IL139911A0 - Detection of ligands with signal amplification - Google Patents

Detection of ligands with signal amplification

Info

Publication number
IL139911A0
IL139911A0 IL13991199A IL13991199A IL139911A0 IL 139911 A0 IL139911 A0 IL 139911A0 IL 13991199 A IL13991199 A IL 13991199A IL 13991199 A IL13991199 A IL 13991199A IL 139911 A0 IL139911 A0 IL 139911A0
Authority
IL
Israel
Prior art keywords
receptor
ligands
detection
enzyme
signal amplification
Prior art date
Application number
IL13991199A
Other languages
English (en)
Original Assignee
Kent Stae University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kent Stae University filed Critical Kent Stae University
Publication of IL139911A0 publication Critical patent/IL139911A0/xx

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/545—Synthetic resin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Inorganic Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Silicon Polymers (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
IL13991199A 1998-06-10 1999-05-12 Detection of ligands with signal amplification IL139911A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/095,196 US6171802B1 (en) 1998-06-10 1998-06-10 Detection and amplification of ligands
PCT/US1999/010413 WO1999064862A1 (en) 1998-06-10 1999-05-12 Detection of ligands with signal amplification

Publications (1)

Publication Number Publication Date
IL139911A0 true IL139911A0 (en) 2002-02-10

Family

ID=22250600

Family Applications (2)

Application Number Title Priority Date Filing Date
IL13991199A IL139911A0 (en) 1998-06-10 1999-05-12 Detection of ligands with signal amplification
IL139911A IL139911A (en) 1998-06-10 2000-11-26 Legend detection device with signal amplification

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL139911A IL139911A (en) 1998-06-10 2000-11-26 Legend detection device with signal amplification

Country Status (10)

Country Link
US (5) US6171802B1 (xx)
EP (1) EP1086374B1 (xx)
JP (1) JP4377058B2 (xx)
AT (1) ATE287539T1 (xx)
AU (1) AU753758B2 (xx)
BR (1) BR9910982A (xx)
CA (1) CA2334712A1 (xx)
DE (1) DE69923313D1 (xx)
IL (2) IL139911A0 (xx)
WO (1) WO1999064862A1 (xx)

Families Citing this family (40)

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US20020052002A1 (en) * 1998-06-10 2002-05-02 Niehaus Gary D. Detection and amplification of ligands
US6171802B1 (en) * 1998-06-10 2001-01-09 Kent State University Detection and amplification of ligands
US6537631B1 (en) * 1999-04-30 2003-03-25 Kimberly-Clark Worldwide, Inc. Roll of wet wipes
EP1255995A2 (en) * 2000-02-16 2002-11-13 Wisconsin Alumni Research Foundation Method and apparatus for detection of microscopic pathogens
DE60142220D1 (de) * 2000-02-16 2010-07-08 Wisconsin Alumni Res Found Biochemische blockierungsschicht für flüssigkristall
US7135143B2 (en) 2001-03-14 2006-11-14 Wisconsin Alumni Research Foundation Detecting compounds with liquid crystals
US6411354B1 (en) * 2001-05-11 2002-06-25 Kent State University Bulk alignment of lyotropic chromonic liquid crystals
US6673398B2 (en) 2001-05-14 2004-01-06 Kent State University Alignment of lyotropic chromonic liquid crystals at surfaces as monolayers and multilayered stacks
US7666661B2 (en) 2001-08-27 2010-02-23 Platypus Technologies, Llc Substrates, devices, and methods for quantitative liquid crystal assays
WO2003021339A2 (en) * 2001-09-04 2003-03-13 Wisconsin Alumni Research Foundation Liquid crystal switching mechanism
US20030099993A1 (en) * 2001-10-04 2003-05-29 Wisconsin Alumni Research Foundation Detection of DNA hybridization on surfaces
US7807348B2 (en) * 2002-03-20 2010-10-05 Wisconsin Alumni Research Foundation Optical imaging of nanostructured substrates
US7125592B2 (en) * 2002-04-10 2006-10-24 Wisconsin Alumni Research Foundation Detecting interactions at biomimetic interfaces with liquid crystals
US8268614B2 (en) * 2002-05-22 2012-09-18 Platypus Technologies, Llc Method for assaying cell movement
EP1549953A4 (en) 2002-05-22 2006-12-06 Platypus Technologies Inc SUBSTRATES, DEVICES AND METHOD FOR CELL TESTS
WO2003106589A1 (en) * 2002-06-13 2003-12-24 Lyotropic Therapeutics, Inc. A nanoporous particle with a retained target
AU2002368337A1 (en) * 2002-11-08 2004-06-03 Wisconsin Alumni Research Foundation Surfaces with gradients in surface topography
CA2523124A1 (en) * 2003-03-20 2004-10-07 Gary D. Niehaus Self-contained assay device for rapid detection of biohazardous agents
US7303694B2 (en) * 2003-07-17 2007-12-04 Wisconsin Alumni Research Foundation Liquid crystals with reduced toxicity and applications thereof
AU2004262301A1 (en) 2003-07-25 2005-02-10 Platypus Technologies, Llc Liquid crystal based analyte detection
WO2005017153A2 (en) * 2003-08-04 2005-02-24 Blue Heron Biotechnology, Inc. Methods for synthesis of defined polynucleotides
US7795007B2 (en) 2003-09-23 2010-09-14 Wisconsin Alumni Research Foundation Detection of post-translationally modified peptides with liquid crystals
DE602004011244T2 (de) * 2003-09-23 2009-02-12 Wisconsin Alumni Research Foundation, Madison Verwendung von flüssigkristallen zum nachweis von affinitätsmikrokontakt-gedruckten biomolekülen
US7531366B2 (en) * 2004-07-23 2009-05-12 Platypus Technologies, Llc Bead based assays using a liquid crystal reporter
US7294370B2 (en) * 2004-08-17 2007-11-13 Kent State University Aligned lyotropic chromonic liquid crystal films
US7662572B2 (en) * 2005-08-25 2010-02-16 Platypus Technologies, Llc. Compositions and liquid crystals
US7407815B2 (en) * 2005-09-28 2008-08-05 Kent State University Liquid crystal cassette
US8586389B2 (en) * 2005-09-28 2013-11-19 Kent State University Ligand concentrating, liquid crystal biosensor system
US20070099306A1 (en) * 2005-09-28 2007-05-03 Kent State University Liquid crystal sensor system
WO2007111681A2 (en) * 2005-10-31 2007-10-04 Wisconsin Alumni Research Foundation Device and methods for liquid crystal-based bioagent detection
EP2057277B1 (en) 2006-08-07 2018-06-13 Platypus Technologies, LLC Substrates, devices, and methods for cellular assays
US7842499B2 (en) * 2006-08-07 2010-11-30 Platypus Technologies, Llc Substrates, devices, and methods for cellular assays
CA2686161A1 (en) * 2007-05-04 2008-11-13 Akermin, Inc. Immobilized enzymes and uses thereof
WO2009026359A2 (en) * 2007-08-20 2009-02-26 Platypus Technologies, Llc Improved devices for cell assays
US8472683B2 (en) * 2008-05-09 2013-06-25 General Electric Company Motion correction in tomographic images
US7947492B2 (en) * 2008-08-20 2011-05-24 Northeastern Ohio Universities College Of Medicine Device improving the detection of a ligand
US8178355B2 (en) * 2008-09-15 2012-05-15 Platypus Technologies, Llc. Detection of vapor phase compounds by changes in physical properties of a liquid crystal
EP2422186A1 (en) 2009-04-22 2012-02-29 Wisconsin Alumni Research Foundation Analyte detection using liquid crystals
US8404318B2 (en) * 2009-06-16 2013-03-26 Kent State University Methods and apparatus to produce aligned film of lyotropic chromonic liquid crystals
US11500247B2 (en) 2015-11-18 2022-11-15 Platypus Technologies, Llc Liquid crystal sensor

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IL83451A (en) * 1987-08-06 1991-06-10 Univ Ramot Stabilized water soluble enzymes and a method for their preparation
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US5596434A (en) * 1993-09-24 1997-01-21 University Research Corporation Self-assembled monolayers for liquid crystal alignment
US5681571A (en) * 1993-10-08 1997-10-28 Duotol Ab Immunological tolerance-inducing agent
JPH10501277A (ja) 1994-06-06 1998-02-03 ヘキスト・セラニーズ・コーポレーション サーモトロピック液晶性ポリ（エステルアミド）
GB9417593D0 (en) * 1994-09-01 1994-10-19 Secr Defence Luciferase labelling method
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US6284197B1 (en) 1998-06-05 2001-09-04 The Regents Of The University Of California Optical amplification of molecular interactions using liquid crystals
US20020052002A1 (en) 1998-06-10 2002-05-02 Niehaus Gary D. Detection and amplification of ligands
US6171802B1 (en) * 1998-06-10 2001-01-09 Kent State University Detection and amplification of ligands
JP2003534563A (ja) * 1999-11-12 2003-11-18 スリーエム イノベイティブ プロパティズ カンパニー 液晶配向構造体およびそれを含む光学装置

Also Published As

Publication number Publication date
WO1999064862A1 (en) 1999-12-16
US20070243593A1 (en) 2007-10-18
US20080138244A1 (en) 2008-06-12
AU3984499A (en) 1999-12-30
IL139911A (en) 2008-06-05
AU753758B2 (en) 2002-10-31
EP1086374B1 (en) 2005-01-19
ATE287539T1 (de) 2005-02-15
BR9910982A (pt) 2001-02-13
US7732219B2 (en) 2010-06-08
US20070218508A1 (en) 2007-09-20
JP4377058B2 (ja) 2009-12-02
DE69923313D1 (de) 2005-02-24
JP2002517756A (ja) 2002-06-18
US20070059780A1 (en) 2007-03-15
US7267957B2 (en) 2007-09-11
US7927827B2 (en) 2011-04-19
US6171802B1 (en) 2001-01-09
EP1086374A1 (en) 2001-03-28
CA2334712A1 (en) 1999-12-16

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Legal Events

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