JP4255514B2 - 疎水性の立体配座制限的微細環境を提供する部分によって強化された重合フルオロホア - Google Patents

疎水性の立体配座制限的微細環境を提供する部分によって強化された重合フルオロホア Download PDF

Info

Publication number
JP4255514B2
JP4255514B2 JP52779397A JP52779397A JP4255514B2 JP 4255514 B2 JP4255514 B2 JP 4255514B2 JP 52779397 A JP52779397 A JP 52779397A JP 52779397 A JP52779397 A JP 52779397A JP 4255514 B2 JP4255514 B2 JP 4255514B2
Authority
JP
Japan
Prior art keywords
polymer
dye
cyclodextrin
group
signal generating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP52779397A
Other languages
English (en)
Japanese (ja)
Other versions
JP2000509412A (ja
JP2000509412A5 (enExample
Inventor
バイエニアーツ,クリストフアー
ハフ,ジエフリイ・ビイ
コーンウエル,マイケル・ジエイ
タタ,ベンカタ・セシヤギリ・アール
Original Assignee
アボツト・ラボラトリーズ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アボツト・ラボラトリーズ filed Critical アボツト・ラボラトリーズ
Publication of JP2000509412A publication Critical patent/JP2000509412A/ja
Publication of JP2000509412A5 publication Critical patent/JP2000509412A5/ja
Application granted granted Critical
Publication of JP4255514B2 publication Critical patent/JP4255514B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00Dyes not provided for by a single group of this subclass
    • C09B69/10Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • G01N33/533Production of labelled immunochemicals with fluorescent label
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/80Fluorescent dyes, e.g. rhodamine
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/141111Diverse hetero atoms in same or different rings [e.g., alkaloids, opiates, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/17Nitrogen containing
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/18Sulfur containing

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Materials For Medical Uses (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
JP52779397A 1996-02-01 1997-01-30 疎水性の立体配座制限的微細環境を提供する部分によって強化された重合フルオロホア Expired - Fee Related JP4255514B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/595,092 US5994143A (en) 1996-02-01 1996-02-01 Polymeric fluorophores enhanced by moieties providing a hydrophobic and conformationally restrictive microenvironment
US08/595,092 1996-02-01
PCT/US1997/001429 WO1997028447A1 (en) 1996-02-01 1997-01-30 Polymeric fluorophores enhanced by moieties providing a hydrophobic and conformationally restrictive microenvironment

Publications (3)

Publication Number Publication Date
JP2000509412A JP2000509412A (ja) 2000-07-25
JP2000509412A5 JP2000509412A5 (enExample) 2004-11-11
JP4255514B2 true JP4255514B2 (ja) 2009-04-15

Family

ID=24381697

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52779397A Expired - Fee Related JP4255514B2 (ja) 1996-02-01 1997-01-30 疎水性の立体配座制限的微細環境を提供する部分によって強化された重合フルオロホア

Country Status (7)

Country Link
US (1) US5994143A (enExample)
EP (1) EP1019722B1 (enExample)
JP (1) JP4255514B2 (enExample)
AT (1) ATE237138T1 (enExample)
DE (1) DE69720809T2 (enExample)
ES (1) ES2197332T3 (enExample)
WO (1) WO1997028447A1 (enExample)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6437099B1 (en) * 1998-01-07 2002-08-20 Hamamatsu Photonics K.K. Fluorescene—activating antisera and IgG fraction therefrom
JP3437094B2 (ja) * 1998-07-03 2003-08-18 松下電器産業株式会社 多波長蛍光偏光法
US20050069962A1 (en) * 2001-10-12 2005-03-31 Archer Robert M Antibody complexes and methods for immunolabeling
US8323903B2 (en) * 2001-10-12 2012-12-04 Life Technologies Corporation Antibody complexes and methods for immunolabeling
DE10331093A1 (de) * 2003-07-09 2005-02-10 Schering Ag Vorrichtung und Verfahren zur direkten quantitativen in vitro-Bestimmung einer in einer Probe enthaltenen Substanz
WO2005119223A1 (en) * 2004-04-14 2005-12-15 Bioprocessors Corp. Compositions of matter useful as ph indicators and related methods
DE102004033050A1 (de) * 2004-07-08 2006-01-26 International University Bremen Gmbh Photostabilisierung von Fluoreszenzfarbstoffen
WO2007053594A2 (en) * 2005-10-31 2007-05-10 Clontech Laboratories, Inc. Large dynamic range proteomic analysis methods and compositions for practicing the same
US7781187B2 (en) * 2005-12-30 2010-08-24 Corning Incorporated Fluorescent dyes
GB2437545B (en) * 2006-04-28 2011-07-06 Novexin Ltd Dextrin-containing reagents for detecting and quantifying proteins
JP2013040136A (ja) * 2011-08-17 2013-02-28 Tosoh Corp 4−アルコキシ−2−(4−アミノスチリル)ベンゾチアゾリウム塩、その製造方法およびそれを用いる核酸の検出方法
KR101847748B1 (ko) 2013-08-22 2018-04-10 소니 주식회사 수용성 형광 또는 유색 염료 및 그의 사용 방법
CN103525117A (zh) * 2013-10-30 2014-01-22 苏州大学 一种半花菁荧光染料、制备方法及应用
US10323104B2 (en) * 2014-08-02 2019-06-18 Lg Chem, Ltd. Dye complex, photoconversion film and electronic element including same
JP6806694B2 (ja) 2015-02-26 2021-01-06 ソニー株式会社 共役基を含む水溶性蛍光染料または有色染料
CN104788991B (zh) * 2015-03-04 2017-01-25 苏州大学 一种二氯三嗪反应基半花菁荧光活性染料及其制备方法
KR102530707B1 (ko) 2016-04-01 2023-05-11 소니그룹주식회사 초휘도 이량체성 또는 중합체성 염료
JP7145079B2 (ja) 2016-04-01 2022-09-30 ソニーグループ株式会社 剛性のスペーシング基を有する超明色ダイマーまたはポリマー染料
EP4641204A2 (en) 2016-04-06 2025-10-29 Sony Group Corporation Ultra bright dimeric or polymeric dyes with spacing linker groups
WO2017196954A1 (en) 2016-05-10 2017-11-16 Sony Corporation Ultra bright polymeric dyes with peptide backbones
EP3455299B1 (en) * 2016-05-10 2024-01-17 Sony Group Corporation Compositions comprising a polymeric dye and a cyclodextrin and uses thereof
WO2017197144A1 (en) 2016-05-11 2017-11-16 Sony Corporation Ultra bright dimeric or polymeric dyes
JP7068191B2 (ja) 2016-06-06 2022-05-16 ソニーグループ株式会社 蛍光または有色レポーター基を含むイオン性ポリマー
US12018159B2 (en) 2016-07-29 2024-06-25 Sony Group Corporation Ultra bright dimeric or polymeric dyes and methods for preparation of the same
CN111093711A (zh) 2017-10-05 2020-05-01 索尼公司 可编程的树枝状药物
JP7551056B2 (ja) 2017-10-05 2024-09-17 ソニーグループ株式会社 プログラマブルなポリマー薬物
JP2021503450A (ja) 2017-11-16 2021-02-12 ソニー株式会社 プログラム可能なポリマー薬
WO2019140301A1 (en) 2018-01-12 2019-07-18 Sony Corporation Polymers with rigid spacing groups comprising biologically active compounds
JP2021510698A (ja) 2018-01-12 2021-04-30 ソニー株式会社 生物学的に活性な化合物を含むホスホアルキルリボースポリマー
CN112041680A (zh) 2018-03-19 2020-12-04 索尼公司 二价金属用于增强荧光信号的应用
US12319817B2 (en) 2018-03-21 2025-06-03 Sony Group Corporation Polymeric tandem dyes with linker groups
JP7580689B2 (ja) 2018-06-27 2024-11-12 ソニーグループ株式会社 デオキシリボースを含むリンカー基を有するポリマー色素
EP3861074A2 (en) 2019-09-26 2021-08-11 Sony Group Corporation Polymeric tandem dyes with linker groups
CN111500110B (zh) * 2020-04-28 2022-09-06 陕西大风印务科技有限公司 烟用包装纸用透明油墨及其涂层、烟用包装纸
EP4256078A1 (en) 2020-12-07 2023-10-11 Sony Group Corporation Spacing linker group design for brightness enhancement in dimeric or polymeric dyes

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4619990A (en) * 1985-03-11 1986-10-28 Minnesota Mining And Manufacturing Company Polymeric dyes with pendent chromophore groups capable of undergoing thermoplastic deformation
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5002883A (en) * 1987-10-30 1991-03-26 Abbott Laboratories Covalent attachment of antibodies and antigens to solid phases using extended length heterobifunctional coupling agents
AU622426B2 (en) * 1987-12-11 1992-04-09 Abbott Laboratories Assay using template-dependent nucleic acid probe reorganization
DE3921498A1 (de) * 1988-09-28 1990-03-29 Bayer Ag Polymer-gebundene-farbstoffe, verfahren zu deren herstellung und verwendung
US5401469A (en) * 1989-04-19 1995-03-28 Ibiden Co., Ltd. Plastic optical biomaterials assay device
ATE137269T1 (de) * 1990-01-26 1996-05-15 Abbott Lab Verbessertes verfahren zur amplifikation von nuklein säurezielsequenz, einsetzbar für die polymerase und ligasekettenreaktion
US5401847A (en) * 1990-03-14 1995-03-28 Regents Of The University Of California DNA complexes with dyes designed for energy transfer as fluorescent markers
DE4114482A1 (de) * 1991-05-03 1992-11-05 Bayer Ag Polymere farbstoffe, verfahren zu deren herstellung und deren verwendung
AU1929292A (en) * 1991-05-14 1992-12-30 Hybritech Incorporated Polymeric compositions having bound antibodies
ES2259791T3 (es) * 1993-07-13 2006-10-16 Abbott Laboratories Conjugados sumamente fluorescentes de polimeros e intermedios.

Also Published As

Publication number Publication date
ES2197332T3 (es) 2004-01-01
ATE237138T1 (de) 2003-04-15
WO1997028447A1 (en) 1997-08-07
DE69720809D1 (de) 2003-05-15
JP2000509412A (ja) 2000-07-25
EP1019722B1 (en) 2003-04-09
DE69720809T2 (de) 2004-04-01
EP1019722A1 (en) 2000-07-19
US5994143A (en) 1999-11-30

Similar Documents

Publication Publication Date Title
JP4255514B2 (ja) 疎水性の立体配座制限的微細環境を提供する部分によって強化された重合フルオロホア
EP0708837B1 (en) Fluorescent polymer labeled conjugates and intermediates
US9720004B2 (en) Immunoassays employing non-particulate chemiluminescent reagent
US6251581B1 (en) Assay method utilizing induced luminescence
JP2898264B2 (ja) 発光アリールスルホネートシアニン染料を用いた物質の標識ないし検出方法
AU657134B2 (en) Assay methods utilizing induced luminescence
US5661040A (en) Fluorescent polymer labeled conjugates and intermediates
US20130210003A1 (en) Compositions for use in detection of multiple analytes
US6060598A (en) Fluorescence immunoassays using fluorescent dyes free of aggregation and serum binding
EP0269451A2 (en) A new labelling design for a binding assay reagent
CA2981768A1 (en) Bioconjugates of heterocyclic compounds
US5846703A (en) Fluorescence immunoassays using fluorescent dyes free of aggregation and serum binding
JPH0115827B2 (enExample)
CA2244768C (en) Polymeric fluorophores enhanced by moieties providing a hydrophobic and conformationally restrictive microenvironment
CN113736285A (zh) 紫外光激发荧光染料及其应用
Pandurangi et al. Chemistry of Bifunctional Photoprobes: 4. Synthesis of the Chromogenic, Cleavable, Water Soluble, and Heterobifunctional Sulfosuccinimidyl (N-methylamino Perfluoroaryl Azido Benzamido)-ethyl-1, 3′-Dithiopropionate: An Efficient Protein Cross-Linking Agent

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20040109

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20040109

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20071030

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20071113

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20080206

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20080324

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080513

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20080812

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20081111

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20090113

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20090128

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120206

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130206

Year of fee payment: 4

LAPS Cancellation because of no payment of annual fees