DE69923313D1 - Nachweis von liganden mit signalverstärkung - Google Patents

Nachweis von liganden mit signalverstärkung

Info

Publication number
DE69923313D1
DE69923313D1 DE69923313T DE69923313T DE69923313D1 DE 69923313 D1 DE69923313 D1 DE 69923313D1 DE 69923313 T DE69923313 T DE 69923313T DE 69923313 T DE69923313 T DE 69923313T DE 69923313 D1 DE69923313 D1 DE 69923313D1
Authority
DE
Germany
Prior art keywords
receptor
ligands
detection
enzyme
ligand
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69923313T
Other languages
German (de)
English (en)
Inventor
J Woolverton
D Niehaus
J Doane
Oleg Lavrentovich
P Schmidt
A Signs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kent State University
Original Assignee
Kent State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kent State University filed Critical Kent State University
Application granted granted Critical
Publication of DE69923313D1 publication Critical patent/DE69923313D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/545—Synthetic resin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Inorganic Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Silicon Polymers (AREA)
DE69923313T 1998-06-10 1999-05-12 Nachweis von liganden mit signalverstärkung Expired - Lifetime DE69923313D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/095,196 US6171802B1 (en) 1998-06-10 1998-06-10 Detection and amplification of ligands
PCT/US1999/010413 WO1999064862A1 (en) 1998-06-10 1999-05-12 Detection of ligands with signal amplification

Publications (1)

Publication Number Publication Date
DE69923313D1 true DE69923313D1 (de) 2005-02-24

Family

ID=22250600

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69923313T Expired - Lifetime DE69923313D1 (de) 1998-06-10 1999-05-12 Nachweis von liganden mit signalverstärkung

Country Status (10)

Country Link
US (5) US6171802B1 (enExample)
EP (1) EP1086374B1 (enExample)
JP (1) JP4377058B2 (enExample)
AT (1) ATE287539T1 (enExample)
AU (1) AU753758B2 (enExample)
BR (1) BR9910982A (enExample)
CA (1) CA2334712A1 (enExample)
DE (1) DE69923313D1 (enExample)
IL (2) IL139911A0 (enExample)
WO (1) WO1999064862A1 (enExample)

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US6171802B1 (en) * 1998-06-10 2001-01-09 Kent State University Detection and amplification of ligands
US20020052002A1 (en) * 1998-06-10 2002-05-02 Niehaus Gary D. Detection and amplification of ligands
US6537631B1 (en) * 1999-04-30 2003-03-25 Kimberly-Clark Worldwide, Inc. Roll of wet wipes
JP3512775B2 (ja) * 2000-02-16 2004-03-31 ウイスコンシン アラムニ リサーチ ファンデーション 液晶アッセイ用の生化学的ブロッキング層
JP3886382B2 (ja) * 2000-02-16 2007-02-28 ウイスコンシン アラムニ リサーチ ファンデーション 顕微鏡的病原体の検出方法及び装置
US7135143B2 (en) 2001-03-14 2006-11-14 Wisconsin Alumni Research Foundation Detecting compounds with liquid crystals
US6411354B1 (en) * 2001-05-11 2002-06-25 Kent State University Bulk alignment of lyotropic chromonic liquid crystals
US6673398B2 (en) 2001-05-14 2004-01-06 Kent State University Alignment of lyotropic chromonic liquid crystals at surfaces as monolayers and multilayered stacks
US7666661B2 (en) 2001-08-27 2010-02-23 Platypus Technologies, Llc Substrates, devices, and methods for quantitative liquid crystal assays
WO2003021339A2 (en) * 2001-09-04 2003-03-13 Wisconsin Alumni Research Foundation Liquid crystal switching mechanism
AU2002341900A1 (en) * 2001-10-04 2003-04-14 Wisconsin Alumni Research Foundation Detection of dna hybridization on surfaces
US7807348B2 (en) * 2002-03-20 2010-10-05 Wisconsin Alumni Research Foundation Optical imaging of nanostructured substrates
US7125592B2 (en) * 2002-04-10 2006-10-24 Wisconsin Alumni Research Foundation Detecting interactions at biomimetic interfaces with liquid crystals
WO2004041061A2 (en) * 2002-05-22 2004-05-21 Platypus Technologies, Llc Substrates, devices, and methods for cellular assays
WO2003106589A1 (en) * 2002-06-13 2003-12-24 Lyotropic Therapeutics, Inc. A nanoporous particle with a retained target
WO2004044583A1 (en) * 2002-11-08 2004-05-27 Wisconsin Alumni Research Foundation Surfaces with gradients in surface topography
CA2523124A1 (en) * 2003-03-20 2004-10-07 Gary D. Niehaus Self-contained assay device for rapid detection of biohazardous agents
WO2005010160A2 (en) * 2003-07-17 2005-02-03 Wisconsin Alumni Research Foundation Liquid crystals with reduced toxicity and applications thereof
EP1654390B1 (en) 2003-07-25 2009-11-11 Platypus Technologies, LLC Liquid crystal based analyte detection
US20050069928A1 (en) * 2003-08-04 2005-03-31 Blue Heron Biotechnology, Inc. Methods for synthesis of defined polynucleotides
US7795007B2 (en) 2003-09-23 2010-09-14 Wisconsin Alumni Research Foundation Detection of post-translationally modified peptides with liquid crystals
DE602004011244T2 (de) * 2003-09-23 2009-02-12 Wisconsin Alumni Research Foundation, Madison Verwendung von flüssigkristallen zum nachweis von affinitätsmikrokontakt-gedruckten biomolekülen
EP1687396A2 (en) 2003-11-10 2006-08-09 Platypus Technologies, LLC Substrates, devices, and methods for cellular assays
US7531366B2 (en) * 2004-07-23 2009-05-12 Platypus Technologies, Llc Bead based assays using a liquid crystal reporter
US7294370B2 (en) * 2004-08-17 2007-11-13 Kent State University Aligned lyotropic chromonic liquid crystal films
US7662572B2 (en) * 2005-08-25 2010-02-16 Platypus Technologies, Llc. Compositions and liquid crystals
US8586389B2 (en) * 2005-09-28 2013-11-19 Kent State University Ligand concentrating, liquid crystal biosensor system
US20070099306A1 (en) * 2005-09-28 2007-05-03 Kent State University Liquid crystal sensor system
US7407815B2 (en) * 2005-09-28 2008-08-05 Kent State University Liquid crystal cassette
US7910382B2 (en) * 2005-10-31 2011-03-22 Wisconsin Alumni Research Foundation Device and methods for liquid crystal-based bioagent detection
US7842499B2 (en) * 2006-08-07 2010-11-30 Platypus Technologies, Llc Substrates, devices, and methods for cellular assays
WO2008021071A2 (en) 2006-08-07 2008-02-21 Platypus Technologies, Llc Substrates, devices, and methods for cellular assays
CN101689638A (zh) * 2007-05-04 2010-03-31 埃克民公司 固定化酶及其用途
WO2009026359A2 (en) * 2007-08-20 2009-02-26 Platypus Technologies, Llc Improved devices for cell assays
US8472683B2 (en) * 2008-05-09 2013-06-25 General Electric Company Motion correction in tomographic images
US7947492B2 (en) * 2008-08-20 2011-05-24 Northeastern Ohio Universities College Of Medicine Device improving the detection of a ligand
US8178355B2 (en) * 2008-09-15 2012-05-15 Platypus Technologies, Llc. Detection of vapor phase compounds by changes in physical properties of a liquid crystal
US9080973B2 (en) * 2009-04-22 2015-07-14 Wisconsin Alumni Research Foundation Analyte detection using liquid crystals
US8404318B2 (en) * 2009-06-16 2013-03-26 Kent State University Methods and apparatus to produce aligned film of lyotropic chromonic liquid crystals
US11500247B2 (en) 2015-11-18 2022-11-15 Platypus Technologies, Llc Liquid crystal sensor

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US3817837A (en) * 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
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IL83451A (en) * 1987-08-06 1991-06-10 Univ Ramot Stabilized water soluble enzymes and a method for their preparation
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US6284197B1 (en) * 1998-06-05 2001-09-04 The Regents Of The University Of California Optical amplification of molecular interactions using liquid crystals
US20020052002A1 (en) 1998-06-10 2002-05-02 Niehaus Gary D. Detection and amplification of ligands
US6171802B1 (en) * 1998-06-10 2001-01-09 Kent State University Detection and amplification of ligands
DE60008137T2 (de) 1999-11-12 2004-09-16 3M Innovative Properties Co., Saint Paul Flüssigkristallorientierunsstrukturen, verfahren zu deren herstellung und anzeigevorrichtungen, die diese strukturen enthalten

Also Published As

Publication number Publication date
EP1086374A1 (en) 2001-03-28
US7267957B2 (en) 2007-09-11
US20070059780A1 (en) 2007-03-15
AU753758B2 (en) 2002-10-31
JP4377058B2 (ja) 2009-12-02
US20070218508A1 (en) 2007-09-20
BR9910982A (pt) 2001-02-13
US20080138244A1 (en) 2008-06-12
AU3984499A (en) 1999-12-30
ATE287539T1 (de) 2005-02-15
US7732219B2 (en) 2010-06-08
WO1999064862A1 (en) 1999-12-16
US7927827B2 (en) 2011-04-19
US6171802B1 (en) 2001-01-09
IL139911A (en) 2008-06-05
JP2002517756A (ja) 2002-06-18
IL139911A0 (en) 2002-02-10
US20070243593A1 (en) 2007-10-18
CA2334712A1 (en) 1999-12-16
EP1086374B1 (en) 2005-01-19

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Legal Events

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8332 No legal effect for de