JP4590260B2 - ヒトアデノシン−a3受容体へのリガンドとしての1,3,5−トリアジン誘導体 - Google Patents
ヒトアデノシン−a3受容体へのリガンドとしての1,3,5−トリアジン誘導体 Download PDFInfo
- Publication number
- JP4590260B2 JP4590260B2 JP2004509671A JP2004509671A JP4590260B2 JP 4590260 B2 JP4590260 B2 JP 4590260B2 JP 2004509671 A JP2004509671 A JP 2004509671A JP 2004509671 A JP2004509671 A JP 2004509671A JP 4590260 B2 JP4590260 B2 JP 4590260B2
- Authority
- JP
- Japan
- Prior art keywords
- formula
- alkyl
- compound
- adenosine
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- IWBLYLBSHCQRLL-UHFFFAOYSA-N CC(C(c1ccccc1)O)Nc1nc(Nc2ccc3O[IH]Oc3c2)nc(Cl)n1 Chemical compound CC(C(c1ccccc1)O)Nc1nc(Nc2ccc3O[IH]Oc3c2)nc(Cl)n1 IWBLYLBSHCQRLL-UHFFFAOYSA-N 0.000 description 1
- 0 C[C@](*)(C=CC([C@](C(*)N(C)*)O)=CC#CC)C=NC Chemical compound C[C@](*)(C=CC([C@](C(*)N(C)*)O)=CC#CC)C=NC 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/12—Antivirals
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- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
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- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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-
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
- C07D251/50—Two nitrogen atoms with a halogen atom attached to the third ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Virology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02077310 | 2002-05-30 | ||
PCT/EP2003/050203 WO2003101980A1 (en) | 2002-05-30 | 2003-05-28 | 1,3,5-triazine derivatives as ligands for human adenosine-a3 receptors |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2005531600A JP2005531600A (ja) | 2005-10-20 |
JP4590260B2 true JP4590260B2 (ja) | 2010-12-01 |
Family
ID=29595045
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004509671A Expired - Fee Related JP4590260B2 (ja) | 2002-05-30 | 2003-05-28 | ヒトアデノシン−a3受容体へのリガンドとしての1,3,5−トリアジン誘導体 |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP1513827A1 (de) |
JP (1) | JP4590260B2 (de) |
CN (1) | CN1329388C (de) |
AR (1) | AR040231A1 (de) |
AU (1) | AU2003250232B2 (de) |
BR (1) | BR0304925A (de) |
CA (1) | CA2484981C (de) |
HK (1) | HK1075045A1 (de) |
HR (1) | HRP20040970A2 (de) |
IL (1) | IL164240A (de) |
MX (1) | MXPA04011948A (de) |
PL (1) | PL372418A1 (de) |
RU (1) | RU2312859C2 (de) |
UA (1) | UA77816C2 (de) |
WO (1) | WO2003101980A1 (de) |
ZA (1) | ZA200408029B (de) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005009980A1 (en) * | 2003-07-22 | 2005-02-03 | Neurogen Corporation | Substituted pyridin-2-ylamine analogues |
US7223759B2 (en) | 2003-09-15 | 2007-05-29 | Anadys Pharmaceuticals, Inc. | Antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds |
GB2465405A (en) * | 2008-11-10 | 2010-05-19 | Univ Basel | Triazine, pyrimidine and pyridine analogues and their use in therapy |
IN2014DN10806A (de) | 2012-07-04 | 2015-09-04 | Agro Kanesho Co Ltd | |
GB201810668D0 (en) | 2018-06-28 | 2018-08-15 | Stiftelsen Alzecure | New compounds |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9226735D0 (en) * | 1992-12-22 | 1993-02-17 | Ici Plc | Azole derivatives |
DE19735800A1 (de) * | 1997-08-18 | 1999-02-25 | Boehringer Ingelheim Pharma | Triazine mit adenosinantagonistischer Wirkung |
JPH11158073A (ja) * | 1997-09-26 | 1999-06-15 | Takeda Chem Ind Ltd | アデノシンa3拮抗剤 |
-
2003
- 2003-05-28 CA CA2484981A patent/CA2484981C/en not_active Expired - Fee Related
- 2003-05-28 WO PCT/EP2003/050203 patent/WO2003101980A1/en active Application Filing
- 2003-05-28 UA UA20041210642A patent/UA77816C2/uk unknown
- 2003-05-28 EP EP03755982A patent/EP1513827A1/de not_active Withdrawn
- 2003-05-28 AU AU2003250232A patent/AU2003250232B2/en not_active Ceased
- 2003-05-28 BR BR0304925-6A patent/BR0304925A/pt not_active IP Right Cessation
- 2003-05-28 JP JP2004509671A patent/JP4590260B2/ja not_active Expired - Fee Related
- 2003-05-28 MX MXPA04011948A patent/MXPA04011948A/es active IP Right Grant
- 2003-05-28 RU RU2004138803/04A patent/RU2312859C2/ru not_active IP Right Cessation
- 2003-05-28 CN CNB038090937A patent/CN1329388C/zh not_active Expired - Fee Related
- 2003-05-28 PL PL03372418A patent/PL372418A1/xx not_active Application Discontinuation
- 2003-05-30 AR ARP030101920A patent/AR040231A1/es unknown
-
2004
- 2004-09-23 IL IL164240A patent/IL164240A/en not_active IP Right Cessation
- 2004-10-05 ZA ZA200408029A patent/ZA200408029B/xx unknown
- 2004-10-15 HR HR20040970A patent/HRP20040970A2/xx not_active Application Discontinuation
-
2005
- 2005-08-22 HK HK05107314A patent/HK1075045A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HK1075045A1 (en) | 2005-12-02 |
AU2003250232A1 (en) | 2003-12-19 |
IL164240A (en) | 2010-12-30 |
CN1329388C (zh) | 2007-08-01 |
MXPA04011948A (es) | 2005-03-31 |
RU2312859C2 (ru) | 2007-12-20 |
JP2005531600A (ja) | 2005-10-20 |
HRP20040970A2 (en) | 2005-06-30 |
WO2003101980A1 (en) | 2003-12-11 |
RU2004138803A (ru) | 2005-06-10 |
CA2484981A1 (en) | 2003-12-11 |
UA77816C2 (en) | 2007-01-15 |
EP1513827A1 (de) | 2005-03-16 |
AR040231A1 (es) | 2005-03-23 |
CA2484981C (en) | 2011-07-26 |
PL372418A1 (en) | 2005-07-25 |
IL164240A0 (en) | 2005-12-18 |
AU2003250232B2 (en) | 2008-09-11 |
CN1646520A (zh) | 2005-07-27 |
ZA200408029B (en) | 2005-10-06 |
BR0304925A (pt) | 2004-09-28 |
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