
| US4847617A (en) | 1987-08-14 | 1989-07-11 | Siemens-Pacesetter, Inc. | High speed digital telemetry system for implantable devices |
| GB8726933D0 (en) | 1987-11-18 | 1987-12-23 | Cadell T E | Telemetry system |
| US4989601A (en) | 1988-05-02 | 1991-02-05 | Medical Engineering & Development Institute, Inc. | Method, apparatus, and substance for treating tissue having neoplastic cells |
| US4846191A (en) | 1988-05-27 | 1989-07-11 | Data Sciences, Inc. | Device for chronic measurement of internal body pressure |
| US4900422A (en) | 1988-07-05 | 1990-02-13 | Bryan Avron I | System for monitoring and reporting the operability and calibration status of a dissolved oxygen sensor |
| WO1990001893A1 (en) | 1988-08-26 | 1990-03-08 | Mountpelier Investments S.A. | Remote sensing tonometric catheter apparatus and method |
| US5098547A (en) | 1988-10-11 | 1992-03-24 | Bryan Avron I | Dissolved oxygen sensor calibration, monitoring and reporting system |
| US5354314A (en) | 1988-12-23 | 1994-10-11 | Medical Instrumentation And Diagnostics Corporation | Three-dimensional beam localization apparatus and microscope for stereotactic diagnoses or surgery mounted on robotic type arm |
| JP2823688B2 (ja) | 1989-02-14 | 1998-11-11 | ペースセッター アクチボラゲット | 生体内に植え込み可能な電気医学装置 |
| US5264843A (en) | 1989-04-05 | 1993-11-23 | Siemens Pacesetter, Inc. | High speed reflected impedance telemetry system for implantable medical device |
| US5166073A (en) | 1989-05-05 | 1992-11-24 | The Dow Chemical Company | Miniaturized sensor for ionizing radiation |
| US4944299A (en) | 1989-08-08 | 1990-07-31 | Siemens-Pacesetter, Inc. | High speed digital telemetry system for implantable device |
| DE3932428A1 (de) | 1989-09-28 | 1991-04-11 | Argumens Gmbh | Vorrichtung zur drahtlosen messung einer lokalen physikalischen groesse |
| US5354319A (en) | 1990-01-22 | 1994-10-11 | Medtronic, Inc. | Telemetry system for an implantable medical device |
| US5127404A (en) | 1990-01-22 | 1992-07-07 | Medtronic, Inc. | Telemetry format for implanted medical device |
| US5109850A (en) | 1990-02-09 | 1992-05-05 | Massachusetts Institute Of Technology | Automatic blood monitoring for medication delivery method and apparatus |
| US5008546A (en) | 1990-06-18 | 1991-04-16 | The Regents Of The University Of California | Intraoperative beta probe and method of using the same |
| US5117113A (en) | 1990-07-06 | 1992-05-26 | Thompson And Nielson Electronics Ltd. | Direct reading dosimeter |
| US5137022A (en) | 1990-07-13 | 1992-08-11 | Cook Pacemaker Corporation | Synchronous telemetry system and method for an implantable medical device |
| US5252962A (en) | 1990-08-03 | 1993-10-12 | Bio Medic Data Systems | System monitoring programmable implantable transponder |
| US5163380A (en) | 1990-08-09 | 1992-11-17 | United States Of America | Method and apparatus for assessing metabolic behavioral and physiological status of animals |
| KR930002824B1 (ko) | 1990-08-21 | 1993-04-10 | 손병기 | 감이온 전계효과 트랜지스터를 이용한 바이오 센서용 측정회로 |
| US5117824A (en) | 1990-11-14 | 1992-06-02 | Medtronic, Inc. | Apparatus for monitoring electrical physiologic signals |
| JP2646848B2 (ja) | 1990-11-30 | 1997-08-27 | 日本電気株式会社 | グルコースセンサの測定方法 |
| US5205294A (en) | 1991-02-19 | 1993-04-27 | Pacific Communications, Inc. | Apparatus and methodology for digital telemetry of biomedical signals |
| US5318023A (en) | 1991-04-03 | 1994-06-07 | Cedars-Sinai Medical Center | Apparatus and method of use for a photosensitizer enhanced fluorescence based biopsy needle |
| US5377676A (en) | 1991-04-03 | 1995-01-03 | Cedars-Sinai Medical Center | Method for determining the biodistribution of substances using fluorescence spectroscopy |
| US5159262A (en) | 1991-07-09 | 1992-10-27 | Cascade Microtech, Inc. | Method for measuring the electrical and optical performance of on-wafer microwave devices |
| US5264103A (en) | 1991-10-18 | 1993-11-23 | Matsushita Electric Industrial Co., Ltd. | Biosensor and a method for measuring a concentration of a substrate in a sample |
| DE4139122C1 (enExample) | 1991-11-28 | 1993-04-08 | Fenzlein, Paul-Gerhard, 8500 Nuernberg, De | |
| GB9200569D0 (en) | 1992-01-11 | 1992-03-11 | Atomic Energy Authority Uk | Semiconductor dosimeter |
| NL9200207A (nl) | 1992-02-05 | 1993-09-01 | Nedap Nv | Implanteerbare biomedische sensorinrichting, in het bijzonder voor meting van de glucoseconcentratie. |
| US5444254A (en) | 1992-06-12 | 1995-08-22 | Thomson And Nielsen Electronics Ltd. | Flexible radiation probe |
| US5355880A (en) | 1992-07-06 | 1994-10-18 | Sandia Corporation | Reliable noninvasive measurement of blood gases |
| US5676651A (en) | 1992-08-06 | 1997-10-14 | Electric Boat Corporation | Surgically implantable pump arrangement and method for pumping body fluids |
| US5330634A (en) | 1992-08-28 | 1994-07-19 | Via Medical Corporation | Calibration solutions useful for analyses of biological fluids and methods employing same |
| JP3393647B2 (ja) | 1992-11-09 | 2003-04-07 | アイライフ、システムズ、インコーポレーテッド | 生理的パラメータのリモートモニタリング装置及び方法 |
| US5620479A (en) | 1992-11-13 | 1997-04-15 | The Regents Of The University Of California | Method and apparatus for thermal therapy of tumors |
| US5383909A (en) | 1993-01-29 | 1995-01-24 | Medtronic, Inc. | Diagnostic telemetry system for an apparatus for detection and treatment of tachycardia and fibrillation |
| US5341805A (en) * | 1993-04-06 | 1994-08-30 | Cedars-Sinai Medical Center | Glucose fluorescence monitor and method |
| US5383912A (en) | 1993-05-05 | 1995-01-24 | Intermedics, Inc. | Apparatus for high speed data communication between an external medical device and an implantable medical device |
| US5431171A (en) | 1993-06-25 | 1995-07-11 | The Regents Of The University Of California | Monitoring fetal characteristics by radiotelemetric transmission |
| US5324315A (en) | 1993-08-12 | 1994-06-28 | Medtronic, Inc. | Closed-loop downlink telemetry and method for implantable medical device |
| US5791344A (en) | 1993-11-19 | 1998-08-11 | Alfred E. Mann Foundation For Scientific Research | Patient monitoring system |
| US5497772A (en) | 1993-11-19 | 1996-03-12 | Alfred E. Mann Foundation For Scientific Research | Glucose monitoring system |
| US5431717A (en) * | 1993-12-03 | 1995-07-11 | Geobiotics, Inc. | Method for rendering refractory sulfide ores more susceptible to biooxidation |
| DE4341903A1 (de) | 1993-12-09 | 1995-06-14 | Josef Prof Dr Rer Nat Binder | Implantierbares telemetrisches Endosystem |
| DE4444577B4 (de) | 1993-12-15 | 2005-02-10 | Bridgestone Corp. | Verfahren zur Herstellung eines Lichtwellenleiters |
| US5476488A (en) | 1993-12-15 | 1995-12-19 | Pacesetter, Inc. | Telemetry system power control for implantable medical devices |
| IES66403B2 (en) | 1993-12-31 | 1995-12-27 | Rodney Arthur Stafford | Electronic animal identification device |
| SE9400622D0 (sv) | 1994-02-23 | 1994-02-23 | Siemens Elema Ab | Medicinskt implantat |
| NL9400534A (nl) | 1994-04-05 | 1995-11-01 | Rijksuniversiteit | Systeem voor het bepalen van een samenstelling van radionucliden. |
| US5507786A (en) | 1994-04-14 | 1996-04-16 | Pacesetter, Inc. | System and method for measuring and storing parametric data pertaining to operating characteristics of an implantable medical device |
| US5549654A (en) | 1994-04-15 | 1996-08-27 | Medtronic, Inc. | Interactive interpretation of event markers in body-implantable medical device |
| SE9401402D0 (sv) | 1994-04-25 | 1994-04-25 | Siemens Elema Ab | Medicinskt implantat |
| US5470345A (en) | 1994-06-16 | 1995-11-28 | Medtronic, Inc. | Implantable medical device with multi-layered ceramic enclosure |
| US6093381A (en) | 1994-07-13 | 2000-07-25 | Neoprobe Corporation | Modulation of the sensitivity of tumor cells to chemotherapeutics |
| US5466246A (en) | 1994-07-29 | 1995-11-14 | Pacesetter, Inc. | Telemetry receiver for implantable device, incorporating digital signal processing |
| US5626862A (en) | 1994-08-02 | 1997-05-06 | Massachusetts Institute Of Technology | Controlled local delivery of chemotherapeutic agents for treating solid tumors |
| US5571148A (en) | 1994-08-10 | 1996-11-05 | Loeb; Gerald E. | Implantable multichannel stimulator |
| US5572996A (en) | 1994-09-19 | 1996-11-12 | Pdt Systems, Inc. | In vivo pharmacokinetics of photosensitive drugs and method |
| US5626630A (en) | 1994-10-13 | 1997-05-06 | Ael Industries, Inc. | Medical telemetry system using an implanted passive transponder |
| US5591217A (en) | 1995-01-04 | 1997-01-07 | Plexus, Inc. | Implantable stimulator with replenishable, high value capacitive power source and method therefor |
| US5606163A (en) | 1995-01-11 | 1997-02-25 | The United States Of America As Represented By The Secretary Of The Navy | All-optical, rapid readout, fiber-coupled thermoluminescent dosimeter system |
| US5620472A (en) | 1995-01-12 | 1997-04-15 | Pacesetter, Inc. | Apparatus and method for dynamically interpreting and displaying a real-time telemetry link |
| US5562713A (en) | 1995-01-18 | 1996-10-08 | Pacesetter, Inc. | Bidirectional telemetry apparatus and method for implantable device |
| US5593430A (en) | 1995-01-27 | 1997-01-14 | Pacesetter, Inc. | Bus system for interconnecting an implantable medical device with a plurality of sensors |
| ES2112069T3 (es) | 1995-02-04 | 1998-03-16 | Baumann & Haldi Sa | Sistema individual de medida, de tratamiento y de transmision de parametros esencialmente fisiologicos. |
| US5596199A (en) | 1995-02-06 | 1997-01-21 | Clemson University | Passive solid state microdosimeter with electronic readout |
| US5517313A (en) | 1995-02-21 | 1996-05-14 | Colvin, Jr.; Arthur E. | Fluorescent optical sensor |
| US5556421A (en) | 1995-02-22 | 1996-09-17 | Intermedics, Inc. | Implantable medical device with enclosed physiological parameter sensors or telemetry link |
| US5535752A (en) | 1995-02-27 | 1996-07-16 | Medtronic, Inc. | Implantable capacitive absolute pressure and temperature monitor system |
| US5564434A (en) | 1995-02-27 | 1996-10-15 | Medtronic, Inc. | Implantable capacitive absolute pressure and temperature sensor |
| US5633161A (en) | 1995-03-29 | 1997-05-27 | Millennium Pharmaceuticals, Inc. | Murine gene fomy030 coding for tumor progression inhibitor |
| US5840148A (en) | 1995-06-30 | 1998-11-24 | Bio Medic Data Systems, Inc. | Method of assembly of implantable transponder |
| US5759199A (en) | 1995-08-02 | 1998-06-02 | Pacesetter, Inc. | System and method for ambulatory monitoring and programming of an implantable medical device |
| US5720771A (en) | 1995-08-02 | 1998-02-24 | Pacesetter, Inc. | Method and apparatus for monitoring physiological data from an implantable medical device |
| US5857463A (en) | 1995-10-13 | 1999-01-12 | Neoprobe Corporation | Remotely controlled apparatus and system for tracking and locating a source of photoemissions |
| US5732704A (en) | 1995-10-13 | 1998-03-31 | Neoprobe Corporation | Radiation based method locating and differentiating sentinel nodes |
| US5656815A (en) | 1996-02-08 | 1997-08-12 | The United States Of America As Represented By The Secretary Of The Navy | Thermoluminescence radiation dosimetry using transparent glass containing nanocrystalline phosphor |
| US5811814A (en) | 1996-02-12 | 1998-09-22 | Cordis Corporation | Radiation measuring catheter apparatus and method |
| JP3796635B2 (ja) | 1996-03-06 | 2006-07-12 | 富士写真フイルム株式会社 | 蛍光検出装置 |
| US5833603A (en) | 1996-03-13 | 1998-11-10 | Lipomatrix, Inc. | Implantable biosensing transponder |
| US5932879A (en) | 1996-05-07 | 1999-08-03 | Regents Of The University Of Michigan | Solid state beta-sensitive surgical probe |
| US6076009A (en) | 1997-05-05 | 2000-06-13 | The University Of Michigan | Solid state beta-sensitive surgical probe |
| US5744805A (en) | 1996-05-07 | 1998-04-28 | University Of Michigan | Solid state beta-sensitive surgical probe |
| DE19621996C2 (de) | 1996-05-31 | 1998-04-09 | Siemens Ag | Verfahren zur Herstellung einer Kombination eines Drucksensors und eines elektrochemischen Sensors |
| US5682888A (en) | 1996-06-13 | 1997-11-04 | Neoprobe Corporation | Apparatus and system for detecting and locating photon emissions with remote switch control |
| JP2000514682A (ja) | 1996-07-11 | 2000-11-07 | メドトロニック・インコーポレーテッド | 生理的事象を監視するための最小限の侵入用植込み可能装置 |
| US5814089A (en) | 1996-12-18 | 1998-09-29 | Medtronic, Inc. | Leadless multisite implantable stimulus and diagnostic system |
| US6862465B2 (en) * | 1997-03-04 | 2005-03-01 | Dexcom, Inc. | Device and method for determining analyte levels |
| USD424453S (en) | 1997-03-18 | 2000-05-09 | Neoprobe Corporation | Detector unit for radiation detecting probe |
| USD423377S (en) | 1997-03-18 | 2000-04-25 | Neoprobe Corporation | Radiation detecting probe |
| CA2284785C (en) | 1997-03-27 | 2006-07-11 | Joseph H. Schulman | System of implantable devices for monitoring and/or affecting body parameters |
| EP0990151A2 (en) | 1997-06-16 | 2000-04-05 | ELAN CORPORATION, Plc | Methods of calibrating and testing a sensor for (in vivo) measurement of an analyte and devices for use in such methods |
| CA2215369C (en) | 1997-09-12 | 2008-11-18 | Nicholas Garry Tarr | Method of monitoring radiation using a floating gate field effect transistor dosimeter, and dosimeter for use therein |
| US5928150A (en) | 1997-10-04 | 1999-07-27 | Neoprobe Corporation | System for locating and detecting a source of photon emissions |
| US5916167A (en) | 1997-10-10 | 1999-06-29 | Neoprobe Corporation | Surgical probe apparatus and system |
| US5987350A (en) | 1997-10-10 | 1999-11-16 | Neoprobe Corporation | Surgical probe apparatus and system |
| US6240312B1 (en) | 1997-10-23 | 2001-05-29 | Robert R. Alfano | Remote-controllable, micro-scale device for use in in vivo medical diagnosis and/or treatment |
| US5891179A (en) | 1997-11-20 | 1999-04-06 | Paceseter, Inc. | Method and apparatus for monitoring and displaying lead impedance in real-time for an implantable medical device |
| US6239724B1 (en) | 1997-12-30 | 2001-05-29 | Remon Medical Technologies, Ltd. | System and method for telemetrically providing intrabody spatial position |
| US6099821A (en) | 1998-01-06 | 2000-08-08 | University Of Virginia | Nuclear scintigraphic assessment of mucosal function |
| US6087666A (en) | 1998-02-18 | 2000-07-11 | The United States Of America As Represented By The Secretary Of The Navy | Optically stimulated luminescent fiber optic radiation dosimeter |
| GB9805896D0 (en) | 1998-03-20 | 1998-05-13 | Eglise David | Remote analysis system |
| EP2289423A1 (en) | 1998-05-14 | 2011-03-02 | David N. Krag | System for bracketing tissue |
| EP1341465B1 (en) | 1998-05-14 | 2010-01-27 | Calypso Medical, Inc | System for locating and defining a target location within a human body |
| US6363940B1 (en) | 1998-05-14 | 2002-04-02 | Calypso Medical Technologies, Inc. | System and method for bracketing and removing tissue |
| US5939453A (en) | 1998-06-04 | 1999-08-17 | Advanced Polymer Systems, Inc. | PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers |
| US6047214A (en) | 1998-06-09 | 2000-04-04 | North Carolina State University | System and method for powering, controlling, and communicating with multiple inductively-powered devices |
| US6015390A (en) | 1998-06-12 | 2000-01-18 | D. Krag Llc | System and method for stabilizing and removing tissue |
| US6295680B1 (en) | 1998-07-05 | 2001-10-02 | The Regents Of The University Of Michigan | Method for detecting early atherosclerosis and vascular damage using radioactive tracers and intravascular radiation detection devices |
| EP2325622B1 (en) * | 1998-08-26 | 2014-03-12 | Sensors for Medicine and Science, Inc. | Optical-based sensing device |
| US6304766B1 (en) | 1998-08-26 | 2001-10-16 | Sensors For Medicine And Science | Optical-based sensing devices, especially for in-situ sensing in humans |
| EP1867275B1 (en) | 1998-09-30 | 2010-12-08 | Sicel Technologies, Inc. | Systems comprising implantable devices for dynamic monitoring of tumors |
| US6272373B1 (en) | 1998-10-23 | 2001-08-07 | Neoprobe Corporation | Scanning system and method for locating sources of radiation emission |
| US6259095B1 (en) | 1998-10-23 | 2001-07-10 | Neoprobe Corporation | System and apparatus for detecting and locating sources of radiation |
| US6242741B1 (en) | 1998-10-23 | 2001-06-05 | United States Surgical Corporation | Radiation detection apparatus |
| US6274159B1 (en) | 1998-10-28 | 2001-08-14 | University Of Florida | Surface modified silicone drug depot |
| US6113795A (en) | 1998-11-17 | 2000-09-05 | The University Of Kansas | Process and apparatus for size selective separation of micro- and nano-particles |
| CA2352571C (en) | 1998-12-02 | 2007-02-27 | Gary S. Sayler | In vivo biosensor apparatus and method of use |
| WO2000040299A1 (en) | 1999-01-06 | 2000-07-13 | Ball Semiconductor, Inc. | Radiation dosimetry system |
| US6179767B1 (en) * | 1999-02-01 | 2001-01-30 | International Business Machines Corporation | Focussing of therapeutic radiation on internal structures of living bodies |
| US6444475B1 (en) | 1999-08-02 | 2002-09-03 | Alltech Associates, Inc. | Ion chromatography apparatus and method for removing gas prior to sample detection |
| US6229684B1 (en) * | 1999-12-15 | 2001-05-08 | Jds Uniphase Inc. | Variable capacitor and associated fabrication method |
| US6614025B2 (en) | 2000-03-28 | 2003-09-02 | Thomson & Nielsen Electronics Ltd. | Radiation sensor and dosimeter incorporating same |
| US7553280B2 (en) * | 2000-06-29 | 2009-06-30 | Sensors For Medicine And Science, Inc. | Implanted sensor processing system and method |
| JP3574383B2 (ja) * | 2000-07-31 | 2004-10-06 | 富士通株式会社 | 半導体装置及びその製造方法 |
| US6717154B2 (en) | 2000-08-02 | 2004-04-06 | Sicel Technologies, Inc. | Evaluation of irradiated foods and other items with telemetric dosimeters and associated methods |
| CA2324048A1 (en) | 2000-10-20 | 2002-04-20 | Wei Ding | Computer assisted radiotherapy dosimeter system and software therefor |
| DE60139705D1 (de) * | 2000-11-09 | 2009-10-08 | Sicel Technologies Inc | In-vivo detektion von biomolekülekonzentrationen mittels fluoreszenzmarker |
| US6627177B2 (en) * | 2000-12-05 | 2003-09-30 | The Regents Of The University Of California | Polyhydroxyl-substituted organic molecule sensing optical in vivo method utilizing a boronic acid adduct and the device thereof |
| US7011814B2 (en) * | 2001-04-23 | 2006-03-14 | Sicel Technologies, Inc. | Systems, methods and devices for in vivo monitoring of a localized response via a radiolabeled analyte in a subject |
| US20020193685A1 (en) | 2001-06-08 | 2002-12-19 | Calypso Medical, Inc. | Guided Radiation Therapy System |
| US7096053B2 (en) * | 2001-10-02 | 2006-08-22 | Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California | Internal biochemical sensing device |
| WO2006086578A1 (en) * | 2002-10-02 | 2006-08-17 | Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California | Internal biochemical sensing device |
-
2004
- 2004-02-17 US US10/779,907 patent/US7510699B2/en not_active Expired - Fee Related
- 2004-02-17 AU AU2004214420A patent/AU2004214420A1/en not_active Abandoned
- 2004-02-17 WO PCT/US2004/005785 patent/WO2004075032A2/en not_active Ceased
- 2004-02-17 CA CA002516497A patent/CA2516497A1/en not_active Abandoned
- 2004-02-17 EP EP04711947A patent/EP1594551A2/en not_active Withdrawn
- 2004-02-17 JP JP2006503890A patent/JP4607859B2/ja not_active Expired - Fee Related
-
2009
- 2009-02-19 US US12/389,012 patent/US7778695B2/en not_active Expired - Fee Related
-
2010
- 2010-06-25 US US12/823,858 patent/US20100298672A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20040197267A1 (en) | 2004-10-07 |
| US20100298672A1 (en) | 2010-11-25 |
| US7778695B2 (en) | 2010-08-17 |
| EP1594551A2 (en) | 2005-11-16 |
| AU2004214420A2 (en) | 2004-09-02 |
| WO2004075032A3 (en) | 2005-04-14 |
| CA2516497A1 (en) | 2004-09-02 |
| AU2004214420A1 (en) | 2004-09-02 |
| US7510699B2 (en) | 2009-03-31 |
| WO2004075032A2 (en) | 2004-09-02 |
| US20090180962A1 (en) | 2009-07-16 |
| JP2006520216A (ja) | 2006-09-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2006520216A (ja) | 蛍光分析物と連動して作動するインビボ蛍光センサ、システム及び関連方法 | |
| US6748259B1 (en) | Optical imaging of induced signals in vivo under ambient light conditions | |
| JP5134977B2 (ja) | 蛍光媒介式分子断層撮影法 | |
| US9724431B2 (en) | Tumor-targeting multi-mode imaging method for living body based on gold nanoclusters | |
| JP4261913B2 (ja) | 被検体内の放射標識されたアナライトによって局在化された応答をインビボでモニタリングするためのシステム、方法および装置 | |
| JP4340392B2 (ja) | 光学コントラスト因子を使用して生体内の内部の現場を検出し、位置測定し、及び目標定めする方法及び装置 | |
| US20250303001A1 (en) | Systems and methods for super-resolution optical imaging technologies and/or nanosensor-driven patient monitoring and/or treatment | |
| WO2006042233A1 (en) | Medical imaging using quantum dots | |
| JP2006520216A5 (enExample) | ||
| US10288568B2 (en) | Raman probe and methods of imaging | |
| Withrow et al. | Assessment of bevacizumab conjugated to Cy5. 5 for detection of head and neck cancer xenografts | |
| Niedre | Prospects for fluorescence molecular in vivo liquid biopsy of circulating tumor cells in humans | |
| US20220370645A1 (en) | Method, device and marker substance kit for multi-parametric x-ray fluorescence imaging | |
| US20080086112A1 (en) | Microdevice for detecting, activating and delivering molecules | |
| Raes et al. | Development of an embedded multimodality imaging platform for onco-pharmacology using a smart anticancer prodrug as an example | |
| CN114699540A (zh) | 一种动态评价乳腺癌免疫治疗效果的荧光/磁共振探针 | |
| Pogue et al. | Fluorescent molecular imaging and dosimetry tools in photodynamic therapy | |
| US20080050316A1 (en) | Molecular imaging of epithelial cells in lymph | |
| US20250367468A1 (en) | Nanoplasmonics-enhanced laser therapy systems and methods thereof | |
| Black et al. | In vivo monitoring of a fluorescently labeled antibody in mice with breast cancer xenografts | |
| Hanif et al. | Revolutionizing Cancer Imaging Techniques with Nanoparticle-Based Near-Infrared Fluorescence Probes for Biomedical Diagnostics | |
| Grosenick | Fluorescence Imaging of Cancer | |
| TWI568464B (zh) | Drug release and detection device, method of operation of drug release and detection device, and method for detecting fluorescent substance | |
| Chernomordik et al. | Application of NIR fluorescent markers to quantify expression level of HER2 receptors in carcinomas in vivo |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20070213 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20070213 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20100219 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20100519 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20100526 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20100621 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100624 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20100628 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20100924 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20101007 |
|
| R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20131015 Year of fee payment: 3 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |