JP4485799B2 - メイタンシノイド産生を増加する突然変異アクチノシネマ・プレチオスム（Ａｃｔｉｎｏｓｙｎｎｅｍａｐｒｅｔｉｏｓｕｍ）株 - Google Patents

メイタンシノイド産生を増加する突然変異アクチノシネマ・プレチオスム（Ａｃｔｉｎｏｓｙｎｎｅｍａｐｒｅｔｉｏｓｕｍ）株 Download PDF

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JP4485799B2
JP4485799B2 JP2003564206A JP2003564206A JP4485799B2 JP 4485799 B2 JP4485799 B2 JP 4485799B2 JP 2003564206 A JP2003564206 A JP 2003564206A JP 2003564206 A JP2003564206 A JP 2003564206A JP 4485799 B2 JP4485799 B2 JP 4485799B2
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ansamitocin
plethiosum
actinocinema
atcc
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JP2005519594A (ja
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チュン，ジョンソン
ビン，グラハム，エス．
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イムノージェン インコーポレーテッド
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2003564206A 2002-01-29 2003-01-15 メイタンシノイド産生を増加する突然変異アクチノシネマ・プレチオスム（Ａｃｔｉｎｏｓｙｎｎｅｍａｐｒｅｔｉｏｓｕｍ）株 Expired - Lifetime JP4485799B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/057,561 US6790954B2 (en) 2002-01-29 2002-01-29 Mutant Actinosynnema pretiosum strain with increased maytansinoid production
PCT/US2003/000026 WO2003064610A2 (en) 2002-01-29 2003-01-15 Mutant actinosynnema pretiosum strain with increased maytansinoid production

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JP2009291891A Division JP2010110328A (ja) 2002-01-29 2009-12-24 メイタンシノイド産生を増加する突然変異アクチノシネマ・プレチオスム（Ａｃｔｉｎｏｓｙｎｎｅｍａｐｒｅｔｉｏｓｕｍ）株

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JP2005519594A JP2005519594A (ja) 2005-07-07
JP4485799B2 true JP4485799B2 (ja) 2010-06-23

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JP2003564206A Expired - Lifetime JP4485799B2 (ja) 2002-01-29 2003-01-15 メイタンシノイド産生を増加する突然変異アクチノシネマ・プレチオスム（Ａｃｔｉｎｏｓｙｎｎｅｍａｐｒｅｔｉｏｓｕｍ）株
JP2009291891A Pending JP2010110328A (ja) 2002-01-29 2009-12-24 メイタンシノイド産生を増加する突然変異アクチノシネマ・プレチオスム（Ａｃｔｉｎｏｓｙｎｎｅｍａｐｒｅｔｉｏｓｕｍ）株
JP2013155694A Expired - Lifetime JP5840656B2 (ja) 2002-01-29 2013-07-26 メイタンシノイド産生を増加する突然変異アクチノシネマ・プレチオスム（Ａｃｔｉｎｏｓｙｎｎｅｍａｐｒｅｔｉｏｓｕｍ）株

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JP2009291891A Pending JP2010110328A (ja) 2002-01-29 2009-12-24 メイタンシノイド産生を増加する突然変異アクチノシネマ・プレチオスム（Ａｃｔｉｎｏｓｙｎｎｅｍａｐｒｅｔｉｏｓｕｍ）株
JP2013155694A Expired - Lifetime JP5840656B2 (ja) 2002-01-29 2013-07-26 メイタンシノイド産生を増加する突然変異アクチノシネマ・プレチオスム（Ａｃｔｉｎｏｓｙｎｎｅｍａｐｒｅｔｉｏｓｕｍ）株

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Country Link
US (2) US6790954B2 (https=)
EP (1) EP1468077B1 (https=)
JP (3) JP4485799B2 (https=)
AT (1) ATE474043T1 (https=)
AU (1) AU2003238752B2 (https=)
CA (1) CA2474639C (https=)
CY (1) CY1111210T1 (https=)
DE (1) DE60333340D1 (https=)
DK (1) DK1468077T3 (https=)
ES (1) ES2348865T3 (https=)
NZ (1) NZ532831A (https=)
PT (1) PT1468077E (https=)
SI (1) SI1468077T1 (https=)
WO (1) WO2003064610A2 (https=)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
JP2013230163A (ja) * 2002-01-29 2013-11-14 Immunogen Inc メイタンシノイド産生を増加する突然変異アクチノシネマ・プレチオスム（Ａｃｔｉｎｏｓｙｎｎｅｍａｐｒｅｔｉｏｓｕｍ）株

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US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
EP1392359B2 (en) 2001-05-11 2013-03-13 Ludwig Institute for Cancer Research Ltd. Specific binding proteins and uses thereof
US7432088B2 (en) * 2003-05-08 2008-10-07 Immunogen Inc. Methods for the production of ansamitocins
US9090693B2 (en) 2007-01-25 2015-07-28 Dana-Farber Cancer Institute Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease
ES2542152T3 (es) 2007-03-15 2015-07-31 Ludwig Institute For Cancer Research Ltd. Método de tratamiento que emplea anticuerpos de EGFR e inhibidores de Src y formulaciones relacionadas
US20090011060A1 (en) * 2007-07-06 2009-01-08 Peter Koepke Campsiandra angustifolia extract and methods of extracting and using such extract
US20090017140A1 (en) * 2007-07-09 2009-01-15 Peter Koepke Maytenus abenfolia extract and methods of extracting and using such extract
US20090035395A1 (en) * 2007-08-01 2009-02-05 Peter Koepke Spondias mombin l. extract and methods of extracting and using such extract
CN108424454B (zh) 2007-08-14 2022-05-31 路德维格癌症研究所有限公司 靶向egf受体的单克隆抗体175及其衍生物和用途
US7879369B2 (en) * 2007-09-18 2011-02-01 Selvamedica, Llc Combretum laurifolium Mart. extract and methods of extracting and using such extract
NZ602675A (en) 2008-03-18 2014-03-28 Genentech Inc Combinations of an anti-her2 antibody-drug conjugate and chemotherapeutic agents, and methods of use
US20110076232A1 (en) * 2009-09-29 2011-03-31 Ludwig Institute For Cancer Research Specific binding proteins and uses thereof
US20110165155A1 (en) 2009-12-04 2011-07-07 Genentech, Inc. Methods of treating metastatic breast cancer with trastuzumab-mcc-dm1
TW201129384A (en) 2010-02-10 2011-09-01 Immunogen Inc CD20 antibodies and uses thereof
JP5889912B2 (ja) 2010-11-17 2016-03-22 ジェネンテック， インコーポレイテッド アラニニルメイタンシノール抗体コンジュゲート
KR20240129101A (ko) 2015-07-07 2024-08-27 제넨테크, 인크. 항-her2 항체-약물 접합체 및 bcl-2 억제제를 사용한 병용 요법
CN108330113B (zh) * 2018-03-08 2019-05-28 山东省医药生物技术研究中心（山东省病毒研究所） 一株高底物专一性酰基转移酶的珍贵束丝放线菌及其应用
DK3956332T3 (da) 2019-04-18 2023-05-01 Indena Spa Diasteroselektiv fremgangsmåde til fremstilling af thiol- eller disulfid-holdige maytansionidestere og mellemprodukter deraf
CN115322918B (zh) * 2021-05-11 2024-03-29 浙江珲达生物科技有限公司 一种高产安丝菌素p-3的菌株及其应用

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JPS6016236B2 (ja) * 1977-11-18 1985-04-24 武田薬品工業株式会社 抗生物質ｃ―１５００３ ｐ―３の製造法
JPS5645483A (en) * 1979-09-19 1981-04-25 Takeda Chem Ind Ltd C-15003phm and its preparation
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JPS626673A (ja) * 1985-07-04 1987-01-13 Zenkoku Nogyo Kyodo Kumiai Rengokai パスツレラ・ムルトシダ変異株、生菌ワクチン及びその菌株の取得法
US5250435A (en) 1991-06-04 1993-10-05 Merck & Co., Inc. Mutant strains of Aspergillus terreus for producing 7-[1,2,6,7,8,8a(R)-hexa-hydro-2(S),6(R)-dimethyl-8(S)-hydroxy-1(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid),I)
US5648261A (en) 1991-12-17 1997-07-15 Gist-Brocades, N.V. Strains of Phaffia rhodozyma containing high levels of astaxanthin and low levels of 3-hydroxy-3',4'-didehydro-β, Ψ-caroten-4-one (HDCO)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013230163A (ja) * 2002-01-29 2013-11-14 Immunogen Inc メイタンシノイド産生を増加する突然変異アクチノシネマ・プレチオスム（Ａｃｔｉｎｏｓｙｎｎｅｍａｐｒｅｔｉｏｓｕｍ）株

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US20030157694A1 (en) 2003-08-21
EP1468077A2 (en) 2004-10-20
PT1468077E (pt) 2010-10-12
US7192750B2 (en) 2007-03-20
WO2003064610A3 (en) 2004-01-22
JP2010110328A (ja) 2010-05-20
US6790954B2 (en) 2004-09-14
CA2474639A1 (en) 2003-08-07
CA2474639C (en) 2015-08-04
AU2003238752B2 (en) 2008-05-29
JP5840656B2 (ja) 2016-01-06
EP1468077A4 (en) 2006-06-07
ES2348865T3 (es) 2010-12-16
ATE474043T1 (de) 2010-07-15
NZ532831A (en) 2009-05-31
JP2005519594A (ja) 2005-07-07
DE60333340D1 (de) 2010-08-26
DK1468077T3 (da) 2010-10-25
EP1468077B1 (en) 2010-07-14
WO2003064610A2 (en) 2003-08-07
US20050003513A1 (en) 2005-01-06
CY1111210T1 (el) 2015-06-11
SI1468077T1 (sl) 2010-11-30
JP2013230163A (ja) 2013-11-14

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