JP4104660B2 - クラリスロマイシンの結晶形態ｉｉの製造 - Google Patents

クラリスロマイシンの結晶形態ｉｉの製造 Download PDF

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Publication number
JP4104660B2
JP4104660B2 JP50903898A JP50903898A JP4104660B2 JP 4104660 B2 JP4104660 B2 JP 4104660B2 JP 50903898 A JP50903898 A JP 50903898A JP 50903898 A JP50903898 A JP 50903898A JP 4104660 B2 JP4104660 B2 JP 4104660B2
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Japan
Prior art keywords
carbon atoms
solvent
methylerythromycin
water
alkanol
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Expired - Lifetime
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JP50903898A
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English (en)
Japanese (ja)
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JP2002514171A5 (cg-RX-API-DMAC7.html
JP2002514171A (ja
Inventor
リウ，ジイ―ホワ
リレイ，デイビツド・エイ
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Abbott Laboratories
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Abbott Laboratories
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Priority claimed from US08/681,695 external-priority patent/US5844105A/en
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
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Publication of JP2002514171A5 publication Critical patent/JP2002514171A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP50903898A 1996-07-29 1997-07-28 クラリスロマイシンの結晶形態ｉｉの製造 Expired - Lifetime JP4104660B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/681,695 US5844105A (en) 1996-07-29 1996-07-29 Preparation of crystal form II of clarithromycin
US90027197A 1997-07-25 1997-07-25
US08/900,271 1997-07-25
US08/681,695 1997-07-25
PCT/US1997/013166 WO1998004574A1 (en) 1996-07-29 1997-07-28 Preparation of crystal form ii of clarithromycin

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2005357782A Division JP2006137765A (ja) 1996-07-29 2005-12-12 クラリスロマイシンの結晶形態ｉｉの製造

Publications (3)

Publication Number Publication Date
JP2002514171A JP2002514171A (ja) 2002-05-14
JP2002514171A5 JP2002514171A5 (cg-RX-API-DMAC7.html) 2005-02-10
JP4104660B2 true JP4104660B2 (ja) 2008-06-18

Family

ID=27102712

Family Applications (4)

Application Number Title Priority Date Filing Date
JP50903898A Expired - Lifetime JP4104660B2 (ja) 1996-07-29 1997-07-28 クラリスロマイシンの結晶形態ｉｉの製造
JP2005357782A Pending JP2006137765A (ja) 1996-07-29 2005-12-12 クラリスロマイシンの結晶形態ｉｉの製造
JP2009141790A Withdrawn JP2009242411A (ja) 1996-07-29 2009-06-15 クラリスロマイシンの結晶形態ｉｉの製造
JP2013077418A Pending JP2013151542A (ja) 1996-07-29 2013-04-03 クラリスロマイシンの結晶形態ｉｉの製造

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2005357782A Pending JP2006137765A (ja) 1996-07-29 2005-12-12 クラリスロマイシンの結晶形態ｉｉの製造
JP2009141790A Withdrawn JP2009242411A (ja) 1996-07-29 2009-06-15 クラリスロマイシンの結晶形態ｉｉの製造
JP2013077418A Pending JP2013151542A (ja) 1996-07-29 2013-04-03 クラリスロマイシンの結晶形態ｉｉの製造

Country Status (12)

Country Link
EP (1) EP0915899B1 (cg-RX-API-DMAC7.html)
JP (4) JP4104660B2 (cg-RX-API-DMAC7.html)
KR (1) KR100524214B1 (cg-RX-API-DMAC7.html)
AT (1) ATE272646T1 (cg-RX-API-DMAC7.html)
AU (1) AU733646B2 (cg-RX-API-DMAC7.html)
CA (1) CA2261732C (cg-RX-API-DMAC7.html)
DE (3) DE69730138T2 (cg-RX-API-DMAC7.html)
DK (1) DK0915899T3 (cg-RX-API-DMAC7.html)
ES (1) ES2173057T3 (cg-RX-API-DMAC7.html)
IL (1) IL127833A (cg-RX-API-DMAC7.html)
PT (1) PT915899E (cg-RX-API-DMAC7.html)
WO (1) WO1998004574A1 (cg-RX-API-DMAC7.html)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5945405A (en) * 1997-01-17 1999-08-31 Abbott Laboratories Crystal form O of clarithromycin
US6245903B1 (en) 1998-08-21 2001-06-12 Apotex, Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
KR100377159B1 (ko) * 1998-09-09 2003-08-19 한미약품공업 주식회사 잔류 용매가 없는 클라리스로마이신의 결정형 2의 제조 방법
GB9827355D0 (en) 1998-12-11 1999-02-03 Biochemie Sa Organic compounds
KR20010008496A (ko) * 1999-07-01 2001-02-05 유충식 6-오-메틸 에리트로마이신의 제조방법
KR100322313B1 (ko) * 1999-10-21 2002-02-06 민경윤 클라리스로마이신 결정형 2의 제조방법 및 이에 사용되는 클라리스로마이신 포르메이트
US6627743B1 (en) 1999-12-03 2003-09-30 Abbott Laboratories 6-O-methylerythromycin A crystal form III
CZ20021999A3 (cs) * 1999-12-16 2003-02-12 Teva Pharmaceutical Industries Ltd. Způsob přípravy klaritromycinových polymorfních forem a nového polymorfu IV
CA2397092A1 (en) * 2000-01-11 2001-07-19 Teva Pharmaceutical Industries Ltd. Processes for preparing clarithromycin polymorphs
WO2001064224A1 (en) 2000-02-29 2001-09-07 Teva Pharmaceutical Industries Ltd. Processes for preparing clarithromycin and clarithromycin intermediate, essentially oxime-free clarithromycin, and pharmaceutical composition comprising the same
KR100361397B1 (ko) * 2000-03-15 2002-11-23 한미약품공업 주식회사 에리스로마이신 에이 9-오-트로필옥심 유도체를 이용한클라리스로마이신의 제조방법
KR100367981B1 (ko) * 2000-11-23 2003-01-14 한미약품공업 주식회사 클라리스로마이신 결정형 2의 제조 방법 및 이 방법에사용되는 결정성 클라리스로마이신 메실레이트 삼수화물
DE60122791T2 (de) * 2000-03-15 2007-10-04 Hanmi Pharm. Co., Ltd. Verfahren zur Herstellung von Clarythromycin mit nicht pharmazeutischer Qualität
KR100408848B1 (ko) * 2001-03-12 2003-12-06 주식회사 씨트리 클래리스로마이신의 정제방법
DE60209704T2 (de) 2001-05-22 2006-11-16 Pfizer Products Inc., Groton Neue kristallforme von azithromycin
US6861413B2 (en) 2001-05-22 2005-03-01 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
EP1652851A1 (en) * 2001-05-22 2006-05-03 Pfizer Products Inc. New crystal form of Azithromycin
KR100372254B1 (en) * 2002-07-15 2003-02-19 Korea United Pharm Inc Erythromycin a 9-o-pseudosaccharinyl oxime derivative and process for preparing clarithromycin using the same
EP1435359A1 (en) * 2002-12-31 2004-07-07 Alembic Limited A process for the purification of roxithromycin
US7384921B2 (en) * 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
MX2009005977A (es) * 2006-12-05 2009-06-17 Pfizer Polimorfos de motilida.
DE102007016367A1 (de) * 2007-04-03 2008-10-09 Grünenthal GmbH Polymorph von Clarithromycin (Form V)
CN103087130B (zh) * 2013-02-06 2015-12-23 浙江国邦药业有限公司 一种克拉霉素晶型转换方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS572298A (en) * 1980-06-04 1982-01-07 Taisho Pharmaceut Co Ltd Erythromycin derivative
JPS5782400A (en) 1980-11-12 1982-05-22 Taisho Pharmaceut Co Ltd Erythromycin derivative
US4331803A (en) 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
JPS60214796A (ja) 1984-04-06 1985-10-28 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシン類の製法
JPS61103890A (ja) 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
US4670549A (en) * 1985-03-18 1987-06-02 Taisho Pharmaceutical Co., Ltd. Method for selective methylation of erythromycin a derivatives
DE3782994T2 (de) 1986-09-18 1993-04-08 Taisho Pharma Co Ltd Erythromycin-a-derivate und verfahren zu ihrer herstellung.
JPH0755958B2 (ja) * 1986-10-03 1995-06-14 大正製薬株式会社 エリスロマイシンａ誘導体の製造方法
KR960000434B1 (ko) * 1986-12-17 1996-01-06 다이쇼 세이야꾸 가부시끼가이샤 에리스로마이신 a유도체 및 그의 제조 방법
JP2526951B2 (ja) * 1986-12-17 1996-08-21 大正製薬株式会社 エリスロマイシンａ誘導体およびその製造方法
JP2782793B2 (ja) * 1988-06-15 1998-08-06 大正製薬株式会社 エリスロマイシンａ誘導体およびその製造方法
ZA922776B (en) * 1991-04-29 1993-10-15 Lilly Co Eli Pharmaceutical compounds
US5872229A (en) 1995-11-21 1999-02-16 Abbott Laboratories Process for 6-O-alkylation of erythromycin derivatives
US5719272A (en) 1996-04-02 1998-02-17 Abbott Laboratories 2'-protected 3'-dimethylamine, 9-etheroxime erythromycin A derivatives
US5837829A (en) 1996-04-02 1998-11-17 Abbott Laboratories 9-oximesilyl erythromycin a derivatives

Also Published As

Publication number Publication date
DE29724846U1 (de) 2004-12-16
CA2261732A1 (en) 1998-02-05
DE69730138D1 (de) 2004-09-30
JP2006137765A (ja) 2006-06-01
KR100524214B1 (ko) 2005-11-01
KR20000029591A (ko) 2000-05-25
JP2013151542A (ja) 2013-08-08
ES2173057T1 (es) 2002-10-16
DE97934319T1 (de) 2004-08-26
IL127833A0 (en) 1999-10-28
JP2009242411A (ja) 2009-10-22
ATE272646T1 (de) 2004-08-15
AU733646B2 (en) 2001-05-17
EP0915899A1 (en) 1999-05-19
CA2261732C (en) 2001-07-24
DE69730138T2 (de) 2005-03-03
WO1998004574A1 (en) 1998-02-05
DK0915899T3 (da) 2004-11-29
IL127833A (en) 2004-06-20
JP2002514171A (ja) 2002-05-14
PT915899E (pt) 2004-11-30
AU3740597A (en) 1998-02-20
ES2173057T3 (es) 2004-11-16
EP0915899B1 (en) 2004-08-04

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