JP4275741B2 - 血小板由来増殖因子タンパク質の分析および分離 - Google Patents

血小板由来増殖因子タンパク質の分析および分離 Download PDF

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JP4275741B2
JP4275741B2 JP52698598A JP52698598A JP4275741B2 JP 4275741 B2 JP4275741 B2 JP 4275741B2 JP 52698598 A JP52698598 A JP 52698598A JP 52698598 A JP52698598 A JP 52698598A JP 4275741 B2 JP4275741 B2 JP 4275741B2
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rpdgf
polypeptide
pdgf
isoforms
clipped
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JP2001518073A (ja
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クニタニ,マイケル
ディー. トラン,アン
パーカー,ヒュー
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ノバルティス バクシンズ アンド ダイアグノスティックス, インコーポレーテッド
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1858Platelet-derived growth factor [PDGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061Use of materials characterised by their function or physical properties
    • A61L26/0066Medicaments; Biocides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/49Platelet-derived growth factor [PDGF]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/65Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412Tissue-regenerating or healing or proliferative agents
    • A61L2300/414Growth factors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Materials Engineering (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
JP52698598A 1996-12-13 1997-12-12 血小板由来増殖因子タンパク質の分析および分離 Expired - Lifetime JP4275741B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3272096P 1996-12-13 1996-12-13
US60/032,720 1996-12-13
PCT/US1997/022815 WO1998025963A1 (en) 1996-12-13 1997-12-12 Analysis and separation of platelet-derived growth factor proteins

Related Child Applications (1)

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JP2007208669A Division JP2008031173A (ja) 1996-12-13 2007-08-09 血小板由来増殖因子タンパク質の分析および分離

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JP2001518073A JP2001518073A (ja) 2001-10-09
JP2001518073A5 JP2001518073A5 (https=) 2005-08-11
JP4275741B2 true JP4275741B2 (ja) 2009-06-10

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JP52698598A Expired - Lifetime JP4275741B2 (ja) 1996-12-13 1997-12-12 血小板由来増殖因子タンパク質の分析および分離
JP52692698A Expired - Fee Related JP4341859B2 (ja) 1996-12-13 1997-12-12 酵母での異種タンパク質の発現の方法
JP2007208669A Withdrawn JP2008031173A (ja) 1996-12-13 2007-08-09 血小板由来増殖因子タンパク質の分析および分離
JP2007338286A Withdrawn JP2008119008A (ja) 1996-12-13 2007-12-27 酵母での異種タンパク質の発現の方法

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JP52692698A Expired - Fee Related JP4341859B2 (ja) 1996-12-13 1997-12-12 酵母での異種タンパク質の発現の方法
JP2007208669A Withdrawn JP2008031173A (ja) 1996-12-13 2007-08-09 血小板由来増殖因子タンパク質の分析および分離
JP2007338286A Withdrawn JP2008119008A (ja) 1996-12-13 2007-12-27 酵母での異種タンパク質の発現の方法

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US (10) US6017731A (https=)
EP (4) EP1935901A1 (https=)
JP (4) JP4275741B2 (https=)
AT (3) ATE253120T1 (https=)
AU (2) AU5465498A (https=)
DE (3) DE69739319D1 (https=)
ES (1) ES2306462T3 (https=)
PT (1) PT948538E (https=)
WO (2) WO1998025963A1 (https=)

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US7166446B2 (en) 2007-01-23
ATE398139T1 (de) 2008-07-15
DE69725881D1 (de) 2003-12-11
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ES2306462T3 (es) 2008-11-01
EP0946736B1 (en) 2003-10-29
DE69739319D1 (de) 2009-04-30
JP2001518073A (ja) 2001-10-09
AU5794598A (en) 1998-07-03
JP4341859B2 (ja) 2009-10-14
PT948538E (pt) 2008-08-05
EP0948538B1 (en) 2008-06-11
EP1365028B1 (en) 2009-03-18
EP0948538A1 (en) 1999-10-13
US20060252695A1 (en) 2006-11-09
WO1998025963A1 (en) 1998-06-18
ATE253120T1 (de) 2003-11-15
JP2008031173A (ja) 2008-02-14
US7084262B2 (en) 2006-08-01
US20030036511A1 (en) 2003-02-20
US6897043B2 (en) 2005-05-24
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US6448382B1 (en) 2002-09-10
US6706496B2 (en) 2004-03-16
EP0946736A1 (en) 1999-10-06
US6083723A (en) 2000-07-04
EP1365028A1 (en) 2003-11-26
EP1935901A1 (en) 2008-06-25
DE69738768D1 (de) 2008-07-24
US20020055169A1 (en) 2002-05-09
ATE426030T1 (de) 2009-04-15
US6017731A (en) 2000-01-25
US20050124042A1 (en) 2005-06-09
JP2001506497A (ja) 2001-05-22
US6312923B1 (en) 2001-11-06
WO1998026080A1 (en) 1998-06-18
US20030077831A1 (en) 2003-04-24
US6083910A (en) 2000-07-04

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