JP3993245B2 - IgEを検出する方法 - Google Patents
IgEを検出する方法 Download PDFInfo
- Publication number
- JP3993245B2 JP3993245B2 JP52673198A JP52673198A JP3993245B2 JP 3993245 B2 JP3993245 B2 JP 3993245B2 JP 52673198 A JP52673198 A JP 52673198A JP 52673198 A JP52673198 A JP 52673198A JP 3993245 B2 JP3993245 B2 JP 3993245B2
- Authority
- JP
- Japan
- Prior art keywords
- ige
- molecule
- fcεr
- substrate
- complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title claims abstract description 52
- 241000282326 Felis catus Species 0.000 claims abstract description 26
- 241000283073 Equus caballus Species 0.000 claims abstract description 22
- 102000009438 IgE Receptors Human genes 0.000 claims abstract description 5
- 108010073816 IgE Receptors Proteins 0.000 claims abstract description 5
- 241000282465 Canis Species 0.000 claims description 70
- 239000000758 substrate Substances 0.000 claims description 67
- 241000282472 Canis lupus familiaris Species 0.000 claims description 65
- 239000013566 allergen Substances 0.000 claims description 63
- 239000000427 antigen Substances 0.000 claims description 63
- 102000036639 antigens Human genes 0.000 claims description 63
- 108091007433 antigens Proteins 0.000 claims description 63
- 108090000623 proteins and genes Proteins 0.000 claims description 52
- 102000004169 proteins and genes Human genes 0.000 claims description 51
- 239000000203 mixture Substances 0.000 claims description 43
- 210000003296 saliva Anatomy 0.000 claims description 33
- 238000001514 detection method Methods 0.000 claims description 28
- 230000027455 binding Effects 0.000 claims description 22
- 241001465754 Metazoa Species 0.000 claims description 19
- 150000001875 compounds Chemical class 0.000 claims description 17
- 239000003550 marker Substances 0.000 claims description 17
- 241000196324 Embryophyta Species 0.000 claims description 12
- 239000000126 substance Substances 0.000 claims description 10
- 230000015572 biosynthetic process Effects 0.000 claims description 9
- 240000007594 Oryza sativa Species 0.000 claims description 7
- 244000045947 parasite Species 0.000 claims description 7
- 241000257303 Hymenoptera Species 0.000 claims description 6
- 241000283690 Bos taurus Species 0.000 claims description 5
- 241000283086 Equidae Species 0.000 claims description 5
- 230000037303 wrinkles Effects 0.000 claims description 5
- 241000255925 Diptera Species 0.000 claims description 4
- 241000233866 Fungi Species 0.000 claims description 4
- 235000007164 Oryza sativa Nutrition 0.000 claims description 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 4
- 240000008042 Zea mays Species 0.000 claims description 4
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 4
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 4
- 235000005822 corn Nutrition 0.000 claims description 4
- 235000013336 milk Nutrition 0.000 claims description 4
- 239000008267 milk Substances 0.000 claims description 4
- 210000004080 milk Anatomy 0.000 claims description 4
- 235000009566 rice Nutrition 0.000 claims description 4
- 235000010469 Glycine max Nutrition 0.000 claims description 3
- 235000021307 Triticum Nutrition 0.000 claims description 3
- 235000013351 cheese Nutrition 0.000 claims description 3
- 235000013601 eggs Nutrition 0.000 claims description 3
- 241000238876 Acari Species 0.000 claims description 2
- 206010004194 Bed bug infestation Diseases 0.000 claims description 2
- 241001414835 Cimicidae Species 0.000 claims description 2
- 244000068988 Glycine max Species 0.000 claims description 2
- 241001494479 Pecora Species 0.000 claims description 2
- 241001674048 Phthiraptera Species 0.000 claims description 2
- 244000144977 poultry Species 0.000 claims description 2
- 241000282898 Sus scrofa Species 0.000 claims 1
- 241000209140 Triticum Species 0.000 claims 1
- 230000016784 immunoglobulin production Effects 0.000 claims 1
- 239000012472 biological sample Substances 0.000 abstract description 11
- 210000004027 cell Anatomy 0.000 description 68
- 150000007523 nucleic acids Chemical class 0.000 description 49
- 210000002966 serum Anatomy 0.000 description 43
- 239000003153 chemical reaction reagent Substances 0.000 description 39
- 108020004707 nucleic acids Proteins 0.000 description 38
- 102000039446 nucleic acids Human genes 0.000 description 38
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical group N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 33
- 239000000523 sample Substances 0.000 description 29
- 238000002372 labelling Methods 0.000 description 24
- 238000010790 dilution Methods 0.000 description 23
- 239000012895 dilution Substances 0.000 description 23
- 238000003556 assay Methods 0.000 description 19
- 239000011616 biotin Substances 0.000 description 18
- 238000002965 ELISA Methods 0.000 description 16
- 108010090804 Streptavidin Proteins 0.000 description 16
- 229960002685 biotin Drugs 0.000 description 15
- 235000020958 biotin Nutrition 0.000 description 15
- 108020004705 Codon Proteins 0.000 description 14
- 208000010668 atopic eczema Diseases 0.000 description 14
- 206010036790 Productive cough Diseases 0.000 description 13
- 239000002773 nucleotide Substances 0.000 description 13
- 210000003802 sputum Anatomy 0.000 description 13
- 208000024794 sputum Diseases 0.000 description 13
- 125000003729 nucleotide group Chemical group 0.000 description 12
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 11
- 108091028043 Nucleic acid sequence Proteins 0.000 description 10
- 230000000172 allergic effect Effects 0.000 description 10
- 210000001124 body fluid Anatomy 0.000 description 10
- 239000000872 buffer Substances 0.000 description 10
- 241000282324 Felis Species 0.000 description 9
- 238000010438 heat treatment Methods 0.000 description 9
- 239000000463 material Substances 0.000 description 9
- 150000001413 amino acids Chemical class 0.000 description 8
- 239000011324 bead Substances 0.000 description 8
- 239000010839 body fluid Substances 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 8
- 244000036975 Ambrosia artemisiifolia Species 0.000 description 7
- 235000003129 Ambrosia artemisiifolia var elatior Nutrition 0.000 description 7
- 238000011534 incubation Methods 0.000 description 7
- 241000972773 Aulopiformes Species 0.000 description 6
- 108060003951 Immunoglobulin Proteins 0.000 description 6
- 102000018358 immunoglobulin Human genes 0.000 description 6
- 208000015181 infectious disease Diseases 0.000 description 6
- 108090000765 processed proteins & peptides Proteins 0.000 description 6
- 235000002020 sage Nutrition 0.000 description 6
- 235000019515 salmon Nutrition 0.000 description 6
- 235000013479 Amaranthus retroflexus Nutrition 0.000 description 5
- 244000237956 Amaranthus retroflexus Species 0.000 description 5
- 108090001008 Avidin Proteins 0.000 description 5
- 102000004190 Enzymes Human genes 0.000 description 5
- 108090000790 Enzymes Proteins 0.000 description 5
- 241000238631 Hexapoda Species 0.000 description 5
- 206010020751 Hypersensitivity Diseases 0.000 description 5
- 108020004511 Recombinant DNA Proteins 0.000 description 5
- 125000003275 alpha amino acid group Chemical group 0.000 description 5
- 239000007850 fluorescent dye Substances 0.000 description 5
- 239000012634 fragment Substances 0.000 description 5
- 150000002430 hydrocarbons Chemical group 0.000 description 5
- 239000003547 immunosorbent Substances 0.000 description 5
- 239000003446 ligand Substances 0.000 description 5
- 239000002609 medium Substances 0.000 description 5
- 108010087904 neutravidin Proteins 0.000 description 5
- 239000002953 phosphate buffered saline Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 241000701447 unidentified baculovirus Species 0.000 description 5
- 241000282421 Canidae Species 0.000 description 4
- 241000251730 Chondrichthyes Species 0.000 description 4
- 206010012434 Dermatitis allergic Diseases 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- 239000000020 Nitrocellulose Substances 0.000 description 4
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 4
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 4
- 230000007815 allergy Effects 0.000 description 4
- 201000008937 atopic dermatitis Diseases 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- 230000000295 complement effect Effects 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 210000000987 immune system Anatomy 0.000 description 4
- 239000004816 latex Substances 0.000 description 4
- 229920000126 latex Polymers 0.000 description 4
- 239000011859 microparticle Substances 0.000 description 4
- 229920001220 nitrocellulos Polymers 0.000 description 4
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 208000016557 Acute basophilic leukemia Diseases 0.000 description 3
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 3
- 101000658547 Escherichia coli (strain K12) Type I restriction enzyme EcoKI endonuclease subunit Proteins 0.000 description 3
- 101000658543 Escherichia coli Type I restriction enzyme EcoAI endonuclease subunit Proteins 0.000 description 3
- 101000658546 Escherichia coli Type I restriction enzyme EcoEI endonuclease subunit Proteins 0.000 description 3
- 101000658530 Escherichia coli Type I restriction enzyme EcoR124II endonuclease subunit Proteins 0.000 description 3
- 101000658540 Escherichia coli Type I restriction enzyme EcoprrI endonuclease subunit Proteins 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 101000658545 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) Type I restriction enyme HindI endonuclease subunit Proteins 0.000 description 3
- 108090001090 Lectins Proteins 0.000 description 3
- 102000004856 Lectins Human genes 0.000 description 3
- 101000658548 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) Putative type I restriction enzyme MjaIXP endonuclease subunit Proteins 0.000 description 3
- 101000658542 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) Putative type I restriction enzyme MjaVIIIP endonuclease subunit Proteins 0.000 description 3
- 101000658529 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) Putative type I restriction enzyme MjaVIIP endonuclease subunit Proteins 0.000 description 3
- 101100350635 Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2)) mgc2 gene Proteins 0.000 description 3
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 3
- 101001042773 Staphylococcus aureus (strain COL) Type I restriction enzyme SauCOLORF180P endonuclease subunit Proteins 0.000 description 3
- 101000838760 Staphylococcus aureus (strain MRSA252) Type I restriction enzyme SauMRSORF196P endonuclease subunit Proteins 0.000 description 3
- 101000838761 Staphylococcus aureus (strain MSSA476) Type I restriction enzyme SauMSSORF170P endonuclease subunit Proteins 0.000 description 3
- 101000838758 Staphylococcus aureus (strain MW2) Type I restriction enzyme SauMW2ORF169P endonuclease subunit Proteins 0.000 description 3
- 101001042566 Staphylococcus aureus (strain Mu50 / ATCC 700699) Type I restriction enzyme SauMu50ORF195P endonuclease subunit Proteins 0.000 description 3
- 101000838763 Staphylococcus aureus (strain N315) Type I restriction enzyme SauN315I endonuclease subunit Proteins 0.000 description 3
- 101000838759 Staphylococcus epidermidis (strain ATCC 35984 / RP62A) Type I restriction enzyme SepRPIP endonuclease subunit Proteins 0.000 description 3
- 101000838756 Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41) Type I restriction enzyme SsaAORF53P endonuclease subunit Proteins 0.000 description 3
- 241000255993 Trichoplusia ni Species 0.000 description 3
- 244000067505 Xanthium strumarium Species 0.000 description 3
- 235000003484 annual ragweed Nutrition 0.000 description 3
- 229940098773 bovine serum albumin Drugs 0.000 description 3
- 235000006263 bur ragweed Nutrition 0.000 description 3
- 235000003488 common ragweed Nutrition 0.000 description 3
- 239000002299 complementary DNA Substances 0.000 description 3
- 230000009918 complex formation Effects 0.000 description 3
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 238000003119 immunoblot Methods 0.000 description 3
- 239000002523 lectin Substances 0.000 description 3
- -1 mixtures (ie Chemical class 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 239000013641 positive control Substances 0.000 description 3
- 235000009736 ragweed Nutrition 0.000 description 3
- 230000009257 reactivity Effects 0.000 description 3
- 108020003175 receptors Proteins 0.000 description 3
- 102000005962 receptors Human genes 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 210000003491 skin Anatomy 0.000 description 3
- 239000007790 solid phase Substances 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 230000009466 transformation Effects 0.000 description 3
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 2
- 241000208140 Acer Species 0.000 description 2
- 241000251468 Actinopterygii Species 0.000 description 2
- 229920000936 Agarose Polymers 0.000 description 2
- 108010088751 Albumins Proteins 0.000 description 2
- 102000009027 Albumins Human genes 0.000 description 2
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 2
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 2
- 241001149224 Ambrosia psilostachya Species 0.000 description 2
- 241000208841 Ambrosia trifida Species 0.000 description 2
- 241001225321 Aspergillus fumigatus Species 0.000 description 2
- 241000190150 Bipolaris sorokiniana Species 0.000 description 2
- 241001674044 Blattodea Species 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- 229920002160 Celluloid Polymers 0.000 description 2
- 241000222290 Cladosporium Species 0.000 description 2
- 241000243988 Dirofilaria immitis Species 0.000 description 2
- 241000283074 Equus asinus Species 0.000 description 2
- 241000287828 Gallus gallus Species 0.000 description 2
- 108010034145 Helminth Proteins Proteins 0.000 description 2
- 208000006968 Helminthiasis Diseases 0.000 description 2
- 241000226709 Hesperocyparis arizonica Species 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 240000004296 Lolium perenne Species 0.000 description 2
- 241000721701 Lynx Species 0.000 description 2
- 108010052285 Membrane Proteins Proteins 0.000 description 2
- 102000018697 Membrane Proteins Human genes 0.000 description 2
- 238000005481 NMR spectroscopy Methods 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
- 108700026244 Open Reading Frames Proteins 0.000 description 2
- 239000002033 PVDF binder Substances 0.000 description 2
- 241000282373 Panthera pardus Species 0.000 description 2
- 241000228143 Penicillium Species 0.000 description 2
- 206010035226 Plasma cell myeloma Diseases 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- 241000218978 Populus deltoides Species 0.000 description 2
- 108010076504 Protein Sorting Signals Proteins 0.000 description 2
- 235000003105 Pyracantha coccinea Nutrition 0.000 description 2
- 244000128206 Pyracantha coccinea Species 0.000 description 2
- 235000002912 Salvia officinalis Nutrition 0.000 description 2
- 240000007164 Salvia officinalis Species 0.000 description 2
- 244000204900 Talipariti tiliaceum Species 0.000 description 2
- 101710120037 Toxin CcdB Proteins 0.000 description 2
- 241000255985 Trichoplusia Species 0.000 description 2
- 244000098338 Triticum aestivum Species 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 239000008351 acetate buffer Substances 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000003302 anti-idiotype Effects 0.000 description 2
- 229940091771 aspergillus fumigatus Drugs 0.000 description 2
- 208000010216 atopic IgE responsiveness Diseases 0.000 description 2
- 210000003719 b-lymphocyte Anatomy 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 210000003651 basophil Anatomy 0.000 description 2
- 235000015278 beef Nutrition 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 239000007975 buffered saline Substances 0.000 description 2
- 239000006172 buffering agent Substances 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 235000013330 chicken meat Nutrition 0.000 description 2
- 239000013068 control sample Substances 0.000 description 2
- 210000005220 cytoplasmic tail Anatomy 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 238000009510 drug design Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 235000019688 fish Nutrition 0.000 description 2
- 239000013568 food allergen Substances 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 244000000013 helminth Species 0.000 description 2
- 238000001114 immunoprecipitation Methods 0.000 description 2
- 239000006249 magnetic particle Substances 0.000 description 2
- 125000000311 mannosyl group Chemical group C1([C@@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 201000000050 myeloid neoplasm Diseases 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 150000002894 organic compounds Chemical class 0.000 description 2
- 208000014837 parasitic helminthiasis infectious disease Diseases 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 235000015277 pork Nutrition 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 230000002285 radioactive effect Effects 0.000 description 2
- 238000003127 radioimmunoassay Methods 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 238000013207 serial dilution Methods 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 239000012089 stop solution Substances 0.000 description 2
- 230000001131 transforming effect Effects 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- 238000011144 upstream manufacturing Methods 0.000 description 2
- VLEIUWBSEKKKFX-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid Chemical compound OCC(N)(CO)CO.OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O VLEIUWBSEKKKFX-UHFFFAOYSA-N 0.000 description 1
- UAIUNKRWKOVEES-UHFFFAOYSA-N 3,3',5,5'-tetramethylbenzidine Chemical compound CC1=C(N)C(C)=CC(C=2C=C(C)C(N)=C(C)C=2)=C1 UAIUNKRWKOVEES-UHFFFAOYSA-N 0.000 description 1
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 description 1
- IJJWOSAXNHWBPR-HUBLWGQQSA-N 5-[(3as,4s,6ar)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-n-(6-hydrazinyl-6-oxohexyl)pentanamide Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)NCCCCCC(=O)NN)SC[C@@H]21 IJJWOSAXNHWBPR-HUBLWGQQSA-N 0.000 description 1
- 241001455214 Acinonyx jubatus Species 0.000 description 1
- 241000223600 Alternaria Species 0.000 description 1
- 241000223602 Alternaria alternata Species 0.000 description 1
- 235000013480 Amaranthus spinosus Nutrition 0.000 description 1
- 244000055702 Amaranthus viridis Species 0.000 description 1
- 235000016140 Artemisia frigida Nutrition 0.000 description 1
- 240000004573 Artemisia frigida Species 0.000 description 1
- 235000003261 Artemisia vulgaris Nutrition 0.000 description 1
- 240000006891 Artemisia vulgaris Species 0.000 description 1
- 241000228212 Aspergillus Species 0.000 description 1
- 208000012657 Atopic disease Diseases 0.000 description 1
- 244000236605 Atriplex canescens Species 0.000 description 1
- 235000008589 Atriplex canescens Nutrition 0.000 description 1
- 235000012137 Atriplex confertifolia Nutrition 0.000 description 1
- 241000223651 Aureobasidium Species 0.000 description 1
- 241000223678 Aureobasidium pullulans Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 235000018185 Betula X alpestris Nutrition 0.000 description 1
- 235000018212 Betula X uliginosa Nutrition 0.000 description 1
- 235000004936 Bromus mango Nutrition 0.000 description 1
- 240000001548 Camellia japonica Species 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 241000218645 Cedrus Species 0.000 description 1
- 241000931705 Cicada Species 0.000 description 1
- 241000320442 Cladosporium sphaerospermum Species 0.000 description 1
- 102000000989 Complement System Proteins Human genes 0.000 description 1
- 108010069112 Complement System Proteins Proteins 0.000 description 1
- 108010062580 Concanavalin A Proteins 0.000 description 1
- 241000218691 Cupressaceae Species 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 241001331845 Equus asinus x caballus Species 0.000 description 1
- 244000004281 Eucalyptus maculata Species 0.000 description 1
- 102000009109 Fc receptors Human genes 0.000 description 1
- 108010087819 Fc receptors Proteins 0.000 description 1
- 241000223218 Fusarium Species 0.000 description 1
- 241000223221 Fusarium oxysporum Species 0.000 description 1
- 241000221779 Fusarium sambucinum Species 0.000 description 1
- 241000282575 Gorilla Species 0.000 description 1
- 239000007995 HEPES buffer Substances 0.000 description 1
- 241000282821 Hippopotamus Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 1
- 235000009496 Juglans regia Nutrition 0.000 description 1
- 240000007049 Juglans regia Species 0.000 description 1
- 241000880493 Leptailurus serval Species 0.000 description 1
- 240000007472 Leucaena leucocephala Species 0.000 description 1
- 235000010643 Leucaena leucocephala Nutrition 0.000 description 1
- 235000014826 Mangifera indica Nutrition 0.000 description 1
- 240000007228 Mangifera indica Species 0.000 description 1
- 235000008708 Morus alba Nutrition 0.000 description 1
- 240000000249 Morus alba Species 0.000 description 1
- 241000235395 Mucor Species 0.000 description 1
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 description 1
- JOCBASBOOFNAJA-UHFFFAOYSA-N N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid Chemical compound OCC(CO)(CO)NCCS(O)(=O)=O JOCBASBOOFNAJA-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 238000012408 PCR amplification Methods 0.000 description 1
- 241000282320 Panthera leo Species 0.000 description 1
- 241000282372 Panthera onca Species 0.000 description 1
- 241000282376 Panthera tigris Species 0.000 description 1
- 208000030852 Parasitic disease Diseases 0.000 description 1
- 241001330451 Paspalum notatum Species 0.000 description 1
- 241000228150 Penicillium chrysogenum Species 0.000 description 1
- 108010067902 Peptide Library Proteins 0.000 description 1
- 241000233805 Phoenix Species 0.000 description 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 1
- 244000134552 Plantago ovata Species 0.000 description 1
- 235000003421 Plantago ovata Nutrition 0.000 description 1
- 241001600434 Plectroglyphidodon lacrymatus Species 0.000 description 1
- 241000269980 Pleuronectidae Species 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 241000219000 Populus Species 0.000 description 1
- 239000009223 Psyllium Substances 0.000 description 1
- 241000282374 Puma concolor Species 0.000 description 1
- 241000219492 Quercus Species 0.000 description 1
- 241000235546 Rhizopus stolonifer Species 0.000 description 1
- 235000015422 Rumex crispus ssp. crispus Nutrition 0.000 description 1
- 235000015426 Rumex crispus ssp. fauriei Nutrition 0.000 description 1
- 244000207667 Rumex vesicarius Species 0.000 description 1
- 235000007658 Salsola kali Nutrition 0.000 description 1
- 244000124765 Salsola kali Species 0.000 description 1
- 244000191542 Sarcobatus vermiculatus Species 0.000 description 1
- 229920002684 Sepharose Polymers 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 235000009184 Spondias indica Nutrition 0.000 description 1
- 108091081024 Start codon Proteins 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 239000008049 TAE buffer Substances 0.000 description 1
- 239000007994 TES buffer Substances 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 241001106462 Ulmus Species 0.000 description 1
- 241001149163 Ulmus americana Species 0.000 description 1
- 244000274883 Urtica dioica Species 0.000 description 1
- 235000009108 Urtica dioica Nutrition 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- HGEVZDLYZYVYHD-UHFFFAOYSA-N acetic acid;2-amino-2-(hydroxymethyl)propane-1,3-diol;2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid Chemical compound CC(O)=O.OCC(N)(CO)CO.OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O HGEVZDLYZYVYHD-UHFFFAOYSA-N 0.000 description 1
- 230000021736 acetylation Effects 0.000 description 1
- 238000006640 acetylation reaction Methods 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 238000001261 affinity purification Methods 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 238000007818 agglutination assay Methods 0.000 description 1
- 230000009435 amidation Effects 0.000 description 1
- 238000007112 amidation reaction Methods 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 230000000692 anti-sense effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 210000001742 aqueous humor Anatomy 0.000 description 1
- 238000002820 assay format Methods 0.000 description 1
- 238000003149 assay kit Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 108091006004 biotinylated proteins Proteins 0.000 description 1
- 230000006287 biotinylation Effects 0.000 description 1
- 238000007413 biotinylation Methods 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 235000018597 common camellia Nutrition 0.000 description 1
- 238000005094 computer simulation Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000009260 cross reactivity Effects 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 235000021186 dishes Nutrition 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 244000078703 ectoparasite Species 0.000 description 1
- 238000004520 electroporation Methods 0.000 description 1
- 244000079386 endoparasite Species 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 210000000224 granular leucocyte Anatomy 0.000 description 1
- 235000012399 greasewood Nutrition 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 210000003630 histaminocyte Anatomy 0.000 description 1
- 230000003284 homeostatic effect Effects 0.000 description 1
- 230000013632 homeostatic process Effects 0.000 description 1
- 210000004408 hybridoma Anatomy 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000003100 immobilizing effect Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 244000142813 lacy ambrosia Species 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000001638 lipofection Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 238000000520 microinjection Methods 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- 210000005087 mononuclear cell Anatomy 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 230000007498 myristoylation Effects 0.000 description 1
- 210000000822 natural killer cell Anatomy 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 230000009826 neoplastic cell growth Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000026792 palmitoylation Effects 0.000 description 1
- 239000000123 paper Substances 0.000 description 1
- 239000011236 particulate material Substances 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 102000013415 peroxidase activity proteins Human genes 0.000 description 1
- 235000020030 perry Nutrition 0.000 description 1
- 238000002823 phage display Methods 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 1
- 235000013594 poultry meat Nutrition 0.000 description 1
- 230000013823 prenylation Effects 0.000 description 1
- 210000001938 protoplast Anatomy 0.000 description 1
- 229940070687 psyllium Drugs 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 239000012508 resin bead Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000006798 ring closing metathesis reaction Methods 0.000 description 1
- 238000007142 ring opening reaction Methods 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000002764 solid phase assay Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 210000001138 tear Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 235000020234 walnut Nutrition 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- 238000002424 x-ray crystallography Methods 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/24—Immunology or allergic disorders
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measurement Of Current Or Voltage (AREA)
- Testing Or Measuring Of Semiconductors Or The Like (AREA)
- Emergency Protection Circuit Devices (AREA)
- Interface Circuits In Exchanges (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/756,387 | 1996-11-26 | ||
| US08/756,387 US5945294A (en) | 1996-11-26 | 1996-11-26 | Method to detect IgE |
| PCT/US1997/021651 WO1998023964A1 (en) | 1996-11-26 | 1997-11-24 | METHOD TO DETECT IgE |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001507792A JP2001507792A (ja) | 2001-06-12 |
| JP2001507792A5 JP2001507792A5 (enExample) | 2005-08-11 |
| JP3993245B2 true JP3993245B2 (ja) | 2007-10-17 |
Family
ID=25043243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP52673198A Expired - Lifetime JP3993245B2 (ja) | 1996-11-26 | 1997-11-24 | IgEを検出する方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (6) | US5945294A (enExample) |
| EP (1) | EP0943097B1 (enExample) |
| JP (1) | JP3993245B2 (enExample) |
| AT (1) | ATE246361T1 (enExample) |
| AU (1) | AU7411498A (enExample) |
| CA (1) | CA2270868C (enExample) |
| DE (1) | DE69723860T2 (enExample) |
| DK (1) | DK0943097T3 (enExample) |
| ES (1) | ES2205266T3 (enExample) |
| WO (1) | WO1998023964A1 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6720096A (en) * | 1995-08-09 | 1997-03-05 | Quidel Corporation | Test strip and method for one step lateral flow assay |
| US6391569B1 (en) * | 1996-09-18 | 2002-05-21 | Heska Corporation | Method to detect Dirofilaria immitis infection |
| US5945294A (en) * | 1996-11-26 | 1999-08-31 | Heska Corporation | Method to detect IgE |
| US7732163B2 (en) * | 1997-08-21 | 2010-06-08 | Board Of Trustees Of The University Of Arkansas | Extracellular serine protease |
| US6057127A (en) * | 1998-01-29 | 2000-05-02 | Heska Corporation | Equine Fc epsilon receptor alpha chain nucleic acid molecules and uses thereof |
| WO1999051988A1 (en) * | 1998-04-08 | 1999-10-14 | Heska Corporation | Method to detect biologically active, allergen-specific immunoglobulins |
| US6504013B1 (en) | 2000-02-01 | 2003-01-07 | Idexx Laboratories, Inc. | Canine allergy therapeutic recombinant chimeric anti-IgE monoclonal antibody |
| US7759133B2 (en) * | 1998-12-22 | 2010-07-20 | Alk-Abello A/S | Method of detecting and/or quantifying a specific IgE antibody in a liquid sample |
| WO2001004310A1 (en) * | 1999-07-13 | 2001-01-18 | Heska Corporation | Fc EPSILON RECEPTOR-LUMINESCENCE INDUCING PROTEIN CHIMERIC NUCLEIC ACID MOLECULES, FUSION PROTEINS AND USES THEREOF |
| JP2003506074A (ja) * | 1999-08-09 | 2003-02-18 | ジェネッサンス ファーマシューティカルズ,インコーポレイティド | 薬剤標的同質遺伝子:免疫グロブリンe受容体ialphaサブユニット遺伝子における多型 |
| WO2001029078A2 (en) * | 1999-10-15 | 2001-04-26 | Heska Corporation | Method for production and use of mite group 1 proteins |
| US6889145B1 (en) | 2000-03-15 | 2005-05-03 | Northwestern University | Three-dimensional model of a Fc region of an IgE antibody and uses thereof |
| EP1195606A1 (en) * | 2000-10-03 | 2002-04-10 | VBC-Genomics Forschungsges.m.b.H. | Allergen-microarray assay |
| US7288381B2 (en) * | 2000-12-29 | 2007-10-30 | Phadia Ab | Group 2 allergen specific IgE-Fabs and use thereof |
| WO2002066602A2 (en) * | 2001-01-03 | 2002-08-29 | Heska Corporation | Detection of allergen-specific ige |
| US7265208B2 (en) * | 2001-05-01 | 2007-09-04 | The Regents Of The University Of California | Fusion molecules and treatment of IgE-mediated allergic diseases |
| US8323903B2 (en) | 2001-10-12 | 2012-12-04 | Life Technologies Corporation | Antibody complexes and methods for immunolabeling |
| US20050069962A1 (en) | 2001-10-12 | 2005-03-31 | Archer Robert M | Antibody complexes and methods for immunolabeling |
| US20030157555A1 (en) * | 2002-01-14 | 2003-08-21 | Lipps Binie V. | Diagnosis and treatment for immunoglobulin E ( IgE) implicated disorders |
| US20040236090A1 (en) * | 2002-03-08 | 2004-11-25 | Shubhada Godbola | Methods and materials relating to fibulin like polypeptides and polynucleotides |
| JP2004286737A (ja) * | 2003-03-04 | 2004-10-14 | Sanyo Chem Ind Ltd | p16遺伝子ファミリーに含まれる癌抑制遺伝子の産物に対する自己抗体を検出するための免疫測定用試薬 |
| EP2360475B1 (en) * | 2003-03-27 | 2019-10-02 | Children's Hospital Medical Center | A method and kit for detecting the early onset of renal tubular cell injury |
| US20050053615A1 (en) * | 2003-07-16 | 2005-03-10 | Best Elaine A. | Variants of mite group 1 allergens for the treatment of house dust mite allergy |
| US20050026881A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anti-IgE antibody for treatment of asthma or chronic obstructive pulmonary disease |
| US20090263381A1 (en) * | 2003-07-31 | 2009-10-22 | Robinson Cynthia B | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anti-ige antibody for treatment of asthma or chronic obstructive pulmonary disease |
| DE102004005710A1 (de) * | 2004-02-05 | 2006-05-04 | Siemens Ag | Biosensor und Verfahren zu dessen Betrieb |
| DE102004005711A1 (de) * | 2004-02-05 | 2006-05-11 | Siemens Ag | Biosensor zur Bestimmung eines Allergenes mit Betriebsverfahren |
| US20050272101A1 (en) * | 2004-06-07 | 2005-12-08 | Prasad Devarajan | Method for the early detection of renal injury |
| US7629127B2 (en) * | 2005-01-21 | 2009-12-08 | Dexall Biomedical Labs, Inc. | Method for the visual detection of specific antibodies by the use of lateral flow assays |
| US20070037232A1 (en) * | 2005-03-31 | 2007-02-15 | Barasch Jonathan M | Detection of NGAL in chronic renal disease |
| WO2006124866A2 (en) * | 2005-05-13 | 2006-11-23 | The Johns Hopkins University | Free human serum ige immunoenzymetric assay and methods of use |
| US20080090304A1 (en) * | 2006-10-13 | 2008-04-17 | Barasch Jonathan Matthew | Diagnosis and monitoring of chronic renal disease using ngal |
| DE602005015981D1 (de) * | 2005-10-17 | 2009-09-24 | Pls Design Gmbh | Chimäre zwischen einer alpha-Kette eines humanen IgE Rezeptor und konstanten Immunoglobulin-Domänen von Vögeln zur Determination von Serum IgE. |
| DE102005057920A1 (de) * | 2005-12-02 | 2007-06-28 | Strohner, Pavel, Dr. | Immunoassay zur simultanen immunchemischen Bestimmung eines Analyten (Antigen) und eines gegen den Analyten gerichteten Therapieantikörpers in Proben |
| JP4942018B2 (ja) * | 2006-04-28 | 2012-05-30 | 生化学工業株式会社 | 抗アカラン硫酸抗体とその応用 |
| US20080003696A1 (en) * | 2006-06-30 | 2008-01-03 | Andrew Rae | Embossed reagent card |
| WO2008028068A2 (en) * | 2006-08-30 | 2008-03-06 | Genentech, Inc. | NON-HUMAN PRIMATE FCεR1α POLYPEPTIDES |
| EP2287607B1 (en) * | 2008-05-12 | 2018-08-22 | Riken | Method for quantification of antigen-specific canine or human ige |
| US10585098B2 (en) | 2009-11-23 | 2020-03-10 | The Johns Hopkins University | Optimizing diagnostics for galactofuranose containing antigens |
| WO2011063395A2 (en) | 2009-11-23 | 2011-05-26 | The Johns Hopkins University | Lateral flow device for diagnosing microbial infections |
| US8927695B2 (en) | 2010-03-30 | 2015-01-06 | The Board Of Trustees Of The Leland Stanford Junior University | Protein-based assays for screening of the IgE-receptor interaction |
| US10107822B2 (en) | 2013-12-16 | 2018-10-23 | The Johns Hopkins University | Interferon-gamma release assays for diagnosis of invasive fungal infections |
| US10900965B2 (en) * | 2015-08-24 | 2021-01-26 | University Of Cincinnati | Methods and compositions for the detection of Fc receptor binding activity of antibodies |
| CN110297095A (zh) * | 2019-07-26 | 2019-10-01 | 四川农业大学 | 一种昆虫致敏蛋白的筛选方法 |
| EP4306956A1 (de) * | 2022-07-15 | 2024-01-17 | Justus-Liebig-Universität Gießen | Verfahren zum in-vitro nachweis antigen-spezifischer ige verursacht durch eine infektion mit parasiten oder pilzen |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4208479A (en) * | 1977-07-14 | 1980-06-17 | Syva Company | Label modified immunoassays |
| US4962035A (en) * | 1987-12-01 | 1990-10-09 | President And Fellows Of Harvard College | DNA encoding IgE receptor alpha-subunit or fragment thereof |
| CA2000878C (en) * | 1988-10-18 | 1999-06-29 | Jean-Pierre Kinet | Cdnas coding for the subunit of the high-affinity receptor for immunoglobulin e |
| WO1991006570A1 (en) * | 1989-10-25 | 1991-05-16 | The University Of Melbourne | HYBRID Fc RECEPTOR MOLECULES |
| US5091318A (en) * | 1990-04-13 | 1992-02-25 | Abbott Laboratories | Binding of allergens to a solid phase |
| JPH05113443A (ja) * | 1991-04-26 | 1993-05-07 | Toray Ind Inc | 酵素免疫測定方法 |
| US5770396A (en) * | 1992-04-16 | 1998-06-23 | The United States Of America As Represented By The Department Of Health And Human Services | Isolation characterization, and use of the human beta subunit of the high affinity receptor for immunoglobulin E |
| JPH0772150A (ja) * | 1993-09-02 | 1995-03-17 | Tonen Corp | IgEの測定方法 |
| JPH0792167A (ja) * | 1993-09-24 | 1995-04-07 | Kinki Univ | IgE吸着材 |
| GB9526599D0 (en) * | 1995-12-28 | 1996-02-28 | Sandoz Ltd | Elisa test system |
| US5945294A (en) * | 1996-11-26 | 1999-08-31 | Heska Corporation | Method to detect IgE |
| US6060326A (en) * | 1997-04-07 | 2000-05-09 | Heska Corporation | Method to detect canine IgE and kit therefor |
-
1996
- 1996-11-26 US US08/756,387 patent/US5945294A/en not_active Expired - Lifetime
-
1997
- 1997-11-24 WO PCT/US1997/021651 patent/WO1998023964A1/en not_active Ceased
- 1997-11-24 AU AU74114/98A patent/AU7411498A/en not_active Abandoned
- 1997-11-24 EP EP97949625A patent/EP0943097B1/en not_active Expired - Lifetime
- 1997-11-24 AT AT97949625T patent/ATE246361T1/de not_active IP Right Cessation
- 1997-11-24 DK DK97949625T patent/DK0943097T3/da active
- 1997-11-24 ES ES97949625T patent/ES2205266T3/es not_active Expired - Lifetime
- 1997-11-24 JP JP52673198A patent/JP3993245B2/ja not_active Expired - Lifetime
- 1997-11-24 DE DE69723860T patent/DE69723860T2/de not_active Expired - Lifetime
- 1997-11-24 CA CA002270868A patent/CA2270868C/en not_active Expired - Lifetime
-
1999
- 1999-03-31 US US09/285,873 patent/US6309832B1/en not_active Expired - Lifetime
-
2001
- 2001-08-30 US US09/944,277 patent/US6682894B2/en not_active Expired - Lifetime
-
2004
- 2004-01-23 US US10/763,400 patent/US20040214209A1/en not_active Abandoned
-
2005
- 2005-12-16 US US11/305,447 patent/US7195767B2/en not_active Expired - Fee Related
-
2007
- 2007-03-08 US US11/683,854 patent/US7691384B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7691384B2 (en) | 2010-04-06 |
| ATE246361T1 (de) | 2003-08-15 |
| ES2205266T3 (es) | 2004-05-01 |
| US5945294A (en) | 1999-08-31 |
| US20070218565A1 (en) | 2007-09-20 |
| AU7411498A (en) | 1998-06-22 |
| EP0943097A1 (en) | 1999-09-22 |
| JP2001507792A (ja) | 2001-06-12 |
| CA2270868A1 (en) | 1998-06-04 |
| EP0943097B1 (en) | 2003-07-30 |
| US20040214209A1 (en) | 2004-10-28 |
| CA2270868C (en) | 2006-01-24 |
| WO1998023964A1 (en) | 1998-06-04 |
| US7195767B2 (en) | 2007-03-27 |
| US20060099659A1 (en) | 2006-05-11 |
| DE69723860D1 (de) | 2003-09-04 |
| DE69723860T2 (de) | 2004-06-03 |
| US20020034771A1 (en) | 2002-03-21 |
| US6309832B1 (en) | 2001-10-30 |
| DK0943097T3 (da) | 2003-11-24 |
| US6682894B2 (en) | 2004-01-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP3993245B2 (ja) | IgEを検出する方法 | |
| JP6861771B2 (ja) | 腎疾患のためのマーカー | |
| Peng et al. | Production and characterization of monoclonal antibodies to two new mosquito Aedes aegypti salivary proteins | |
| JP2011232361A (ja) | 動物において早期腎疾患を検出する方法 | |
| US6060326A (en) | Method to detect canine IgE and kit therefor | |
| US20100209947A1 (en) | Free human serum IgE immunoenzymetric assay and methods of use | |
| JP2018507703A (ja) | ユニバーサル抗体媒介バイオセンサー | |
| JP2001502896A (ja) | イヌ糸状虫感染を検出する方法 | |
| AU780041B2 (en) | Organ transplant rejection and associated conditions | |
| EP0950104B1 (en) | NOVEL FELINE Fc EPSILON RECEPTOR ALPHA CHAIN NUCLEIC ACID MOLECULES, PROTEINS AND USES THEREOF | |
| US7897153B1 (en) | Chimera of human IgE receptor α-chain and avian constant immuno-globulin domains for the determination of serum IgE | |
| CA2319310A1 (en) | Equine fc epsilon receptor alpha chain nucleic acid molecules, corresponding proteins and uses thereof | |
| EP2287607B1 (en) | Method for quantification of antigen-specific canine or human ige | |
| AU769954B2 (en) | Method to detect IgE | |
| WO1999051988A1 (en) | Method to detect biologically active, allergen-specific immunoglobulins | |
| US4868107A (en) | Method for detecting antibodies against neuropeptides and drugs in human body fluid |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20041124 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20041124 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20051018 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20060113 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20060307 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20060607 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20060724 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20060904 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20061031 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20070131 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20070402 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20070426 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20070626 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20070726 |
|
| R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20100803 Year of fee payment: 3 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20110803 Year of fee payment: 4 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20110803 Year of fee payment: 4 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20120803 Year of fee payment: 5 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130803 Year of fee payment: 6 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| EXPY | Cancellation because of completion of term |