WO1999045951A3 - Thy-1 expression in angiogenesis - Google Patents

Thy-1 expression in angiogenesis Download PDF

Info

Publication number
WO1999045951A3
WO1999045951A3 PCT/US1999/005256 US9905256W WO9945951A3 WO 1999045951 A3 WO1999045951 A3 WO 1999045951A3 US 9905256 W US9905256 W US 9905256W WO 9945951 A3 WO9945951 A3 WO 9945951A3
Authority
WO
WIPO (PCT)
Prior art keywords
thy
angiogenesis
expression
mammal
inhibits
Prior art date
Application number
PCT/US1999/005256
Other languages
French (fr)
Other versions
WO1999045951A2 (en
Inventor
Edgar Di Haber
Shyh-Yu Shaw
Mukesh K Jain
Wen-Sen Lee
Original Assignee
Harvard College
Haber Carol Ef
Shaw Shyh Yu
Mukesh K Jain
Lee Wen Sen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College, Haber Carol Ef, Shaw Shyh Yu, Mukesh K Jain, Lee Wen Sen filed Critical Harvard College
Publication of WO1999045951A2 publication Critical patent/WO1999045951A2/en
Publication of WO1999045951A3 publication Critical patent/WO1999045951A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

A method of inhibiting angiogenesis in a mammal by administering to the mammal a compound that inhibits Thy-1-associated proliferation of endothelial cells.
PCT/US1999/005256 1998-03-11 1999-03-11 Thy-1 expression in angiogenesis WO1999045951A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7752498P 1998-03-11 1998-03-11
US60/077,524 1998-03-11

Publications (2)

Publication Number Publication Date
WO1999045951A2 WO1999045951A2 (en) 1999-09-16
WO1999045951A3 true WO1999045951A3 (en) 1999-12-16

Family

ID=22138583

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/005256 WO1999045951A2 (en) 1998-03-11 1999-03-11 Thy-1 expression in angiogenesis

Country Status (1)

Country Link
WO (1) WO1999045951A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19845798A1 (en) * 1998-09-29 2000-04-13 Schering Ag Use of neoangiogenesis markers for diagnosis and therapy of tumors, agents containing them, and methods for their production
EP2908853B1 (en) * 2012-10-21 2018-12-05 University Of Rochester Thy1 (cd90) as a therapy to control adipose tissue accumulation
US20220135643A1 (en) * 2020-10-29 2022-05-05 The University Of North Carolina At Chapel Hill Soluble thy-1 compositions and use thereof to treat or reverse fibrosis

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
LEE W S ET AL: "Thy - 1, a novel marker for angiogenesis upregulated by inflammatory cytokines [see comments].", CIRCULATION RESEARCH, (1998 MAY 4) 82 (8) 845-51., XP002119748 *
PARUMS, DINAH V. (1) ET AL: "Thy - 1 expression by new vessels associated with atherosclerosis.", JOURNAL OF PATHOLOGY, (1996) VOL. 179, NO. SUPPL., PP. 46A. MEETING INFO.: 173RD MEETING OF THE PATHOLOGICAL SOCIETY OF GREAT BRITAIN AND IRELAND SOUTHAMPTON, ENGLAND, UK JULY 10-12, 1996, XP002119747 *
SEKI T ET AL: "The human Thy-1 gene: structure and chromosomal location.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (1985 OCT) 82 (19) 6657-61., XP002119746 *

Also Published As

Publication number Publication date
WO1999045951A2 (en) 1999-09-16

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