JP4439814B2 - 動脈性高血圧症、他の心血管疾患、及びその合併症を治療するためのアンギオテンシンｉｉａｔ１受容体拮抗薬製剤の調製 - Google Patents
動脈性高血圧症、他の心血管疾患、及びその合併症を治療するためのアンギオテンシンｉｉａｔ１受容体拮抗薬製剤の調製 Download PDFInfo
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- JP4439814B2 JP4439814B2 JP2002578949A JP2002578949A JP4439814B2 JP 4439814 B2 JP4439814 B2 JP 4439814B2 JP 2002578949 A JP2002578949 A JP 2002578949A JP 2002578949 A JP2002578949 A JP 2002578949A JP 4439814 B2 JP4439814 B2 JP 4439814B2
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/085—Angiotensins
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- A—HUMAN NECESSITIES
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
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- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| PCT/BR2002/000051 WO2002080910A1 (en) | 2001-04-10 | 2002-04-09 | Preparation of formulations of angiotensin ii at1 receptors antagonists for the treatment of arterial hypertension, other cardiovascular illnesses and its complications |
Related Child Applications (1)
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| JP2009272002A Division JP2010047611A (ja) | 2001-04-10 | 2009-11-30 | 動脈性高血圧症、他の心血管疾患、及びその合併症を治療するためのアンギオテンシンｉｉａｔ１受容体拮抗薬製剤の調製 |
Publications (2)
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| JP4439814B2 true JP4439814B2 (ja) | 2010-03-24 |
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| JP2002578949A Expired - Fee Related JP4439814B2 (ja) | 2001-04-10 | 2002-04-09 | 動脈性高血圧症、他の心血管疾患、及びその合併症を治療するためのアンギオテンシンｉｉａｔ１受容体拮抗薬製剤の調製 |
| JP2009272002A Pending JP2010047611A (ja) | 2001-04-10 | 2009-11-30 | 動脈性高血圧症、他の心血管疾患、及びその合併症を治療するためのアンギオテンシンｉｉａｔ１受容体拮抗薬製剤の調製 |
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| EP (1) | EP1389106A1 (enExample) |
| JP (2) | JP4439814B2 (enExample) |
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| BR (1) | BR0102252B1 (enExample) |
| CA (1) | CA2444145C (enExample) |
| WO (1) | WO2002080910A1 (enExample) |
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| BR0102252B1 (pt) * | 2001-04-10 | 2013-10-22 | Sistema de liberação controlada para antagonista do receptor AT1 da angiotensina II, composição farmacêutica e seu uso | |
| US8101209B2 (en) | 2001-10-09 | 2012-01-24 | Flamel Technologies | Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles |
| BRPI0105509B8 (pt) * | 2001-11-05 | 2021-05-25 | Univ Minas Gerais | formulações do peptídeo angiotensina-(1-7) usando as ciclodextrinas, lipossomas e o polímero plga |
| AU2003246791A1 (en) | 2002-04-09 | 2003-10-20 | Flamel Technologies | Oral suspension of amoxicillin capsules |
| PT1492511E (pt) | 2002-04-09 | 2009-04-09 | Flamel Tech Sa | Formulação farmacêutica oral na forma de suspensão aquosa de microcápsulas para libertação modificada de princípio(s) activo(s) |
| ES2259412T3 (es) | 2002-04-29 | 2006-10-01 | Teva Pharmaceutical Industries Ltd. | Procedimientos para la preparacion de losartan y losartan potasico. |
| KR100554156B1 (ko) * | 2003-07-26 | 2006-02-22 | 학교법인 포항공과대학교 | 쿠커비투릴 유도체가 응집되어 형성된 나노 입자, 그 나노입자에 약물이 담지된 약제학적 조성물, 및 이들의 제조방법 |
| HRP20031029A2 (en) * | 2003-12-12 | 2005-08-31 | Belupo - Lijekovi I Kozmetika D.D. | Process for production of inclusion complexes of valsartan with?-cylodextrin |
| FR2882260A1 (fr) * | 2005-02-21 | 2006-08-25 | Flamel Technologies Sa | Forme pharmaceutique orale multimicroparticulaire a liberation modifiee d'antagonistes des recepteurs de l'angiotensine ii |
| FR2884145A1 (fr) * | 2005-04-06 | 2006-10-13 | Flamel Technologies Sa | Forme pharmaceutique orale de losartan |
| CA2598410A1 (fr) * | 2005-02-21 | 2006-08-24 | Flamel Technologies | Forme pharmaceutique orale de losartan |
| WO2008052295A1 (en) * | 2006-10-30 | 2008-05-08 | Universidade Federal De Minas Gerais | Process for the preparation of compounds of at1 receptor antagonists with angiotensin-(1-7), analogues thereof and/or mixtures of these systems, pharmaceutical compositions thereof and use of their derivative products |
| US8575111B2 (en) | 2007-01-26 | 2013-11-05 | Universidade Federal de Minas Garais-UFMG | Pharmaceutical compositions and methods for treating erectile dysfunction |
| RU2487710C2 (ru) * | 2007-10-09 | 2013-07-20 | Новартис Аг | Фармацевтическая композиция валсартана |
| BRPI0800585B8 (pt) | 2008-02-13 | 2021-05-25 | Univ Minas Gerais | composições farmacêuticas do peptídeo des-[asp1]-[ala1]-angiotensina-(1-7) e uso do peptídeo des-[asp1]-[ala1]-angiotensina-(1-7) |
| BR102012009317B1 (pt) * | 2012-04-20 | 2022-05-31 | Universidade Federal De Minas Gerais - Ufmg | Processo de preparação de compostos de inclusão envolvendo ciclodextrinas e fármacos, usando um sistema de fluxo contínuo |
| US10441548B2 (en) | 2015-11-12 | 2019-10-15 | Graybug Vision, Inc. | Aggregating microparticles for medical therapy |
| EP3600324A4 (en) | 2017-03-23 | 2020-12-09 | Graybug Vision, Inc. | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF EYE DISORDERS |
| JP2020519585A (ja) | 2017-05-10 | 2020-07-02 | グレイバグ ビジョン インコーポレイテッド | 医学療法のための延長放出マイクロ粒子及びその懸濁液 |
| EP4125809A1 (en) * | 2020-03-25 | 2023-02-08 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | Liposomal formulations comprising at1 receptor blockers and uses thereof |
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| JPS5671073A (en) * | 1979-11-12 | 1981-06-13 | Takeda Chem Ind Ltd | Imidazole derivative |
| JPS6025967A (ja) * | 1983-07-21 | 1985-02-08 | Eisai Co Ltd | トリパミド包接化合物 |
| US4576958A (en) * | 1984-01-23 | 1986-03-18 | E. I. Du Pont De Nemours And Company | Antihypertensive 4,5-diaryl-1H-imidazole-2-methanol derivatives |
| US4666705A (en) * | 1985-06-03 | 1987-05-19 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
| US5256687A (en) * | 1985-09-09 | 1993-10-26 | Hoechst Aktiengesellschaft | Pharmaceutical composition for the treatment of high blood pressure |
| GB8613688D0 (en) * | 1986-06-05 | 1986-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| US5138069A (en) * | 1986-07-11 | 1992-08-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
| CA1334092C (en) * | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
| DK406686D0 (da) * | 1986-08-26 | 1986-08-26 | Hans Bundgaard | Carboxylsyrederivater |
| US5210079A (en) * | 1988-01-07 | 1993-05-11 | E. I. Du Pont De Nemours And Company | Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists |
| GB8911854D0 (en) * | 1989-05-23 | 1989-07-12 | Ici Plc | Heterocyclic compounds |
| US5064825A (en) * | 1989-06-01 | 1991-11-12 | Merck & Co., Inc. | Angiotensin ii antagonists |
| KR0166088B1 (ko) * | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| JPH03275617A (ja) * | 1990-03-22 | 1991-12-06 | Teikoku Seiyaku Co Ltd | サイクロデキストリン類包接生理活性物質含有ポリ乳酸類マイクロスフェア及びその製造方法 |
| IL100917A0 (en) * | 1991-02-16 | 1992-11-15 | Fisons Plc | Pyridinone and pyrimidinone derivatives,their preparation and pharmaceutical compositions containing them |
| HU209658B (en) * | 1992-02-21 | 1994-10-28 | Cyclolab Kft | Process for producing cyklodextrin inclusion compexes of fatty acids and their alkalimetal salts, as well as aqueous solutions of the complexes, and microbiological culture medium containing the complexes |
| AT399718B (de) * | 1992-04-16 | 1995-07-25 | Lek Tovarna Farmacevtskih | Inklusionskomplexe von optisch aktiven und racemischen 1,4-dihydropyridinen mit methyl-beta- cyclodextrin oder anderen cyclodextrinderivaten, ein verfahren zur herstellung von optisch aktiven dihydropyridinen und deren inklusionskomplexen und diese komplexe enthaltende pharmazeutische formulierungen |
| US5472954A (en) * | 1992-07-14 | 1995-12-05 | Cyclops H.F. | Cyclodextrin complexation |
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| RU2128499C1 (ru) * | 1992-12-23 | 1999-04-10 | Сайтек С.Р.Л. | Способ получения фармацевтических форм с контролированным высвобождением действующего вещества и формы, полученные данным способом |
| DK0695169T3 (da) * | 1993-04-22 | 2003-03-17 | Skyepharma Inc | Multivesikulære liposomer med indkapslet cyclodextrin og farmakologisk aktive forbindelser samt fremgangsmåder til anvendelse af disse |
| BE1008307A3 (fr) * | 1994-06-16 | 1996-04-02 | Europharmaceuticals Sa | Sel de nimesulide hydrosoluble, solution aqueuse le contenant, sa preparation et son utilisation. |
| US5728402A (en) * | 1994-11-16 | 1998-03-17 | Andrx Pharmaceuticals Inc. | Controlled release formulation of captopril or a prodrug of captopril |
| US5834432A (en) * | 1995-06-06 | 1998-11-10 | The University Of Southern California | Use of angiotensin II Type 2 receptor agonists in tissue repair |
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| US6087386A (en) * | 1996-06-24 | 2000-07-11 | Merck & Co., Inc. | Composition of enalapril and losartan |
| ATE214388T1 (de) * | 1996-10-29 | 2002-03-15 | Merck & Co Inc | Verfahren zur kristallisation von losartan |
| US5916883A (en) * | 1996-11-01 | 1999-06-29 | Poly-Med, Inc. | Acylated cyclodextrin derivatives |
| IT1295405B1 (it) | 1997-09-30 | 1999-05-12 | Merck Sharp & Dohme Italia S P | Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di |
| JPH11315034A (ja) * | 1998-03-04 | 1999-11-16 | Takeda Chem Ind Ltd | アンギオテンシンｉｉ拮抗作用を有する化合物の徐放性製剤、その製造法および用途 |
| ES2154191B1 (es) | 1998-11-24 | 2001-10-16 | Ferrer Int | Nuevos acetales derivados de los 2-alquil-5-halo-3-(2'-(tetrazol-5-il)-bifenil-4-ilmetil)-3h-imidazol-4-carbaldehidos. |
| FR2787330A1 (fr) | 1998-12-18 | 2000-06-23 | Sanofi Sa | Composition pharmaceutique contenant, en association, un antagoniste des recepteurs at1 de l'angiotensine ii et un immunosuppresseur pour la prevention ou le traitement des complications vasculaires du rejet de greffe |
| ATE487491T1 (de) * | 1999-02-19 | 2010-11-15 | Takeda Pharmaceutical | Präparationen zur perkutanen aufnahme von zusammnesetzungen die einen angiotensin-ii- rezeptorantagonismus aufweisen |
| US6383471B1 (en) * | 1999-04-06 | 2002-05-07 | Lipocine, Inc. | Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents |
| US6178349B1 (en) * | 1999-04-15 | 2001-01-23 | Medtronic, Inc. | Drug delivery neural stimulation device for treatment of cardiovascular disorders |
| IT1307265B1 (it) | 1999-08-09 | 2001-10-30 | P F C Italiana Srl Speciality | Procedimento per la preparazione di prodotti intermedi nella sintesidi lisinopril. |
| BR0102252B1 (pt) * | 2001-04-10 | 2013-10-22 | Sistema de liberação controlada para antagonista do receptor AT1 da angiotensina II, composição farmacêutica e seu uso |
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2002
- 2002-04-09 JP JP2002578949A patent/JP4439814B2/ja not_active Expired - Fee Related
- 2002-04-09 WO PCT/BR2002/000051 patent/WO2002080910A1/en not_active Ceased
- 2002-04-09 US US10/474,640 patent/US7858597B2/en not_active Expired - Fee Related
- 2002-04-09 CN CN028106814A patent/CN1523985B/zh not_active Expired - Fee Related
- 2002-04-09 EP EP02713951A patent/EP1389106A1/en not_active Withdrawn
- 2002-04-09 CA CA002444145A patent/CA2444145C/en not_active Expired - Fee Related
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2012
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Also Published As
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|---|---|
| US8293723B2 (en) | 2012-10-23 |
| JP2004525167A (ja) | 2004-08-19 |
| BR0102252A (pt) | 2003-01-21 |
| US20040171584A1 (en) | 2004-09-02 |
| US20080108575A1 (en) | 2008-05-08 |
| US20130164341A1 (en) | 2013-06-27 |
| BR0102252B1 (pt) | 2013-10-22 |
| WO2002080910A1 (en) | 2002-10-17 |
| US20110091541A1 (en) | 2011-04-21 |
| JP2010047611A (ja) | 2010-03-04 |
| CN1523985A (zh) | 2004-08-25 |
| CA2444145A1 (en) | 2002-10-17 |
| US7858597B2 (en) | 2010-12-28 |
| CA2444145C (en) | 2009-11-10 |
| CN1523985B (zh) | 2010-05-12 |
| EP1389106A1 (en) | 2004-02-18 |
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