ZA200408029B - Novel 1,3,5-triazine derivatives as ligands for human adenosine-A3 receptors. - Google Patents

Novel 1,3,5-triazine derivatives as ligands for human adenosine-A3 receptors.

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Publication number
ZA200408029B
ZA200408029B ZA200408029A ZA200408029A ZA200408029B ZA 200408029 B ZA200408029 B ZA 200408029B ZA 200408029 A ZA200408029 A ZA 200408029A ZA 200408029 A ZA200408029 A ZA 200408029A ZA 200408029 B ZA200408029 B ZA 200408029B
Authority
ZA
South Africa
Prior art keywords
ligands
receptors
novel
triazine derivatives
human adenosine
Prior art date
Application number
ZA200408029A
Other languages
English (en)
Inventor
Hartog Jacobus A J Den
Van Gustaaf J M Scharrenburg
Gary R Gustafson
Jan H Reinders
Maria L Pras-Raves
Original Assignee
Solvay Pharm Bv
Arqule Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Bv, Arqule Inc filed Critical Solvay Pharm Bv
Publication of ZA200408029B publication Critical patent/ZA200408029B/xx

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • C07D251/50—Two nitrogen atoms with a halogen atom attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Virology (AREA)
  • Otolaryngology (AREA)
  • Endocrinology (AREA)
ZA200408029A 2002-05-30 2004-10-05 Novel 1,3,5-triazine derivatives as ligands for human adenosine-A3 receptors. ZA200408029B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02077310 2002-05-30

Publications (1)

Publication Number Publication Date
ZA200408029B true ZA200408029B (en) 2005-10-06

Family

ID=29595045

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200408029A ZA200408029B (en) 2002-05-30 2004-10-05 Novel 1,3,5-triazine derivatives as ligands for human adenosine-A3 receptors.

Country Status (16)

Country Link
EP (1) EP1513827A1 (de)
JP (1) JP4590260B2 (de)
CN (1) CN1329388C (de)
AR (1) AR040231A1 (de)
AU (1) AU2003250232B2 (de)
BR (1) BR0304925A (de)
CA (1) CA2484981C (de)
HK (1) HK1075045A1 (de)
HR (1) HRP20040970A2 (de)
IL (1) IL164240A (de)
MX (1) MXPA04011948A (de)
PL (1) PL372418A1 (de)
RU (1) RU2312859C2 (de)
UA (1) UA77816C2 (de)
WO (1) WO2003101980A1 (de)
ZA (1) ZA200408029B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005009980A1 (en) * 2003-07-22 2005-02-03 Neurogen Corporation Substituted pyridin-2-ylamine analogues
WO2005028467A1 (en) 2003-09-15 2005-03-31 Anadys Pharmaceuticals, Inc. Antibacterial 3,5-diaminopiperidine-substitute aromatic and heteroaromatic compounds
GB2465405A (en) * 2008-11-10 2010-05-19 Univ Basel Triazine, pyrimidine and pyridine analogues and their use in therapy
BR112014032873B1 (pt) 2012-07-04 2019-02-12 Agro-Kanesho Co., Ltd. Derivado de éster de ácido 2-aminonicotínico, e, bactericida
GB201810668D0 (en) 2018-06-28 2018-08-15 Stiftelsen Alzecure New compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9226735D0 (en) * 1992-12-22 1993-02-17 Ici Plc Azole derivatives
DE19735800A1 (de) * 1997-08-18 1999-02-25 Boehringer Ingelheim Pharma Triazine mit adenosinantagonistischer Wirkung
JPH11158073A (ja) * 1997-09-26 1999-06-15 Takeda Chem Ind Ltd アデノシンａ３拮抗剤

Also Published As

Publication number Publication date
JP4590260B2 (ja) 2010-12-01
CN1329388C (zh) 2007-08-01
AU2003250232B2 (en) 2008-09-11
IL164240A0 (en) 2005-12-18
RU2004138803A (ru) 2005-06-10
IL164240A (en) 2010-12-30
JP2005531600A (ja) 2005-10-20
RU2312859C2 (ru) 2007-12-20
HRP20040970A2 (en) 2005-06-30
AR040231A1 (es) 2005-03-23
AU2003250232A1 (en) 2003-12-19
UA77816C2 (en) 2007-01-15
WO2003101980A1 (en) 2003-12-11
PL372418A1 (en) 2005-07-25
CN1646520A (zh) 2005-07-27
EP1513827A1 (de) 2005-03-16
CA2484981C (en) 2011-07-26
CA2484981A1 (en) 2003-12-11
BR0304925A (pt) 2004-09-28
MXPA04011948A (es) 2005-03-31
HK1075045A1 (en) 2005-12-02

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