JP4543344B2 - フェニルピラゾール誘導体 - Google Patents
フェニルピラゾール誘導体 Download PDFInfo
- Publication number
- JP4543344B2 JP4543344B2 JP2009541174A JP2009541174A JP4543344B2 JP 4543344 B2 JP4543344 B2 JP 4543344B2 JP 2009541174 A JP2009541174 A JP 2009541174A JP 2009541174 A JP2009541174 A JP 2009541174A JP 4543344 B2 JP4543344 B2 JP 4543344B2
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- propoxy
- methylpyrrolidin
- pyrazol
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 C*N(*)CC(C)CC(C)COc(cc1)ccc1-[n]1ncc(*)c1 Chemical compound C*N(*)CC(C)CC(C)COc(cc1)ccc1-[n]1ncc(*)c1 0.000 description 2
- ASZRXWXQDSWRAY-UHFFFAOYSA-N CC1N(CCCOc(cc2)ccc2-[n]2ncc(C(C)=O)c2)CCC1 Chemical compound CC1N(CCCOc(cc2)ccc2-[n]2ncc(C(C)=O)c2)CCC1 ASZRXWXQDSWRAY-UHFFFAOYSA-N 0.000 description 1
- BPPLZEUEZFFAGT-UHFFFAOYSA-N CC1N(CCCOc(cc2)ccc2-[n]2ncc(C(N(CCO)CC(OC(C)(C)C)=O)=O)c2)CCC1 Chemical compound CC1N(CCCOc(cc2)ccc2-[n]2ncc(C(N(CCO)CC(OC(C)(C)C)=O)=O)c2)CCC1 BPPLZEUEZFFAGT-UHFFFAOYSA-N 0.000 description 1
- IABXVJILZYNSTM-UHFFFAOYSA-N CC1N(CCCOc(cc2)ccc2-[n]2ncc(C(N3CCOCC3)=O)c2)CCC1 Chemical compound CC1N(CCCOc(cc2)ccc2-[n]2ncc(C(N3CCOCC3)=O)c2)CCC1 IABXVJILZYNSTM-UHFFFAOYSA-N 0.000 description 1
- NKTQIIIJPHVFEB-UHFFFAOYSA-N CC1N(CCCOc(cc2)ccc2-[n]2ncc(C(N3CCOCCC3)=O)c2)CCC1 Chemical compound CC1N(CCCOc(cc2)ccc2-[n]2ncc(C(N3CCOCCC3)=O)c2)CCC1 NKTQIIIJPHVFEB-UHFFFAOYSA-N 0.000 description 1
- PDLBRJUCXDROTG-UHFFFAOYSA-N CC1N(CCCOc(cc2)ccc2-[n]2ncc(NC(c(cc3)ccc3O)=O)c2)CCC1 Chemical compound CC1N(CCCOc(cc2)ccc2-[n]2ncc(NC(c(cc3)ccc3O)=O)c2)CCC1 PDLBRJUCXDROTG-UHFFFAOYSA-N 0.000 description 1
- NGXBUOLSJRIYMR-UHFFFAOYSA-O CC1N(CCCOc(cc2)ccc2-[n]2ncc(NS(c3cccnc3)([OH2+])=O)c2)CCC1 Chemical compound CC1N(CCCOc(cc2)ccc2-[n]2ncc(NS(c3cccnc3)([OH2+])=O)c2)CCC1 NGXBUOLSJRIYMR-UHFFFAOYSA-O 0.000 description 1
- UTRJNWWLPXDHJU-UHFFFAOYSA-N CC1N(CCCOc(cc2)ccc2I)CCC1 Chemical compound CC1N(CCCOc(cc2)ccc2I)CCC1 UTRJNWWLPXDHJU-UHFFFAOYSA-N 0.000 description 1
- FGSOIUAPUZWMAP-WRDKKKNXSA-N CCCCN(C)CCCOC(C)(CC1)C[C@H]1C(C)[n]1ncc(C(Nc(cc2)ccc2F)=O)c1 Chemical compound CCCCN(C)CCCOC(C)(CC1)C[C@H]1C(C)[n]1ncc(C(Nc(cc2)ccc2F)=O)c1 FGSOIUAPUZWMAP-WRDKKKNXSA-N 0.000 description 1
- PJZXYQHKCKLJLX-CQSZACIVSA-N C[C@H]1N(CCCOc(cc2)ccc2-[n]2ncc(C(N)=O)c2)CCC1 Chemical compound C[C@H]1N(CCCOc(cc2)ccc2-[n]2ncc(C(N)=O)c2)CCC1 PJZXYQHKCKLJLX-CQSZACIVSA-N 0.000 description 1
- ZUUUWBCNBMSCFN-MRXNPFEDSA-N C[C@H]1N(CCCOc(cc2)ccc2-[n]2ncc(N(C)S(C)(=O)=O)c2)CCC1 Chemical compound C[C@H]1N(CCCOc(cc2)ccc2-[n]2ncc(N(C)S(C)(=O)=O)c2)CCC1 ZUUUWBCNBMSCFN-MRXNPFEDSA-N 0.000 description 1
- PEWUJQSDWONAOM-UHFFFAOYSA-N O=C(c1c[n](-c(cc2)ccc2OCCCN2CCCC2)nc1)N1CCOCC1 Chemical compound O=C(c1c[n](-c(cc2)ccc2OCCCN2CCCC2)nc1)N1CCOCC1 PEWUJQSDWONAOM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007294040 | 2007-11-13 | ||
| JP2007294040 | 2007-11-13 | ||
| JP2008153736 | 2008-06-12 | ||
| JP2008153736 | 2008-06-12 | ||
| PCT/JP2008/070712 WO2009063953A1 (ja) | 2007-11-13 | 2008-11-13 | フェニルピラゾール誘導体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010024303A Division JP5375639B2 (ja) | 2007-11-13 | 2010-02-05 | フェニルピラゾール誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP4543344B2 true JP4543344B2 (ja) | 2010-09-15 |
| JPWO2009063953A1 JPWO2009063953A1 (ja) | 2011-03-31 |
Family
ID=40638800
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009541174A Active JP4543344B2 (ja) | 2007-11-13 | 2008-11-13 | フェニルピラゾール誘導体 |
| JP2010024303A Expired - Fee Related JP5375639B2 (ja) | 2007-11-13 | 2010-02-05 | フェニルピラゾール誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010024303A Expired - Fee Related JP5375639B2 (ja) | 2007-11-13 | 2010-02-05 | フェニルピラゾール誘導体 |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US7888354B2 (enExample) |
| EP (1) | EP2221298B1 (enExample) |
| JP (2) | JP4543344B2 (enExample) |
| KR (1) | KR101571176B1 (enExample) |
| CN (1) | CN101855211B (enExample) |
| AU (1) | AU2008321823B2 (enExample) |
| BR (1) | BRPI0820432B8 (enExample) |
| CA (1) | CA2705502C (enExample) |
| CY (1) | CY1114877T1 (enExample) |
| DK (1) | DK2221298T3 (enExample) |
| ES (1) | ES2436146T3 (enExample) |
| HR (1) | HRP20131060T1 (enExample) |
| IL (2) | IL205509A (enExample) |
| MX (1) | MX2010005225A (enExample) |
| MY (1) | MY173546A (enExample) |
| NZ (1) | NZ585661A (enExample) |
| PH (1) | PH12012501917A1 (enExample) |
| PL (1) | PL2221298T3 (enExample) |
| PT (1) | PT2221298E (enExample) |
| RS (1) | RS53125B (enExample) |
| RU (1) | RU2480456C2 (enExample) |
| SI (1) | SI2221298T1 (enExample) |
| WO (1) | WO2009063953A1 (enExample) |
| ZA (1) | ZA201003111B (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010143943A (ja) * | 2007-11-13 | 2010-07-01 | Taisho Pharmaceutical Co Ltd | フェニルピラゾール誘導体 |
| JP2010285423A (ja) * | 2009-05-12 | 2010-12-24 | Taisho Pharmaceutical Co Ltd | フェニルピラゾール誘導体 |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008072724A1 (ja) * | 2006-12-14 | 2008-06-19 | Taisho Pharmaceutical Co., Ltd. | ピラゾール誘導体 |
| TWI555741B (zh) | 2011-12-08 | 2016-11-01 | 大正製藥股份有限公司 | Phenylpyrrole derivatives |
| US20150045553A1 (en) * | 2011-12-27 | 2015-02-12 | Taisho Pharmaceutical Co., Ltd | Phenyltriazole derivative |
| WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
| DK2928474T3 (en) | 2012-12-07 | 2019-02-11 | Chemocentryx Inc | Diazollactamer |
| WO2014111356A1 (en) * | 2013-01-17 | 2014-07-24 | F. Hoffmann-La Roche Ag | Oxytocin receptor agonists for the treatment of cns diseases |
| RU2745195C2 (ru) | 2016-04-07 | 2021-03-22 | Кемосентрикс, Инк. | Уменьшение массы опухоли путем введения ccr1 антагонистов в комбинации с pd-1 ингибиторами или pd-l1 ингибиторами |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002040461A2 (en) * | 2000-11-17 | 2002-05-23 | Abbott Laboratories | Aminoalkoxybiphenyl carboxamides as histamine-3 receptor ligands and their therapeutic applications |
| WO2006059778A1 (ja) * | 2004-12-01 | 2006-06-08 | Banyu Pharmaceutical Co., Ltd. | 置換ピリドン誘導体 |
| WO2006103045A1 (en) * | 2005-03-31 | 2006-10-05 | Ucb Pharma S.A. | Compounds comprising an oxazole or thiazole moiety, processes for making them, and their uses |
| WO2007009741A1 (en) * | 2005-07-19 | 2007-01-25 | Glaxo Group Limited | Piperazinone derivatives useful as histamine h3 receptor antagonists and/or inverse agonists |
| WO2007009739A1 (en) * | 2005-07-19 | 2007-01-25 | Glaxo Group Limited | Compounds |
| WO2007094962A2 (en) * | 2006-02-09 | 2007-08-23 | Athersys, Inc. | Pyrazoles for the treatment of obesity and other cns disorders |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL104311A (en) * | 1992-02-05 | 1997-07-13 | Fujisawa Pharmaceutical Co | Pyrazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same |
| PL360373A1 (en) | 2000-08-08 | 2004-09-06 | Ortho Mcneil Pharmaceutical, Inc. | Non-imidazole aryloxypiperidines as h3 receptor ligands |
| CA2440238C (en) * | 2001-03-16 | 2011-09-13 | Abbott Laboratories | Novel amines as histamine-3 receptor ligands and their therapeutic applications |
| WO2005007644A1 (ja) | 2003-06-27 | 2005-01-27 | Banyu Pharmaceutical Co., Ltd | ヘテロアリールオキシ含窒素飽和へテロ環誘導体 |
| CN1972914A (zh) | 2004-03-31 | 2007-05-30 | 詹森药业有限公司 | 作为组胺h3受体配合体的非咪唑杂环化合物 |
| GB0408083D0 (en) | 2004-04-08 | 2004-05-12 | Glaxo Group Ltd | Novel compounds |
| FR2870846B1 (fr) | 2004-05-25 | 2006-08-04 | Sanofi Synthelabo | Derives de tetrahydroisoquinolylsulfonamides, leur preparation et leur utilisation en therapeutique |
| SE0401971D0 (sv) | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Piperidne derivatives |
| EP1784400B1 (en) | 2004-08-23 | 2015-01-14 | Eli Lilly And Company | Histamine h3 receptor agents, preparation and therapeutic uses |
| ATE517882T1 (de) | 2004-10-19 | 2011-08-15 | Hoffmann La Roche | Chinolinderivate |
| WO2006046131A1 (en) | 2004-10-29 | 2006-05-04 | Pfizer Products Inc. | Tetralin histamine-3 receptor antagonists |
| CA2589831A1 (en) | 2004-12-07 | 2006-06-15 | Glaxo Group Limited | Indenyl derivatives and use thereof for the treatment of neurological disorders |
| CN101151244B (zh) | 2005-04-01 | 2014-09-03 | 伊莱利利公司 | 组胺h3受体活性剂、制备和治疗用途 |
| DE102005033448A1 (de) * | 2005-07-18 | 2007-01-25 | Josef Gail | Druckgas-Zylinderläufermotor |
| WO2008072724A1 (ja) | 2006-12-14 | 2008-06-19 | Taisho Pharmaceutical Co., Ltd. | ピラゾール誘導体 |
| US20100113778A1 (en) * | 2007-04-12 | 2010-05-06 | John-Matthias Wiegand | Process for preparing o-chloromethylphenylglyoxylic esters, improved process for preparing (e)-2-(2-chloromethylphenyl)-2-alkoximinoacetic esters, and novel intermediates for their preparation |
| CN101855211B (zh) * | 2007-11-13 | 2013-06-12 | 大正制药株式会社 | 苯基吡唑衍生物 |
-
2008
- 2008-11-13 CN CN200880115707XA patent/CN101855211B/zh not_active Expired - Fee Related
- 2008-11-13 PL PL08849725T patent/PL2221298T3/pl unknown
- 2008-11-13 HR HRP20131060AT patent/HRP20131060T1/hr unknown
- 2008-11-13 MX MX2010005225A patent/MX2010005225A/es active IP Right Grant
- 2008-11-13 DK DK08849725.0T patent/DK2221298T3/da active
- 2008-11-13 US US12/741,754 patent/US7888354B2/en active Active
- 2008-11-13 RS RS20130586A patent/RS53125B/sr unknown
- 2008-11-13 PT PT88497250T patent/PT2221298E/pt unknown
- 2008-11-13 MY MYPI2010002187A patent/MY173546A/en unknown
- 2008-11-13 SI SI200831096T patent/SI2221298T1/sl unknown
- 2008-11-13 NZ NZ585661A patent/NZ585661A/en not_active IP Right Cessation
- 2008-11-13 AU AU2008321823A patent/AU2008321823B2/en not_active Ceased
- 2008-11-13 CA CA2705502A patent/CA2705502C/en active Active
- 2008-11-13 ES ES08849725T patent/ES2436146T3/es active Active
- 2008-11-13 WO PCT/JP2008/070712 patent/WO2009063953A1/ja not_active Ceased
- 2008-11-13 RU RU2010123924/04A patent/RU2480456C2/ru active
- 2008-11-13 BR BRPI0820432A patent/BRPI0820432B8/pt not_active IP Right Cessation
- 2008-11-13 EP EP08849725.0A patent/EP2221298B1/en active Active
- 2008-11-13 PH PH1/2012/501917A patent/PH12012501917A1/en unknown
- 2008-11-13 JP JP2009541174A patent/JP4543344B2/ja active Active
- 2008-11-13 KR KR1020107009179A patent/KR101571176B1/ko not_active Expired - Fee Related
-
2010
- 2010-02-05 JP JP2010024303A patent/JP5375639B2/ja not_active Expired - Fee Related
- 2010-05-03 IL IL205509A patent/IL205509A/en active IP Right Grant
- 2010-05-04 ZA ZA2010/03111A patent/ZA201003111B/en unknown
- 2010-11-22 US US12/951,978 patent/US8193176B2/en not_active Expired - Fee Related
- 2010-11-22 US US12/951,964 patent/US8183387B2/en not_active Expired - Fee Related
-
2014
- 2014-01-09 CY CY20141100018T patent/CY1114877T1/el unknown
- 2014-12-04 IL IL236083A patent/IL236083A/en active IP Right Grant
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002040461A2 (en) * | 2000-11-17 | 2002-05-23 | Abbott Laboratories | Aminoalkoxybiphenyl carboxamides as histamine-3 receptor ligands and their therapeutic applications |
| WO2006059778A1 (ja) * | 2004-12-01 | 2006-06-08 | Banyu Pharmaceutical Co., Ltd. | 置換ピリドン誘導体 |
| WO2006103045A1 (en) * | 2005-03-31 | 2006-10-05 | Ucb Pharma S.A. | Compounds comprising an oxazole or thiazole moiety, processes for making them, and their uses |
| WO2006103057A1 (en) * | 2005-03-31 | 2006-10-05 | Ucb Pharma, S.A. | Compounds comprising an oxazoline or thiazoline moiety, processes for making them, and their uses |
| WO2007009741A1 (en) * | 2005-07-19 | 2007-01-25 | Glaxo Group Limited | Piperazinone derivatives useful as histamine h3 receptor antagonists and/or inverse agonists |
| WO2007009739A1 (en) * | 2005-07-19 | 2007-01-25 | Glaxo Group Limited | Compounds |
| WO2007094962A2 (en) * | 2006-02-09 | 2007-08-23 | Athersys, Inc. | Pyrazoles for the treatment of obesity and other cns disorders |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010143943A (ja) * | 2007-11-13 | 2010-07-01 | Taisho Pharmaceutical Co Ltd | フェニルピラゾール誘導体 |
| JP2010285423A (ja) * | 2009-05-12 | 2010-12-24 | Taisho Pharmaceutical Co Ltd | フェニルピラゾール誘導体 |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5375639B2 (ja) | フェニルピラゾール誘導体 | |
| AU2004228120B2 (en) | Substituted pyrazoles | |
| US20100113776A1 (en) | Pyrazole derivative | |
| JP6098892B2 (ja) | フェニルピロール誘導体 | |
| CA2521199A1 (en) | Pyrazole compounds | |
| CN101395139A (zh) | 西格玛受体化合物 | |
| JP5740838B2 (ja) | フェニルピラゾール誘導体 | |
| HK1145834B (en) | Phenylpyrazole derivatives | |
| JP2010090067A (ja) | 含窒素複素環誘導体 | |
| JPWO2013100054A1 (ja) | フェニルトリアゾール誘導体 | |
| JP2010090075A (ja) | インドール又はインドリン誘導体 | |
| JP2015027999A (ja) | フェニルトリアゾール誘導体を含有する医薬 | |
| JP2015013853A (ja) | フェニルピロール誘導体を含有する医薬 | |
| HK1228379A1 (en) | Morpholin-pyridine derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20100603 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20100616 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130709 Year of fee payment: 3 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 4543344 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130709 Year of fee payment: 3 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |