DK1448544T3 - Substituerede benzopyraner som selektive estrogenreceptor-beta-agonister - Google Patents

Substituerede benzopyraner som selektive estrogenreceptor-beta-agonister

Info

Publication number
DK1448544T3
DK1448544T3 DK02793806T DK02793806T DK1448544T3 DK 1448544 T3 DK1448544 T3 DK 1448544T3 DK 02793806 T DK02793806 T DK 02793806T DK 02793806 T DK02793806 T DK 02793806T DK 1448544 T3 DK1448544 T3 DK 1448544T3
Authority
DK
Denmark
Prior art keywords
estrogen receptor
receptor beta
selective estrogen
beta agonists
agonists
Prior art date
Application number
DK02793806T
Other languages
English (en)
Inventor
Jeffrey Alan Dodge
Venkatesh Gary Krishnan
Charles Willis Lugar Iii
Blake Lee Neubauer
Bryan Hurst Norman
Lance Allen Pfeifer
Timothy Ivo Richardson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK1448544T3 publication Critical patent/DK1448544T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Obesity (AREA)
  • Pyrane Compounds (AREA)
DK02793806T 2001-11-19 2002-11-07 Substituerede benzopyraner som selektive estrogenreceptor-beta-agonister DK1448544T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33276601P 2001-11-19 2001-11-19
US36362202P 2002-03-11 2002-03-11
PCT/US2002/033622 WO2003044006A1 (en) 2001-11-19 2002-11-07 Substituted benzopyrans as selective estrogen receptor-beta agonists

Publications (1)

Publication Number Publication Date
DK1448544T3 true DK1448544T3 (da) 2007-10-08

Family

ID=26988373

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02793806T DK1448544T3 (da) 2001-11-19 2002-11-07 Substituerede benzopyraner som selektive estrogenreceptor-beta-agonister

Country Status (24)

Country Link
US (1) US7217734B2 (da)
EP (1) EP1448544B1 (da)
JP (1) JP4381810B2 (da)
KR (1) KR100950616B1 (da)
CN (1) CN1312147C (da)
AT (1) ATE362471T1 (da)
AU (1) AU2002359283B2 (da)
CA (1) CA2467013C (da)
CY (1) CY1106726T1 (da)
DE (1) DE60220179T2 (da)
DK (1) DK1448544T3 (da)
EA (1) EA007382B1 (da)
EC (1) ECSP045113A (da)
ES (1) ES2286322T3 (da)
HK (1) HK1068349A1 (da)
HR (1) HRP20040439A2 (da)
HU (1) HU229351B1 (da)
IL (3) IL161325A0 (da)
MX (1) MXPA04004703A (da)
NO (1) NO328563B1 (da)
NZ (1) NZ531850A (da)
PL (1) PL205733B1 (da)
PT (1) PT1448544E (da)
WO (1) WO2003044006A1 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA05011243A (es) * 2003-04-21 2005-12-15 Lilly Co Eli Benzopiranos substituidos como agonistas selectivos del receptor beta de estrogeno.
DE602004025460D1 (de) 2003-04-21 2010-03-25 Lilly Co Eli Substituierte benzopyrane als selektive antagonisten am östrogenrezeptor-beta
BRPI0514974A (pt) 2004-09-07 2008-07-01 Wyeth Corp composto, composição, métodos de tratar ou inibir uma doença ou condição, estados de doença induzidos por radical livre em um mamìfero, dano à junta secundário aos procedimentos artroscópicos ou cirúrgicos em um mamìfero, infertilidade em um mamìfero, de diminuir os nìveis de colesterol, triglicerìdeos, lp(a), ou ldl, de fornecer realce na cognição ou neuroproteção, de contracepção em um mamìfero, e para preparar um composto, e, produto
ES2361031T3 (es) * 2004-10-18 2011-06-13 Eli Lilly And Company Benzopiranos sustituidos como agonistas selectivos del receptor beta de estrógenos.
SI1812417T1 (sl) * 2004-11-18 2009-04-30 Janssen Pharmaceutica Nv Novi derivati 2H-kromena kot selektivni modulatorji estrogenskega receptorja
US8093302B2 (en) 2005-02-15 2012-01-10 Eli Lilly And Company Substituted tetralins as selective estrogen receptor-β agonists
US9604931B2 (en) 2007-01-22 2017-03-28 Gtx, Inc. Nuclear receptor binding agents
US9623021B2 (en) 2007-01-22 2017-04-18 Gtx, Inc. Nuclear receptor binding agents
US8063102B2 (en) 2009-03-13 2011-11-22 N.V. Organon Tetrahydronaphthalen-2-ol derivatives
TW201043595A (en) 2009-03-13 2010-12-16 Organon Nv Tetrahydronaphthalen-2-ol derivatives
EP3076964A1 (en) 2013-12-05 2016-10-12 Karo Pharma AB Estrogen receptor beta agonists for use in treating mesothelioma
WO2017049307A1 (en) 2015-09-17 2017-03-23 Ohio State Innovation Foundation Carborane compounds and methods of use thereof
US20230114408A1 (en) * 2020-03-11 2023-04-13 Ohio State Innovation Foundation Methods of modulating t-cell activation using estrogen receptor beta (erb) agonists

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3901926A (en) 1973-04-02 1975-08-26 Abbott Lab Alkylphenyl benzopyrans
DE792292T1 (de) 1995-09-08 1998-09-03 Karo Bio Ab, Huddinge Waisen-rezeptor
WO1999002512A1 (en) 1997-07-09 1999-01-21 Novo Nordisk A/S Dl-2,3-diaryl-2h-1-benzopyrans
JP2003521468A (ja) 1999-03-17 2003-07-15 シグナル ファーマシューティカルズ， インコーポレイテッド エストロゲンレセプタを変調させるための化合物及び方法
US6593322B1 (en) 1999-03-17 2003-07-15 Signal Pharmaceuticals, Inc. Compounds and methods for modulation of estrogen receptors
BR0009814A (pt) 1999-04-16 2002-01-08 Astrazeneca Ab Processo para tratar de uma doença associada com o receptor-beta estrogênico
DK1246814T3 (da) 1999-12-30 2005-05-30 Signal Pharm Llc Forbindelser og fremgangsmåder til modulation af östrogenreceptorer
JP4896335B2 (ja) * 2000-03-01 2012-03-14 ナームローゼ・フエンノートチヤツプ・オルガノン エストロゲン化合物としてのクロマン誘導体
ES2293986T3 (es) 2000-03-27 2008-04-01 N.V. Organon Compuestos no esteroides tetraciclicos para tratamientos relacionados con el estrogeno.
GB2361642A (en) 2000-10-24 2001-10-31 Karobio Ab Estrogen receptor beta (ERbeta) agonists for use in cancer treatment
UA83620C2 (ru) 2001-12-05 2008-08-11 Уайт Замещенные бензоксазолы и их аналоги как эстрогенные агенты
TWI306450B (en) 2001-12-13 2009-02-21 Wyeth Corp Substituted phenyl naphthalenes as estrogenic agents
US6630508B1 (en) 2002-02-11 2003-10-07 Eli Lilly And Company Substituted benzopyrans as selective estrogen receptor β agonists

Also Published As

Publication number Publication date
JP4381810B2 (ja) 2009-12-09
PL205733B1 (pl) 2010-05-31
CA2467013C (en) 2010-08-10
EP1448544A1 (en) 2004-08-25
CY1106726T1 (el) 2012-05-23
ES2286322T3 (es) 2007-12-01
ECSP045113A (es) 2004-07-23
WO2003044006A1 (en) 2003-05-30
CN1589268A (zh) 2005-03-02
DE60220179D1 (de) 2007-06-28
IL161325A0 (en) 2004-09-27
EA200400695A1 (ru) 2004-12-30
PT1448544E (pt) 2007-08-10
EA007382B1 (ru) 2006-10-27
DE60220179T2 (de) 2008-02-07
NO20042583L (no) 2004-06-18
JP2005513027A (ja) 2005-05-12
AU2002359283B8 (en) 2003-06-10
NZ531850A (en) 2007-01-26
KR20040063963A (ko) 2004-07-15
US7217734B2 (en) 2007-05-15
AU2002359283A1 (en) 2003-06-10
AU2002359283B2 (en) 2007-06-21
CA2467013A1 (en) 2003-05-30
PL374510A1 (en) 2005-10-31
ATE362471T1 (de) 2007-06-15
IL185867A0 (en) 2008-01-06
EP1448544B1 (en) 2007-05-16
IL185867A (en) 2009-09-22
KR100950616B1 (ko) 2010-04-01
HRP20040439A2 (en) 2005-04-30
IL161325A (en) 2008-07-08
US20040249167A1 (en) 2004-12-09
HUP0402628A2 (hu) 2005-04-28
HK1068349A1 (en) 2005-04-29
HU229351B1 (en) 2013-11-28
MXPA04004703A (es) 2004-08-19
NO328563B1 (no) 2010-03-22
CN1312147C (zh) 2007-04-25

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