BR9910982A - Método e dispositivo para a detecção de ligantes - Google Patents

Método e dispositivo para a detecção de ligantes

Info

Publication number
BR9910982A
BR9910982A BR9910982-4A BR9910982A BR9910982A BR 9910982 A BR9910982 A BR 9910982A BR 9910982 A BR9910982 A BR 9910982A BR 9910982 A BR9910982 A BR 9910982A
Authority
BR
Brazil
Prior art keywords
receptor
enzyme
ligands
ligand
detection
Prior art date
Application number
BR9910982-4A
Other languages
English (en)
Portuguese (pt)
Inventor
Christopher J Woolverton
Gary D Niehaus
Kathleen J Doane
Oleg Lavrentovich
Steven P Schmidt
Steven A Signs
Original Assignee
Univ Kent State Ohio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Kent State Ohio filed Critical Univ Kent State Ohio
Publication of BR9910982A publication Critical patent/BR9910982A/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/545—Synthetic resin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Inorganic Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Silicon Polymers (AREA)
BR9910982-4A 1998-06-10 1999-05-12 Método e dispositivo para a detecção de ligantes BR9910982A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/095,196 US6171802B1 (en) 1998-06-10 1998-06-10 Detection and amplification of ligands
PCT/US1999/010413 WO1999064862A1 (en) 1998-06-10 1999-05-12 Detection of ligands with signal amplification

Publications (1)

Publication Number Publication Date
BR9910982A true BR9910982A (pt) 2001-02-13

Family

ID=22250600

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9910982-4A BR9910982A (pt) 1998-06-10 1999-05-12 Método e dispositivo para a detecção de ligantes

Country Status (10)

Country Link
US (5) US6171802B1 (enExample)
EP (1) EP1086374B1 (enExample)
JP (1) JP4377058B2 (enExample)
AT (1) ATE287539T1 (enExample)
AU (1) AU753758B2 (enExample)
BR (1) BR9910982A (enExample)
CA (1) CA2334712A1 (enExample)
DE (1) DE69923313D1 (enExample)
IL (2) IL139911A0 (enExample)
WO (1) WO1999064862A1 (enExample)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6171802B1 (en) * 1998-06-10 2001-01-09 Kent State University Detection and amplification of ligands
US20020052002A1 (en) * 1998-06-10 2002-05-02 Niehaus Gary D. Detection and amplification of ligands
US6537631B1 (en) * 1999-04-30 2003-03-25 Kimberly-Clark Worldwide, Inc. Roll of wet wipes
JP3512775B2 (ja) * 2000-02-16 2004-03-31 ウイスコンシン アラムニ リサーチ ファンデーション 液晶アッセイ用の生化学的ブロッキング層
JP3886382B2 (ja) * 2000-02-16 2007-02-28 ウイスコンシン アラムニ リサーチ ファンデーション 顕微鏡的病原体の検出方法及び装置
US7135143B2 (en) 2001-03-14 2006-11-14 Wisconsin Alumni Research Foundation Detecting compounds with liquid crystals
US6411354B1 (en) * 2001-05-11 2002-06-25 Kent State University Bulk alignment of lyotropic chromonic liquid crystals
US6673398B2 (en) 2001-05-14 2004-01-06 Kent State University Alignment of lyotropic chromonic liquid crystals at surfaces as monolayers and multilayered stacks
US7666661B2 (en) 2001-08-27 2010-02-23 Platypus Technologies, Llc Substrates, devices, and methods for quantitative liquid crystal assays
WO2003021339A2 (en) * 2001-09-04 2003-03-13 Wisconsin Alumni Research Foundation Liquid crystal switching mechanism
AU2002341900A1 (en) * 2001-10-04 2003-04-14 Wisconsin Alumni Research Foundation Detection of dna hybridization on surfaces
US7807348B2 (en) * 2002-03-20 2010-10-05 Wisconsin Alumni Research Foundation Optical imaging of nanostructured substrates
US7125592B2 (en) * 2002-04-10 2006-10-24 Wisconsin Alumni Research Foundation Detecting interactions at biomimetic interfaces with liquid crystals
WO2004041061A2 (en) * 2002-05-22 2004-05-21 Platypus Technologies, Llc Substrates, devices, and methods for cellular assays
WO2003106589A1 (en) * 2002-06-13 2003-12-24 Lyotropic Therapeutics, Inc. A nanoporous particle with a retained target
WO2004044583A1 (en) * 2002-11-08 2004-05-27 Wisconsin Alumni Research Foundation Surfaces with gradients in surface topography
CA2523124A1 (en) * 2003-03-20 2004-10-07 Gary D. Niehaus Self-contained assay device for rapid detection of biohazardous agents
WO2005010160A2 (en) * 2003-07-17 2005-02-03 Wisconsin Alumni Research Foundation Liquid crystals with reduced toxicity and applications thereof
EP1654390B1 (en) 2003-07-25 2009-11-11 Platypus Technologies, LLC Liquid crystal based analyte detection
US20050069928A1 (en) * 2003-08-04 2005-03-31 Blue Heron Biotechnology, Inc. Methods for synthesis of defined polynucleotides
US7795007B2 (en) 2003-09-23 2010-09-14 Wisconsin Alumni Research Foundation Detection of post-translationally modified peptides with liquid crystals
DE602004011244T2 (de) * 2003-09-23 2009-02-12 Wisconsin Alumni Research Foundation, Madison Verwendung von flüssigkristallen zum nachweis von affinitätsmikrokontakt-gedruckten biomolekülen
EP1687396A2 (en) 2003-11-10 2006-08-09 Platypus Technologies, LLC Substrates, devices, and methods for cellular assays
US7531366B2 (en) * 2004-07-23 2009-05-12 Platypus Technologies, Llc Bead based assays using a liquid crystal reporter
US7294370B2 (en) * 2004-08-17 2007-11-13 Kent State University Aligned lyotropic chromonic liquid crystal films
US7662572B2 (en) * 2005-08-25 2010-02-16 Platypus Technologies, Llc. Compositions and liquid crystals
US8586389B2 (en) * 2005-09-28 2013-11-19 Kent State University Ligand concentrating, liquid crystal biosensor system
US20070099306A1 (en) * 2005-09-28 2007-05-03 Kent State University Liquid crystal sensor system
US7407815B2 (en) * 2005-09-28 2008-08-05 Kent State University Liquid crystal cassette
US7910382B2 (en) * 2005-10-31 2011-03-22 Wisconsin Alumni Research Foundation Device and methods for liquid crystal-based bioagent detection
US7842499B2 (en) * 2006-08-07 2010-11-30 Platypus Technologies, Llc Substrates, devices, and methods for cellular assays
WO2008021071A2 (en) 2006-08-07 2008-02-21 Platypus Technologies, Llc Substrates, devices, and methods for cellular assays
CN101689638A (zh) * 2007-05-04 2010-03-31 埃克民公司 固定化酶及其用途
WO2009026359A2 (en) * 2007-08-20 2009-02-26 Platypus Technologies, Llc Improved devices for cell assays
US8472683B2 (en) * 2008-05-09 2013-06-25 General Electric Company Motion correction in tomographic images
US7947492B2 (en) * 2008-08-20 2011-05-24 Northeastern Ohio Universities College Of Medicine Device improving the detection of a ligand
US8178355B2 (en) * 2008-09-15 2012-05-15 Platypus Technologies, Llc. Detection of vapor phase compounds by changes in physical properties of a liquid crystal
US9080973B2 (en) * 2009-04-22 2015-07-14 Wisconsin Alumni Research Foundation Analyte detection using liquid crystals
US8404318B2 (en) * 2009-06-16 2013-03-26 Kent State University Methods and apparatus to produce aligned film of lyotropic chromonic liquid crystals
US11500247B2 (en) 2015-11-18 2022-11-15 Platypus Technologies, Llc Liquid crystal sensor

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4067774A (en) * 1971-05-14 1978-01-10 Syva Company Compounds for enzyme amplification assay
US4203802A (en) * 1971-05-14 1980-05-20 Syva Company Inhibitable enzyme amplification assay
US3817837A (en) * 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3975237A (en) * 1972-11-06 1976-08-17 Syva Company Compounds for enzyme amplification assay - - ecgonine analogs
US4604364A (en) 1974-01-04 1986-08-05 Kosak Kenneth M Bioluminescent tracer composition and method of use in immunoassays
US4600690A (en) * 1978-08-07 1986-07-15 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Immunoassay
US5156965A (en) * 1983-11-29 1992-10-20 Igen, Inc. Catalytic antibodies
US5096807A (en) * 1985-03-06 1992-03-17 Murex Corporation Imaging immunoassay detection system with background compensation and its use
JPS61271460A (ja) 1985-05-28 1986-12-01 Olympus Optical Co Ltd 免疫学的分析方法
US4693970A (en) * 1985-06-21 1987-09-15 Becton, Dickinson And Company Immunoassay using complement
US5149626A (en) 1987-05-14 1992-09-22 Mclean Hospital Corporation Multiple antigen immunoassay
US5447837A (en) 1987-08-05 1995-09-05 Calypte, Inc. Multi-immunoassay diagnostic system for antigens or antibodies or both
IL83451A (en) * 1987-08-06 1991-06-10 Univ Ramot Stabilized water soluble enzymes and a method for their preparation
US4943525A (en) 1987-11-02 1990-07-24 Bioventures, Inc. Simultaneous immunoassay for the determination of antigens and antibodies
US5252459A (en) * 1988-09-23 1993-10-12 Abbott Laboratories Indicator reagents, diagnostic assays and test kits employing organic polymer latex particles
AU665758B2 (en) * 1991-04-26 1996-01-18 Surface Active Limited Novel antibodies, and methods for their use
US5596434A (en) * 1993-09-24 1997-01-21 University Research Corporation Self-assembled monolayers for liquid crystal alignment
US5681571A (en) * 1993-10-08 1997-10-28 Duotol Ab Immunological tolerance-inducing agent
JPH10501277A (ja) 1994-06-06 1998-02-03 ヘキスト・セラニーズ・コーポレーション サーモトロピック液晶性ポリ（エステルアミド）
GB9417593D0 (en) * 1994-09-01 1994-10-19 Secr Defence Luciferase labelling method
US6207369B1 (en) * 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
US6001571A (en) * 1995-11-30 1999-12-14 Mandecki; Wlodek Multiplex assay for nucleic acids employing transponders
GB9712818D0 (en) * 1996-07-08 1997-08-20 Cambridge Antibody Tech Labelling and selection of specific binding molecules
GB9622524D0 (en) * 1996-10-29 1997-01-08 London Biotechnology Ltd Enzyme labels for assays
US5763158A (en) * 1997-02-06 1998-06-09 The United States Of America As Represented By The Secretary Of The Army Detection of multiple antigens or antibodies
KR100551221B1 (ko) * 1997-09-09 2006-02-10 리오트로픽테라피우틱스 인코퍼레이션 코팅된 입자, 그 제조방법 및 그 사용방법
US6284197B1 (en) * 1998-06-05 2001-09-04 The Regents Of The University Of California Optical amplification of molecular interactions using liquid crystals
US20020052002A1 (en) 1998-06-10 2002-05-02 Niehaus Gary D. Detection and amplification of ligands
US6171802B1 (en) * 1998-06-10 2001-01-09 Kent State University Detection and amplification of ligands
DE60008137T2 (de) 1999-11-12 2004-09-16 3M Innovative Properties Co., Saint Paul Flüssigkristallorientierunsstrukturen, verfahren zu deren herstellung und anzeigevorrichtungen, die diese strukturen enthalten

Also Published As

Publication number Publication date
EP1086374A1 (en) 2001-03-28
US7267957B2 (en) 2007-09-11
DE69923313D1 (de) 2005-02-24
US20070059780A1 (en) 2007-03-15
AU753758B2 (en) 2002-10-31
JP4377058B2 (ja) 2009-12-02
US20070218508A1 (en) 2007-09-20
US20080138244A1 (en) 2008-06-12
AU3984499A (en) 1999-12-30
ATE287539T1 (de) 2005-02-15
US7732219B2 (en) 2010-06-08
WO1999064862A1 (en) 1999-12-16
US7927827B2 (en) 2011-04-19
US6171802B1 (en) 2001-01-09
IL139911A (en) 2008-06-05
JP2002517756A (ja) 2002-06-18
IL139911A0 (en) 2002-02-10
US20070243593A1 (en) 2007-10-18
CA2334712A1 (en) 1999-12-16
EP1086374B1 (en) 2005-01-19

Similar Documents

Publication Publication Date Title
BR9910982A (pt) Método e dispositivo para a detecção de ligantes
EP1436616A4 (en) DETECTION AND AMPLIFICATION OF LIGANDS
AU6104598A (en) Method for isolating, in particular for detecting or quantifying an analyte in amedium
DK0975807T3 (da) To-trins hybridisering og indfangning af et polynukleotid
WO2003062445A3 (en) Real-time linear detection probes: sensitive 5'-minor groove binder-containing probes for pcr analysis
ES2177093T3 (es) Aislamiento de acidos nucleicos.
NO20015935L (no) Anordning for feste av forankringsflak
DE60018084D1 (de) Audiosignalverarbeitung
WO2003073817A3 (en) Rapid and sensitive detection of cells and viruses
WO2005050164A3 (en) Detection systems and methods
BR0005799B1 (pt) sistema hidrÁulico.
DE69326685D1 (de) Amplifikation von test reporters durch nukleinsäure replikation
NO20083200L (no) Tempereringsmatte
ATE491806T1 (de) Signal-amplifikation mittels synthetischem zymogen
DK1543204T3 (da) Indretning til fastgørelse af termoglas
FR2649586B1 (fr) Dispositif d'epandage destine notamment aux granules antilimaces
FR2787199B1 (fr) Procede de detection, notamment de petites cibles marines
AU2003243375A1 (en) Improved receptor detection
WO2004085618A3 (en) Method of screening for target ligands
FR2817346B1 (fr) Procede de detection et imagerie de polluants notamment en milieu liquide par fluorescence et/ou absorption induites par laser et dispositifs associes
EP1628392A4 (en) GAIN SETUP
EP1203958A3 (en) High-throughput screening method
WO2001086288A3 (en) Early diagnosis of bladder tumor in urine samples
TR200200779T2 (tr) Madde karışımları içinden farmakolojik olarak aktif bileşiklerin tespit edilerek ayrıştırılmasına yönelik bir yöntem ile bu yöntemin uygulanmasında kullanılan cihaz.
FR2812725B1 (fr) Dispositif et procede de determination des caracteristiques de biomasse

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1911 DE 21/08/2007.