JP4445128B2 - ヘリコバクター ピロリを阻害する方法 - Google Patents
ヘリコバクター ピロリを阻害する方法 Download PDFInfo
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- JP4445128B2 JP4445128B2 JP2000557387A JP2000557387A JP4445128B2 JP 4445128 B2 JP4445128 B2 JP 4445128B2 JP 2000557387 A JP2000557387 A JP 2000557387A JP 2000557387 A JP2000557387 A JP 2000557387A JP 4445128 B2 JP4445128 B2 JP 4445128B2
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- urei
- gene
- cassette
- pylori
- helicobacter
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- 239000002601 urease inhibitor Substances 0.000 description 1
- 230000003604 ureolytic effect Effects 0.000 description 1
- 230000007923 virulence factor Effects 0.000 description 1
- 239000000304 virulence factor Substances 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
Images
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/58—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving urea or urease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/121—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Helicobacter (Campylobacter) (G)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/18—Testing for antimicrobial activity of a material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/205—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Campylobacter (G)
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Communicable Diseases (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/107,383 | 1998-06-30 | ||
| US09/107,383 US6190667B1 (en) | 1998-06-30 | 1998-06-30 | Methods of inhibiting Helicobacter pylori |
| PCT/EP1999/004490 WO2000000634A2 (en) | 1998-06-30 | 1999-06-29 | METHODS OF INHIBITING $i(HELICOBACTER PYLORI) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002519039A JP2002519039A (ja) | 2002-07-02 |
| JP2002519039A5 JP2002519039A5 (enExample) | 2006-08-17 |
| JP4445128B2 true JP4445128B2 (ja) | 2010-04-07 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000557387A Expired - Fee Related JP4445128B2 (ja) | 1998-06-30 | 1999-06-29 | ヘリコバクター ピロリを阻害する方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US6190667B1 (enExample) |
| EP (1) | EP1092040B1 (enExample) |
| JP (1) | JP4445128B2 (enExample) |
| AT (1) | ATE288498T1 (enExample) |
| AU (1) | AU4779599A (enExample) |
| DE (1) | DE69923559T2 (enExample) |
| ES (1) | ES2237119T3 (enExample) |
| PT (1) | PT1092040E (enExample) |
| WO (1) | WO2000000634A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6190667B1 (en) * | 1998-06-30 | 2001-02-20 | Institut Pasteur | Methods of inhibiting Helicobacter pylori |
| US5942409A (en) * | 1998-07-31 | 1999-08-24 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Process for identification of substances modulating ureI dependent mechanisms of Helicobacter pylori metabolism |
| US20030113742A1 (en) * | 2001-04-20 | 2003-06-19 | University Of Iowa Research Foundation | Methods and compositions for the modulation of biofilm formation |
| US20070092502A1 (en) * | 2005-09-01 | 2007-04-26 | Allergan, Inc. | Method of Treating Glaucoma |
| ATE465928T1 (de) | 2005-11-21 | 2010-05-15 | Faroex Ltd | Verbundkarosserie für ein fahrzeug |
| CA2599560C (en) | 2006-09-01 | 2011-04-12 | Faroex Ltd. | Structural shear plate for a vehicle |
| DK2270133T3 (en) | 2008-04-22 | 2015-09-07 | Corporación Alimentaria Peñasanta Capsa | Method of obtaining a new strain of Bifidobacterium bidifum with effect against infection with Helicobacter pylori |
| CN111471780A (zh) * | 2020-03-16 | 2020-07-31 | 上海力拜生物科技有限公司 | 幽门螺杆菌唾液检测生物标志物及其应用 |
| CN117050169B (zh) * | 2023-08-14 | 2024-04-26 | 苏州东抗生物科技有限公司 | 一种针对UreA蛋白的单克隆抗体及其应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
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| USH25H (en) | 1985-06-17 | 1986-02-04 | Tennessee Valley Authority | Thiophosphoryl triamide as a urease inhibitor |
| FR2637612B1 (fr) | 1988-10-06 | 1993-09-10 | Pasteur Institut | Sequences de nucleotides codant pour une proteine a activite ureasique |
| GB8928625D0 (en) | 1989-12-19 | 1990-02-21 | 3I Res Expl Ltd | H.pylori dna probes |
| JPH04364160A (ja) | 1990-08-03 | 1992-12-16 | Terumo Corp | チオウレア誘導体およびこれを含有する抗菌剤および抗潰瘍剤 |
| JPH0559038A (ja) | 1991-09-06 | 1993-03-09 | Terumo Corp | チオウレア誘導体及びこれを含有する医薬製剤 |
| FR2682122B1 (fr) * | 1991-10-03 | 1995-06-09 | Pasteur Institut | Nouveaux genes d'helicobacter pylori. leur utilisation pour la preparation de souches recombinantes de h. pylori. |
| US5409903A (en) | 1992-02-18 | 1995-04-25 | Urecap Corporation | Method and compositions for the treatment of H. pylori and dermatitis |
| US5472695A (en) * | 1992-06-25 | 1995-12-05 | Technion Research And Development Foundation Ltd. | Therapeutic application of a thyme extract and in - vitro methods for inhibiting the growth and urease activity of helicobacter pylori |
| MX9304638A (es) | 1992-07-31 | 1994-05-31 | Neose Pharm Inc | Composicion para tratar e inhibir las ulceras gastricas y duodenales. |
| US5972336A (en) * | 1992-11-03 | 1999-10-26 | Oravax Merieux Co. | Urease-based vaccine against helicobacter infection |
| US6258359B1 (en) * | 1993-05-19 | 2001-07-10 | Institut Pasteur | Immunogenic compositions against helicobacter infection, polypeptides for use in the compositions, and nucleic acid sequences encoding said polypeptides |
| JPH08509873A (ja) * | 1993-05-19 | 1996-10-22 | アンスティテュ・パストゥール | ヘリコバクター感染に対する免疫組成物、該組成物に用いられるポリペプチドおよび該ポリペプチドをコードする核酸配列 |
| US5441875A (en) | 1993-07-23 | 1995-08-15 | Brigham And Women's Hospital | Urea transporter polypeptide |
| US5560912A (en) * | 1994-06-27 | 1996-10-01 | Technion Research & Development Foundation Ltd. | Method for inhibiting growth of helicobacter pylori |
| DE69637947D1 (de) | 1995-04-28 | 2009-07-23 | Merieux Oravax Snc | Multimerer, rekombinanter urease impfstoff |
| DE69636320T2 (de) | 1995-06-02 | 2007-07-26 | Eisai R&D Management Co., Ltd. | Helicobacter Polypeptide, deren Herstellung und Verwendung |
| SK165197A3 (en) | 1995-06-07 | 1999-01-11 | Astra Ab | Nucleic acid and amino acid sequences relating to helicobacter pylori for diagnostics and therapeutics |
| US6087358A (en) * | 1995-06-26 | 2000-07-11 | Pathogenesis Corporation | Nitro-[2,1-b]imidazopyran compounds and antibacterial uses thereof |
| FR2736360B1 (fr) * | 1995-07-04 | 1997-09-05 | Pasteur Institut | Clonage et caracterisation du gene fiba de h.pylori, production de souches aflagellees |
| TW290498B (en) * | 1995-07-19 | 1996-11-11 | Andover Coated Products Inc | Elastic bandage |
| SE506529C2 (sv) | 1996-01-23 | 1997-12-22 | Semper Ab | Användning av ett laktoperoxidassystem för framställning av ett läkemedel mot Helicobacter pylori |
| US5900410A (en) | 1996-08-27 | 1999-05-04 | Hartmann; John F. | Monotherapy of peptic ulcers and gastritis |
| EP0939800A2 (en) * | 1996-10-17 | 1999-09-08 | Institut Pasteur | HELICOBACTER ANTIGEN (gamma-GLUTAMYLTRANSFERASE) AND SEQUENCES ENCODING THE SAME |
| AU742521B2 (en) * | 1997-01-24 | 2002-01-03 | Avi Biopharma, Inc. | Method and conjugate for treating H. pylori infection |
| US5876946A (en) * | 1997-06-03 | 1999-03-02 | Pharmacopeia, Inc. | High-throughput assay |
| US5985631A (en) * | 1997-09-12 | 1999-11-16 | Oravax-Merieux Co. | Method for preventing the activation of inactive, recombinant Helicobacter pylori apourease |
| US6190667B1 (en) * | 1998-06-30 | 2001-02-20 | Institut Pasteur | Methods of inhibiting Helicobacter pylori |
| US5942409A (en) * | 1998-07-31 | 1999-08-24 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Process for identification of substances modulating ureI dependent mechanisms of Helicobacter pylori metabolism |
| ES2191470T3 (es) * | 1998-10-02 | 2003-09-01 | 3M Innovative Properties Co | Material compuesto, elastico y estratificado. |
| US20040142343A1 (en) * | 2002-08-16 | 2004-07-22 | Yung-Fu Chang | Helicobacter bizzozeronii urease genes and their uses in diagnostic and treatment methods |
-
1998
- 1998-06-30 US US09/107,383 patent/US6190667B1/en not_active Expired - Fee Related
-
1999
- 1999-06-29 EP EP99931212A patent/EP1092040B1/en not_active Expired - Lifetime
- 1999-06-29 PT PT99931212T patent/PT1092040E/pt unknown
- 1999-06-29 AU AU47795/99A patent/AU4779599A/en not_active Abandoned
- 1999-06-29 JP JP2000557387A patent/JP4445128B2/ja not_active Expired - Fee Related
- 1999-06-29 AT AT99931212T patent/ATE288498T1/de not_active IP Right Cessation
- 1999-06-29 ES ES99931212T patent/ES2237119T3/es not_active Expired - Lifetime
- 1999-06-29 DE DE69923559T patent/DE69923559T2/de not_active Expired - Lifetime
- 1999-06-29 WO PCT/EP1999/004490 patent/WO2000000634A2/en not_active Ceased
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2000
- 2000-08-23 US US09/643,914 patent/US6416968B1/en not_active Expired - Fee Related
- 2000-12-22 US US09/742,361 patent/US6762051B2/en not_active Expired - Fee Related
-
2003
- 2003-11-25 US US10/720,470 patent/US20040115772A1/en not_active Abandoned
-
2005
- 2005-03-02 US US11/068,826 patent/US7517666B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002519039A (ja) | 2002-07-02 |
| AU4779599A (en) | 2000-01-17 |
| DE69923559D1 (de) | 2005-03-10 |
| US7517666B2 (en) | 2009-04-14 |
| US20040115772A1 (en) | 2004-06-17 |
| EP1092040A2 (en) | 2001-04-18 |
| WO2000000634A2 (en) | 2000-01-06 |
| US20020102269A1 (en) | 2002-08-01 |
| US20050176077A1 (en) | 2005-08-11 |
| DE69923559T2 (de) | 2006-02-16 |
| EP1092040B1 (en) | 2005-02-02 |
| WO2000000634A3 (en) | 2000-04-13 |
| ES2237119T3 (es) | 2005-07-16 |
| US6416968B1 (en) | 2002-07-09 |
| US6762051B2 (en) | 2004-07-13 |
| PT1092040E (pt) | 2005-06-30 |
| ATE288498T1 (de) | 2005-02-15 |
| US6190667B1 (en) | 2001-02-20 |
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