KR101571176B1 - 페닐피라졸 유도체 - Google Patents
페닐피라졸 유도체 Download PDFInfo
- Publication number
- KR101571176B1 KR101571176B1 KR1020107009179A KR20107009179A KR101571176B1 KR 101571176 B1 KR101571176 B1 KR 101571176B1 KR 1020107009179 A KR1020107009179 A KR 1020107009179A KR 20107009179 A KR20107009179 A KR 20107009179A KR 101571176 B1 KR101571176 B1 KR 101571176B1
- Authority
- KR
- South Korea
- Prior art keywords
- phenyl
- alkyl
- halogen
- propoxy
- methylpyrrolidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CCC(*)*(CC*)CCC(CC)CC(CCOc1ccc(*2*=CC(*C)=C2)cc1)*C1[C@@](C)C1 Chemical compound CCC(*)*(CC*)CCC(CC)CC(CCOc1ccc(*2*=CC(*C)=C2)cc1)*C1[C@@](C)C1 0.000 description 7
- NBIDEINMRVXYIS-UHFFFAOYSA-N CCC1N(CCCOc(cc2)ccc2-[n]2ncc(C(N3CCOCC3)=O)c2)CCC1 Chemical compound CCC1N(CCCOc(cc2)ccc2-[n]2ncc(C(N3CCOCC3)=O)c2)CCC1 NBIDEINMRVXYIS-UHFFFAOYSA-N 0.000 description 1
- MYNJNHNWYBRDDJ-MRXNPFEDSA-N CCOC(c1c[n](-c(cc2)ccc2OCCCN2[C@H](C)CCC2)nc1)=O Chemical compound CCOC(c1c[n](-c(cc2)ccc2OCCCN2[C@H](C)CCC2)nc1)=O MYNJNHNWYBRDDJ-MRXNPFEDSA-N 0.000 description 1
- OPDVSLWLTBBRLQ-UHFFFAOYSA-N CCOCCN(C)C(c1c[n](C(CC2)=CC=C2OCCCN2[IH]CCC2C)nc1)=O Chemical compound CCOCCN(C)C(c1c[n](C(CC2)=CC=C2OCCCN2[IH]CCC2C)nc1)=O OPDVSLWLTBBRLQ-UHFFFAOYSA-N 0.000 description 1
- LESTYABWGBPGNU-LJQANCHMSA-N C[C@H]1N(CCCCOc(cc2)ccc2-[n]2ncc(C(N3CCOCC3)=O)c2)CCC1 Chemical compound C[C@H]1N(CCCCOc(cc2)ccc2-[n]2ncc(C(N3CCOCC3)=O)c2)CCC1 LESTYABWGBPGNU-LJQANCHMSA-N 0.000 description 1
- MEBVCKZTEDADOU-AQNXPRMDSA-N C[C@H]1N(CCCOc(cc2)ccc2-[n]2ncc(C(N3C[C@H](C)O[C@H](C)C3)=O)c2)CCC1 Chemical compound C[C@H]1N(CCCOc(cc2)ccc2-[n]2ncc(C(N3C[C@H](C)O[C@H](C)C3)=O)c2)CCC1 MEBVCKZTEDADOU-AQNXPRMDSA-N 0.000 description 1
- PZRVQACPBLRYTI-MRXNPFEDSA-N C[C@H]1N(CCCOc(cc2)ccc2-[n]2ncc(C(NCCO)=O)c2)CCC1 Chemical compound C[C@H]1N(CCCOc(cc2)ccc2-[n]2ncc(C(NCCO)=O)c2)CCC1 PZRVQACPBLRYTI-MRXNPFEDSA-N 0.000 description 1
- TYMPTWLKVMOQKK-GOSISDBHSA-N C[C@H]1N(CCCOc(cc2)ccc2-[n]2ncc(C(NCCOCCO)=O)c2)CCC1 Chemical compound C[C@H]1N(CCCOc(cc2)ccc2-[n]2ncc(C(NCCOCCO)=O)c2)CCC1 TYMPTWLKVMOQKK-GOSISDBHSA-N 0.000 description 1
- BKUDAPZYHOIWPF-LJQANCHMSA-N C[C@H]1N(CCCOc(cc2)ccc2-[n]2ncc(NC(Cc(cc3)ccc3O)=O)c2)CCC1 Chemical compound C[C@H]1N(CCCOc(cc2)ccc2-[n]2ncc(NC(Cc(cc3)ccc3O)=O)c2)CCC1 BKUDAPZYHOIWPF-LJQANCHMSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JPJP-P-2007-294040 | 2007-11-13 | ||
| JP2007294040 | 2007-11-13 | ||
| JPJP-P-2008-153736 | 2008-06-12 | ||
| JP2008153736 | 2008-06-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20100083795A KR20100083795A (ko) | 2010-07-22 |
| KR101571176B1 true KR101571176B1 (ko) | 2015-11-23 |
Family
ID=40638800
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020107009179A Expired - Fee Related KR101571176B1 (ko) | 2007-11-13 | 2008-11-13 | 페닐피라졸 유도체 |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US7888354B2 (enExample) |
| EP (1) | EP2221298B1 (enExample) |
| JP (2) | JP4543344B2 (enExample) |
| KR (1) | KR101571176B1 (enExample) |
| CN (1) | CN101855211B (enExample) |
| AU (1) | AU2008321823B2 (enExample) |
| BR (1) | BRPI0820432B8 (enExample) |
| CA (1) | CA2705502C (enExample) |
| CY (1) | CY1114877T1 (enExample) |
| DK (1) | DK2221298T3 (enExample) |
| ES (1) | ES2436146T3 (enExample) |
| HR (1) | HRP20131060T1 (enExample) |
| IL (2) | IL205509A (enExample) |
| MX (1) | MX2010005225A (enExample) |
| MY (1) | MY173546A (enExample) |
| NZ (1) | NZ585661A (enExample) |
| PH (1) | PH12012501917A1 (enExample) |
| PL (1) | PL2221298T3 (enExample) |
| PT (1) | PT2221298E (enExample) |
| RS (1) | RS53125B (enExample) |
| RU (1) | RU2480456C2 (enExample) |
| SI (1) | SI2221298T1 (enExample) |
| WO (1) | WO2009063953A1 (enExample) |
| ZA (1) | ZA201003111B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008072724A1 (ja) * | 2006-12-14 | 2008-06-19 | Taisho Pharmaceutical Co., Ltd. | ピラゾール誘導体 |
| CN101855211B (zh) * | 2007-11-13 | 2013-06-12 | 大正制药株式会社 | 苯基吡唑衍生物 |
| JP5740838B2 (ja) * | 2009-05-12 | 2015-07-01 | 大正製薬株式会社 | フェニルピラゾール誘導体 |
| WO2013085018A1 (ja) * | 2011-12-08 | 2013-06-13 | 大正製薬株式会社 | フェニルピロール誘導体 |
| EP2799436A4 (en) * | 2011-12-27 | 2015-07-01 | Taisho Pharmaceutical Co Ltd | PHENYLTRIAZOLDERIVAT |
| WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
| ES2707323T3 (es) | 2012-12-07 | 2019-04-03 | Chemocentryx Inc | Diazol lactamas |
| CN104936593B (zh) * | 2013-01-17 | 2018-05-18 | 霍夫曼-拉罗奇有限公司 | 用于治疗cns疾病的催产素受体激动剂 |
| WO2017176965A1 (en) | 2016-04-07 | 2017-10-12 | Chemocentryx, Inc. | Reducing tumor burden by administering ccr1 antagonists in combination with pd-1 inhibitors or pd-l1 inhibitors |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002040461A2 (en) * | 2000-11-17 | 2002-05-23 | Abbott Laboratories | Aminoalkoxybiphenyl carboxamides as histamine-3 receptor ligands and their therapeutic applications |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL104311A (en) * | 1992-02-05 | 1997-07-13 | Fujisawa Pharmaceutical Co | Pyrazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same |
| KR100852362B1 (ko) | 2000-08-08 | 2008-08-14 | 오르토-맥네일 파마슈티칼, 인코퍼레이티드 | 비-이미다졸 아릴옥시피페리딘 |
| BR0205829A (pt) * | 2001-03-16 | 2005-03-08 | Abbott Lab | Novas aminas como ligantes dos receptores de histamina-3 e suas aplicações terapêuticas |
| CN1812981A (zh) | 2003-06-27 | 2006-08-02 | 万有制药株式会社 | 杂芳氧基含氮饱和杂环衍生物 |
| WO2005097751A2 (en) | 2004-03-31 | 2005-10-20 | Janssen Pharmaceutica, N.V. | Non-imidazole heterocyclic compounds as histamine h3-receptor ligands |
| GB0408083D0 (en) | 2004-04-08 | 2004-05-12 | Glaxo Group Ltd | Novel compounds |
| FR2870846B1 (fr) * | 2004-05-25 | 2006-08-04 | Sanofi Synthelabo | Derives de tetrahydroisoquinolylsulfonamides, leur preparation et leur utilisation en therapeutique |
| SE0401971D0 (sv) | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Piperidne derivatives |
| JP4942654B2 (ja) | 2004-08-23 | 2012-05-30 | イーライ リリー アンド カンパニー | ヒスタミンｈ３受容体薬剤、製剤及び治療的使用 |
| MX2007004465A (es) | 2004-10-19 | 2007-05-07 | Hoffmann La Roche | Derivados de quinolina. |
| WO2006046131A1 (en) | 2004-10-29 | 2006-05-04 | Pfizer Products Inc. | Tetralin histamine-3 receptor antagonists |
| WO2006059778A1 (ja) | 2004-12-01 | 2006-06-08 | Banyu Pharmaceutical Co., Ltd. | 置換ピリドン誘導体 |
| EP1833796A1 (en) | 2004-12-07 | 2007-09-19 | Glaxo Group Limited | Indenyl derivatives and use thereof for the treatment of neurological disorders |
| EP1866293A1 (en) * | 2005-03-31 | 2007-12-19 | UCB Pharma, S.A. | Compounds comprising an oxazole or thiazole moiety, processes for making them, and their uses |
| CA2602234C (en) | 2005-04-01 | 2014-01-14 | Eli Lilly And Company | Histamine h3 receptor agents, preparation and therapeutic uses |
| DE102005033448A1 (de) * | 2005-07-18 | 2007-01-25 | Josef Gail | Druckgas-Zylinderläufermotor |
| GB0514812D0 (en) | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
| GB0514811D0 (en) * | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
| US7897634B2 (en) * | 2006-02-09 | 2011-03-01 | Athersys, Inc. | Pyrazoles for the treatment of obesity and other CNS disorders |
| WO2008072724A1 (ja) | 2006-12-14 | 2008-06-19 | Taisho Pharmaceutical Co., Ltd. | ピラゾール誘導体 |
| CN101711232A (zh) * | 2007-04-12 | 2010-05-19 | Dsm精细化学奥地利Nfg两合公司 | 邻-氯甲基苯基乙醛酸酯、(e)-2-(2-氯甲基苯基)-2-烷氧亚胺基乙酸酯的改进制备方法以及用于这些制备方法的新型中间体 |
| CN101855211B (zh) * | 2007-11-13 | 2013-06-12 | 大正制药株式会社 | 苯基吡唑衍生物 |
-
2008
- 2008-11-13 CN CN200880115707XA patent/CN101855211B/zh not_active Expired - Fee Related
- 2008-11-13 RU RU2010123924/04A patent/RU2480456C2/ru active
- 2008-11-13 JP JP2009541174A patent/JP4543344B2/ja active Active
- 2008-11-13 AU AU2008321823A patent/AU2008321823B2/en not_active Ceased
- 2008-11-13 MY MYPI2010002187A patent/MY173546A/en unknown
- 2008-11-13 CA CA2705502A patent/CA2705502C/en active Active
- 2008-11-13 PH PH1/2012/501917A patent/PH12012501917A1/en unknown
- 2008-11-13 DK DK08849725.0T patent/DK2221298T3/da active
- 2008-11-13 US US12/741,754 patent/US7888354B2/en active Active
- 2008-11-13 WO PCT/JP2008/070712 patent/WO2009063953A1/ja not_active Ceased
- 2008-11-13 BR BRPI0820432A patent/BRPI0820432B8/pt not_active IP Right Cessation
- 2008-11-13 HR HRP20131060AT patent/HRP20131060T1/hr unknown
- 2008-11-13 SI SI200831096T patent/SI2221298T1/sl unknown
- 2008-11-13 NZ NZ585661A patent/NZ585661A/en not_active IP Right Cessation
- 2008-11-13 MX MX2010005225A patent/MX2010005225A/es active IP Right Grant
- 2008-11-13 KR KR1020107009179A patent/KR101571176B1/ko not_active Expired - Fee Related
- 2008-11-13 PT PT88497250T patent/PT2221298E/pt unknown
- 2008-11-13 ES ES08849725T patent/ES2436146T3/es active Active
- 2008-11-13 RS RS20130586A patent/RS53125B/sr unknown
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002040461A2 (en) * | 2000-11-17 | 2002-05-23 | Abbott Laboratories | Aminoalkoxybiphenyl carboxamides as histamine-3 receptor ligands and their therapeutic applications |
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