DE60217532T8 - Carboline derivate als ikb-inhibitoren zur behandlung des m ultiplen myelomas - Google Patents

Carboline derivate als ikb-inhibitoren zur behandlung des m ultiplen myelomas Download PDF

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Publication number
DE60217532T8
DE60217532T8 DE60217532T DE60217532T DE60217532T8 DE 60217532 T8 DE60217532 T8 DE 60217532T8 DE 60217532 T DE60217532 T DE 60217532T DE 60217532 T DE60217532 T DE 60217532T DE 60217532 T8 DE60217532 T8 DE 60217532T8
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DE
Germany
Prior art keywords
ultiplen
myelomas
treatment
carboline derivatives
ikb
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE60217532T
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German (de)
English (en)
Other versions
DE60217532D1 (de
DE60217532T2 (de
Inventor
Julian Brooklin ADAMS
Kenneth C Wellesley ANDERSON
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Millennium Pharmaceuticals Inc
Original Assignee
Millennium Pharmaceuticals Inc
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Filing date
Publication date
Application filed by Millennium Pharmaceuticals Inc filed Critical Millennium Pharmaceuticals Inc
Publication of DE60217532D1 publication Critical patent/DE60217532D1/de
Application granted granted Critical
Publication of DE60217532T2 publication Critical patent/DE60217532T2/de
Publication of DE60217532T8 publication Critical patent/DE60217532T8/de
Active legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE60217532T 2001-11-07 2002-11-06 Carboline derivate als ikb-inhibitoren zur behandlung des m ultiplen myelomas Active DE60217532T8 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34491101P 2001-11-07 2001-11-07
US344911P 2001-11-07
PCT/US2002/035645 WO2003039545A2 (en) 2001-11-07 2002-11-06 Carboline derivatives as inhibitors of ikb in the treatment of multiple myeloma and others cancers

Publications (3)

Publication Number Publication Date
DE60217532D1 DE60217532D1 (de) 2007-02-22
DE60217532T2 DE60217532T2 (de) 2007-10-31
DE60217532T8 true DE60217532T8 (de) 2008-02-07

Family

ID=23352621

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60217532T Active DE60217532T8 (de) 2001-11-07 2002-11-06 Carboline derivate als ikb-inhibitoren zur behandlung des m ultiplen myelomas

Country Status (6)

Country Link
US (1) US9248124B2 (enExample)
EP (1) EP1443927B1 (enExample)
JP (2) JP4599501B2 (enExample)
AU (1) AU2002352498A1 (enExample)
DE (1) DE60217532T8 (enExample)
WO (1) WO2003039545A2 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60217532T8 (de) * 2001-11-07 2008-02-07 Millennium Pharmaceuticals, Inc., Cambridge Carboline derivate als ikb-inhibitoren zur behandlung des m ultiplen myelomas
US7393862B2 (en) 2002-05-17 2008-07-01 Celgene Corporation Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias
USRE48890E1 (en) 2002-05-17 2022-01-11 Celgene Corporation Methods for treating multiple myeloma with 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione after stem cell transplantation
US7968569B2 (en) 2002-05-17 2011-06-28 Celgene Corporation Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
EP1556053A4 (en) 2002-10-31 2006-04-19 Amgen Inc ANTI-INFLAMMATORY AGENTS
CN1802375A (zh) * 2003-04-09 2006-07-12 千禧药品公司 用于治疗炎性疾病的β－咔啉
DE10326821A1 (de) * 2003-06-11 2005-01-05 Medical Enzymes Ag Pharmazeutische Kombinationspräparate zur Krebstherapie
WO2005111037A1 (en) 2004-04-09 2005-11-24 Millennium Pharmaceuticals, Inc. Beta-carbolines useful for treating inflammatory disease
CN100443178C (zh) 2006-03-10 2008-12-17 中国石油天然气股份有限公司 一种乙烯低聚的催化剂组合物及其应用
CA2646316C (en) 2006-03-15 2016-05-24 Theralogics, Inc. Methods of treating muscular wasting diseases using nf-kb activation inhibitors
CA2699461A1 (en) * 2007-08-03 2009-02-12 The Regents Of The University Of California Inhibitors of intracellular urokinase plasminogen activator and methods of use thereof
WO2009054970A1 (en) * 2007-10-23 2009-04-30 Millennium Pharmaceuticals, Inc. Mesylate salt of an ikk inhibitor
WO2009054965A1 (en) * 2007-10-23 2009-04-30 Millennium Pharmaceuticals, Inc. Salts of n- (6-chloro-9h-pyrido [3,4-b] ind0l-8-yl) -4- [2- (2, 6-dimethyl-4-morpholinyl) -2-0x0e thyl] -6, 6-dimethyl-morpholinecarboxamide
EP2706059A1 (en) * 2008-06-11 2014-03-12 Genentech, Inc. Diazacarbazoles and methods of use
EP2161271A1 (en) * 2008-09-08 2010-03-10 Università Degli Studi Di Milano - Bicocca Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl
WO2010099445A2 (en) * 2009-02-26 2010-09-02 Board Of Trustees Of Michigan State University Non-covalent inhibition of the 26s proteasome and uses thereof
FR2953838B1 (fr) * 2009-12-10 2012-02-24 Sanofi Aventis Derives de 9h-beta-carboline (ou 9h-pyridino[3,4-b]indole) trisubstitues, leur preparation et leur utilisation therapeutique
FR2953837B1 (fr) * 2009-12-10 2012-03-09 Sanofi Aventis Derives 9h-pyridino[3,4-b]indole disubstitues, leur preparation et leur utilisation therapeutique
US20110183938A1 (en) 2009-12-16 2011-07-28 Genentech, Inc. 1,7-diazacarbazoles and methods of use
EP3318563A1 (en) 2016-11-07 2018-05-09 Sanofi Substituted pyrido[3,4-b]indoles for the treatment of cartilage disorders

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2303627B (en) 1995-07-26 1997-07-09 Arab Pharmaceutical Mfg Co Ltd Anti-tumour platinum-harmine complex
EP1011724A4 (en) * 1997-09-10 2002-08-21 Uab Research Foundation REGULATION OF OSTEOCLASTIC FORMATION BY INHIBITING EAST EOBLASTIC STEM CELL FACTORS
JPH11180873A (ja) * 1997-12-22 1999-07-06 Kaken Shoyaku Kk ＮＦ−κＢ活性阻害剤
DE19807993A1 (de) 1998-02-26 1999-09-02 Bayer Ag Verwendung von ß-Carbolinderivaten zur Bekämpfung von TNF-alpha-abhängigen Krankheiten
HUP0102782A3 (en) * 1998-06-19 2002-12-28 Smithkline Beecham Corp Salycilanilide as inhibitors of transcription factor nf-kb
DE19951360A1 (de) 1999-10-26 2001-05-03 Aventis Pharma Gmbh Substituierte Indole
EP1268477B1 (en) * 2000-03-15 2010-04-21 Sanofi-Aventis Deutschland GmbH Substituted beta-carbolines with ikb-kinase inhibiting activity
ATE465161T1 (de) 2000-03-15 2010-05-15 Sanofi Aventis Deutschland Substituierte beta-carboline mit ikb-kinase hemmender wirkung
DE60217532T8 (de) * 2001-11-07 2008-02-07 Millennium Pharmaceuticals, Inc., Cambridge Carboline derivate als ikb-inhibitoren zur behandlung des m ultiplen myelomas

Also Published As

Publication number Publication date
WO2003039545A3 (en) 2003-10-30
US9248124B2 (en) 2016-02-02
EP1443927A2 (en) 2004-08-11
AU2002352498A1 (en) 2003-05-19
JP2005529842A (ja) 2005-10-06
US20050049265A1 (en) 2005-03-03
JP2010031061A (ja) 2010-02-12
HK1069311A1 (en) 2005-05-20
WO2003039545A2 (en) 2003-05-15
EP1443927B1 (en) 2007-01-10
DE60217532D1 (de) 2007-02-22
JP4599501B2 (ja) 2010-12-15
DE60217532T2 (de) 2007-10-31

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