JP4409097B2 - 複数の共刺激分子を発現する組換えベクターおよびその利用 - Google Patents

複数の共刺激分子を発現する組換えベクターおよびその利用 Download PDF

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JP4409097B2
JP4409097B2 JP2000586927A JP2000586927A JP4409097B2 JP 4409097 B2 JP4409097 B2 JP 4409097B2 JP 2000586927 A JP2000586927 A JP 2000586927A JP 2000586927 A JP2000586927 A JP 2000586927A JP 4409097 B2 JP4409097 B2 JP 4409097B2
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cells
recombinant
cell
gene
icam
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JP2002531133A (ja
JP2002531133A5 (https=
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シュロム，ジェフリー
ホッジ，ジェームズ
パニカリ，デニス
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JP2000586927A 1998-12-09 1999-11-12 複数の共刺激分子を発現する組換えベクターおよびその利用 Expired - Lifetime JP4409097B2 (ja)

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Application Number Priority Date Filing Date Title
US11158298P 1998-12-09 1998-12-09
US60/111,582 1998-12-09
PCT/US1999/026866 WO2000034494A1 (en) 1998-12-09 1999-11-12 A recombinant vector expressing multiple costimulatory molecules and uses thereof

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JP2009187330A Division JP5254153B2 (ja) 1998-12-09 2009-08-12 複数の共刺激分子を発現する組換えベクターおよびその利用

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JP2002531133A JP2002531133A (ja) 2002-09-24
JP2002531133A5 JP2002531133A5 (https=) 2005-12-22
JP4409097B2 true JP4409097B2 (ja) 2010-02-03

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JP2000586927A Expired - Lifetime JP4409097B2 (ja) 1998-12-09 1999-11-12 複数の共刺激分子を発現する組換えベクターおよびその利用
JP2009187330A Expired - Lifetime JP5254153B2 (ja) 1998-12-09 2009-08-12 複数の共刺激分子を発現する組換えベクターおよびその利用

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JP2009187330A Expired - Lifetime JP5254153B2 (ja) 1998-12-09 2009-08-12 複数の共刺激分子を発現する組換えベクターおよびその利用

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EP (1) EP1137792B9 (https=)
JP (2) JP4409097B2 (https=)
AT (1) ATE361988T1 (https=)
AU (1) AU774076C (https=)
CA (2) CA2354024C (https=)
CY (1) CY1107698T1 (https=)
DE (1) DE69936061T2 (https=)
DK (1) DK1137792T3 (https=)
ES (1) ES2286902T3 (https=)
PT (1) PT1137792E (https=)
WO (1) WO2000034494A1 (https=)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6756038B1 (en) * 1997-10-10 2004-06-29 The United States Of America As Represented By The Department Of Health And Human Services Agonist and antagonist peptides of carcinoembryonic antigen (CEA)
AU1991901A (en) * 1999-09-27 2001-05-10 Gabriele Pecher Pharmaceutical composition for treating and preventing human tumors, which express the tumor antigen mucin and/or the carcinoembryonic antigen (cea), and the use thereof
ATE395930T1 (de) * 1999-10-22 2008-06-15 Aventis Pasteur Verfahren zur erregung und/oder verstärkung der immunantwort gegen tumorantigene
US7186515B1 (en) 2000-06-02 2007-03-06 University Of Connecticut Health Center Alpha(2) macroglobulin receptor as a heat shock protein receptor and uses thereof
US7179462B2 (en) 2000-06-02 2007-02-20 University Of Connecticut Health Center α (2) macroglobulin receptor as a heat shock protein receptor and uses thereof
US7449557B2 (en) 2000-06-02 2008-11-11 University Of Connecticut Health Center Complexes of alpha (2) macroglobulin and antigenic molecules for immunotherapy
CA2416893A1 (en) * 2000-07-31 2002-02-07 Aventis Pasteur Limited Modified cea and uses thereof
CA2420944A1 (en) 2000-08-30 2002-03-07 Chemocentryx, Inc. Inhibition of cmv infection and dissemination
EP2336339A3 (en) 2000-09-25 2011-09-14 The Regents of the University of Michigan Production of viral vectors
CA2437201C (en) 2001-02-02 2008-11-18 Chemocentryx, Inc. Methods and compositions useful for stimulating an immune response
WO2003008537A2 (en) * 2001-04-06 2003-01-30 Mannkind Corporation Epitope sequences
US7414032B2 (en) 2001-06-25 2008-08-19 Immunofrontier, Inc. Vaccine comprising a polynucleotide encoding an antigen recognized by a CD4+ helper T-cell and a polynucleotide encoding a tumor specific or associated antigen recognized by a CD8+ CTL
AU2004280608B2 (en) * 2002-04-09 2012-04-05 Sanofi Pasteur, Inc. Modified CEA/B7 vector
CN102370974B (zh) 2002-12-16 2014-09-17 全球免疫股份有限公司 用于免疫治疗的基于酵母的疫苗
CA2537931A1 (en) * 2003-09-05 2005-03-24 Dennis Panicali Multi-antigen vectors for melanoma
ES2623812T3 (es) 2003-11-12 2017-07-12 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Vectores a medida para tratar y prevenir cáncer pancreático
ES2476990T3 (es) * 2003-11-12 2014-07-15 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Sistema para tratar y prevenir cáncer de mama
US20090156519A1 (en) * 2003-12-23 2009-06-18 Aventis Pasteur, Inc. Modified KSA and Uses Thereof
US7785875B2 (en) 2004-07-03 2010-08-31 Mogam Biotechnology Research Institute Polynucleotide encoding HCV epitopes which can bind to various HLA supertypes, immunogenic composition comprising same and method of inducing an HCV-specific immune response using same
CN1976946A (zh) * 2004-07-03 2007-06-06 财团法人牧岩生命工学研究所 诱导抗hcv有效ctl应答的超型表位、其编码寡核苷酸及其应用
ES2313807B1 (es) * 2005-07-30 2009-12-23 Consejo Superior De Investigaciones Cientificas Vectores recombinantes basados en el virus vaccinia modificado de ankara (mva) como vacunas contra la leishmaniasis.
EP1792996A1 (en) * 2005-12-01 2007-06-06 Consejo Superior de Investigaciones Cientificas Nucleic acid sequences encoding vaccines against Porcine reproductive and respiratory syndrome virus (PRRSV)
CA2682527C (en) 2007-03-30 2017-07-11 Memorial Sloan-Kettering Cancer Center Constitutive expression of costimulatory ligands on adoptively transferred t lymphocytes
ES2725450T3 (es) 2007-07-02 2019-09-24 Etubics Corp Métodos y composiciones para la producción de un vector adenoviral para su uso en vacunaciones múltiples
NZ601827A (en) * 2007-10-18 2014-01-31 Bavarian Nordic Inc Use of mva to treat prostate cancer
WO2010042433A1 (en) 2008-10-06 2010-04-15 Bristol-Myers Squibb Company Combination of cd137 antibody and ctla-4 antibody for the treatment of proliferative diseases
AU2008363648B9 (en) * 2008-10-31 2013-08-22 Tremrx, Inc. Vaccination with poxvirus vectors via mechanical epidermal disruption
US8691502B2 (en) 2008-10-31 2014-04-08 Tremrx, Inc. T-cell vaccination with viral vectors via mechanical epidermal disruption
KR101781966B1 (ko) * 2009-04-17 2017-09-27 글로브이뮨 암에 대한 병용 면역요법 조성물 및 방법
KR102049928B1 (ko) 2011-08-17 2019-11-28 글로브이뮨 효모-muc1 면역요법 조성물 및 그 용도
WO2014031178A1 (en) 2012-08-24 2014-02-27 Etubics Corporation Replication defective adenovirus vector in vaccination
RU2671558C2 (ru) 2013-06-14 2018-11-02 Псайоксус Терапьютикс Лимитед Режим введения и составы для аденовирусов типа в
AU2014338864C1 (en) 2013-10-25 2020-07-16 Akamis Bio Limited Oncolytic adenoviruses armed with heterologous genes
CN105829537B (zh) * 2013-11-28 2020-09-22 巴法里安诺迪克有限公司 用于使用痘病毒载体诱导增强的免疫应答的组合物和方法载体
JP5917626B2 (ja) * 2014-07-28 2016-05-18 トレムアールエックス， インコーポレイテッド 機械的表皮破壊を介したポックスウイルスベクターによるワクチン接種
CA2973109A1 (en) 2015-01-09 2016-07-14 Etubics Corporation Methods and compositions for ebola virus vaccination
KR102193635B1 (ko) 2015-01-09 2020-12-21 이투빅스 코포레이션 복합 면역요법을 위한 방법 및 조성물
WO2016172249A1 (en) 2015-04-20 2016-10-27 Etubics Corporation Methods and compositions for combination immunotherapy
PE20180241A1 (es) 2015-04-30 2018-01-31 Psioxus Therapeutics Ltd Adenovirus oncolitico que codifica una proteina b7
EA201891022A1 (ru) 2015-12-17 2019-01-31 Псайоксус Терапьютикс Лимитед Вирус, кодирующий антитело к комплексу tcr или фрагмент указанного антитела
US20210198689A1 (en) * 2016-03-18 2021-07-01 Nant Holdings Ip, Llc Multimodal Vector for Dendritic Cell Infection
CN109890408A (zh) * 2016-05-27 2019-06-14 埃特彼塞斯公司 新表位疫苗组合物及其使用方法
CN119614520A (zh) 2016-08-29 2025-03-14 阿卡米斯生物公司 携带双特异性t细胞衔接器的腺病毒
GB201713765D0 (en) 2017-08-28 2017-10-11 Psioxus Therapeutics Ltd Modified adenovirus
JP2021514678A (ja) * 2018-03-06 2021-06-17 ペップバックス・インコーポレイテッド 核酸分子およびそれを使用する方法
US20210290708A1 (en) 2018-09-21 2021-09-23 Nantcell, Inc. Methods and compositions for modulating myeloid-derived suppressor cells
GB202010095D0 (en) * 2020-07-01 2020-08-12 Tcer Ab Immunotherapy

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6816194A (en) * 1993-04-20 1994-11-08 Robinson, William S. Methods and materials for treatment of individuals infected with intracellular infectious agents
JP3907698B2 (ja) * 1994-10-03 2007-04-18 アメリカ合衆国 抗原を発現する組み換えウイルスと免疫刺激分子を発現する組み換えウイルスとを含む組成物
CA2261989C (en) * 1996-07-25 2008-09-30 Therion Biologics Corporation Recombinant pox virus for immunization against tumor-associated antigens

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