JP4381810B2 - 選択的エストロゲン受容体βアゴニストとしての置換ベンゾピラン - Google Patents
選択的エストロゲン受容体βアゴニストとしての置換ベンゾピラン Download PDFInfo
- Publication number
- JP4381810B2 JP4381810B2 JP2003545643A JP2003545643A JP4381810B2 JP 4381810 B2 JP4381810 B2 JP 4381810B2 JP 2003545643 A JP2003545643 A JP 2003545643A JP 2003545643 A JP2003545643 A JP 2003545643A JP 4381810 B2 JP4381810 B2 JP 4381810B2
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- JP
- Japan
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- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 0 COc(cc1)cc(C2[C@@]3CCC2)c1OC3(*)c(cc1)ccc1O Chemical compound COc(cc1)cc(C2[C@@]3CCC2)c1OC3(*)c(cc1)ccc1O 0.000 description 3
- KGIPJPQBLJMWFA-UHFFFAOYSA-O CC(C)(C)[Si+](C)(C)Oc1ccc(C(C(CCC2)=C2c(cc(cc2)O[SH+](C)(C)C(C)(C)C)c2O)O)cc1 Chemical compound CC(C)(C)[Si+](C)(C)Oc1ccc(C(C(CCC2)=C2c(cc(cc2)O[SH+](C)(C)C(C)(C)C)c2O)O)cc1 KGIPJPQBLJMWFA-UHFFFAOYSA-O 0.000 description 1
- KEGMFYPHSQLNOE-LJQANCHMSA-N CCC(CC)(CC=C1C(OC)=O)[C@H]1c(cc(cc1)OCOC)c1OCOC Chemical compound CCC(CC)(CC=C1C(OC)=O)[C@H]1c(cc(cc1)OCOC)c1OCOC KEGMFYPHSQLNOE-LJQANCHMSA-N 0.000 description 1
- YXSARWFSYZHULU-UHFFFAOYSA-N COC(C(CCC1)=C1OS(C(F)(F)F)(=O)=O)=O Chemical compound COC(C(CCC1)=C1OS(C(F)(F)F)(=O)=O)=O YXSARWFSYZHULU-UHFFFAOYSA-N 0.000 description 1
- QOMQLXKAQVCVFQ-UHFFFAOYSA-N COC(C(CCCCC1)=C1OS(C(F)(F)F)(=O)=O)=O Chemical compound COC(C(CCCCC1)=C1OS(C(F)(F)F)(=O)=O)=O QOMQLXKAQVCVFQ-UHFFFAOYSA-N 0.000 description 1
- NDJYFZYBEBEYQM-CFMCSPIPSA-N COCOC(CC1)=CC(OCOC)=C1[C@H](CCC1)C1C(OC)=O Chemical compound COCOC(CC1)=CC(OCOC)=C1[C@H](CCC1)C1C(OC)=O NDJYFZYBEBEYQM-CFMCSPIPSA-N 0.000 description 1
- IYRTUBZEGWZSGL-CVEARBPZSA-N COCOc(cc1)cc([C@H](CCCCC2)[C@H]2C(OC)=O)c1OCOC Chemical compound COCOc(cc1)cc([C@H](CCCCC2)[C@H]2C(OC)=O)c1OCOC IYRTUBZEGWZSGL-CVEARBPZSA-N 0.000 description 1
- FWLPGESRIHBBJV-UHFFFAOYSA-N COCOc(cc1)ccc1OCOC Chemical compound COCOc(cc1)ccc1OCOC FWLPGESRIHBBJV-UHFFFAOYSA-N 0.000 description 1
- VWVUGKXYBUTSFI-UHFFFAOYSA-N COCOc1ccc(C(F)(F)F)cc1 Chemical compound COCOc1ccc(C(F)(F)F)cc1 VWVUGKXYBUTSFI-UHFFFAOYSA-N 0.000 description 1
- SEQDQSYKDMQNTD-HXCIKOOASA-N COc1ccc([C@@H]([C@H](CCC2)C2c2c3)Oc2ccc3OC)cc1 Chemical compound COc1ccc([C@@H]([C@H](CCC2)C2c2c3)Oc2ccc3OC)cc1 SEQDQSYKDMQNTD-HXCIKOOASA-N 0.000 description 1
- SEQDQSYKDMQNTD-HMEKMZBJSA-N COc1ccc([C@H]([C@H]2C3CCC2)Oc(cc2)c3cc2OC)cc1 Chemical compound COc1ccc([C@H]([C@H]2C3CCC2)Oc(cc2)c3cc2OC)cc1 SEQDQSYKDMQNTD-HMEKMZBJSA-N 0.000 description 1
- OBORCZCJWPDWDP-UHFFFAOYSA-N Cc(cc(cc1)Br)c1OCOC Chemical compound Cc(cc(cc1)Br)c1OCOC OBORCZCJWPDWDP-UHFFFAOYSA-N 0.000 description 1
- RFMWCECIGZNYNJ-HDMKZQKVSA-N NC(c1ccc([C@H]([C@H](CCC2)[C@H]2c2c3)Oc2ccc3C(N)=O)cc1)=O Chemical compound NC(c1ccc([C@H]([C@H](CCC2)[C@H]2c2c3)Oc2ccc3C(N)=O)cc1)=O RFMWCECIGZNYNJ-HDMKZQKVSA-N 0.000 description 1
- LYCZVRBMNHDJRO-UHFFFAOYSA-N Oc(cc1C2=C3CCC2)ccc1OC3=O Chemical compound Oc(cc1C2=C3CCC2)ccc1OC3=O LYCZVRBMNHDJRO-UHFFFAOYSA-N 0.000 description 1
- XIESSJVMWNJCGZ-SWKXRBFHSA-N Oc1ccc(C([C@H]2C3CCC2)Oc(cc2)c3cc2O)cc1 Chemical compound Oc1ccc(C([C@H]2C3CCC2)Oc(cc2)c3cc2O)cc1 XIESSJVMWNJCGZ-SWKXRBFHSA-N 0.000 description 1
- KUGZPMBUEPNCPY-BFHRDPOASA-N Oc1ccc(C([C@H]2C3CCC2)Oc2c3cccc2)cc1 Chemical compound Oc1ccc(C([C@H]2C3CCC2)Oc2c3cccc2)cc1 KUGZPMBUEPNCPY-BFHRDPOASA-N 0.000 description 1
- SHUMXHZGMOYSRM-KOHRHEQBSA-N Oc1ccc(C([C@H]2C3CCCC2)Oc(cc2)c3cc2O)cc1 Chemical compound Oc1ccc(C([C@H]2C3CCCC2)Oc(cc2)c3cc2O)cc1 SHUMXHZGMOYSRM-KOHRHEQBSA-N 0.000 description 1
- XCZLBAHLLDZLTP-HDMKZQKVSA-N Oc1ccc([C@H]([C@H]2[C@@H]3CCC2)Oc(cc2)c3cc2F)cc1 Chemical compound Oc1ccc([C@H]([C@H]2[C@@H]3CCC2)Oc(cc2)c3cc2F)cc1 XCZLBAHLLDZLTP-HDMKZQKVSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33276601P | 2001-11-19 | 2001-11-19 | |
| US36362202P | 2002-03-11 | 2002-03-11 | |
| PCT/US2002/033622 WO2003044006A1 (en) | 2001-11-19 | 2002-11-07 | Substituted benzopyrans as selective estrogen receptor-beta agonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005513027A JP2005513027A (ja) | 2005-05-12 |
| JP2005513027A5 JP2005513027A5 (enExample) | 2006-01-05 |
| JP4381810B2 true JP4381810B2 (ja) | 2009-12-09 |
Family
ID=26988373
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003545643A Expired - Fee Related JP4381810B2 (ja) | 2001-11-19 | 2002-11-07 | 選択的エストロゲン受容体βアゴニストとしての置換ベンゾピラン |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7217734B2 (enExample) |
| EP (1) | EP1448544B1 (enExample) |
| JP (1) | JP4381810B2 (enExample) |
| KR (1) | KR100950616B1 (enExample) |
| CN (1) | CN1312147C (enExample) |
| AT (1) | ATE362471T1 (enExample) |
| AU (1) | AU2002359283B2 (enExample) |
| CA (1) | CA2467013C (enExample) |
| CY (1) | CY1106726T1 (enExample) |
| DE (1) | DE60220179T2 (enExample) |
| DK (1) | DK1448544T3 (enExample) |
| EA (1) | EA007382B1 (enExample) |
| EC (1) | ECSP045113A (enExample) |
| ES (1) | ES2286322T3 (enExample) |
| HR (1) | HRP20040439A2 (enExample) |
| HU (1) | HU229351B1 (enExample) |
| IL (3) | IL161325A0 (enExample) |
| MX (1) | MXPA04004703A (enExample) |
| NO (1) | NO328563B1 (enExample) |
| NZ (1) | NZ531850A (enExample) |
| PL (1) | PL205733B1 (enExample) |
| PT (1) | PT1448544E (enExample) |
| WO (1) | WO2003044006A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7279499B2 (en) | 2003-04-21 | 2007-10-09 | Eli Lilly And Company | Substituted benzopyrans as selective estrogen receptor-beta agonists |
| EP1626974B1 (en) * | 2003-04-21 | 2008-08-27 | Eli Lilly And Company | Substituted benzopyrans as selective estrogen receptor-beta agonists |
| JP2008512458A (ja) | 2004-09-07 | 2008-04-24 | ワイス | ６Ｈ−［１］ベンゾピラノ［４，３−ｂ］キノリン及びエストロゲン様物質としてのそれらの使用 |
| ATE504582T1 (de) * | 2004-10-18 | 2011-04-15 | Lilly Co Eli | Substituierte benzopyrane als selektive östrogenrezeptor-beta-agonisten |
| US20060166933A1 (en) * | 2004-11-18 | 2006-07-27 | Jain Nareshkumar F | Novel 2H-chromene derivatives as selective estrogen receptor modulators |
| US8093302B2 (en) | 2005-02-15 | 2012-01-10 | Eli Lilly And Company | Substituted tetralins as selective estrogen receptor-β agonists |
| US9604931B2 (en) | 2007-01-22 | 2017-03-28 | Gtx, Inc. | Nuclear receptor binding agents |
| US9623021B2 (en) | 2007-01-22 | 2017-04-18 | Gtx, Inc. | Nuclear receptor binding agents |
| US8063102B2 (en) | 2009-03-13 | 2011-11-22 | N.V. Organon | Tetrahydronaphthalen-2-ol derivatives |
| TW201043595A (en) | 2009-03-13 | 2010-12-16 | Organon Nv | Tetrahydronaphthalen-2-ol derivatives |
| CN105960236A (zh) | 2013-12-05 | 2016-09-21 | 卡罗医药股份公司 | 用于治疗间皮瘤的雌激素受体β激动剂 |
| JP6978420B2 (ja) | 2015-09-17 | 2021-12-08 | オハイオ・ステート・イノヴェーション・ファウンデーション | カルボラン化合物及びその使用方法 |
| WO2021183760A1 (en) * | 2020-03-11 | 2021-09-16 | Ohio State Innovation Foundation | Methods of modulating t-cell activation using estrogen receptor beta (erβ) agonists |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3901926A (en) * | 1973-04-02 | 1975-08-26 | Abbott Lab | Alkylphenyl benzopyrans |
| EP0935000A3 (en) | 1995-09-08 | 1999-09-08 | Karo Bio Ab | Orphan receptor |
| AU8102398A (en) * | 1997-07-09 | 1999-02-08 | Central Drug Research Institute | (dl)-2,3-diaryl-2h-1-benzopyrans |
| US6593322B1 (en) | 1999-03-17 | 2003-07-15 | Signal Pharmaceuticals, Inc. | Compounds and methods for modulation of estrogen receptors |
| JP2003521468A (ja) | 1999-03-17 | 2003-07-15 | シグナル ファーマシューティカルズ， インコーポレイテッド | エストロゲンレセプタを変調させるための化合物及び方法 |
| TR200102992T2 (tr) | 1999-04-16 | 2004-12-21 | Astrazeneca Ab | ß östrojen reseptörü ligandları. |
| CA2396059A1 (en) | 1999-12-30 | 2001-07-12 | Signal Pharmaceuticals, Inc. | Compounds and methods for modulation of estrogen receptors |
| US7214706B2 (en) * | 2000-03-01 | 2007-05-08 | Akzo Nobel N.V. | Chroman derivatives as estrogenic compounds |
| ES2293986T3 (es) | 2000-03-27 | 2008-04-01 | N.V. Organon | Compuestos no esteroides tetraciclicos para tratamientos relacionados con el estrogeno. |
| GB2361642A (en) | 2000-10-24 | 2001-10-31 | Karobio Ab | Estrogen receptor beta (ERbeta) agonists for use in cancer treatment |
| UA83620C2 (ru) | 2001-12-05 | 2008-08-11 | Уайт | Замещенные бензоксазолы и их аналоги как эстрогенные агенты |
| TWI306450B (en) | 2001-12-13 | 2009-02-21 | Wyeth Corp | Substituted phenyl naphthalenes as estrogenic agents |
| US6630508B1 (en) * | 2002-02-11 | 2003-10-07 | Eli Lilly And Company | Substituted benzopyrans as selective estrogen receptor β agonists |
-
2002
- 2002-11-07 DE DE60220179T patent/DE60220179T2/de not_active Expired - Lifetime
- 2002-11-07 IL IL16132502A patent/IL161325A0/xx unknown
- 2002-11-07 PT PT02793806T patent/PT1448544E/pt unknown
- 2002-11-07 US US10/493,092 patent/US7217734B2/en not_active Expired - Fee Related
- 2002-11-07 EP EP02793806A patent/EP1448544B1/en not_active Expired - Lifetime
- 2002-11-07 CN CNB028229916A patent/CN1312147C/zh not_active Expired - Fee Related
- 2002-11-07 JP JP2003545643A patent/JP4381810B2/ja not_active Expired - Fee Related
- 2002-11-07 HU HU0402628A patent/HU229351B1/hu not_active IP Right Cessation
- 2002-11-07 DK DK02793806T patent/DK1448544T3/da active
- 2002-11-07 AT AT02793806T patent/ATE362471T1/de active
- 2002-11-07 PL PL374510A patent/PL205733B1/pl unknown
- 2002-11-07 WO PCT/US2002/033622 patent/WO2003044006A1/en not_active Ceased
- 2002-11-07 MX MXPA04004703A patent/MXPA04004703A/es active IP Right Grant
- 2002-11-07 CA CA2467013A patent/CA2467013C/en not_active Expired - Fee Related
- 2002-11-07 HR HR20040439A patent/HRP20040439A2/hr not_active Application Discontinuation
- 2002-11-07 NZ NZ531850A patent/NZ531850A/en not_active IP Right Cessation
- 2002-11-07 EA EA200400695A patent/EA007382B1/ru not_active IP Right Cessation
- 2002-11-07 KR KR1020047007563A patent/KR100950616B1/ko not_active Expired - Fee Related
- 2002-11-07 AU AU2002359283A patent/AU2002359283B2/en not_active Ceased
- 2002-11-07 ES ES02793806T patent/ES2286322T3/es not_active Expired - Lifetime
-
2004
- 2004-04-08 IL IL161325A patent/IL161325A/en not_active IP Right Cessation
- 2004-05-19 EC EC2004005113A patent/ECSP045113A/es unknown
- 2004-06-18 NO NO20042583A patent/NO328563B1/no not_active IP Right Cessation
-
2007
- 2007-07-13 CY CY20071100932T patent/CY1106726T1/el unknown
- 2007-09-10 IL IL185867A patent/IL185867A/en not_active IP Right Cessation
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Free format text: JAPANESE INTERMEDIATE CODE: R250 |
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| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
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| LAPS | Cancellation because of no payment of annual fees |