JP4377058B2 - リガンドの検出及び増幅 - Google Patents

リガンドの検出及び増幅 Download PDF

Info

Publication number
JP4377058B2
JP4377058B2 JP2000553806A JP2000553806A JP4377058B2 JP 4377058 B2 JP4377058 B2 JP 4377058B2 JP 2000553806 A JP2000553806 A JP 2000553806A JP 2000553806 A JP2000553806 A JP 2000553806A JP 4377058 B2 JP4377058 B2 JP 4377058B2
Authority
JP
Japan
Prior art keywords
receptor
ligand
enzyme
liquid crystal
signal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2000553806A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002517756A5 (enExample
JP2002517756A (ja
Inventor
クリストファー ジェー ウールバートン
ギャリー ディー ニーハウス
キャサリーン ジェー ドーン
オレグ ラブレントビチ
スティーブン ピー シュミット
スティーブン エー サインズ
Original Assignee
ケント ステート ユニバーシティ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ケント ステート ユニバーシティ filed Critical ケント ステート ユニバーシティ
Publication of JP2002517756A publication Critical patent/JP2002517756A/ja
Publication of JP2002517756A5 publication Critical patent/JP2002517756A5/ja
Application granted granted Critical
Publication of JP4377058B2 publication Critical patent/JP4377058B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/545—Synthetic resin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Inorganic Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Silicon Polymers (AREA)
JP2000553806A 1998-06-10 1999-05-12 リガンドの検出及び増幅 Expired - Fee Related JP4377058B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/095,196 1998-06-10
US09/095,196 US6171802B1 (en) 1998-06-10 1998-06-10 Detection and amplification of ligands
PCT/US1999/010413 WO1999064862A1 (en) 1998-06-10 1999-05-12 Detection of ligands with signal amplification

Publications (3)

Publication Number Publication Date
JP2002517756A JP2002517756A (ja) 2002-06-18
JP2002517756A5 JP2002517756A5 (enExample) 2006-06-08
JP4377058B2 true JP4377058B2 (ja) 2009-12-02

Family

ID=22250600

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000553806A Expired - Fee Related JP4377058B2 (ja) 1998-06-10 1999-05-12 リガンドの検出及び増幅

Country Status (10)

Country Link
US (5) US6171802B1 (enExample)
EP (1) EP1086374B1 (enExample)
JP (1) JP4377058B2 (enExample)
AT (1) ATE287539T1 (enExample)
AU (1) AU753758B2 (enExample)
BR (1) BR9910982A (enExample)
CA (1) CA2334712A1 (enExample)
DE (1) DE69923313D1 (enExample)
IL (2) IL139911A0 (enExample)
WO (1) WO1999064862A1 (enExample)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6171802B1 (en) * 1998-06-10 2001-01-09 Kent State University Detection and amplification of ligands
US20020052002A1 (en) * 1998-06-10 2002-05-02 Niehaus Gary D. Detection and amplification of ligands
US6537631B1 (en) * 1999-04-30 2003-03-25 Kimberly-Clark Worldwide, Inc. Roll of wet wipes
JP3512775B2 (ja) * 2000-02-16 2004-03-31 ウイスコンシン アラムニ リサーチ ファンデーション 液晶アッセイ用の生化学的ブロッキング層
JP3886382B2 (ja) * 2000-02-16 2007-02-28 ウイスコンシン アラムニ リサーチ ファンデーション 顕微鏡的病原体の検出方法及び装置
US7135143B2 (en) 2001-03-14 2006-11-14 Wisconsin Alumni Research Foundation Detecting compounds with liquid crystals
US6411354B1 (en) * 2001-05-11 2002-06-25 Kent State University Bulk alignment of lyotropic chromonic liquid crystals
US6673398B2 (en) 2001-05-14 2004-01-06 Kent State University Alignment of lyotropic chromonic liquid crystals at surfaces as monolayers and multilayered stacks
US7666661B2 (en) 2001-08-27 2010-02-23 Platypus Technologies, Llc Substrates, devices, and methods for quantitative liquid crystal assays
WO2003021339A2 (en) * 2001-09-04 2003-03-13 Wisconsin Alumni Research Foundation Liquid crystal switching mechanism
AU2002341900A1 (en) * 2001-10-04 2003-04-14 Wisconsin Alumni Research Foundation Detection of dna hybridization on surfaces
US7807348B2 (en) * 2002-03-20 2010-10-05 Wisconsin Alumni Research Foundation Optical imaging of nanostructured substrates
US7125592B2 (en) * 2002-04-10 2006-10-24 Wisconsin Alumni Research Foundation Detecting interactions at biomimetic interfaces with liquid crystals
WO2004041061A2 (en) * 2002-05-22 2004-05-21 Platypus Technologies, Llc Substrates, devices, and methods for cellular assays
WO2003106589A1 (en) * 2002-06-13 2003-12-24 Lyotropic Therapeutics, Inc. A nanoporous particle with a retained target
WO2004044583A1 (en) * 2002-11-08 2004-05-27 Wisconsin Alumni Research Foundation Surfaces with gradients in surface topography
CA2523124A1 (en) * 2003-03-20 2004-10-07 Gary D. Niehaus Self-contained assay device for rapid detection of biohazardous agents
WO2005010160A2 (en) * 2003-07-17 2005-02-03 Wisconsin Alumni Research Foundation Liquid crystals with reduced toxicity and applications thereof
EP1654390B1 (en) 2003-07-25 2009-11-11 Platypus Technologies, LLC Liquid crystal based analyte detection
US20050069928A1 (en) * 2003-08-04 2005-03-31 Blue Heron Biotechnology, Inc. Methods for synthesis of defined polynucleotides
US7795007B2 (en) 2003-09-23 2010-09-14 Wisconsin Alumni Research Foundation Detection of post-translationally modified peptides with liquid crystals
DE602004011244T2 (de) * 2003-09-23 2009-02-12 Wisconsin Alumni Research Foundation, Madison Verwendung von flüssigkristallen zum nachweis von affinitätsmikrokontakt-gedruckten biomolekülen
EP1687396A2 (en) 2003-11-10 2006-08-09 Platypus Technologies, LLC Substrates, devices, and methods for cellular assays
US7531366B2 (en) * 2004-07-23 2009-05-12 Platypus Technologies, Llc Bead based assays using a liquid crystal reporter
US7294370B2 (en) * 2004-08-17 2007-11-13 Kent State University Aligned lyotropic chromonic liquid crystal films
US7662572B2 (en) * 2005-08-25 2010-02-16 Platypus Technologies, Llc. Compositions and liquid crystals
US8586389B2 (en) * 2005-09-28 2013-11-19 Kent State University Ligand concentrating, liquid crystal biosensor system
US20070099306A1 (en) * 2005-09-28 2007-05-03 Kent State University Liquid crystal sensor system
US7407815B2 (en) * 2005-09-28 2008-08-05 Kent State University Liquid crystal cassette
US7910382B2 (en) * 2005-10-31 2011-03-22 Wisconsin Alumni Research Foundation Device and methods for liquid crystal-based bioagent detection
US7842499B2 (en) * 2006-08-07 2010-11-30 Platypus Technologies, Llc Substrates, devices, and methods for cellular assays
WO2008021071A2 (en) 2006-08-07 2008-02-21 Platypus Technologies, Llc Substrates, devices, and methods for cellular assays
CN101689638A (zh) * 2007-05-04 2010-03-31 埃克民公司 固定化酶及其用途
WO2009026359A2 (en) * 2007-08-20 2009-02-26 Platypus Technologies, Llc Improved devices for cell assays
US8472683B2 (en) * 2008-05-09 2013-06-25 General Electric Company Motion correction in tomographic images
US7947492B2 (en) * 2008-08-20 2011-05-24 Northeastern Ohio Universities College Of Medicine Device improving the detection of a ligand
US8178355B2 (en) * 2008-09-15 2012-05-15 Platypus Technologies, Llc. Detection of vapor phase compounds by changes in physical properties of a liquid crystal
US9080973B2 (en) * 2009-04-22 2015-07-14 Wisconsin Alumni Research Foundation Analyte detection using liquid crystals
US8404318B2 (en) * 2009-06-16 2013-03-26 Kent State University Methods and apparatus to produce aligned film of lyotropic chromonic liquid crystals
US11500247B2 (en) 2015-11-18 2022-11-15 Platypus Technologies, Llc Liquid crystal sensor

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4067774A (en) * 1971-05-14 1978-01-10 Syva Company Compounds for enzyme amplification assay
US4203802A (en) * 1971-05-14 1980-05-20 Syva Company Inhibitable enzyme amplification assay
US3817837A (en) * 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3975237A (en) * 1972-11-06 1976-08-17 Syva Company Compounds for enzyme amplification assay - - ecgonine analogs
US4604364A (en) 1974-01-04 1986-08-05 Kosak Kenneth M Bioluminescent tracer composition and method of use in immunoassays
US4600690A (en) * 1978-08-07 1986-07-15 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Immunoassay
US5156965A (en) * 1983-11-29 1992-10-20 Igen, Inc. Catalytic antibodies
US5096807A (en) * 1985-03-06 1992-03-17 Murex Corporation Imaging immunoassay detection system with background compensation and its use
JPS61271460A (ja) 1985-05-28 1986-12-01 Olympus Optical Co Ltd 免疫学的分析方法
US4693970A (en) * 1985-06-21 1987-09-15 Becton, Dickinson And Company Immunoassay using complement
US5149626A (en) 1987-05-14 1992-09-22 Mclean Hospital Corporation Multiple antigen immunoassay
US5447837A (en) 1987-08-05 1995-09-05 Calypte, Inc. Multi-immunoassay diagnostic system for antigens or antibodies or both
IL83451A (en) * 1987-08-06 1991-06-10 Univ Ramot Stabilized water soluble enzymes and a method for their preparation
US4943525A (en) 1987-11-02 1990-07-24 Bioventures, Inc. Simultaneous immunoassay for the determination of antigens and antibodies
US5252459A (en) * 1988-09-23 1993-10-12 Abbott Laboratories Indicator reagents, diagnostic assays and test kits employing organic polymer latex particles
AU665758B2 (en) * 1991-04-26 1996-01-18 Surface Active Limited Novel antibodies, and methods for their use
US5596434A (en) * 1993-09-24 1997-01-21 University Research Corporation Self-assembled monolayers for liquid crystal alignment
US5681571A (en) * 1993-10-08 1997-10-28 Duotol Ab Immunological tolerance-inducing agent
JPH10501277A (ja) 1994-06-06 1998-02-03 ヘキスト・セラニーズ・コーポレーション サーモトロピック液晶性ポリ（エステルアミド）
GB9417593D0 (en) * 1994-09-01 1994-10-19 Secr Defence Luciferase labelling method
US6207369B1 (en) * 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
US6001571A (en) * 1995-11-30 1999-12-14 Mandecki; Wlodek Multiplex assay for nucleic acids employing transponders
GB9712818D0 (en) * 1996-07-08 1997-08-20 Cambridge Antibody Tech Labelling and selection of specific binding molecules
GB9622524D0 (en) * 1996-10-29 1997-01-08 London Biotechnology Ltd Enzyme labels for assays
US5763158A (en) * 1997-02-06 1998-06-09 The United States Of America As Represented By The Secretary Of The Army Detection of multiple antigens or antibodies
KR100551221B1 (ko) * 1997-09-09 2006-02-10 리오트로픽테라피우틱스 인코퍼레이션 코팅된 입자, 그 제조방법 및 그 사용방법
US6284197B1 (en) * 1998-06-05 2001-09-04 The Regents Of The University Of California Optical amplification of molecular interactions using liquid crystals
US20020052002A1 (en) 1998-06-10 2002-05-02 Niehaus Gary D. Detection and amplification of ligands
US6171802B1 (en) * 1998-06-10 2001-01-09 Kent State University Detection and amplification of ligands
DE60008137T2 (de) 1999-11-12 2004-09-16 3M Innovative Properties Co., Saint Paul Flüssigkristallorientierunsstrukturen, verfahren zu deren herstellung und anzeigevorrichtungen, die diese strukturen enthalten

Also Published As

Publication number Publication date
EP1086374A1 (en) 2001-03-28
US7267957B2 (en) 2007-09-11
DE69923313D1 (de) 2005-02-24
US20070059780A1 (en) 2007-03-15
AU753758B2 (en) 2002-10-31
US20070218508A1 (en) 2007-09-20
BR9910982A (pt) 2001-02-13
US20080138244A1 (en) 2008-06-12
AU3984499A (en) 1999-12-30
ATE287539T1 (de) 2005-02-15
US7732219B2 (en) 2010-06-08
WO1999064862A1 (en) 1999-12-16
US7927827B2 (en) 2011-04-19
US6171802B1 (en) 2001-01-09
IL139911A (en) 2008-06-05
JP2002517756A (ja) 2002-06-18
IL139911A0 (en) 2002-02-10
US20070243593A1 (en) 2007-10-18
CA2334712A1 (en) 1999-12-16
EP1086374B1 (en) 2005-01-19

Similar Documents

Publication Publication Date Title
JP4377058B2 (ja) リガンドの検出及び増幅
Liu et al. Removal of endotoxin from recombinant protein preparations
CN101925819B (zh) 结核分歧杆菌复合群的免疫检出方法
JP2002510385A (ja) クロストリジウム・ディフィシル用診断テストおよび診断キット
JP2009185037A (ja) ＥｈｒｌｉｃｈｉａｃａｎｉｓおよびＥｈｒｌｉｃｈｉａｃｈａｆｆｅｅｎｓｉｓ抗体の検出のための組成物および方法
JP2005509133A (ja) リガンドの検出及び増幅
EP2972367A1 (en) Biomarkers for detecting the presence of bacteria
US5601830A (en) Staphylococcus aureus enterotoxin H and methods of use
US6858400B2 (en) Detection of surface-associated human leukocyte elastase
AU763916B2 (en) Lipopolysaccharide immunoassay and test device
US20170137501A1 (en) Anti-Bed Bug Monoclonal Antibodies and Methods of Making and Uses Thereof
JPH05508770A (ja) 膵臓エラスターゼ１特異性抗体、その獲得方法および該抗体を含有するテストキット
Frank et al. Bioluminescent signal system: bioluminescence immunoassay of pathogenic organisms
RU2478970C1 (ru) Способ иммунофлуоресцентного определения протективного антигена возбудителя сибирской язвы
KR102244121B1 (ko) 브루셀라균의 omp28에 특이적으로 결합하는 단일클론항체, 상기 항체를 생산하는 하이브리도마 세포주 및 이의 용도
MXPA00012140A (en) Detection of ligands with signal amplification
US20240418719A1 (en) Device and method for pathogen detection
US20250155438A1 (en) Device and method for pathogen detection
KR102404143B1 (ko) 라싸 바이러스 핵단백질에 특이적인 항체, 이를 생산하는 하이브리도마 세포주 및 이를 이용한 라싸 바이러스 검출 키트
KR20200049388A (ko) 페스트균의 f1 캡슐 단백질에 특이적으로 결합하는 단일클론항체, 상기 항체를 생산하는 하이브리도마 세포주 및 이의 용도
Kinning et al. The resonant mirror optical biosensor
TRAN Nanobodies for the early detection of cancer: a case study on ovarian cancer
Abdel-Hamid Development of a portable immunoassay system for rapid and sensitive analyte detection
YAMAMOTO et al. Determination of specific antibody value in patients with tuberculosis and atypical mycobacteriosis.
JPH07501396A (ja) Ｈｌａ（ヒト白血球抗原）のタイプ分け方法

Legal Events

Date Code Title Description
RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20051216

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20060302

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20060417

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20060417

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20090401

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090422

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090722

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20090812

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20090910

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120918

Year of fee payment: 3

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130918

Year of fee payment: 4

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees