JP4599501B2 - 多発性骨髄腫および他の癌の処置におけるＩκＢのインヒビターとしてのカルボリン誘導体 - Google Patents
多発性骨髄腫および他の癌の処置におけるＩκＢのインヒビターとしてのカルボリン誘導体 Download PDFInfo
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- JP4599501B2 JP4599501B2 JP2003541836A JP2003541836A JP4599501B2 JP 4599501 B2 JP4599501 B2 JP 4599501B2 JP 2003541836 A JP2003541836 A JP 2003541836A JP 2003541836 A JP2003541836 A JP 2003541836A JP 4599501 B2 JP4599501 B2 JP 4599501B2
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
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| US34491101P | 2001-11-07 | 2001-11-07 | |
| PCT/US2002/035645 WO2003039545A2 (en) | 2001-11-07 | 2002-11-06 | Carboline derivatives as inhibitors of ikb in the treatment of multiple myeloma and others cancers |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2009262389A Division JP2010031061A (ja) | 2001-11-07 | 2009-11-17 | 多発性骨髄腫および他の癌の処置におけるＩκＢのインヒビターとしてのカルボリン誘導体 |
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| JP2005529842A JP2005529842A (ja) | 2005-10-06 |
| JP2005529842A5 JP2005529842A5 (enExample) | 2006-01-05 |
| JP4599501B2 true JP4599501B2 (ja) | 2010-12-15 |
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| JP2003541836A Expired - Fee Related JP4599501B2 (ja) | 2001-11-07 | 2002-11-06 | 多発性骨髄腫および他の癌の処置におけるＩκＢのインヒビターとしてのカルボリン誘導体 |
| JP2009262389A Withdrawn JP2010031061A (ja) | 2001-11-07 | 2009-11-17 | 多発性骨髄腫および他の癌の処置におけるＩκＢのインヒビターとしてのカルボリン誘導体 |
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| JP2009262389A Withdrawn JP2010031061A (ja) | 2001-11-07 | 2009-11-17 | 多発性骨髄腫および他の癌の処置におけるＩκＢのインヒビターとしてのカルボリン誘導体 |
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| US (1) | US9248124B2 (enExample) |
| EP (1) | EP1443927B1 (enExample) |
| JP (2) | JP4599501B2 (enExample) |
| AU (1) | AU2002352498A1 (enExample) |
| DE (1) | DE60217532T8 (enExample) |
| WO (1) | WO2003039545A2 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60217532T8 (de) * | 2001-11-07 | 2008-02-07 | Millennium Pharmaceuticals, Inc., Cambridge | Carboline derivate als ikb-inhibitoren zur behandlung des m ultiplen myelomas |
| US7393862B2 (en) | 2002-05-17 | 2008-07-01 | Celgene Corporation | Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias |
| USRE48890E1 (en) | 2002-05-17 | 2022-01-11 | Celgene Corporation | Methods for treating multiple myeloma with 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione after stem cell transplantation |
| US7968569B2 (en) | 2002-05-17 | 2011-06-28 | Celgene Corporation | Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione |
| EP1556053A4 (en) | 2002-10-31 | 2006-04-19 | Amgen Inc | ANTI-INFLAMMATORY AGENTS |
| CN1802375A (zh) * | 2003-04-09 | 2006-07-12 | 千禧药品公司 | 用于治疗炎性疾病的β－咔啉 |
| DE10326821A1 (de) * | 2003-06-11 | 2005-01-05 | Medical Enzymes Ag | Pharmazeutische Kombinationspräparate zur Krebstherapie |
| WO2005111037A1 (en) | 2004-04-09 | 2005-11-24 | Millennium Pharmaceuticals, Inc. | Beta-carbolines useful for treating inflammatory disease |
| CN100443178C (zh) | 2006-03-10 | 2008-12-17 | 中国石油天然气股份有限公司 | 一种乙烯低聚的催化剂组合物及其应用 |
| CA2646316C (en) | 2006-03-15 | 2016-05-24 | Theralogics, Inc. | Methods of treating muscular wasting diseases using nf-kb activation inhibitors |
| CA2699461A1 (en) * | 2007-08-03 | 2009-02-12 | The Regents Of The University Of California | Inhibitors of intracellular urokinase plasminogen activator and methods of use thereof |
| WO2009054970A1 (en) * | 2007-10-23 | 2009-04-30 | Millennium Pharmaceuticals, Inc. | Mesylate salt of an ikk inhibitor |
| WO2009054965A1 (en) * | 2007-10-23 | 2009-04-30 | Millennium Pharmaceuticals, Inc. | Salts of n- (6-chloro-9h-pyrido [3,4-b] ind0l-8-yl) -4- [2- (2, 6-dimethyl-4-morpholinyl) -2-0x0e thyl] -6, 6-dimethyl-morpholinecarboxamide |
| EP2706059A1 (en) * | 2008-06-11 | 2014-03-12 | Genentech, Inc. | Diazacarbazoles and methods of use |
| EP2161271A1 (en) * | 2008-09-08 | 2010-03-10 | Università Degli Studi Di Milano - Bicocca | Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl |
| WO2010099445A2 (en) * | 2009-02-26 | 2010-09-02 | Board Of Trustees Of Michigan State University | Non-covalent inhibition of the 26s proteasome and uses thereof |
| FR2953838B1 (fr) * | 2009-12-10 | 2012-02-24 | Sanofi Aventis | Derives de 9h-beta-carboline (ou 9h-pyridino[3,4-b]indole) trisubstitues, leur preparation et leur utilisation therapeutique |
| FR2953837B1 (fr) * | 2009-12-10 | 2012-03-09 | Sanofi Aventis | Derives 9h-pyridino[3,4-b]indole disubstitues, leur preparation et leur utilisation therapeutique |
| US20110183938A1 (en) | 2009-12-16 | 2011-07-28 | Genentech, Inc. | 1,7-diazacarbazoles and methods of use |
| EP3318563A1 (en) | 2016-11-07 | 2018-05-09 | Sanofi | Substituted pyrido[3,4-b]indoles for the treatment of cartilage disorders |
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| GB2303627B (en) | 1995-07-26 | 1997-07-09 | Arab Pharmaceutical Mfg Co Ltd | Anti-tumour platinum-harmine complex |
| EP1011724A4 (en) * | 1997-09-10 | 2002-08-21 | Uab Research Foundation | REGULATION OF OSTEOCLASTIC FORMATION BY INHIBITING EAST EOBLASTIC STEM CELL FACTORS |
| JPH11180873A (ja) * | 1997-12-22 | 1999-07-06 | Kaken Shoyaku Kk | ＮＦ−κＢ活性阻害剤 |
| DE19807993A1 (de) | 1998-02-26 | 1999-09-02 | Bayer Ag | Verwendung von ß-Carbolinderivaten zur Bekämpfung von TNF-alpha-abhängigen Krankheiten |
| HUP0102782A3 (en) * | 1998-06-19 | 2002-12-28 | Smithkline Beecham Corp | Salycilanilide as inhibitors of transcription factor nf-kb |
| DE19951360A1 (de) | 1999-10-26 | 2001-05-03 | Aventis Pharma Gmbh | Substituierte Indole |
| EP1268477B1 (en) * | 2000-03-15 | 2010-04-21 | Sanofi-Aventis Deutschland GmbH | Substituted beta-carbolines with ikb-kinase inhibiting activity |
| ATE465161T1 (de) | 2000-03-15 | 2010-05-15 | Sanofi Aventis Deutschland | Substituierte beta-carboline mit ikb-kinase hemmender wirkung |
| DE60217532T8 (de) * | 2001-11-07 | 2008-02-07 | Millennium Pharmaceuticals, Inc., Cambridge | Carboline derivate als ikb-inhibitoren zur behandlung des m ultiplen myelomas |
-
2002
- 2002-11-06 DE DE60217532T patent/DE60217532T8/de active Active
- 2002-11-06 EP EP02789471A patent/EP1443927B1/en not_active Expired - Lifetime
- 2002-11-06 AU AU2002352498A patent/AU2002352498A1/en not_active Abandoned
- 2002-11-06 JP JP2003541836A patent/JP4599501B2/ja not_active Expired - Fee Related
- 2002-11-06 US US10/495,041 patent/US9248124B2/en not_active Expired - Fee Related
- 2002-11-06 WO PCT/US2002/035645 patent/WO2003039545A2/en not_active Ceased
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2009
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2003039545A3 (en) | 2003-10-30 |
| US9248124B2 (en) | 2016-02-02 |
| EP1443927A2 (en) | 2004-08-11 |
| AU2002352498A1 (en) | 2003-05-19 |
| JP2005529842A (ja) | 2005-10-06 |
| US20050049265A1 (en) | 2005-03-03 |
| JP2010031061A (ja) | 2010-02-12 |
| DE60217532T8 (de) | 2008-02-07 |
| HK1069311A1 (en) | 2005-05-20 |
| WO2003039545A2 (en) | 2003-05-15 |
| EP1443927B1 (en) | 2007-01-10 |
| DE60217532D1 (de) | 2007-02-22 |
| DE60217532T2 (de) | 2007-10-31 |
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