JP4398150B2 - ベンゾ(f)イソインドール誘導体およびそのEP4受容体リガンドとしての使用 - Google Patents
ベンゾ(f)イソインドール誘導体およびそのEP4受容体リガンドとしての使用 Download PDFInfo
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- JP4398150B2 JP4398150B2 JP2002551530A JP2002551530A JP4398150B2 JP 4398150 B2 JP4398150 B2 JP 4398150B2 JP 2002551530 A JP2002551530 A JP 2002551530A JP 2002551530 A JP2002551530 A JP 2002551530A JP 4398150 B2 JP4398150 B2 JP 4398150B2
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- Prior art keywords
- phenyl
- benzo
- isoindol
- dihydro
- bis
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- C07D209/58—[b]- or [c]-condensed
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0031295.9A GB0031295D0 (en) | 2000-12-21 | 2000-12-21 | Naphthalene derivatives |
| PCT/GB2001/005706 WO2002050033A1 (en) | 2000-12-21 | 2001-12-20 | Benzo(f) isoindol derivatives and their use as ep4 receptor ligands |
Publications (3)
| Publication Number | Publication Date |
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| JP2004517847A JP2004517847A (ja) | 2004-06-17 |
| JP2004517847A5 JP2004517847A5 (enExample) | 2005-12-22 |
| JP4398150B2 true JP4398150B2 (ja) | 2010-01-13 |
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| JP2002551530A Expired - Fee Related JP4398150B2 (ja) | 2000-12-21 | 2001-12-20 | ベンゾ(f)イソインドール誘導体およびそのEP4受容体リガンドとしての使用 |
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| Country | Link |
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| US (2) | US7173047B2 (enExample) |
| EP (1) | EP1343759A1 (enExample) |
| JP (1) | JP4398150B2 (enExample) |
| AU (1) | AU2002217287A1 (enExample) |
| GB (1) | GB0031295D0 (enExample) |
| WO (1) | WO2002050033A1 (enExample) |
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| HN2001000224A (es) | 2000-10-19 | 2002-06-13 | Pfizer | Compuestos de imidazol condensado con arilo o heteroarilo como agentes anti - inflamatorios y analgesicos. |
| GB0103269D0 (en) * | 2001-02-09 | 2001-03-28 | Glaxo Group Ltd | Napthalene derivatives |
| MXPA04009243A (es) | 2002-04-12 | 2005-06-08 | Pfizer | Uso de ligandos para el receptor ep4 en el tratamiento de enfermedades vinculadas a il-6. |
| WO2004073589A2 (en) * | 2003-02-24 | 2004-09-02 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g-protein coupled receptor prostaglandin e2 ep4 (prostaglandin e2 ep4) |
| US20090036495A1 (en) * | 2004-04-20 | 2009-02-05 | Pfizer, Inc. | Combinations Comprising Alpha-2-Delta Ligands and Ep4 Receptor Antagonists |
| JP5289046B2 (ja) * | 2005-05-19 | 2013-09-11 | メルク カナダ インコーポレイテッド | Ep4アンタゴニストとしてのキノリン誘導体 |
| AU2007211483B2 (en) * | 2006-02-03 | 2012-08-16 | Glaxo Group Limited | Benzoisoindole derivatives for the treatment of pain |
| UY30121A1 (es) | 2006-02-03 | 2007-08-31 | Glaxo Group Ltd | Nuevos compuestos |
| GB0602900D0 (en) | 2006-02-13 | 2006-03-22 | Glaxo Group Ltd | Novel Compounds |
| GB0615111D0 (en) * | 2006-07-28 | 2006-09-06 | Glaxo Group Ltd | Novel compounds |
| GB0615105D0 (en) | 2006-07-28 | 2006-09-06 | Glaxo Group Ltd | Novel compounds |
| GB0616498D0 (en) * | 2006-08-18 | 2006-09-27 | Glaxo Group Ltd | Novel compounds |
| CA2672631A1 (en) | 2006-12-15 | 2008-06-19 | Glaxo Group Limited | Benzamide derivatives as ep4 receptor agonists |
| GB0721611D0 (en) | 2007-11-02 | 2007-12-12 | Glaxo Group Ltd | Novel compounds |
| WO2010087425A1 (ja) | 2009-01-30 | 2010-08-05 | 国立大学法人京都大学 | 前立腺癌の進行抑制剤および進行抑制方法 |
| JP2013508282A (ja) | 2009-10-14 | 2013-03-07 | ジェンムス ファーマ インコーポレイティド | ウイルス感染のための併用療法処置 |
| WO2014143591A1 (en) * | 2013-03-12 | 2014-09-18 | Allergan, Inc. | Inhibition of neovascularization by simultaneous inhibition of prostanoid ip and ep4 receptors |
| AU2014305843B2 (en) | 2013-08-09 | 2019-08-29 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| CR20180323A (es) | 2015-11-20 | 2018-08-06 | Idorsia Pharmaceuticals Ltd | Derivados de indol n-sustituídos como moduladores de los receptores de pge2 |
| HRP20211533T1 (hr) | 2017-05-18 | 2022-01-07 | Idorsia Pharmaceuticals Ltd | Derivati fenila kao modulatori receptora pge2 |
| TWI768043B (zh) | 2017-05-18 | 2022-06-21 | 瑞士商愛杜西亞製藥有限公司 | N-取代吲哚衍生物 |
| US11325899B2 (en) | 2017-05-18 | 2022-05-10 | Idorsia Pharmaceuticals Ltd | Benzofurane and benzothiophene derivatives as PGE2 receptor modulators |
| AR111808A1 (es) | 2017-05-18 | 2019-08-21 | Idorsia Pharmaceuticals Ltd | Derivados de pirimidina como moduladores del receptor de pge2 |
| ES2896476T3 (es) | 2017-05-18 | 2022-02-24 | Idorsia Pharmaceuticals Ltd | Derivados de pirimidina |
| US20200368223A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Methods for inhibiting phosphate transport |
| KR20230107228A (ko) | 2020-11-13 | 2023-07-14 | 오노 야꾸힝 고교 가부시키가이샤 | Ep4 길항약과 면역 체크포인트 저해 물질의 병용에 의한 암 치료 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6018068A (en) * | 1995-07-26 | 2000-01-25 | Ono Pharmaceutical Co., Ltd. | Naphthyloxyacetic acid derivatives and drugs comprising the same as active ingredients |
| US6437146B1 (en) | 1998-09-25 | 2002-08-20 | Fujisawa Pharmaceutical Co., Ltd. | Oxazole compounds as prostaglandin e2 agonists or antagonists |
| ATE272398T1 (de) * | 1999-08-10 | 2004-08-15 | Glaxo Group Ltd | Verwendung von ep4 rezeptorliganden zur behandlung von neuropathischen schmerz |
| GB0031302D0 (en) * | 2000-12-21 | 2001-01-31 | Glaxo Group Ltd | Napthalene derivatives |
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2000
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2001
- 2001-12-20 JP JP2002551530A patent/JP4398150B2/ja not_active Expired - Fee Related
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2006
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Also Published As
| Publication number | Publication date |
|---|---|
| US7173047B2 (en) | 2007-02-06 |
| AU2002217287A1 (en) | 2002-07-01 |
| JP2004517847A (ja) | 2004-06-17 |
| US20060252799A1 (en) | 2006-11-09 |
| US20040087624A1 (en) | 2004-05-06 |
| GB0031295D0 (en) | 2001-01-31 |
| EP1343759A1 (en) | 2003-09-17 |
| WO2002050033A1 (en) | 2002-06-27 |
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