JP4502408B2 - Cxcr3ケモカイン受容体、抗体、核酸および使用方法 - Google Patents

Cxcr3ケモカイン受容体、抗体、核酸および使用方法 Download PDF

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Publication number
JP4502408B2
JP4502408B2 JP51377198A JP51377198A JP4502408B2 JP 4502408 B2 JP4502408 B2 JP 4502408B2 JP 51377198 A JP51377198 A JP 51377198A JP 51377198 A JP51377198 A JP 51377198A JP 4502408 B2 JP4502408 B2 JP 4502408B2
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cxcr3
antibody
protein
binding
human
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Expired - Fee Related
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JP51377198A
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Japanese (ja)
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JP2002513388A (ja
JP2002513388A5 (https=
Inventor
レッチャー,マルセル
モーゼル,ベルンハルト
チン,シーシン
マッケイ,チャールズ,アール.
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Millennium Pharmaceuticals Inc
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Millennium Pharmaceuticals Inc
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Priority claimed from US08/709,838 external-priority patent/US6140064A/en
Application filed by Millennium Pharmaceuticals Inc filed Critical Millennium Pharmaceuticals Inc
Publication of JP2002513388A publication Critical patent/JP2002513388A/ja
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7158Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/642Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP51377198A 1996-09-10 1997-09-10 Cxcr3ケモカイン受容体、抗体、核酸および使用方法 Expired - Fee Related JP4502408B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/709,838 US6140064A (en) 1996-09-10 1996-09-10 Method of detecting or identifying ligands, inhibitors or promoters of CXC chemokine receptor 3
US08/709,838 1996-09-10
US08/829,839 1997-03-31
US08/829,839 US6184358B1 (en) 1996-09-10 1997-03-31 IP-10/Mig receptor designated CXCR3, antibodies, nucleic acids, and methods of use therefor
PCT/US1997/015915 WO1998011218A1 (en) 1996-09-10 1997-09-10 Cxcr3 chemokine receptor, antibodies, nucleic acids, and methods of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009167709A Division JP4955040B2 (ja) 1996-09-10 2009-07-16 Cxcr3ケモカイン受容体、抗体、核酸および使用方法

Publications (3)

Publication Number Publication Date
JP2002513388A JP2002513388A (ja) 2002-05-08
JP2002513388A5 JP2002513388A5 (https=) 2005-05-12
JP4502408B2 true JP4502408B2 (ja) 2010-07-14

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ID=27108320

Family Applications (1)

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JP51377198A Expired - Fee Related JP4502408B2 (ja) 1996-09-10 1997-09-10 Cxcr3ケモカイン受容体、抗体、核酸および使用方法

Country Status (8)

Country Link
EP (1) EP0925358B1 (https=)
JP (1) JP4502408B2 (https=)
AT (1) ATE360689T1 (https=)
AU (1) AU734090B2 (https=)
CA (1) CA2265915C (https=)
DE (1) DE69737656T2 (https=)
ES (1) ES2288305T3 (https=)
WO (1) WO1998011218A1 (https=)

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US7834155B2 (en) 2003-07-21 2010-11-16 Immunogen Inc. CA6 antigen-specific cytotoxic conjugate and methods of using the same
US7842790B2 (en) 1996-09-26 2010-11-30 Chugai Seiyaku Kabushiki Kaisha Antibodies against human parathyroid hormone related protein
US8029793B2 (en) 2000-04-28 2011-10-04 Chugai Seiyaku Kabushiki Kaisha Methods for inhibiting cell proliferation

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US6025154A (en) 1995-06-06 2000-02-15 Human Genome Sciences, Inc. Polynucleotides encoding human G-protein chemokine receptor HDGNR10
US7888466B2 (en) 1996-01-11 2011-02-15 Human Genome Sciences, Inc. Human G-protein chemokine receptor HSATU68
SE9801098D0 (sv) * 1998-03-30 1998-03-30 Astra Pharma Prod Receptors
AU3962099A (en) * 1998-05-07 1999-11-23 William Douglas Mckee Valve assembly
US6171590B1 (en) 1998-09-30 2001-01-09 Corixa Corporation Chemokine receptor peptide for inducing an immune response
WO2000028028A1 (en) * 1998-11-06 2000-05-18 Millennium Pharmaceuticals, Inc. G-protein coupled receptors, homologous to ebv-induced gpcr 2 (ebi-2). methods to seek for ligands thereof
US6329159B1 (en) * 1999-03-11 2001-12-11 Millennium Pharmaceuticals, Inc. Anti-GPR-9-6 antibodies and methods of identifying agents which modulate GPR-9-6 function
US6358697B2 (en) 1999-04-21 2002-03-19 Children's Hospital Medical Center Intracellular pharmaceutical targeting
JP2003506042A (ja) 1999-08-03 2003-02-18 ミレニアム ファーマシューティカルズ インク. セクレチン様ファミリーの新規gpcr様分子15571及びその使用
EP2261256A3 (en) * 1999-11-24 2011-03-02 Schering Corporation Methods of inhibiting metastasis
US6949243B1 (en) 1999-11-24 2005-09-27 Schering Corporation Methods of inhibiting metastasis
AU2001249546A1 (en) * 2000-03-27 2001-10-08 Corixa Corporation Methods for treating disease with antibodies to cxcr3
US7052676B2 (en) 2000-09-26 2006-05-30 The Regents Of The University Of Michigan Methods for inhibition of HIV replication using a small molecule inhibitor
US7175988B2 (en) 2001-02-09 2007-02-13 Human Genome Sciences, Inc. Human G-protein Chemokine Receptor (CCR5) HDGNR10
AU2002316674B2 (en) * 2001-07-12 2007-09-13 The Regents Of The University Of California CXCL10 treatment of secondary tissue degeneration
US7442512B2 (en) 2001-11-30 2008-10-28 Chemocentryx, Inc. Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors
US7871619B2 (en) 2001-11-30 2011-01-18 Chemocentryx, Inc. Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors
US7253007B2 (en) 2001-11-30 2007-08-07 Chemocentryx, Inc. Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors
US7413866B2 (en) 2001-11-30 2008-08-19 Chemocentryx, Inc. Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors
US7393934B2 (en) 2001-12-21 2008-07-01 Human Genome Sciences, Inc. Human G-protein chemokine receptor (CCR5) HDGNR10
EP1491209A4 (en) * 2002-02-28 2006-05-17 Kyowa Hakko Kogyo Kk MEANS FOR DIAGNOSIS AND TREATMENT OF INTERSTITIAL PNEUMONIA
JPWO2003082335A1 (ja) * 2002-04-03 2005-07-28 住友製薬株式会社 新規血糖調節薬及びそのスクリーニング方法
NZ566263A (en) 2002-05-24 2009-09-25 Millennium Pharm Inc CCR9 inhibitors and methods of use thereof
US7420055B2 (en) 2002-11-18 2008-09-02 Chemocentryx, Inc. Aryl sulfonamides
KR100874292B1 (ko) 2002-11-18 2008-12-18 케모센트릭스 아릴 술폰아마이드
US7741519B2 (en) 2007-04-23 2010-06-22 Chemocentryx, Inc. Bis-aryl sulfonamides
US7227035B2 (en) 2002-11-18 2007-06-05 Chemocentryx Bis-aryl sulfonamides
KR101061352B1 (ko) 2002-12-20 2011-08-31 케모센트릭스 인간 종양-발현된 ccxckr2의 저해물질
WO2005030793A2 (en) 2003-09-24 2005-04-07 Millennium Pharmaceuticals, Inc. Antibodies which bind human cxcr3
EP1723970A4 (en) * 2004-03-09 2009-08-12 Univ Kyoto MEDICAL COMPOSITION WITH CXCR3 INHIBITOR
EP1723178A4 (en) 2004-03-12 2007-12-12 Human Genome Sciences Inc HUMAN G-PROTEIN CHEMOKIN RECEPTOR (CCR5) HDGNR10
US7622583B2 (en) 2005-01-14 2009-11-24 Chemocentryx, Inc. Heteroaryl sulfonamides and CCR2
ES2434852T3 (es) 2005-04-21 2013-12-17 Chemocentryx, Inc. Anticuerpos que se unen a CCX-CKR2
EP2004675A1 (en) 2006-03-16 2008-12-24 Protagonists Ltd. Combination of cytokine and cytokine receptor for altering immune system functioning
US8519135B2 (en) 2006-07-14 2013-08-27 Chemocentryx, Inc. Heteroaryl sulfonamides and CCR2/CCR9
JP5371780B2 (ja) * 2007-02-01 2013-12-18 テバ バイオファーマシューティカルズ ユーエスエー インコーポレーティッド Cxcr3に対するヒト化抗体
US7776877B2 (en) 2007-06-22 2010-08-17 Chemocentryx, Inc. N-(2-(hetaryl)aryl) arylsulfonamides and N-(2-(hetaryl) hetaryl arylsulfonamides
JP5306344B2 (ja) 2007-07-12 2013-10-02 ケモセントリックス, インコーポレイテッド 炎症の治療のためのccr2モジュレーターとしての縮合ヘテロアリールピリジルおよびフェニルベンゼンスルホンアミド
WO2013109974A2 (en) * 2012-01-20 2013-07-25 Genzyme Corporation Anti-cxcr3 antibodies
HK1212628A1 (zh) * 2012-06-27 2016-06-17 吉安特科技公司 用於抑制炎症的抗-cxcl9、抗-cxcl10、抗-cxcl11、抗-cxcl13、抗-cxcr3和抗-cxcr5试剂
US9681647B2 (en) 2012-07-05 2017-06-20 Cornell University Mammal with an orthotopic tumor capable of metastasis, a method of making and a method of using
WO2014186842A1 (en) * 2013-05-22 2014-11-27 Monash University Antibodies and uses thereof
RU2765737C2 (ru) 2016-11-23 2022-02-02 Хемоцентрикс, Инк. Способ лечения фокально-сегментарного гломерулосклероза
WO2018106945A1 (en) 2016-12-07 2018-06-14 Progenity Inc. Gastrointestinal tract detection methods, devices and systems
EP3554541B1 (en) 2016-12-14 2023-06-07 Biora Therapeutics, Inc. Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor
RU2020113612A (ru) 2017-10-11 2021-11-12 Хемоцентрикс, Инк. Лечение фокально-сегментарного гломерулосклероза антагонистами ccr2
EP3883635A1 (en) 2018-11-19 2021-09-29 Progenity, Inc. Methods and devices for treating a disease with biotherapeutics
CN115666704B (zh) 2019-12-13 2025-09-26 比特比德科有限责任公司 用于将治疗剂递送至胃肠道的可摄取装置
EP4277924A2 (en) * 2021-01-12 2023-11-22 Charité - Universitätsmedizin Berlin A cxcr3+ cell or cell preparation for use in cancer treatment
WO2025185738A1 (zh) * 2024-03-08 2025-09-12 演生潮(北京)生物科技有限公司 靶向cxcr3的抗原结合蛋白及其应用

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US6806061B1 (en) * 1995-01-19 2004-10-19 Children's Medical Center Corporation G protein-coupled receptor gene and methods of use therefor

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7842790B2 (en) 1996-09-26 2010-11-30 Chugai Seiyaku Kabushiki Kaisha Antibodies against human parathyroid hormone related protein
US8029793B2 (en) 2000-04-28 2011-10-04 Chugai Seiyaku Kabushiki Kaisha Methods for inhibiting cell proliferation
US7834155B2 (en) 2003-07-21 2010-11-16 Immunogen Inc. CA6 antigen-specific cytotoxic conjugate and methods of using the same

Also Published As

Publication number Publication date
ATE360689T1 (de) 2007-05-15
DE69737656T2 (de) 2008-01-03
JP2002513388A (ja) 2002-05-08
ES2288305T3 (es) 2008-01-01
AU4260897A (en) 1998-04-02
CA2265915C (en) 2012-11-20
WO1998011218A1 (en) 1998-03-19
EP0925358A1 (en) 1999-06-30
DE69737656D1 (de) 2007-06-06
AU734090B2 (en) 2001-06-07
CA2265915A1 (en) 1998-03-19
EP0925358B1 (en) 2007-04-25

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