JP4398150B2 - ベンゾ（ｆ）イソインドール誘導体およびそのＥＰ４受容体リガンドとしての使用 - Google Patents

ベンゾ（ｆ）イソインドール誘導体およびそのＥＰ４受容体リガンドとしての使用 Download PDF

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JP4398150B2
JP4398150B2 JP2002551530A JP2002551530A JP4398150B2 JP 4398150 B2 JP4398150 B2 JP 4398150B2 JP 2002551530 A JP2002551530 A JP 2002551530A JP 2002551530 A JP2002551530 A JP 2002551530A JP 4398150 B2 JP4398150 B2 JP 4398150B2
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phenyl
benzo
isoindol
dihydro
bis
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JP2004517847A (ja
JP2004517847A5 (enExample
Inventor
ギブリン，ジェラード，マルティン，ポール
フリエ，ステッファン，バーノン
ルーマンズ，スーザン
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Glaxo Group Ltd
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Glaxo Group Ltd
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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JP2002551530A 2000-12-21 2001-12-20 ベンゾ（ｆ）イソインドール誘導体およびそのＥＰ４受容体リガンドとしての使用 Expired - Fee Related JP4398150B2 (ja)

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GBGB0031295.9A GB0031295D0 (en) 2000-12-21 2000-12-21 Naphthalene derivatives
PCT/GB2001/005706 WO2002050033A1 (en) 2000-12-21 2001-12-20 Benzo(f) isoindol derivatives and their use as ep4 receptor ligands

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JP2004517847A JP2004517847A (ja) 2004-06-17
JP2004517847A5 JP2004517847A5 (enExample) 2005-12-22
JP4398150B2 true JP4398150B2 (ja) 2010-01-13

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US (2) US7173047B2 (enExample)
EP (1) EP1343759A1 (enExample)
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AU (1) AU2002217287A1 (enExample)
GB (1) GB0031295D0 (enExample)
WO (1) WO2002050033A1 (enExample)

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HN2001000224A (es) 2000-10-19 2002-06-13 Pfizer Compuestos de imidazol condensado con arilo o heteroarilo como agentes anti - inflamatorios y analgesicos.
GB0103269D0 (en) * 2001-02-09 2001-03-28 Glaxo Group Ltd Napthalene derivatives
IL164263A0 (en) * 2002-04-12 2005-12-18 Pfizer Use of ep4 receptor ligands on the treatment of il-6 involved diseases
WO2004073589A2 (en) * 2003-02-24 2004-09-02 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g-protein coupled receptor prostaglandin e2 ep4 (prostaglandin e2 ep4)
CN1946391A (zh) * 2004-04-20 2007-04-11 辉瑞产品公司 包含α－2－δ配体的组合
US8013159B2 (en) 2005-05-19 2011-09-06 Merck Canada Inc. Quinoline derivatives as EP4 antagonists
UY30121A1 (es) 2006-02-03 2007-08-31 Glaxo Group Ltd Nuevos compuestos
ES2393800T3 (es) * 2006-02-03 2012-12-28 Glaxo Group Limited Derivados de benzoisoindol para el tratamiento del dolor
GB0602900D0 (en) 2006-02-13 2006-03-22 Glaxo Group Ltd Novel Compounds
GB0615111D0 (en) * 2006-07-28 2006-09-06 Glaxo Group Ltd Novel compounds
GB0615105D0 (en) 2006-07-28 2006-09-06 Glaxo Group Ltd Novel compounds
GB0616498D0 (en) * 2006-08-18 2006-09-27 Glaxo Group Ltd Novel compounds
NZ577109A (en) 2006-12-15 2011-12-22 Glaxo Group Ltd Benzamide derivatives as ep4 receptor agonists
GB0721611D0 (en) 2007-11-02 2007-12-12 Glaxo Group Ltd Novel compounds
US20110287112A1 (en) 2009-01-30 2011-11-24 Ono Pharmaceutical Co., Ltd. Prostate cancer progression inhibitor and progression inhibition method
KR20120093955A (ko) 2009-10-14 2012-08-23 젬머스 파마 인코포레이티드 바이러스 감염에 대한 병용 요법 치료
WO2014143591A1 (en) * 2013-03-12 2014-09-18 Allergan, Inc. Inhibition of neovascularization by simultaneous inhibition of prostanoid ip and ep4 receptors
KR20160042039A (ko) 2013-08-09 2016-04-18 알데릭스, 인코포레이티드 인산염 수송을 억제하기 위한 화합물 및 방법
CR20180323A (es) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
TW201900180A (zh) 2017-05-18 2019-01-01 瑞士商愛杜西亞製藥有限公司 嘧啶衍生物
MX394108B (es) 2017-05-18 2025-03-21 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituidos.
JP7093791B2 (ja) 2017-05-18 2022-06-30 イドーシア ファーマシューティカルズ リミテッド Ｐｇｅ２レセプター調節剤としてのベンゾフラン及びベンゾチオフェン誘導体
CN110612296A (zh) 2017-05-18 2019-12-24 爱杜西亚药品有限公司 作为pge2受体调节剂的苯基衍生物
AU2018268311B2 (en) 2017-05-18 2022-02-10 Idorsia Pharmaceuticals Ltd Pyrimidine derivatives as PGE2 receptor modulators
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient
KR20230107228A (ko) 2020-11-13 2023-07-14 오노 야꾸힝 고교 가부시키가이샤 Ep4 길항약과 면역 체크포인트 저해 물질의 병용에 의한 암 치료

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997005091A1 (en) * 1995-07-26 1997-02-13 Ono Pharmaceutical Co., Ltd. Naphthyloxyacetic acid derivatives and drugs comprising the same as active ingredients
US6437146B1 (en) 1998-09-25 2002-08-20 Fujisawa Pharmaceutical Co., Ltd. Oxazole compounds as prostaglandin e2 agonists or antagonists
ATE348608T1 (de) * 1999-08-10 2007-01-15 Glaxo Group Ltd Ep4 rezeptor ligand und verwendung gegen neuropatischen schmerzen, colon krebs, hiv und migräne
GB0031302D0 (en) * 2000-12-21 2001-01-31 Glaxo Group Ltd Napthalene derivatives

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