JP4184785B2 - 抗ヒスタミン薬及び抗アレルギー薬としてのインドリルピペリジン誘導体 - Google Patents
抗ヒスタミン薬及び抗アレルギー薬としてのインドリルピペリジン誘導体 Download PDFInfo
- Publication number
- JP4184785B2 JP4184785B2 JP2002539348A JP2002539348A JP4184785B2 JP 4184785 B2 JP4184785 B2 JP 4184785B2 JP 2002539348 A JP2002539348 A JP 2002539348A JP 2002539348 A JP2002539348 A JP 2002539348A JP 4184785 B2 JP4184785 B2 JP 4184785B2
- Authority
- JP
- Japan
- Prior art keywords
- ylmethyl
- piperidin
- indol
- mmol
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 C=CN*1c2ccccc2C(C(CC2)CC*2O)=C1 Chemical compound C=CN*1c2ccccc2C(C(CC2)CC*2O)=C1 0.000 description 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200002615A ES2172436B1 (es) | 2000-10-31 | 2000-10-31 | Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. |
| PCT/EP2001/012450 WO2002036589A1 (en) | 2000-10-31 | 2001-10-26 | Indolylpiperidine derivatives as antihistaminic and antiallergic agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004513127A JP2004513127A (ja) | 2004-04-30 |
| JP2004513127A5 JP2004513127A5 (US07816364-20101019-C00082.png) | 2005-04-28 |
| JP4184785B2 true JP4184785B2 (ja) | 2008-11-19 |
Family
ID=8495472
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002539348A Expired - Fee Related JP4184785B2 (ja) | 2000-10-31 | 2001-10-26 | 抗ヒスタミン薬及び抗アレルギー薬としてのインドリルピペリジン誘導体 |
Country Status (16)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2201899B1 (es) * | 2002-04-01 | 2005-06-01 | Almirall Prodesfarma, S.A. | Derivados de la azaindolilpiperidina como agentes antihistaminicos y antialergicos. |
| ES2201907B1 (es) * | 2002-05-29 | 2005-06-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de indolilpiperidina como potentes agentes antihistaminicos y antialergicos. |
| JP4326468B2 (ja) * | 2002-06-24 | 2009-09-09 | シェーリング コーポレイション | ヒスタミンｈ３アンタゴニストとして有用なインドール誘導体 |
| WO2004047769A2 (en) * | 2002-11-26 | 2004-06-10 | Isis Pharmaceuticals, Inc. | Benzimidazoles and analogs thereof as antibacterials |
| US20080015214A1 (en) * | 2005-10-24 | 2008-01-17 | Bignan Gilles C | 3-piperidin-4-yl-indole orl-1 receptor modulators |
| JP5581055B2 (ja) * | 2006-10-27 | 2014-08-27 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ピペリジル−プロパン−チオールｃｃｒ３モジュレーター |
| PE20090188A1 (es) * | 2007-03-15 | 2009-03-20 | Novartis Ag | Compuestos heterociclicos como moduladores de la senda de hedgehog |
| US20100041663A1 (en) | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK471479A (da) | 1978-12-13 | 1980-06-14 | Pfizer | Fremgangsmaade til fremstilling af imidazolderivater og salte deraf |
| US4742057A (en) * | 1985-12-05 | 1988-05-03 | Fujisawa Pharmaceutical Co., Ltd. | Antiallergic thiazole compounds |
| US4843068A (en) | 1985-12-27 | 1989-06-27 | Nihon Nohyaku Co., Ltd. | Pyrazole oxime derivatives and compositions |
| DK733788A (da) | 1988-01-14 | 1989-07-15 | Fujisawa Pharmaceutical Co | Indolylpiperidinderivater og fremgangsmaade til fremstilling deraf |
| CA2129995C (en) * | 1992-02-13 | 2000-04-11 | Albert A. Carr | Piperidinyl thiacyclic derivatives |
| JP3338913B2 (ja) * | 1993-06-29 | 2002-10-28 | 大鵬薬品工業株式会社 | テトラゾール誘導体 |
| IT1271417B (it) | 1993-10-15 | 1997-05-28 | Erregierre Ind Chim | Composti ad attivita' antiistaminica procedimento per la loro preperazione e composizioni farmaceutiche che li contengono. |
| DE19500689A1 (de) | 1995-01-12 | 1996-07-18 | Merck Patent Gmbh | Indolpiperidin-Derivate |
| DE19707628A1 (de) | 1997-02-26 | 1998-08-27 | Merck Patent Gmbh | Oxazolidinone |
| AR013669A1 (es) | 1997-10-07 | 2001-01-10 | Smithkline Beecham Corp | Compuestos y metodos |
| ES2165274B1 (es) | 1999-06-04 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. |
| AR028685A1 (es) | 2000-06-14 | 2003-05-21 | Lundbeck & Co As H | Derivados de indol |
-
2000
- 2000-10-31 ES ES200002615A patent/ES2172436B1/es not_active Expired - Fee Related
-
2001
- 2001-10-26 AU AU2002223655A patent/AU2002223655A1/en not_active Abandoned
- 2001-10-26 AT AT01992709T patent/ATE321761T1/de not_active IP Right Cessation
- 2001-10-26 DE DE60118434T patent/DE60118434T2/de not_active Expired - Lifetime
- 2001-10-26 DK DK01992709T patent/DK1330453T3/da active
- 2001-10-26 EP EP01992709A patent/EP1330453B1/en not_active Expired - Lifetime
- 2001-10-26 US US10/415,693 patent/US7189741B2/en not_active Expired - Fee Related
- 2001-10-26 ES ES01992709T patent/ES2259052T3/es not_active Expired - Lifetime
- 2001-10-26 SI SI200130521T patent/SI1330453T1/sl unknown
- 2001-10-26 WO PCT/EP2001/012450 patent/WO2002036589A1/en active IP Right Grant
- 2001-10-26 JP JP2002539348A patent/JP4184785B2/ja not_active Expired - Fee Related
- 2001-10-26 CA CA002427589A patent/CA2427589A1/en not_active Abandoned
- 2001-10-26 PT PT01992709T patent/PT1330453E/pt unknown
- 2001-10-30 MY MYPI20015021A patent/MY155914A/en unknown
- 2001-10-30 AR ARP010105068A patent/AR031168A1/es not_active Application Discontinuation
- 2001-10-30 PE PE2001001079A patent/PE20020543A1/es not_active Application Discontinuation
- 2001-10-31 UY UY27001A patent/UY27001A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2172436B1 (es) | 2004-01-16 |
| DE60118434D1 (de) | 2006-05-18 |
| ATE321761T1 (de) | 2006-04-15 |
| DE60118434T2 (de) | 2006-12-14 |
| EP1330453A1 (en) | 2003-07-30 |
| AR031168A1 (es) | 2003-09-10 |
| PT1330453E (pt) | 2006-07-31 |
| CA2427589A1 (en) | 2002-05-10 |
| PE20020543A1 (es) | 2002-07-17 |
| ES2259052T3 (es) | 2006-09-16 |
| WO2002036589A1 (en) | 2002-05-10 |
| SI1330453T1 (sl) | 2006-08-31 |
| DK1330453T3 (da) | 2006-08-07 |
| UY27001A1 (es) | 2001-12-28 |
| US20040116471A1 (en) | 2004-06-17 |
| US7189741B2 (en) | 2007-03-13 |
| AU2002223655A1 (en) | 2002-05-15 |
| JP2004513127A (ja) | 2004-04-30 |
| EP1330453B1 (en) | 2006-03-29 |
| ES2172436A1 (es) | 2002-09-16 |
| MY155914A (en) | 2015-12-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4485353B2 (ja) | 有効な抗ヒスタミン剤および抗アレルギー剤としての新規インドリルピペリジン誘導体 | |
| US5576321A (en) | Compounds having effects on serotonin-related systems | |
| US5614523A (en) | Compounds having effects on serotonin-related systems | |
| US5627196A (en) | Compounds having effects on serotonin-related systems | |
| US6172073B1 (en) | Compounds having effects on serotonin-related systems | |
| US5789402A (en) | Compounds having effects on serotonin-related systems | |
| JPH064587B2 (ja) | 新規なインドール誘導体およびその酸付加塩ならびにそれらを含有する精神病治療剤 | |
| KR100683454B1 (ko) | 항히스타민제 그리고 항알레르기제로서의 인돌일피페리딘유도체 | |
| CN1318416C (zh) | 5－羟色胺能试剂吲唑酰胺化合物 | |
| TW200800194A (en) | Kinase inhibitors | |
| JP4184785B2 (ja) | 抗ヒスタミン薬及び抗アレルギー薬としてのインドリルピペリジン誘導体 | |
| WO1994021627A1 (en) | Indole derivatives as dopamine d4 antagonists | |
| ES2265577T3 (es) | Derivados de azaindolilpiperidina como agentes antihistaminicos y antialergicos. | |
| JPS6257606B2 (US07816364-20101019-C00082.png) | ||
| JP2000080081A (ja) | １―〔（１―置換―４―ピペリジニル）メチル〕―４―ピペリジン誘導体及びそれを含有する医薬組成物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20041025 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20080723 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20080805 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20080904 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20110912 Year of fee payment: 3 |
|
| R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| S533 | Written request for registration of change of name |
Free format text: JAPANESE INTERMEDIATE CODE: R313533 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20110912 Year of fee payment: 3 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| LAPS | Cancellation because of no payment of annual fees |