DK1448544T3 - Substituerede benzopyraner som selektive estrogenreceptor-beta-agonister - Google Patents
Substituerede benzopyraner som selektive estrogenreceptor-beta-agonisterInfo
- Publication number
- DK1448544T3 DK1448544T3 DK02793806T DK02793806T DK1448544T3 DK 1448544 T3 DK1448544 T3 DK 1448544T3 DK 02793806 T DK02793806 T DK 02793806T DK 02793806 T DK02793806 T DK 02793806T DK 1448544 T3 DK1448544 T3 DK 1448544T3
- Authority
- DK
- Denmark
- Prior art keywords
- estrogen receptor
- receptor beta
- selective estrogen
- beta agonists
- agonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Reproductive Health (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33276601P | 2001-11-19 | 2001-11-19 | |
US36362202P | 2002-03-11 | 2002-03-11 | |
PCT/US2002/033622 WO2003044006A1 (en) | 2001-11-19 | 2002-11-07 | Substituted benzopyrans as selective estrogen receptor-beta agonists |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1448544T3 true DK1448544T3 (da) | 2007-10-08 |
Family
ID=26988373
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02793806T DK1448544T3 (da) | 2001-11-19 | 2002-11-07 | Substituerede benzopyraner som selektive estrogenreceptor-beta-agonister |
Country Status (24)
Country | Link |
---|---|
US (1) | US7217734B2 (da) |
EP (1) | EP1448544B1 (da) |
JP (1) | JP4381810B2 (da) |
KR (1) | KR100950616B1 (da) |
CN (1) | CN1312147C (da) |
AT (1) | ATE362471T1 (da) |
AU (1) | AU2002359283B2 (da) |
CA (1) | CA2467013C (da) |
CY (1) | CY1106726T1 (da) |
DE (1) | DE60220179T2 (da) |
DK (1) | DK1448544T3 (da) |
EA (1) | EA007382B1 (da) |
EC (1) | ECSP045113A (da) |
ES (1) | ES2286322T3 (da) |
HK (1) | HK1068349A1 (da) |
HR (1) | HRP20040439A2 (da) |
HU (1) | HU229351B1 (da) |
IL (3) | IL161325A0 (da) |
MX (1) | MXPA04004703A (da) |
NO (1) | NO328563B1 (da) |
NZ (1) | NZ531850A (da) |
PL (1) | PL205733B1 (da) |
PT (1) | PT1448544E (da) |
WO (1) | WO2003044006A1 (da) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE602004016150D1 (de) * | 2003-04-21 | 2008-10-09 | Lilly Co Eli | Substituierte benzopyrane als selektive antagonisten am östrogenrezeptor-beta |
ES2338119T3 (es) | 2003-04-21 | 2010-05-04 | Eli Lilly And Company | Benzopiranos sustituidos como agonistas selectivos del receptor-beta de estrogeno. |
JP2008512458A (ja) | 2004-09-07 | 2008-04-24 | ワイス | 6H−[1]ベンゾピラノ[4,3−b]キノリン及びエストロゲン様物質としてのそれらの使用 |
ES2361031T3 (es) * | 2004-10-18 | 2011-06-13 | Eli Lilly And Company | Benzopiranos sustituidos como agonistas selectivos del receptor beta de estrógenos. |
DE602005010735D1 (de) * | 2004-11-18 | 2008-12-11 | Janssen Pharmaceutica Nv | Neue 2h-chromenderivate als selektive östrogenrezeptor-modulatoren |
US8093302B2 (en) | 2005-02-15 | 2012-01-10 | Eli Lilly And Company | Substituted tetralins as selective estrogen receptor-β agonists |
US9604931B2 (en) | 2007-01-22 | 2017-03-28 | Gtx, Inc. | Nuclear receptor binding agents |
US9623021B2 (en) | 2007-01-22 | 2017-04-18 | Gtx, Inc. | Nuclear receptor binding agents |
TW201043595A (en) | 2009-03-13 | 2010-12-16 | Organon Nv | Tetrahydronaphthalen-2-ol derivatives |
US8063102B2 (en) | 2009-03-13 | 2011-11-22 | N.V. Organon | Tetrahydronaphthalen-2-ol derivatives |
JP2016539954A (ja) | 2013-12-05 | 2016-12-22 | カロ ファーマ エービーKaro Pharma Ab | 中皮腫の処置で使用するためのエストロゲン受容体ベータアゴニスト |
US11020411B2 (en) | 2015-09-17 | 2021-06-01 | Ohio State Innovation Foundation | Carborane compounds and methods of use thereof |
US20230114408A1 (en) * | 2020-03-11 | 2023-04-13 | Ohio State Innovation Foundation | Methods of modulating t-cell activation using estrogen receptor beta (erb) agonists |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3901926A (en) | 1973-04-02 | 1975-08-26 | Abbott Lab | Alkylphenyl benzopyrans |
DK0792292T4 (da) | 1995-09-08 | 2009-07-20 | Karobio Ab | Orphan-receptor |
AU8102398A (en) * | 1997-07-09 | 1999-02-08 | Central Drug Research Institute | (dl)-2,3-diaryl-2h-1-benzopyrans |
US6593322B1 (en) | 1999-03-17 | 2003-07-15 | Signal Pharmaceuticals, Inc. | Compounds and methods for modulation of estrogen receptors |
CA2367895A1 (en) | 1999-03-17 | 2000-09-21 | Signal Pharmaceuticals, Inc. | Compounds and methods for modulation of estrogen receptors |
TR200102992T2 (tr) | 1999-04-16 | 2004-12-21 | Astrazeneca Ab | ß östrojen reseptörü ligandları. |
CA2396059A1 (en) | 1999-12-30 | 2001-07-12 | Signal Pharmaceuticals, Inc. | Compounds and methods for modulation of estrogen receptors |
US7214706B2 (en) * | 2000-03-01 | 2007-05-08 | Akzo Nobel N.V. | Chroman derivatives as estrogenic compounds |
EP1272471B1 (en) | 2000-03-27 | 2007-10-03 | N.V. Organon | Non-steroidal, tetracyclic compounds for estrogen-related treatments |
GB2361642A (en) | 2000-10-24 | 2001-10-31 | Karobio Ab | Estrogen receptor beta (ERbeta) agonists for use in cancer treatment |
UA83620C2 (ru) | 2001-12-05 | 2008-08-11 | Уайт | Замещенные бензоксазолы и их аналоги как эстрогенные агенты |
TWI306450B (en) | 2001-12-13 | 2009-02-21 | Wyeth Corp | Substituted phenyl naphthalenes as estrogenic agents |
US6630508B1 (en) | 2002-02-11 | 2003-10-07 | Eli Lilly And Company | Substituted benzopyrans as selective estrogen receptor β agonists |
-
2002
- 2002-11-07 JP JP2003545643A patent/JP4381810B2/ja not_active Expired - Fee Related
- 2002-11-07 EA EA200400695A patent/EA007382B1/ru not_active IP Right Cessation
- 2002-11-07 KR KR1020047007563A patent/KR100950616B1/ko not_active IP Right Cessation
- 2002-11-07 IL IL16132502A patent/IL161325A0/xx unknown
- 2002-11-07 WO PCT/US2002/033622 patent/WO2003044006A1/en active IP Right Grant
- 2002-11-07 DE DE60220179T patent/DE60220179T2/de not_active Expired - Lifetime
- 2002-11-07 ES ES02793806T patent/ES2286322T3/es not_active Expired - Lifetime
- 2002-11-07 US US10/493,092 patent/US7217734B2/en not_active Expired - Fee Related
- 2002-11-07 HU HU0402628A patent/HU229351B1/hu not_active IP Right Cessation
- 2002-11-07 MX MXPA04004703A patent/MXPA04004703A/es active IP Right Grant
- 2002-11-07 AU AU2002359283A patent/AU2002359283B2/en not_active Ceased
- 2002-11-07 NZ NZ531850A patent/NZ531850A/en not_active IP Right Cessation
- 2002-11-07 CA CA2467013A patent/CA2467013C/en not_active Expired - Fee Related
- 2002-11-07 EP EP02793806A patent/EP1448544B1/en not_active Expired - Lifetime
- 2002-11-07 CN CNB028229916A patent/CN1312147C/zh not_active Expired - Fee Related
- 2002-11-07 PL PL374510A patent/PL205733B1/pl unknown
- 2002-11-07 AT AT02793806T patent/ATE362471T1/de active
- 2002-11-07 DK DK02793806T patent/DK1448544T3/da active
- 2002-11-07 PT PT02793806T patent/PT1448544E/pt unknown
-
2004
- 2004-04-08 IL IL161325A patent/IL161325A/en not_active IP Right Cessation
- 2004-05-18 HR HR20040439A patent/HRP20040439A2/hr not_active Application Discontinuation
- 2004-05-19 EC EC2004005113A patent/ECSP045113A/es unknown
- 2004-06-18 NO NO20042583A patent/NO328563B1/no not_active IP Right Cessation
-
2005
- 2005-01-24 HK HK05100628A patent/HK1068349A1/xx not_active IP Right Cessation
-
2007
- 2007-07-13 CY CY20071100932T patent/CY1106726T1/el unknown
- 2007-09-10 IL IL185867A patent/IL185867A/en not_active IP Right Cessation
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