JP2002519039A5 - - Google Patents
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- Publication number
- JP2002519039A5 JP2002519039A5 JP2000557387A JP2000557387A JP2002519039A5 JP 2002519039 A5 JP2002519039 A5 JP 2002519039A5 JP 2000557387 A JP2000557387 A JP 2000557387A JP 2000557387 A JP2000557387 A JP 2000557387A JP 2002519039 A5 JP2002519039 A5 JP 2002519039A5
- Authority
- JP
- Japan
- Prior art keywords
- urei
- pylori
- molecule
- helicobacter
- inhibiting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 description 22
- 230000002401 inhibitory effect Effects 0.000 description 8
- 101150055940 ureI gene Proteins 0.000 description 6
- 238000001727 in vivo Methods 0.000 description 5
- 241000589989 Helicobacter Species 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 230000004083 survival effect Effects 0.000 description 4
- 230000002950 deficient Effects 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 241000590002 Helicobacter pylori Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 108010046334 Urease Proteins 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229940037467 helicobacter pylori Drugs 0.000 description 2
- 230000002163 immunogen Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 230000003834 intracellular effect Effects 0.000 description 2
- 239000013612 plasmid Substances 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241001503513 Helicobacter bilis Species 0.000 description 1
- 241001148144 Helicobacter canis Species 0.000 description 1
- 241000590017 Helicobacter felis Species 0.000 description 1
- 241001495142 Helicobacter heilmannii Species 0.000 description 1
- 241001453258 Helicobacter hepaticus Species 0.000 description 1
- 206010019375 Helicobacter infections Diseases 0.000 description 1
- 241000590012 Helicobacter muridarum Species 0.000 description 1
- 241000590006 Helicobacter mustelae Species 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/107,383 US6190667B1 (en) | 1998-06-30 | 1998-06-30 | Methods of inhibiting Helicobacter pylori |
| US09/107,383 | 1998-06-30 | ||
| PCT/EP1999/004490 WO2000000634A2 (en) | 1998-06-30 | 1999-06-29 | METHODS OF INHIBITING $i(HELICOBACTER PYLORI) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002519039A JP2002519039A (ja) | 2002-07-02 |
| JP2002519039A5 true JP2002519039A5 (enExample) | 2006-08-17 |
| JP4445128B2 JP4445128B2 (ja) | 2010-04-07 |
Family
ID=22316366
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000557387A Expired - Fee Related JP4445128B2 (ja) | 1998-06-30 | 1999-06-29 | ヘリコバクター ピロリを阻害する方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US6190667B1 (enExample) |
| EP (1) | EP1092040B1 (enExample) |
| JP (1) | JP4445128B2 (enExample) |
| AT (1) | ATE288498T1 (enExample) |
| AU (1) | AU4779599A (enExample) |
| DE (1) | DE69923559T2 (enExample) |
| ES (1) | ES2237119T3 (enExample) |
| PT (1) | PT1092040E (enExample) |
| WO (1) | WO2000000634A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6190667B1 (en) * | 1998-06-30 | 2001-02-20 | Institut Pasteur | Methods of inhibiting Helicobacter pylori |
| US5942409A (en) * | 1998-07-31 | 1999-08-24 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Process for identification of substances modulating ureI dependent mechanisms of Helicobacter pylori metabolism |
| US20030113742A1 (en) * | 2001-04-20 | 2003-06-19 | University Of Iowa Research Foundation | Methods and compositions for the modulation of biofilm formation |
| US20070092502A1 (en) * | 2005-09-01 | 2007-04-26 | Allergan, Inc. | Method of Treating Glaucoma |
| CA2688924C (en) | 2005-11-21 | 2012-12-04 | Faroex Ltd. | Joint for a composite vehicle body |
| CA2599560C (en) | 2006-09-01 | 2011-04-12 | Faroex Ltd. | Structural shear plate for a vehicle |
| DK2270133T3 (en) | 2008-04-22 | 2015-09-07 | Corporación Alimentaria Peñasanta Capsa | Method of obtaining a new strain of Bifidobacterium bidifum with effect against infection with Helicobacter pylori |
| CN111471780A (zh) * | 2020-03-16 | 2020-07-31 | 上海力拜生物科技有限公司 | 幽门螺杆菌唾液检测生物标志物及其应用 |
| CN117050169B (zh) * | 2023-08-14 | 2024-04-26 | 苏州东抗生物科技有限公司 | 一种针对UreA蛋白的单克隆抗体及其应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USH25H (en) | 1985-06-17 | 1986-02-04 | Tennessee Valley Authority | Thiophosphoryl triamide as a urease inhibitor |
| FR2637612B1 (fr) | 1988-10-06 | 1993-09-10 | Pasteur Institut | Sequences de nucleotides codant pour une proteine a activite ureasique |
| GB8928625D0 (en) | 1989-12-19 | 1990-02-21 | 3I Res Expl Ltd | H.pylori dna probes |
| JPH04364160A (ja) | 1990-08-03 | 1992-12-16 | Terumo Corp | チオウレア誘導体およびこれを含有する抗菌剤および抗潰瘍剤 |
| JPH0559038A (ja) | 1991-09-06 | 1993-03-09 | Terumo Corp | チオウレア誘導体及びこれを含有する医薬製剤 |
| FR2682122B1 (fr) * | 1991-10-03 | 1995-06-09 | Pasteur Institut | Nouveaux genes d'helicobacter pylori. leur utilisation pour la preparation de souches recombinantes de h. pylori. |
| US5409903A (en) | 1992-02-18 | 1995-04-25 | Urecap Corporation | Method and compositions for the treatment of H. pylori and dermatitis |
| US5472695A (en) * | 1992-06-25 | 1995-12-05 | Technion Research And Development Foundation Ltd. | Therapeutic application of a thyme extract and in - vitro methods for inhibiting the growth and urease activity of helicobacter pylori |
| MX9304638A (es) | 1992-07-31 | 1994-05-31 | Neose Pharm Inc | Composicion para tratar e inhibir las ulceras gastricas y duodenales. |
| US5972336A (en) * | 1992-11-03 | 1999-10-26 | Oravax Merieux Co. | Urease-based vaccine against helicobacter infection |
| JPH08509873A (ja) * | 1993-05-19 | 1996-10-22 | アンスティテュ・パストゥール | ヘリコバクター感染に対する免疫組成物、該組成物に用いられるポリペプチドおよび該ポリペプチドをコードする核酸配列 |
| US6258359B1 (en) * | 1993-05-19 | 2001-07-10 | Institut Pasteur | Immunogenic compositions against helicobacter infection, polypeptides for use in the compositions, and nucleic acid sequences encoding said polypeptides |
| US5441875A (en) | 1993-07-23 | 1995-08-15 | Brigham And Women's Hospital | Urea transporter polypeptide |
| US5560912A (en) * | 1994-06-27 | 1996-10-01 | Technion Research & Development Foundation Ltd. | Method for inhibiting growth of helicobacter pylori |
| PL185013B1 (pl) | 1995-04-28 | 2003-01-31 | Oravax Inc | Szczepionka do indukowania odpowiedzi immunologicznej i zestaw farmaceutyczny |
| DE69636320T2 (de) | 1995-06-02 | 2007-07-26 | Eisai R&D Management Co., Ltd. | Helicobacter Polypeptide, deren Herstellung und Verwendung |
| WO1996040893A1 (en) | 1995-06-07 | 1996-12-19 | Astra Aktiebolag | Nucleic acid and amino acid sequences relating to helicobacter pylori for diagnostics and therapeutics |
| US6087358A (en) * | 1995-06-26 | 2000-07-11 | Pathogenesis Corporation | Nitro-[2,1-b]imidazopyran compounds and antibacterial uses thereof |
| FR2736360B1 (fr) * | 1995-07-04 | 1997-09-05 | Pasteur Institut | Clonage et caracterisation du gene fiba de h.pylori, production de souches aflagellees |
| TW290498B (en) * | 1995-07-19 | 1996-11-11 | Andover Coated Products Inc | Elastic bandage |
| SE506529C2 (sv) | 1996-01-23 | 1997-12-22 | Semper Ab | Användning av ett laktoperoxidassystem för framställning av ett läkemedel mot Helicobacter pylori |
| US5900410A (en) | 1996-08-27 | 1999-05-04 | Hartmann; John F. | Monotherapy of peptic ulcers and gastritis |
| WO1998017804A2 (en) * | 1996-10-17 | 1998-04-30 | Institut Pasteur | A HELICOBACTER ANTIGEN (η-GLUTAMYLTRANSFERASE) AND SEQUENCES ENCODING THE SAME |
| CA2278924A1 (en) * | 1997-01-24 | 1998-07-30 | Avi Biopharma, Inc. | Method and conjugate for treating h. pylori infection |
| US5876946A (en) * | 1997-06-03 | 1999-03-02 | Pharmacopeia, Inc. | High-throughput assay |
| US5985631A (en) * | 1997-09-12 | 1999-11-16 | Oravax-Merieux Co. | Method for preventing the activation of inactive, recombinant Helicobacter pylori apourease |
| US6190667B1 (en) * | 1998-06-30 | 2001-02-20 | Institut Pasteur | Methods of inhibiting Helicobacter pylori |
| US5942409A (en) * | 1998-07-31 | 1999-08-24 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Process for identification of substances modulating ureI dependent mechanisms of Helicobacter pylori metabolism |
| DE69905059T2 (de) * | 1998-10-02 | 2003-11-20 | 3M Innovative Properties Co., Saint Paul | Elastische verbundwerkstoffe |
| US20040142343A1 (en) * | 2002-08-16 | 2004-07-22 | Yung-Fu Chang | Helicobacter bizzozeronii urease genes and their uses in diagnostic and treatment methods |
-
1998
- 1998-06-30 US US09/107,383 patent/US6190667B1/en not_active Expired - Fee Related
-
1999
- 1999-06-29 AT AT99931212T patent/ATE288498T1/de not_active IP Right Cessation
- 1999-06-29 WO PCT/EP1999/004490 patent/WO2000000634A2/en not_active Ceased
- 1999-06-29 EP EP99931212A patent/EP1092040B1/en not_active Expired - Lifetime
- 1999-06-29 ES ES99931212T patent/ES2237119T3/es not_active Expired - Lifetime
- 1999-06-29 AU AU47795/99A patent/AU4779599A/en not_active Abandoned
- 1999-06-29 JP JP2000557387A patent/JP4445128B2/ja not_active Expired - Fee Related
- 1999-06-29 DE DE69923559T patent/DE69923559T2/de not_active Expired - Lifetime
- 1999-06-29 PT PT99931212T patent/PT1092040E/pt unknown
-
2000
- 2000-08-23 US US09/643,914 patent/US6416968B1/en not_active Expired - Fee Related
- 2000-12-22 US US09/742,361 patent/US6762051B2/en not_active Expired - Fee Related
-
2003
- 2003-11-25 US US10/720,470 patent/US20040115772A1/en not_active Abandoned
-
2005
- 2005-03-02 US US11/068,826 patent/US7517666B2/en not_active Expired - Fee Related
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