DE60217532T8 - Carboline derivate als ikb-inhibitoren zur behandlung des m ultiplen myelomas - Google Patents
Carboline derivate als ikb-inhibitoren zur behandlung des m ultiplen myelomas Download PDFInfo
- Publication number
- DE60217532T8 DE60217532T8 DE60217532T DE60217532T DE60217532T8 DE 60217532 T8 DE60217532 T8 DE 60217532T8 DE 60217532 T DE60217532 T DE 60217532T DE 60217532 T DE60217532 T DE 60217532T DE 60217532 T8 DE60217532 T8 DE 60217532T8
- Authority
- DE
- Germany
- Prior art keywords
- ultiplen
- myelomas
- treatment
- carboline derivatives
- ikb
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34491101P | 2001-11-07 | 2001-11-07 | |
US344911P | 2001-11-07 | ||
PCT/US2002/035645 WO2003039545A2 (en) | 2001-11-07 | 2002-11-06 | Carboline derivatives as inhibitors of ikb in the treatment of multiple myeloma and others cancers |
Publications (3)
Publication Number | Publication Date |
---|---|
DE60217532D1 DE60217532D1 (de) | 2007-02-22 |
DE60217532T2 DE60217532T2 (de) | 2007-10-31 |
DE60217532T8 true DE60217532T8 (de) | 2008-02-07 |
Family
ID=23352621
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60217532T Active DE60217532T8 (de) | 2001-11-07 | 2002-11-06 | Carboline derivate als ikb-inhibitoren zur behandlung des m ultiplen myelomas |
Country Status (7)
Country | Link |
---|---|
US (1) | US9248124B2 (de) |
EP (1) | EP1443927B1 (de) |
JP (2) | JP4599501B2 (de) |
AU (1) | AU2002352498A1 (de) |
DE (1) | DE60217532T8 (de) |
HK (1) | HK1069311A1 (de) |
WO (1) | WO2003039545A2 (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1443927B1 (de) * | 2001-11-07 | 2007-01-10 | Millennium Pharmaceuticals, Inc. | Carboline derivate als ikb-inhibitoren zur behandlung des m ultiplen myelomas |
USRE48890E1 (en) | 2002-05-17 | 2022-01-11 | Celgene Corporation | Methods for treating multiple myeloma with 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione after stem cell transplantation |
US7968569B2 (en) * | 2002-05-17 | 2011-06-28 | Celgene Corporation | Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione |
US7393862B2 (en) | 2002-05-17 | 2008-07-01 | Celgene Corporation | Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias |
WO2004041285A1 (en) | 2002-10-31 | 2004-05-21 | Amgen Inc. | Antiinflammation agents |
BRPI0409263A (pt) * | 2003-04-09 | 2006-03-28 | Millennium Pharm Inc | composto; composição farmacêutica; método para tratar uma doença mediada por ikk e método para inibir ikk em um paciente que dele necessita |
DE10326821A1 (de) * | 2003-06-11 | 2005-01-05 | Medical Enzymes Ag | Pharmazeutische Kombinationspräparate zur Krebstherapie |
KR20070014166A (ko) | 2004-04-09 | 2007-01-31 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 염증 질환 치료에 유용한 베타-카르볼린 |
CN100443178C (zh) | 2006-03-10 | 2008-12-17 | 中国石油天然气股份有限公司 | 一种乙烯低聚的催化剂组合物及其应用 |
CA2646316C (en) | 2006-03-15 | 2016-05-24 | Theralogics, Inc. | Methods of treating muscular wasting diseases using nf-kb activation inhibitors |
WO2009020877A2 (en) * | 2007-08-03 | 2009-02-12 | The Regents Of The University Of California | Inhibitors of intracellular urokinase plasminogen activator and methods of use thereof |
WO2009054965A1 (en) * | 2007-10-23 | 2009-04-30 | Millennium Pharmaceuticals, Inc. | Salts of n- (6-chloro-9h-pyrido [3,4-b] ind0l-8-yl) -4- [2- (2, 6-dimethyl-4-morpholinyl) -2-0x0e thyl] -6, 6-dimethyl-morpholinecarboxamide |
US20090137579A1 (en) * | 2007-10-23 | 2009-05-28 | Millennium Pharmaceuticals, Inc. | Mesylate salt of an IKK inhibitor |
CN104059066A (zh) * | 2008-06-11 | 2014-09-24 | 健泰科生物技术公司 | 二氮杂咔唑和使用方法 |
EP2161271A1 (de) * | 2008-09-08 | 2010-03-10 | Università Degli Studi Di Milano - Bicocca | Alpha-Carbolin-Hemmer von NMP-ALK, RET und Bcr-Abl |
WO2010099445A2 (en) * | 2009-02-26 | 2010-09-02 | Board Of Trustees Of Michigan State University | Non-covalent inhibition of the 26s proteasome and uses thereof |
FR2953838B1 (fr) * | 2009-12-10 | 2012-02-24 | Sanofi Aventis | Derives de 9h-beta-carboline (ou 9h-pyridino[3,4-b]indole) trisubstitues, leur preparation et leur utilisation therapeutique |
FR2953837B1 (fr) * | 2009-12-10 | 2012-03-09 | Sanofi Aventis | Derives 9h-pyridino[3,4-b]indole disubstitues, leur preparation et leur utilisation therapeutique |
US20110183938A1 (en) | 2009-12-16 | 2011-07-28 | Genentech, Inc. | 1,7-diazacarbazoles and methods of use |
EP3318563A1 (de) | 2016-11-07 | 2018-05-09 | Sanofi | Substituierte pyrido[3,4-b]indole zur behandlung von knorpelerkrankungen |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2303627B (en) | 1995-07-26 | 1997-07-09 | Arab Pharmaceutical Mfg Co Ltd | Anti-tumour platinum-harmine complex |
WO1999012567A1 (en) * | 1997-09-10 | 1999-03-18 | Uab Research Foundation | Regulation of osteoclast formation by inhibition of osteoblastic stem cell factor |
JPH11180873A (ja) * | 1997-12-22 | 1999-07-06 | Kaken Shoyaku Kk | NF−κB活性阻害剤 |
DE19807993A1 (de) | 1998-02-26 | 1999-09-02 | Bayer Ag | Verwendung von ß-Carbolinderivaten zur Bekämpfung von TNF-alpha-abhängigen Krankheiten |
HUP0102782A3 (en) * | 1998-06-19 | 2002-12-28 | Smithkline Beecham Corp | Salycilanilide as inhibitors of transcription factor nf-kb |
DE19951360A1 (de) | 1999-10-26 | 2001-05-03 | Aventis Pharma Gmbh | Substituierte Indole |
WO2001068648A1 (en) * | 2000-03-15 | 2001-09-20 | Aventis Pharma Deutschland Gmbh | Substituted beta-carbolines with ikb-kinase inhibiting activity |
AU3741801A (en) | 2000-03-15 | 2001-09-24 | Aventis Pharma Gmbh | Substituted beta-carbolines with ikb-kinase inhibiting activity |
EP1443927B1 (de) * | 2001-11-07 | 2007-01-10 | Millennium Pharmaceuticals, Inc. | Carboline derivate als ikb-inhibitoren zur behandlung des m ultiplen myelomas |
-
2002
- 2002-11-06 EP EP02789471A patent/EP1443927B1/de not_active Expired - Lifetime
- 2002-11-06 DE DE60217532T patent/DE60217532T8/de active Active
- 2002-11-06 WO PCT/US2002/035645 patent/WO2003039545A2/en active IP Right Grant
- 2002-11-06 US US10/495,041 patent/US9248124B2/en not_active Expired - Fee Related
- 2002-11-06 AU AU2002352498A patent/AU2002352498A1/en not_active Abandoned
- 2002-11-06 JP JP2003541836A patent/JP4599501B2/ja not_active Expired - Fee Related
-
2005
- 2005-02-12 HK HK05101152A patent/HK1069311A1/xx not_active IP Right Cessation
-
2009
- 2009-11-17 JP JP2009262389A patent/JP2010031061A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
US20050049265A1 (en) | 2005-03-03 |
HK1069311A1 (en) | 2005-05-20 |
EP1443927B1 (de) | 2007-01-10 |
AU2002352498A1 (en) | 2003-05-19 |
JP2010031061A (ja) | 2010-02-12 |
DE60217532T2 (de) | 2007-10-31 |
JP2005529842A (ja) | 2005-10-06 |
DE60217532D1 (de) | 2007-02-22 |
EP1443927A2 (de) | 2004-08-11 |
JP4599501B2 (ja) | 2010-12-15 |
WO2003039545A2 (en) | 2003-05-15 |
WO2003039545A3 (en) | 2003-10-30 |
US9248124B2 (en) | 2016-02-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |