JP4243202B2 - シワ改善用皮膚外用剤 - Google Patents
シワ改善用皮膚外用剤 Download PDFInfo
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- JP4243202B2 JP4243202B2 JP2004011467A JP2004011467A JP4243202B2 JP 4243202 B2 JP4243202 B2 JP 4243202B2 JP 2004011467 A JP2004011467 A JP 2004011467A JP 2004011467 A JP2004011467 A JP 2004011467A JP 4243202 B2 JP4243202 B2 JP 4243202B2
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Description
sinensis Oliver)の幹・枝等の地上部抽出物の一種又は二種以上と線維芽細胞のコラーゲン産生能を高めるブドウ(Vitis vinifera L)果皮又はブドウ(Vitis vinifera L)葉又はイタドリ(Reynoutria japonica Houtt.var.japnica)根抽出物の一種又は二種以上を併用して皮膚に塗布することにより、シワや小ジワ改善効果に優れたシワ改善用皮膚外用剤に関する。
sinensis Oliver)の幹・枝等の地上部出物より選ばれる1種又は2種以上を併用して皮膚に塗布することにより、極めて優れたシワ改善効果があることを見出し、本発明を完成するに至った。
obovata Thunberg)樹皮抽出物、モクレン〔Magnolia quinquepeta(Buc’hoz)Dandy〕花抽出物、釣籐鈎(Uncaria
rhynchophylla Miquel又はUncaria sinensis Oliver)の幹・枝等の地上部抽出物が利用される。
載する。
イタドリ根の細切物500gに50%ブチレングリコールを5L加え、室温で1週間放置した。種子をろ別し、イタドリ根50%ブチレングリコール抽出液を得た。本抽出液を減圧下、溶媒を留去することによって、イタドリ根50%ブチレングリコール抽出物を得た。
イタドリ根の細切物500gに99.5%エタノール5L加え、室温で1週間放置した。種子をろ別し、イタドリ根エタノール抽出液を得た。本抽出液を減圧下、溶媒を留去することによって、イタドリ根エタノール抽出物を得た。
ブドウ果実から果肉を取り除いた果皮100gに50%エタノール500mLを加え、室温で1週間放置した。ろ別し、ブドウ果皮50%エタノール抽出液を得た。本抽出液を減圧下、溶媒を留去することによって、ブドウ果皮50%エタノール抽出物を得た。
ブドウ果実から果肉を取り除いた果皮100gに50%ブチレングリコール500mLを加え、室温で1週間放置した。ろ別し、ブドウ果皮50%ブチレングリコール抽出液を得た。本抽出液を減圧下、溶媒を留去することによって、ブドウ果皮50%ブチレングリコール抽出物を得た。
ブドウ葉の細切物100gに50%エタノール600g加え、室温で1週間放置した。ろ別し、ブドウ葉50%エタノール抽出液を得た。本抽出液を減圧下、溶媒を留去することによって、ブドウ葉50%エタノール抽出物を得た。
ブドウ葉の細切物100gに99.5%エタノール600g加え、室温で1週間放置した。ろ別し、ブドウ葉エタノール抽出液を得た。本抽出液を減圧下、溶媒を留去することによって、ブドウ葉エタノール抽出物を得た。
バレリアナ根の細切物1kgに70%エタノール5L加え、室温で1週間放置した。ろ別し、バレリアナ根70%エタノール抽出液を得た。本抽出液を減圧下、溶媒を留去することによって、バレリアナ根70%エタノール抽出物を得た。
カバカバ根の細切物100gに50%エタノール600g加え、室温で1週間放置した。ろ別し、カバカバ根50%エタノール抽出液を得た。本抽出液を減圧下、溶媒を留去することによって、カバカバ根50%エタノール抽出物を得た。
ホオノキ樹皮の細切物100gに50%エタノール600g加え、室温で1週間放置した。ろ別し、ホオノキ樹皮50%エタノール抽出液を得た。本抽出液を減圧下、溶媒を留去することによって、ホオノキ樹皮50%エタノール抽出物を得た。
モクレン花弁100gに水1000g加え、60℃で3時間抽出した。冷後、ろ別し、モクレン花弁水抽出液を得た。本抽出液を減圧下、溶媒を留去することによって、モクレン花弁水抽出物を得た。
釣籐鈎幹細切物100gに50%エタノールを1000g加え、室温で1週間放置した。ろ別し、釣籐鈎幹50%エタノール抽出液を得た。本抽出液を減圧下、溶媒を留去することによって、釣籐鈎幹50%エタノール抽出物を得た。
24wellシャレーに線維芽細胞(HFSKF-II)を1.0×105播種し、15%FBS含有Ham’sF-12培地でコンフルエントまで培養した。FBS不含Ham’sF-12に各種試料を加え、48時間培養を行った。合成されたコラーゲンをヒトI型コラーゲン測定用ELISAキット(Chondrex,Inc)で定量した。
シワが気になる男女120名(1群10名)に対して、洗顔料を用いて顔面をよく洗浄した後、全顔に各々表2に示した皮膚外用剤を1日に1回塗布して4週間後にシワの目視評価及びレプリカを採取し観察を行った。
◎:改善度で10名中、症状の改善が7名以上。
○:改善度で10名中、症状の改善が5〜6名。
△:改善度で10名中、症状の改善が3〜4名。
×:改善度で10名中、症状の改善が2名以下。
〜 6 、比較例1 〜 6 、表1 に示した処方のローションタイプの皮膚外用剤を調製して、上記の手法によりその有用性を評価した。その結果を併せて表2 に示した。尚、実施例1〜3は参考例である。
<処方例1>化粧水
(重量%)
イタドリ根エタノール抽出液
0.01
バレリアナ根70%エタノール抽出液 0.1
ポリオキシエチレンソルビタンモノラウレート(20E.0.) 1.5
エタノール
10.0
防腐剤・酸化防止剤 適量
香料
適量
精製水
残部
(重量%)
ブドウ果皮50%エタノール抽出液 20.0
ホオノキ樹皮50%エタノール抽出液 2.0
ミツロウ
2.0
ステアリルアルコール
5.0
ステアリン酸
8.0
スクワラン
10.0
自己乳化型グリセリルモノステアレート
3.0
ポリオキシエチレンセチルエーテル(20E.0.)
1.0
プロピレングリコール
5.0
水酸化カリウム
0.3
香料
適量
防腐剤・酸化防止剤
適量
精製水
残部
(重量%)
ブドウ葉エタノール抽出液 5.0
釣籐鈎幹50%エタノール抽出液 0.01
スクワラン
8.0
ワセリン
2.0
ミツロウ
0.5
ソルビタンセスキオレエート
0.8
ポリオキシエチレンオレイルエーテル(20E.0)
1.2
カルボキシビニルポリマー
0.2
プロピレングリコール
0.5
水酸化カリウム
0.1
エタノール
7.0
香料 適量
防腐剤・酸化防止剤
適量
精製水
残部
(重量%)
イタドリ根エタノール抽出液 0.001
モクレン花水抽出液 10.0
酢酸ビニル樹脂エマルジョン
15.0
ポリビニルアルコール
10.0
ホホバ油
3.0
グリセリン
5.0
酸化チタン
8.0
カオリン
7.0
エタノール
5.0
香料
適量
防腐剤・酸化防止剤 適量
精製水
残部
(重量%)
ブドウ葉50%エタノール抽出物
0.1
バレリアナ根70%エタノール抽出物 0.001
パラジメチルアミノ安息香酸オクチル 4.0
ブチルメトキシベンゾイルメタン
4.0
ステアリルアルコール
18.0
モクロウ
20.0
グリセリンモノステアリン酸エステル
0.3
ワセリン
33.0
香料
適量
防腐剤・酸化防止剤
適量
精製水
残部
Claims (3)
- イタドリ(Reynoutria
japonica Houtt.var.japnica)根抽出物とバレリアナ(Valeriana officinalis L.)根抽出物を有効成分とするシワ改善用皮膚外用剤。 - イタドリ(Reynoutria
japonica Houtt.var.japnica)根抽出物とホオノキ(Magnoliaceae obovata
Thunberg)樹皮抽出物を有効成分とするシワ改善用皮膚外用剤。 - イタドリ(Reynoutria
japonica Houtt.var.japnica)根抽出物とカバカバ(Piper methysticum)根抽出物とモクレン〔Magnolia
quinquepeta(Buc’hoz)Dandy〕花抽出物を有効成分とするシワ改善用皮膚外用剤。
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KR100825835B1 (ko) * | 2006-12-05 | 2008-04-28 | (주)아모레퍼시픽 | 길초근 추출물을 유효성분으로 함유하는 화장료 조성물 |
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