CY1107698T1 - Ανασυνδυασμενος φορεας που εκφραζει πολλαπλα συνδιεργερτικα μορια και οι χρησεις του - Google Patents

Ανασυνδυασμενος φορεας που εκφραζει πολλαπλα συνδιεργερτικα μορια και οι χρησεις του

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Publication number
CY1107698T1
CY1107698T1 CY20071100941T CY071100941T CY1107698T1 CY 1107698 T1 CY1107698 T1 CY 1107698T1 CY 20071100941 T CY20071100941 T CY 20071100941T CY 071100941 T CY071100941 T CY 071100941T CY 1107698 T1 CY1107698 T1 CY 1107698T1
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Cyprus
Prior art keywords
stimulatory
stimulatory molecules
recombinant vector
recombinant
vectors
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Application number
CY20071100941T
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English (en)
Inventor
Jeffrey Schlom
James Hodge
Dennis Panicali
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The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
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Application filed by The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services filed Critical The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
Publication of CY1107698T1 publication Critical patent/CY1107698T1/el

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Abstract

Η παρούσα εφεύρεση είναι ένας ανασυνδυασμένος φορέας που κωδικοποιεί και εκφράζει τουλάχιστον τρία ή περισσότερα συνδιεγερτικά μόρια. Ο ανασυνδυασμένος φορέας μπορεί επιπλέον να περιέχει ένα γονίδιο που κωδικοποιεί ένα ή περισσότερα αντιγόνα-στόχους ή άνοσο επίτοπο αυτών. Αποδεικνύεται η συνεργιστική επίδραση αυτών των συνδιεγερτικών μορίων στην αυξημένη ενεργοποίηση Τ-λεμφοκυττάρων. Ο βαθμός της ενεργοποίησης Τ-λεμφοκυττάρων, χρησιμοποιώντας ανασυνδυασμένους φορείς που περιέχουν γονίδια που κωδικοποιούν τρία συνδιεγερτικά μόρια, ήταν κατά πολυ μεγαλύτερος από το άθροισμα των παρασκευασμάτων ανασυνδυασμένου φορέα που περιέχουν ένα συνδιεγερτικό μόριο και μεγαλύτερη από τη χρήση δύο συνδιεγερτικών μορίων. Τα αποτελέσματα της εφαρμογής των τριπλών συνδιεγερτικών φορέων ήταν περισσότερο δραματικά υπό συνθήκες είτε χαμηλών επιπέδων πρώτου σήματος ή χαμηλών αναλογιών διεγέρτη προς Τ-λεμφοκύτταρα. Αυτό το φαινόμενο παρατηρήθηκε τόσο με τα απομονωμένα CD4+ όσο και με τα CD8+ Τ-λεμφοκύτταρα. Οι ανασυνδυασμένοι φορείς της παρούσας εφεύρεσης είναι χρήσιμοι ως ανοσογόνα και εμβόλια ενάντια στον καρκίνο και σε παθογόνους μικροοργανισμούς και στο να παρέχουν σε κύτταρα ξενιστή, συμπεριλαμβανομένων των δενδριτικών κυττάρων και σπληνο-κυττάρων, ενισχυμένες λειτουργίες που παρουσιάζουν αντιγόνο.
CY20071100941T 1998-12-09 2007-07-13 Ανασυνδυασμενος φορεας που εκφραζει πολλαπλα συνδιεργερτικα μορια και οι χρησεις του CY1107698T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11158298P 1998-12-09 1998-12-09
EP99958951A EP1137792B9 (en) 1998-12-09 1999-11-12 A recombinant vector expressing multiple costimulatory molecules and uses thereof

Publications (1)

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CY1107698T1 true CY1107698T1 (el) 2013-04-18

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EP (1) EP1137792B9 (el)
JP (2) JP4409097B2 (el)
AT (1) ATE361988T1 (el)
AU (1) AU774076C (el)
CA (2) CA2678259C (el)
CY (1) CY1107698T1 (el)
DE (1) DE69936061T2 (el)
DK (1) DK1137792T3 (el)
ES (1) ES2286902T3 (el)
PT (1) PT1137792E (el)
WO (1) WO2000034494A1 (el)

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