CA2334712A1 - Detection of ligands with signal amplification - Google Patents
Detection of ligands with signal amplification Download PDFInfo
- Publication number
- CA2334712A1 CA2334712A1 CA002334712A CA2334712A CA2334712A1 CA 2334712 A1 CA2334712 A1 CA 2334712A1 CA 002334712 A CA002334712 A CA 002334712A CA 2334712 A CA2334712 A CA 2334712A CA 2334712 A1 CA2334712 A1 CA 2334712A1
- Authority
- CA
- Canada
- Prior art keywords
- receptor
- ligand
- enzyme
- binding
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 230000003321 amplification Effects 0.000 title claims abstract description 42
- 238000003199 nucleic acid amplification method Methods 0.000 title claims abstract description 42
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
- G01N33/545—Synthetic resin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Inorganic Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Absorbent Articles And Supports Therefor (AREA)
- Silicon Polymers (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/095,196 | 1998-06-10 | ||
| US09/095,196 US6171802B1 (en) | 1998-06-10 | 1998-06-10 | Detection and amplification of ligands |
| PCT/US1999/010413 WO1999064862A1 (en) | 1998-06-10 | 1999-05-12 | Detection of ligands with signal amplification |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2334712A1 true CA2334712A1 (en) | 1999-12-16 |
Family
ID=22250600
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002334712A Abandoned CA2334712A1 (en) | 1998-06-10 | 1999-05-12 | Detection of ligands with signal amplification |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US6171802B1 (enExample) |
| EP (1) | EP1086374B1 (enExample) |
| JP (1) | JP4377058B2 (enExample) |
| AT (1) | ATE287539T1 (enExample) |
| AU (1) | AU753758B2 (enExample) |
| BR (1) | BR9910982A (enExample) |
| CA (1) | CA2334712A1 (enExample) |
| DE (1) | DE69923313D1 (enExample) |
| IL (2) | IL139911A0 (enExample) |
| WO (1) | WO1999064862A1 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6171802B1 (en) * | 1998-06-10 | 2001-01-09 | Kent State University | Detection and amplification of ligands |
| US20020052002A1 (en) * | 1998-06-10 | 2002-05-02 | Niehaus Gary D. | Detection and amplification of ligands |
| US6537631B1 (en) * | 1999-04-30 | 2003-03-25 | Kimberly-Clark Worldwide, Inc. | Roll of wet wipes |
| JP3512775B2 (ja) * | 2000-02-16 | 2004-03-31 | ウイスコンシン アラムニ リサーチ ファンデーション | 液晶アッセイ用の生化学的ブロッキング層 |
| JP3886382B2 (ja) * | 2000-02-16 | 2007-02-28 | ウイスコンシン アラムニ リサーチ ファンデーション | 顕微鏡的病原体の検出方法及び装置 |
| US7135143B2 (en) | 2001-03-14 | 2006-11-14 | Wisconsin Alumni Research Foundation | Detecting compounds with liquid crystals |
| US6411354B1 (en) * | 2001-05-11 | 2002-06-25 | Kent State University | Bulk alignment of lyotropic chromonic liquid crystals |
| US6673398B2 (en) | 2001-05-14 | 2004-01-06 | Kent State University | Alignment of lyotropic chromonic liquid crystals at surfaces as monolayers and multilayered stacks |
| US7666661B2 (en) | 2001-08-27 | 2010-02-23 | Platypus Technologies, Llc | Substrates, devices, and methods for quantitative liquid crystal assays |
| WO2003021339A2 (en) * | 2001-09-04 | 2003-03-13 | Wisconsin Alumni Research Foundation | Liquid crystal switching mechanism |
| AU2002341900A1 (en) * | 2001-10-04 | 2003-04-14 | Wisconsin Alumni Research Foundation | Detection of dna hybridization on surfaces |
| US7807348B2 (en) * | 2002-03-20 | 2010-10-05 | Wisconsin Alumni Research Foundation | Optical imaging of nanostructured substrates |
| US7125592B2 (en) * | 2002-04-10 | 2006-10-24 | Wisconsin Alumni Research Foundation | Detecting interactions at biomimetic interfaces with liquid crystals |
| WO2004041061A2 (en) * | 2002-05-22 | 2004-05-21 | Platypus Technologies, Llc | Substrates, devices, and methods for cellular assays |
| WO2003106589A1 (en) * | 2002-06-13 | 2003-12-24 | Lyotropic Therapeutics, Inc. | A nanoporous particle with a retained target |
| WO2004044583A1 (en) * | 2002-11-08 | 2004-05-27 | Wisconsin Alumni Research Foundation | Surfaces with gradients in surface topography |
| CA2523124A1 (en) * | 2003-03-20 | 2004-10-07 | Gary D. Niehaus | Self-contained assay device for rapid detection of biohazardous agents |
| WO2005010160A2 (en) * | 2003-07-17 | 2005-02-03 | Wisconsin Alumni Research Foundation | Liquid crystals with reduced toxicity and applications thereof |
| EP1654390B1 (en) | 2003-07-25 | 2009-11-11 | Platypus Technologies, LLC | Liquid crystal based analyte detection |
| US20050069928A1 (en) * | 2003-08-04 | 2005-03-31 | Blue Heron Biotechnology, Inc. | Methods for synthesis of defined polynucleotides |
| US7795007B2 (en) | 2003-09-23 | 2010-09-14 | Wisconsin Alumni Research Foundation | Detection of post-translationally modified peptides with liquid crystals |
| DE602004011244T2 (de) * | 2003-09-23 | 2009-02-12 | Wisconsin Alumni Research Foundation, Madison | Verwendung von flüssigkristallen zum nachweis von affinitätsmikrokontakt-gedruckten biomolekülen |
| EP1687396A2 (en) | 2003-11-10 | 2006-08-09 | Platypus Technologies, LLC | Substrates, devices, and methods for cellular assays |
| US7531366B2 (en) * | 2004-07-23 | 2009-05-12 | Platypus Technologies, Llc | Bead based assays using a liquid crystal reporter |
| US7294370B2 (en) * | 2004-08-17 | 2007-11-13 | Kent State University | Aligned lyotropic chromonic liquid crystal films |
| US7662572B2 (en) * | 2005-08-25 | 2010-02-16 | Platypus Technologies, Llc. | Compositions and liquid crystals |
| US8586389B2 (en) * | 2005-09-28 | 2013-11-19 | Kent State University | Ligand concentrating, liquid crystal biosensor system |
| US20070099306A1 (en) * | 2005-09-28 | 2007-05-03 | Kent State University | Liquid crystal sensor system |
| US7407815B2 (en) * | 2005-09-28 | 2008-08-05 | Kent State University | Liquid crystal cassette |
| US7910382B2 (en) * | 2005-10-31 | 2011-03-22 | Wisconsin Alumni Research Foundation | Device and methods for liquid crystal-based bioagent detection |
| US7842499B2 (en) * | 2006-08-07 | 2010-11-30 | Platypus Technologies, Llc | Substrates, devices, and methods for cellular assays |
| WO2008021071A2 (en) | 2006-08-07 | 2008-02-21 | Platypus Technologies, Llc | Substrates, devices, and methods for cellular assays |
| CN101689638A (zh) * | 2007-05-04 | 2010-03-31 | 埃克民公司 | 固定化酶及其用途 |
| WO2009026359A2 (en) * | 2007-08-20 | 2009-02-26 | Platypus Technologies, Llc | Improved devices for cell assays |
| US8472683B2 (en) * | 2008-05-09 | 2013-06-25 | General Electric Company | Motion correction in tomographic images |
| US7947492B2 (en) * | 2008-08-20 | 2011-05-24 | Northeastern Ohio Universities College Of Medicine | Device improving the detection of a ligand |
| US8178355B2 (en) * | 2008-09-15 | 2012-05-15 | Platypus Technologies, Llc. | Detection of vapor phase compounds by changes in physical properties of a liquid crystal |
| US9080973B2 (en) * | 2009-04-22 | 2015-07-14 | Wisconsin Alumni Research Foundation | Analyte detection using liquid crystals |
| US8404318B2 (en) * | 2009-06-16 | 2013-03-26 | Kent State University | Methods and apparatus to produce aligned film of lyotropic chromonic liquid crystals |
| US11500247B2 (en) | 2015-11-18 | 2022-11-15 | Platypus Technologies, Llc | Liquid crystal sensor |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4067774A (en) * | 1971-05-14 | 1978-01-10 | Syva Company | Compounds for enzyme amplification assay |
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-
1998
- 1998-06-10 US US09/095,196 patent/US6171802B1/en not_active Expired - Lifetime
-
1999
- 1999-05-12 DE DE69923313T patent/DE69923313D1/de not_active Expired - Lifetime
- 1999-05-12 AT AT99922970T patent/ATE287539T1/de not_active IP Right Cessation
- 1999-05-12 WO PCT/US1999/010413 patent/WO1999064862A1/en not_active Ceased
- 1999-05-12 IL IL13991199A patent/IL139911A0/xx active IP Right Grant
- 1999-05-12 BR BR9910982-4A patent/BR9910982A/pt not_active IP Right Cessation
- 1999-05-12 AU AU39844/99A patent/AU753758B2/en not_active Ceased
- 1999-05-12 CA CA002334712A patent/CA2334712A1/en not_active Abandoned
- 1999-05-12 JP JP2000553806A patent/JP4377058B2/ja not_active Expired - Fee Related
- 1999-05-12 EP EP99922970A patent/EP1086374B1/en not_active Expired - Lifetime
-
2000
- 2000-11-26 IL IL139911A patent/IL139911A/en not_active IP Right Cessation
-
2002
- 2002-04-26 US US10/133,610 patent/US7267957B2/en not_active Expired - Fee Related
-
2007
- 2007-05-21 US US11/751,065 patent/US7927827B2/en not_active Expired - Fee Related
- 2007-05-21 US US11/751,108 patent/US20070243593A1/en not_active Abandoned
- 2007-09-10 US US11/852,662 patent/US7732219B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1086374A1 (en) | 2001-03-28 |
| US7267957B2 (en) | 2007-09-11 |
| DE69923313D1 (de) | 2005-02-24 |
| US20070059780A1 (en) | 2007-03-15 |
| AU753758B2 (en) | 2002-10-31 |
| JP4377058B2 (ja) | 2009-12-02 |
| US20070218508A1 (en) | 2007-09-20 |
| BR9910982A (pt) | 2001-02-13 |
| US20080138244A1 (en) | 2008-06-12 |
| AU3984499A (en) | 1999-12-30 |
| ATE287539T1 (de) | 2005-02-15 |
| US7732219B2 (en) | 2010-06-08 |
| WO1999064862A1 (en) | 1999-12-16 |
| US7927827B2 (en) | 2011-04-19 |
| US6171802B1 (en) | 2001-01-09 |
| IL139911A (en) | 2008-06-05 |
| JP2002517756A (ja) | 2002-06-18 |
| IL139911A0 (en) | 2002-02-10 |
| US20070243593A1 (en) | 2007-10-18 |
| EP1086374B1 (en) | 2005-01-19 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request | ||
| FZDE | Discontinued |