JP4427687B2 - 子宮体癌の再発予防剤 - Google Patents
子宮体癌の再発予防剤 Download PDFInfo
- Publication number
- JP4427687B2 JP4427687B2 JP2004077555A JP2004077555A JP4427687B2 JP 4427687 B2 JP4427687 B2 JP 4427687B2 JP 2004077555 A JP2004077555 A JP 2004077555A JP 2004077555 A JP2004077555 A JP 2004077555A JP 4427687 B2 JP4427687 B2 JP 4427687B2
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- Japan
- Prior art keywords
- acid
- recurrence
- mycelium
- culture
- endometrial cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
実施例1
シイタケ菌糸体の培養は、バガス80%、脱脂米糠20%を配合し、水分を70%となるように調製して個体培地を作り、常法に従って殺菌し、これにシイタケ菌の種菌を接種した。培地を22°〜24℃に温度調整した室内で4ヶ月間培養し、培地中に菌糸体が蔓延した後、温度処理室に移して32℃〜34℃で24時間加温し、次いで10℃の低温室で5日間処理した。その後、培養室で培地を粉砕機で開粉砕した。粉砕した、培地を50℃で4時間処理し、自己消化を促進させた後、タンクに詰め、60℃の温水を循環させなから16時間抽出した。得られた懸濁液を珪藻土のフィルタケーキで予備濾過し、さらにメンブランフィルターで濾過除菌後、濃縮し、凍結乾燥により褐色の粉末を得た。
実施例2
患者は、当院に来診して診断・治療された子宮体癌患者14例で、患者の平均年齢は60.2±11.4歳(M±SD)、術後進行度Ia〜IIb(内、リンパ節転移を認めるもの2例)である。全例が広汎子宮全摘出例であり、術後、2週間目よりCAP療法(カルボプラチン、エンドキサン、アドリアマイシン)を3クール行った。同時にシイタケ菌糸体培養抽出物(LEM)を6g/日(3g×2回)投与した。退院後は、化学療法や、ホルモン療法を行わず、LEMの単独投与とした。また、2〜3ヶ月おきに、超音波、CTーscan、膣断端部スメア、及び腫瘍マーカー(CA−125、199)で治療経過をチェックした。
Claims (3)
- シイタケ菌糸体の培養物を40〜90℃で3〜6時間処理して、菌糸体を自己消化させたシイタケ菌糸体培養抽出物を含有することを特徴とする子宮体癌の再発予防剤。
- シイタケ菌糸体の培養物を40〜90℃で3〜6時間処理して、菌糸体を自己消化させたシイタケ菌糸体培養抽出物を2−4g含有することを特徴とする請求項1記載の子宮体癌の再発予防剤。
- シイタケ菌糸体の培養物を40〜90℃で3〜6時間処理して、菌糸体を自己消化させたシイタケ菌糸体培養抽出物を含有する製剤と化学療法剤とからなることを特徴とする請求項1記載の子宮体癌の再発予防剤。
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ITUA20161865A1 (it) * | 2016-03-21 | 2017-09-21 | Progine Farm S R L | Uso di lentinano per il trattamento e la prevenzione di endometriosi. |
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