JP4317920B2 - α−ケトアミド多機能性プロテアーゼインヒビター - Google Patents
α−ケトアミド多機能性プロテアーゼインヒビター Download PDFInfo
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- JP4317920B2 JP4317920B2 JP2000514649A JP2000514649A JP4317920B2 JP 4317920 B2 JP4317920 B2 JP 4317920B2 JP 2000514649 A JP2000514649 A JP 2000514649A JP 2000514649 A JP2000514649 A JP 2000514649A JP 4317920 B2 JP4317920 B2 JP 4317920B2
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P35/00—Antineoplastic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Public Health (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| US6138297P | 1997-10-07 | 1997-10-07 | |
| US60/061,382 | 1997-10-07 | ||
| US09/167,163 US6096778A (en) | 1997-10-07 | 1998-10-06 | α-ketoamide multicatalytic protease inhibitors |
| US09/167,163 | 1998-10-06 | ||
| PCT/US1998/021053 WO1999017778A1 (en) | 1997-10-07 | 1998-10-07 | α-KETOAMIDE MULTICATALYTIC PROTEASE INHIBITORS |
Publications (3)
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| JP2002516817A JP2002516817A (ja) | 2002-06-11 |
| JP2002516817A5 JP2002516817A5 (https=) | 2006-02-16 |
| JP4317920B2 true JP4317920B2 (ja) | 2009-08-19 |
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| JP2000514649A Expired - Fee Related JP4317920B2 (ja) | 1997-10-07 | 1998-10-07 | α−ケトアミド多機能性プロテアーゼインヒビター |
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| US (2) | US6096778A (https=) |
| EP (1) | EP1027056B1 (https=) |
| JP (1) | JP4317920B2 (https=) |
| KR (1) | KR100648578B1 (https=) |
| CN (1) | CN1172672C (https=) |
| AT (1) | ATE423562T1 (https=) |
| AU (1) | AU751963B2 (https=) |
| CA (1) | CA2303428C (https=) |
| DE (1) | DE69840603D1 (https=) |
| ES (1) | ES2321249T3 (https=) |
| NZ (1) | NZ503308A (https=) |
| WO (1) | WO1999017778A1 (https=) |
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| US6150378A (en) * | 1997-10-07 | 2000-11-21 | Cephalon, Inc. | Peptidyl-containing α-ketoamide cysteine and serine protease inhibitors |
| US6902721B1 (en) * | 1998-07-10 | 2005-06-07 | Osteoscreen, Inc. | Inhibitors of proteasomal activity for stimulating bone growth |
| US6455587B1 (en) * | 2000-03-15 | 2002-09-24 | Pharmacor Inc. | Amino acid derivatives as HIV aspartyl protease inhibitors |
| JP4666440B2 (ja) * | 2000-06-30 | 2011-04-06 | 生化学工業株式会社 | アミノアルコール誘導体 |
| AU2001267886A1 (en) | 2000-06-30 | 2002-01-14 | Seikagaku Corporation | Epoxycarboxylic acid amides, azides and amino alcohols and processes for preparation of alpha-keto amides by using them |
| FR2813315B1 (fr) | 2000-08-23 | 2002-10-18 | Genfit S A | Procede d'identification de substances utiles pour le traitement de l'inflammation mettant en oeuvre l'element de reponse du recepteur ror du gene ikbalpha |
| EP1465862A1 (en) | 2002-01-17 | 2004-10-13 | SmithKline Beecham Corporation | Cycloalkyl ketoamides derivatives useful as cathepsin k inhibitors |
| US7223745B2 (en) * | 2003-08-14 | 2007-05-29 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
| US7576206B2 (en) | 2003-08-14 | 2009-08-18 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
| US7468383B2 (en) * | 2005-02-11 | 2008-12-23 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
| US20070027067A1 (en) * | 2005-05-13 | 2007-02-01 | Felicia Etzkorn | Transition-state Inhibitors of Pin1, alpha-Ketoamide-containing peptidomimetics, and synthesis thereof |
| EP2095828A1 (en) * | 2008-02-29 | 2009-09-02 | Gnosis S.p.A. | Use of S-adenosylmethionine (SAM) and superoxide dismutase (SOD) for the preparation of medicaments for the treatment of Alzeimer's disease |
| US20110111417A1 (en) | 2008-05-14 | 2011-05-12 | Millennium Pharmaceuticals, Inc. | Methods and kits for monitoring the effects of immunomodulators on adaptive immunity |
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-
1998
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- 1998-10-07 JP JP2000514649A patent/JP4317920B2/ja not_active Expired - Fee Related
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- 1998-10-07 DE DE69840603T patent/DE69840603D1/de not_active Expired - Lifetime
- 1998-10-07 EP EP98953274A patent/EP1027056B1/en not_active Expired - Lifetime
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- 1998-10-07 KR KR1020007003684A patent/KR100648578B1/ko not_active Expired - Fee Related
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| EP1027056A1 (en) | 2000-08-16 |
| CN1274285A (zh) | 2000-11-22 |
| EP1027056A4 (en) | 2001-03-21 |
| AU751963B2 (en) | 2002-09-05 |
| AU1068599A (en) | 1999-04-27 |
| CA2303428C (en) | 2011-05-24 |
| ATE423562T1 (de) | 2009-03-15 |
| CN1172672C (zh) | 2004-10-27 |
| CA2303428A1 (en) | 1999-04-15 |
| US6310057B1 (en) | 2001-10-30 |
| US6096778A (en) | 2000-08-01 |
| EP1027056B1 (en) | 2009-02-25 |
| ES2321249T3 (es) | 2009-06-03 |
| JP2002516817A (ja) | 2002-06-11 |
| KR100648578B1 (ko) | 2006-11-24 |
| HK1028568A1 (en) | 2001-02-23 |
| KR20010030944A (ko) | 2001-04-16 |
| WO1999017778A1 (en) | 1999-04-15 |
| NZ503308A (en) | 2001-02-23 |
| DE69840603D1 (de) | 2009-04-09 |
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