JP3819032B2 - 組織およびその他のランダム媒体における蛍光寿命に基づく撮像および分光分析 - Google Patents

組織およびその他のランダム媒体における蛍光寿命に基づく撮像および分光分析 Download PDF

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Publication number
JP3819032B2
JP3819032B2 JP51047197A JP51047197A JP3819032B2 JP 3819032 B2 JP3819032 B2 JP 3819032B2 JP 51047197 A JP51047197 A JP 51047197A JP 51047197 A JP51047197 A JP 51047197A JP 3819032 B2 JP3819032 B2 JP 3819032B2
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fluorescence
tissue
light
emission
excitation
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JP2000500228A (ja
JP2000500228A5 (OSRAM
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セヴィック−ムラカ，エヴァ・エム
パイサンカー，ディリップ・ワイ
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Texas A&M University
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G01J3/4406—Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
JP51047197A 1995-08-24 1996-08-23 組織およびその他のランダム媒体における蛍光寿命に基づく撮像および分光分析 Expired - Lifetime JP3819032B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US274695P 1995-08-24 1995-08-24
US60/002,746 1995-08-24
PCT/US1996/013658 WO1997008538A1 (en) 1995-08-24 1996-08-23 Fluorescence lifetime-based imaging and spectroscopy in tissues and other random media

Publications (3)

Publication Number Publication Date
JP2000500228A JP2000500228A (ja) 2000-01-11
JP2000500228A5 JP2000500228A5 (OSRAM) 2004-09-09
JP3819032B2 true JP3819032B2 (ja) 2006-09-06

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JP51047197A Expired - Lifetime JP3819032B2 (ja) 1995-08-24 1996-08-23 組織およびその他のランダム媒体における蛍光寿命に基づく撮像および分光分析

Country Status (9)

Country Link
US (1) US5865754A (OSRAM)
EP (1) EP0846262A4 (OSRAM)
JP (1) JP3819032B2 (OSRAM)
CN (1) CN1200174A (OSRAM)
AU (1) AU1130797A (OSRAM)
CA (1) CA2230228C (OSRAM)
MX (1) MX9801351A (OSRAM)
NO (1) NO980750L (OSRAM)
WO (1) WO1997008538A1 (OSRAM)

Families Citing this family (267)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5353799A (en) * 1991-01-22 1994-10-11 Non Invasive Technology, Inc. Examination of subjects using photon migration with high directionality techniques
US6304771B1 (en) * 1993-10-29 2001-10-16 The Trustees Of The University Of Pennsylvania Systems and methods for imaging fluorophores
US5919140A (en) * 1995-02-21 1999-07-06 Massachusetts Institute Of Technology Optical imaging using time gated scattered light
US7328059B2 (en) * 1996-08-23 2008-02-05 The Texas A & M University System Imaging of light scattering tissues with fluorescent contrast agents
US6766183B2 (en) 1995-11-22 2004-07-20 Medtronic Minimed, Inc. Long wave fluorophore sensor compounds and other fluorescent sensor compounds in polymers
US6571119B2 (en) 1996-03-06 2003-05-27 Fuji Photo Film Co., Ltd. Fluorescence detecting apparatus
JP3796635B2 (ja) * 1996-03-06 2006-07-12 富士写真フイルム株式会社 蛍光検出装置
US6525862B2 (en) * 1996-10-30 2003-02-25 Photogen, Inc. Methods and apparatus for optical imaging
EP0983501A1 (en) 1996-11-08 2000-03-08 Purdue Research Foundation Particle analysis system and method
US5952664A (en) * 1997-01-17 1999-09-14 Imaging Diagnostic Systems, Inc. Laser imaging apparatus using biomedical markers that bind to cancer cells
US5963658A (en) * 1997-01-27 1999-10-05 University Of North Carolina Method and apparatus for detecting an abnormality within a host medium
US7865230B1 (en) 1997-02-07 2011-01-04 Texas A&M University System Method and system for detecting sentinel lymph nodes
US6208886B1 (en) * 1997-04-04 2001-03-27 The Research Foundation Of City College Of New York Non-linear optical tomography of turbid media
US6124597A (en) * 1997-07-07 2000-09-26 Cedars-Sinai Medical Center Method and devices for laser induced fluorescence attenuation spectroscopy
US6422994B1 (en) * 1997-09-24 2002-07-23 Olympus Optical Co., Ltd. Fluorescent diagnostic system and method providing color discrimination enhancement
DE69938493T2 (de) * 1998-01-26 2009-05-20 Massachusetts Institute Of Technology, Cambridge Endoskop zur erfassung von fluoreszenzbilder
US6592847B1 (en) 1998-05-14 2003-07-15 The General Hospital Corporation Intramolecularly-quenched near infrared flourescent probes
US6059820A (en) 1998-10-16 2000-05-09 Paradigm Medical Corporation Tissue cooling rod for laser surgery
US7107116B2 (en) 1999-03-29 2006-09-12 Genex Technologies, Inc. Diffuse optical tomography system and method of use
CN1325022C (zh) * 1999-04-01 2007-07-11 成象诊断系统公司 使用约束肿瘤细胞的生化标记的激光成像装置
US6167297A (en) * 1999-05-05 2000-12-26 Benaron; David A. Detecting, localizing, and targeting internal sites in vivo using optical contrast agents
WO2001020306A1 (en) * 1999-09-14 2001-03-22 The Research Foundation Of State University Of New York System and method for tomographic imaging of dynamic properties of a scattering medium
US6795195B1 (en) * 1999-09-14 2004-09-21 Research Foundation Of State University Of New York System and method for tomographic imaging of dynamic properties of a scattering medium
US20050182434A1 (en) 2000-08-11 2005-08-18 National Research Council Of Canada Method and apparatus for performing intra-operative angiography
US6915154B1 (en) 1999-09-24 2005-07-05 National Research Council Of Canada Method and apparatus for performing intra-operative angiography
US7054002B1 (en) 1999-10-08 2006-05-30 The Texas A&M University System Characterization of luminescence in a scattering medium
US7006676B1 (en) 2000-01-21 2006-02-28 Medical Optical Imaging, Inc. Method and apparatus for detecting an abnormality within a host medium utilizing frequency-swept modulation diffusion tomography
US20010032053A1 (en) * 2000-01-24 2001-10-18 Hielscher Andreas H. Imaging of a scattering medium using the equation of radiative transfer
EP1257192A1 (en) * 2000-02-18 2002-11-20 Argose, Inc. Generation of spatially-averaged excitation-emission map in heterogeneous tissue
WO2001092859A1 (en) * 2000-06-02 2001-12-06 Medicometrics Aps Method and system for classifying a biological sample
US6748259B1 (en) 2000-06-15 2004-06-08 Spectros Corporation Optical imaging of induced signals in vivo under ambient light conditions
US6587703B2 (en) 2000-09-18 2003-07-01 Photonify Technologies, Inc. System and method for measuring absolute oxygen saturation
US6801648B2 (en) * 2000-08-04 2004-10-05 Xuefeng Cheng Optical imaging system with symmetric optical probe
US6597931B1 (en) 2000-09-18 2003-07-22 Photonify Technologies, Inc. System and method for absolute oxygen saturation
US6516209B2 (en) 2000-08-04 2003-02-04 Photonify Technologies, Inc. Self-calibrating optical imaging system
WO2002028273A2 (en) 2000-10-06 2002-04-11 Yang Victor X D Multi-spectral fluorescence imaging and spectroscopy device
DE60141090D1 (de) * 2000-10-30 2010-03-04 Gen Hospital Corp Optische systeme zur gewebeanalyse
US9295391B1 (en) 2000-11-10 2016-03-29 The General Hospital Corporation Spectrally encoded miniature endoscopic imaging probe
US6615063B1 (en) * 2000-11-27 2003-09-02 The General Hospital Corporation Fluorescence-mediated molecular tomography
US7383076B2 (en) * 2000-11-27 2008-06-03 The General Hospital Corporation Fluorescence-mediated molecular tomography
US6826424B1 (en) * 2000-12-19 2004-11-30 Haishan Zeng Methods and apparatus for fluorescence and reflectance imaging and spectroscopy and for contemporaneous measurements of electromagnetic radiation with multiple measuring devices
US20030044353A1 (en) * 2001-01-05 2003-03-06 Ralph Weissleder Activatable imaging probes
US6609015B2 (en) * 2001-01-18 2003-08-19 Koninklijke Philips Electronics N.V. Analysis of a composition
AU2002251944A1 (en) * 2001-02-15 2002-09-04 Medtronic Minimed, Inc. Polymers functionalized with fluorescent boronate motifs
NO325061B1 (no) * 2001-03-06 2008-01-28 Photosense As Fremgangsmate og arrangement for bestemmelse av den optiske egenskap av et multisjiktvev
US6930777B1 (en) * 2001-04-03 2005-08-16 The Texas A&M University System Method for characterizing particles in suspension from frequency domain photon migration measurements
EP1390714A2 (en) * 2001-04-03 2004-02-25 THE TEXAS A & M UNIVERSITY SYSTEMS Method for characterising particles in suspension from frequency domain photon migration measurements
EP2333522A1 (en) * 2001-04-30 2011-06-15 The General Hospital Corporation Method and apparatus for improving image clarity and sensitivity in optical coherence tomography using dynamic feedback to control focal properties and coherence gating
US7865231B2 (en) * 2001-05-01 2011-01-04 The General Hospital Corporation Method and apparatus for determination of atherosclerotic plaque type by measurement of tissue optical properties
ATE336717T1 (de) 2001-05-17 2006-09-15 Xenogen Corp Verfahren und vorrichtung zur feststellung von zieltiefe, helligkeit und grösse in einer körperregion
US7116354B2 (en) 2001-06-20 2006-10-03 Xenogen Corporation Absolute intensity determination for a light source in low level light imaging systems
US7298415B2 (en) * 2001-07-13 2007-11-20 Xenogen Corporation Structured light imaging apparatus
US7045361B2 (en) 2001-09-12 2006-05-16 Medtronic Minimed, Inc. Analyte sensing via acridine-based boronate biosensors
US6980299B1 (en) 2001-10-16 2005-12-27 General Hospital Corporation Systems and methods for imaging a sample
US20040082940A1 (en) * 2002-10-22 2004-04-29 Michael Black Dermatological apparatus and method
US20030216719A1 (en) * 2001-12-12 2003-11-20 Len Debenedictis Method and apparatus for treating skin using patterns of optical energy
US20030109860A1 (en) * 2001-12-12 2003-06-12 Michael Black Multiple laser treatment
US20050049582A1 (en) * 2001-12-12 2005-03-03 Debenedictis Leonard C. Method and apparatus for fractional photo therapy of skin
US20030109787A1 (en) * 2001-12-12 2003-06-12 Michael Black Multiple laser diagnostics
EP1468245B1 (en) * 2002-01-11 2011-03-30 The General Hospital Corporation Apparatus for OCT imaging with axial line focus for improved resolution and depth of field
US7355716B2 (en) * 2002-01-24 2008-04-08 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
US7649185B2 (en) * 2002-02-06 2010-01-19 Xenogen Corporation Fluorescent phantom device
US7629573B2 (en) * 2002-02-06 2009-12-08 Xenogen Corporation Tissue phantom calibration device for low level light imaging systems
US20110201924A1 (en) * 2002-04-30 2011-08-18 The General Hospital Corporation Method and Apparatus for Improving Image Clarity and Sensitivity in Optical Tomography Using Dynamic Feedback to Control Focal Properties and Coherence Gating
EP1514093B1 (en) 2002-06-04 2021-04-28 Visen Medical, Inc. Imaging volumes with arbitrary geometries in non-contact tomography
US7616985B2 (en) * 2002-07-16 2009-11-10 Xenogen Corporation Method and apparatus for 3-D imaging of internal light sources
US7599731B2 (en) * 2002-07-16 2009-10-06 Xenogen Corporation Fluorescent light tomography
ES2646622T3 (es) * 2002-07-31 2017-12-14 Premium Genetics (Uk) Limited Sistema y método de clasificación de materiales usando dirección de láser holográfica
DE10255013B4 (de) * 2002-11-25 2004-12-09 Siemens Ag Verfahren und Vorrichtung zur Lokalisierung von Licht emittierenden Bereichen
US7297962B2 (en) * 2003-01-23 2007-11-20 Horiba Jobin Yvon, Inc. Method for performing spacially coordinated high speed fluorometric measurements
US7582882B2 (en) * 2003-01-23 2009-09-01 Horiba Jobin Yvon, Inc. Solid state multi frequency fluorometric measurements system and method
US7317194B2 (en) * 2003-01-23 2008-01-08 Horiba Jobin Yuon, Inc. Microscope for performing multiple frequency fluorometric measurements
US7643153B2 (en) * 2003-01-24 2010-01-05 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
CN1741768A (zh) * 2003-01-24 2006-03-01 通用医疗有限公司 利用低相干干涉测量法识别组织的系统和方法
WO2004072906A1 (en) * 2003-02-05 2004-08-26 The General Hospital Corporation Method and system for free space optical tomography of diffuse media
DE602004006396T2 (de) * 2003-03-18 2008-01-10 Koninklijke Philips Electronics N.V. Analyse einer zusammenstellung mit beobachtung
JP4769580B2 (ja) * 2003-03-27 2011-09-07 ザ ジェネラル ホスピタル コーポレイション 皮膚科的処置及び部分的な皮膚の表面再形成のための装置
EP1611470B1 (en) * 2003-03-31 2015-10-14 The General Hospital Corporation Speckle reduction in optical coherence tomography by path length encoded angular compounding
WO2004090786A2 (en) * 2003-04-04 2004-10-21 Lumidigm, Inc. Multispectral biometric sensor
US7181219B2 (en) 2003-05-22 2007-02-20 Lucent Technologies Inc. Wireless handover using anchor termination
EP2280260B1 (en) 2003-06-06 2017-03-08 The General Hospital Corporation Process and apparatus for a wavelength tuned light source
CA2533621C (en) * 2003-06-20 2013-12-10 The Texas A & M University System Method and system for near-infrared fluorescence contrast-enhanced imaging with area illumination and area detection
WO2005002425A2 (en) * 2003-07-02 2005-01-13 U.S. Government As Represented By The Secretary Of The Army Wearable tissue viability diagnostic unit
US7920908B2 (en) 2003-10-16 2011-04-05 David Hattery Multispectral imaging for quantitative contrast of functional and structural features of layers inside optically dense media such as tissue
CN1875242A (zh) 2003-10-27 2006-12-06 通用医疗公司 用于使用频域干涉测量法进行光学成像的方法和设备
EP1687587B1 (en) * 2003-11-28 2020-01-08 The General Hospital Corporation Method and apparatus for three-dimensional spectrally encoded imaging
US7330032B2 (en) * 2003-12-30 2008-02-12 The Mitre Corporation Techniques for building-scale electrostatic tomography
US20050165427A1 (en) * 2004-01-22 2005-07-28 Jahns Scott E. Vessel sealing devices
US8353896B2 (en) * 2004-04-19 2013-01-15 The Invention Science Fund I, Llc Controllable release nasal system
US9011329B2 (en) 2004-04-19 2015-04-21 Searete Llc Lumenally-active device
US8512219B2 (en) * 2004-04-19 2013-08-20 The Invention Science Fund I, Llc Bioelectromagnetic interface system
US8337482B2 (en) * 2004-04-19 2012-12-25 The Invention Science Fund I, Llc System for perfusion management
US8024036B2 (en) * 2007-03-19 2011-09-20 The Invention Science Fund I, Llc Lumen-traveling biological interface device and method of use
US20070244520A1 (en) * 2004-04-19 2007-10-18 Searete Llc Lumen-traveling biological interface device and method of use
US8092549B2 (en) * 2004-09-24 2012-01-10 The Invention Science Fund I, Llc Ciliated stent-like-system
US8361013B2 (en) * 2004-04-19 2013-01-29 The Invention Science Fund I, Llc Telescoping perfusion management system
US20050234440A1 (en) * 2004-04-19 2005-10-20 Searete Llc, A Limited Liability Corporation Of The State Of Delaware System with a sensor for perfusion management
US20070010868A1 (en) * 2004-04-19 2007-01-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Lumenally-active device
DE102004024494B4 (de) * 2004-05-16 2019-10-17 Dürr Dental SE Medizinische Kamera
WO2005117534A2 (en) 2004-05-29 2005-12-15 The General Hospital Corporation Process, system and software arrangement for a chromatic dispersion compensation using reflective layers in optical coherence tomography (oct) imaging
US7413572B2 (en) * 2004-06-14 2008-08-19 Reliant Technologies, Inc. Adaptive control of optical pulses for laser medicine
JP4995720B2 (ja) 2004-07-02 2012-08-08 ザ ジェネラル ホスピタル コーポレイション ダブルクラッドファイバを有する内視鏡撮像プローブ
US20060217788A1 (en) * 2004-07-09 2006-09-28 Herron G S Method of using laser induced injury to activate topical prodrugs
US8081316B2 (en) 2004-08-06 2011-12-20 The General Hospital Corporation Process, system and software arrangement for determining at least one location in a sample using an optical coherence tomography
WO2006024015A1 (en) 2004-08-24 2006-03-02 The General Hospital Corporation Method and apparatus for imaging of vessel segments
EP1793730B1 (en) * 2004-08-24 2011-12-28 The General Hospital Corporation Process, system and software arrangement for determining elastic modulus
KR101269455B1 (ko) * 2004-09-10 2013-05-30 더 제너럴 하스피탈 코포레이션 광 간섭 영상화를 위한 시스템 및 방법
WO2006037132A1 (en) 2004-09-29 2006-04-06 The General Hospital Corporation System and method for optical coherence imaging
US20060122584A1 (en) * 2004-10-27 2006-06-08 Bommannan D B Apparatus and method to treat heart disease using lasers to form microchannels
WO2006050320A2 (en) * 2004-10-29 2006-05-11 The General Hospital Corporation Polarization-sensitive optical coherence tomography
WO2006050453A1 (en) * 2004-11-02 2006-05-11 The General Hospital Corporation Fiber-optic rotational device, optical system and method for imaging a sample
EP1825214A1 (en) * 2004-11-24 2007-08-29 The General Hospital Corporation Common-path interferometer for endoscopic oct
WO2006058346A1 (en) * 2004-11-29 2006-06-01 The General Hospital Corporation Arrangements, devices, endoscopes, catheters and methods for performing optical imaging by simultaneously illuminating and detecting multiple points on a sample
US7966051B2 (en) * 2005-01-11 2011-06-21 Olympus Corporation Fluorescent agent concentration measuring apparatus, dose control apparatus, administration system, fluorescent agent concentration measuring method, and dose control method
US7729750B2 (en) * 2005-01-20 2010-06-01 The Regents Of The University Of California Method and apparatus for high resolution spatially modulated fluorescence imaging and tomography
JP2008538612A (ja) * 2005-04-22 2008-10-30 ザ ジェネラル ホスピタル コーポレイション スペクトルドメイン偏光感受型光コヒーレンストモグラフィを提供することの可能な構成、システム、及び方法
US20060239921A1 (en) 2005-04-26 2006-10-26 Novadaq Technologies Inc. Real time vascular imaging during solid organ transplant
EP2325803A1 (en) 2005-04-28 2011-05-25 The General Hospital Corporation Evaluating optical coherence tomography information for an anatomical structure
US8044996B2 (en) * 2005-05-11 2011-10-25 Xenogen Corporation Surface construction using combined photographic and structured light information
US20070009935A1 (en) * 2005-05-13 2007-01-11 The General Hospital Corporation Arrangements, systems and methods capable of providing spectral-domain optical coherence reflectometry for a sensitive detection of chemical and biological sample
US7859679B2 (en) * 2005-05-31 2010-12-28 The General Hospital Corporation System, method and arrangement which can use spectral encoding heterodyne interferometry techniques for imaging
WO2006130802A2 (en) * 2005-06-01 2006-12-07 The General Hospital Corporation Apparatus, method and system for performing phase-resolved optical frequency domain imaging
CN101238347B (zh) * 2005-08-09 2011-05-25 通用医疗公司 执行光学相干层析术中的基于偏振的正交解调的设备、方法和存储介质
US20070049833A1 (en) * 2005-08-16 2007-03-01 The General Hospital Corporation Arrangements and methods for imaging in vessels
JP2009506835A (ja) * 2005-08-29 2009-02-19 リライアント・テクノロジーズ・インコーポレイテッド 熱誘起組織治療を監視し制御する方法および装置
US20070049996A1 (en) * 2005-08-29 2007-03-01 Reliant Technologies, Inc. Monitoring Method and Apparatus for Fractional Photo-Therapy Treatment
US20070122344A1 (en) 2005-09-02 2007-05-31 University Of Rochester Medical Center Office Of Technology Transfer Intraoperative determination of nerve location
EP1940286A1 (en) 2005-09-29 2008-07-09 General Hospital Corporation Method and apparatus for method for viewing and analyzing of one or more biological samples with progressively increasing resolutions
EP1945094B1 (en) * 2005-10-14 2018-09-05 The General Hospital Corporation Spectral- and frequency- encoded fluorescence imaging
US20070178067A1 (en) * 2005-11-09 2007-08-02 John Maier System and method for cytological analysis by raman spectroscopic imaging
JP2009515583A (ja) * 2005-11-10 2009-04-16 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 光学蛍光断層撮影のための吸収及び散乱マップ再構成
ATE426154T1 (de) * 2005-11-23 2009-04-15 Koninkl Philips Electronics Nv Vorrichtung zur abbildung des inneren eines truben mediums
CN101312684A (zh) * 2005-11-25 2008-11-26 皇家飞利浦电子股份有限公司 光学荧光断层摄影
JP5680826B2 (ja) * 2006-01-10 2015-03-04 ザ ジェネラル ホスピタル コーポレイション １以上のスペクトルを符号化する内視鏡技術によるデータ生成システム
US8145018B2 (en) 2006-01-19 2012-03-27 The General Hospital Corporation Apparatus for obtaining information for a structure using spectrally-encoded endoscopy techniques and methods for producing one or more optical arrangements
EP2289398A3 (en) 2006-01-19 2011-04-06 The General Hospital Corporation Methods and systems for optical imaging of epithelial luminal organs by beam scanning thereof
US20070223006A1 (en) * 2006-01-19 2007-09-27 The General Hospital Corporation Systems and methods for performing rapid fluorescence lifetime, excitation and emission spectral measurements
WO2007084933A2 (en) * 2006-01-20 2007-07-26 The General Hospital Corporation Systems and processes for providing endogenous molecular imaging with mid-infared light
CN101370426A (zh) * 2006-01-20 2009-02-18 通用医疗公司 利用对光学相干断层扫描的波阵面调制来提供散斑减少的系统、装置和过程
WO2007084959A1 (en) * 2006-01-20 2007-07-26 The General Hospital Corporation Systems and methods for providing mirror tunnel microscopy
US9186066B2 (en) * 2006-02-01 2015-11-17 The General Hospital Corporation Apparatus for applying a plurality of electro-magnetic radiations to a sample
JP5524487B2 (ja) * 2006-02-01 2014-06-18 ザ ジェネラル ホスピタル コーポレイション コンフォーマルレーザ治療手順を用いてサンプルの少なくとも一部分に電磁放射を放射する方法及びシステム。
JP2009537024A (ja) * 2006-02-01 2009-10-22 ザ ジェネラル ホスピタル コーポレイション 少なくとも一つのファイバの少なくとも二つの部位の少なくとも一つを制御する装置
WO2007092911A2 (en) 2006-02-08 2007-08-16 The General Hospital Corporation Methods, arrangements and systems for obtaining information associated with an anatomical sample using optical microscopy
JP2009527770A (ja) * 2006-02-24 2009-07-30 ザ ジェネラル ホスピタル コーポレイション 角度分解型のフーリエドメイン光干渉断層撮影法を遂行する方法及びシステム
EP1991313A2 (en) * 2006-03-01 2008-11-19 The General Hospital Corporation System and method for providing cell specific laser therapy of atherosclerotic plaques by targeting light absorbers in macrophages
WO2007109540A2 (en) * 2006-03-17 2007-09-27 The General Hospital Corporation Arrangement, method and computer-accessible medium for identifying characteristics of at least a portion of a blood vessel contained within a tissue using spectral domain low coherence interferometry
EP2004041B1 (en) * 2006-04-05 2013-11-06 The General Hospital Corporation Methods, arrangements and systems for polarization-sensitive optical frequency domain imaging of a sample
US20120035439A1 (en) 2006-04-12 2012-02-09 Bran Ferren Map-based navigation of a body tube tree by a lumen traveling device
US20080058786A1 (en) * 2006-04-12 2008-03-06 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Autofluorescent imaging and target ablation
US20080058785A1 (en) * 2006-04-12 2008-03-06 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Autofluorescent imaging and target ablation
US8755866B2 (en) * 2006-05-03 2014-06-17 Covidien Lp Method and apparatus for lymph node mapping
WO2007133961A2 (en) * 2006-05-10 2007-11-22 The General Hospital Corporation Processes, arrangements and systems for providing frequency domain imaging of a sample
US7782464B2 (en) * 2006-05-12 2010-08-24 The General Hospital Corporation Processes, arrangements and systems for providing a fiber layer thickness map based on optical coherence tomography images
DE602007008571D1 (de) * 2006-07-07 2010-09-30 Philips Intellectual Property Optisches abbildungssystem und entsprechendes verfahren
US20100165335A1 (en) * 2006-08-01 2010-07-01 The General Hospital Corporation Systems and methods for receiving and/or analyzing information associated with electro-magnetic radiation
JP2008043396A (ja) * 2006-08-11 2008-02-28 Olympus Corp 内視鏡システム
WO2008025005A2 (en) * 2006-08-24 2008-02-28 Baylor College Of Medicine Method of measuring propulsion in lymphatic structures
US10335038B2 (en) 2006-08-24 2019-07-02 Xenogen Corporation Spectral unmixing for in-vivo imaging
US10775308B2 (en) * 2006-08-24 2020-09-15 Xenogen Corporation Apparatus and methods for determining optical tissue properties
US20080050316A1 (en) * 2006-08-24 2008-02-28 Baylor College Of Medicine Molecular imaging of epithelial cells in lymph
US7920271B2 (en) * 2006-08-25 2011-04-05 The General Hospital Corporation Apparatus and methods for enhancing optical coherence tomography imaging using volumetric filtering techniques
US20080058782A1 (en) * 2006-08-29 2008-03-06 Reliant Technologies, Inc. Method and apparatus for monitoring and controlling density of fractional tissue treatments
US20110042580A1 (en) * 2006-09-06 2011-02-24 University Health Network Fluorescence quantification and image acquisition in highly turbid media
US20080161744A1 (en) 2006-09-07 2008-07-03 University Of Rochester Medical Center Pre-And Intra-Operative Localization of Penile Sentinel Nodes
JP2010503475A (ja) * 2006-09-12 2010-02-04 ザ ジェネラル ホスピタル コーポレイション 解剖学的構造における深度の評価を提供する装置、プローブ、および方法
US8838213B2 (en) 2006-10-19 2014-09-16 The General Hospital Corporation Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample, and effecting such portion(s)
WO2008060833A2 (en) 2006-10-24 2008-05-22 The Research Foundation Of State University Of New York Composition, method, system, and kit for optical electrophysiology
US20080161782A1 (en) * 2006-10-26 2008-07-03 Reliant Technologies, Inc. Micropore delivery of active substances
JP2008148791A (ja) * 2006-12-14 2008-07-03 Olympus Corp 内視鏡システム
US7911621B2 (en) 2007-01-19 2011-03-22 The General Hospital Corporation Apparatus and method for controlling ranging depth in optical frequency domain imaging
EP2104968A1 (en) * 2007-01-19 2009-09-30 The General Hospital Corporation Rotating disk reflection for fast wavelength scanning of dispersed broadband light
US20080206804A1 (en) * 2007-01-19 2008-08-28 The General Hospital Corporation Arrangements and methods for multidimensional multiplexed luminescence imaging and diagnosis
US20080234567A1 (en) * 2007-03-19 2008-09-25 The General Hospital Corporation Apparatus and method for providing a noninvasive diagnosis of internal bleeding
US20080234586A1 (en) * 2007-03-19 2008-09-25 The General Hospital Corporation System and method for providing noninvasive diagnosis of compartment syndrome using exemplary laser speckle imaging procedure
US9176319B2 (en) * 2007-03-23 2015-11-03 The General Hospital Corporation Methods, arrangements and apparatus for utilizing a wavelength-swept laser using angular scanning and dispersion procedures
US10534129B2 (en) * 2007-03-30 2020-01-14 The General Hospital Corporation System and method providing intracoronary laser speckle imaging for the detection of vulnerable plaque
US8045177B2 (en) * 2007-04-17 2011-10-25 The General Hospital Corporation Apparatus and methods for measuring vibrations using spectrally-encoded endoscopy
EP2155048B1 (en) * 2007-04-25 2014-10-15 Ruder Boskovic Institute Method for real time tumour visualisation and demarcation by means of photodynamic diagnosis
US8115919B2 (en) * 2007-05-04 2012-02-14 The General Hospital Corporation Methods, arrangements and systems for obtaining information associated with a sample using optical microscopy
US7692160B2 (en) * 2007-05-31 2010-04-06 General Electric Company Method and system of optical imaging for target detection in a scattering medium
US7812945B2 (en) * 2007-06-15 2010-10-12 Art Advanced Research Technologies Inc. Fluorescence tomography using line-by-line forward model
EP2173254A2 (en) * 2007-07-31 2010-04-14 The General Hospital Corporation Systems and methods for providing beam scan patterns for high speed doppler optical frequency domain imaging
WO2009029843A1 (en) * 2007-08-31 2009-03-05 The General Hospital Corporation System and method for self-interference fluoresence microscopy, and computer-accessible medium associated therewith
WO2009036396A1 (en) * 2007-09-14 2009-03-19 Light Sciences Oncology, Inc. Systems, devices, and methods for photoactive assisted resection
US20090073439A1 (en) * 2007-09-15 2009-03-19 The General Hospital Corporation Apparatus, computer-accessible medium and method for measuring chemical and/or molecular compositions of coronary atherosclerotic plaques in anatomical structures
JP2011500173A (ja) * 2007-10-12 2011-01-06 ザ ジェネラル ホスピタル コーポレイション 管腔解剖構造の光学イメージングのためのシステムおよびプロセス
US7933021B2 (en) * 2007-10-30 2011-04-26 The General Hospital Corporation System and method for cladding mode detection
US20090225324A1 (en) * 2008-01-17 2009-09-10 The General Hospital Corporation Apparatus for providing endoscopic high-speed optical coherence tomography
EP2732826B1 (en) 2008-01-18 2017-11-08 Visen Medical, Inc. Fluorescent imaging agents
US8406860B2 (en) 2008-01-25 2013-03-26 Novadaq Technologies Inc. Method for evaluating blush in myocardial tissue
US11123047B2 (en) 2008-01-28 2021-09-21 The General Hospital Corporation Hybrid systems and methods for multi-modal acquisition of intravascular imaging data and counteracting the effects of signal absorption in blood
US9332942B2 (en) * 2008-01-28 2016-05-10 The General Hospital Corporation Systems, processes and computer-accessible medium for providing hybrid flourescence and optical coherence tomography imaging
US20090240138A1 (en) * 2008-03-18 2009-09-24 Steven Yi Diffuse Optical Tomography System and Method of Use
US20090240139A1 (en) * 2008-03-18 2009-09-24 Steven Yi Diffuse Optical Tomography System and Method of Use
WO2009120228A1 (en) * 2008-03-24 2009-10-01 General Electric Company Image processing systems and methods for surgical applications
US20090236541A1 (en) * 2008-03-24 2009-09-24 General Electric Company System and Methods for Optical Imaging
EP2259717A1 (en) * 2008-03-27 2010-12-15 Koninklijke Philips Electronics N.V. Method for reconstructing a fluorescent image of the interior of a turbid medium and device for imaging the interior of a turbid medium
US10219742B2 (en) 2008-04-14 2019-03-05 Novadaq Technologies ULC Locating and analyzing perforator flaps for plastic and reconstructive surgery
ES2671710T3 (es) 2008-05-02 2018-06-08 Novadaq Technologies ULC Métodos para la producción y uso de eritrocitos cargados con sustancias para la observación y el tratamiento de la hemodinámica microvascular
JP5607610B2 (ja) * 2008-05-07 2014-10-15 ザ ジェネラル ホスピタル コーポレイション 構造の特徴を決定する装置、装置の作動方法およびコンピュータアクセス可能な媒体
CA3162577C (en) * 2008-05-20 2023-09-26 University Health Network Device and method for fluorescence-based imaging and monitoring
JP4575474B2 (ja) * 2008-06-11 2010-11-04 国立大学法人東京工業大学 生体組織識別装置および方法
EP2288948A4 (en) * 2008-06-20 2011-12-28 Gen Hospital Corp Fused fiber optic coupler arrangement and method for use thereof
JP5667051B2 (ja) 2008-07-14 2015-02-12 ザ ジェネラル ホスピタル コーポレイション カラー内視鏡検査のための装置
WO2010042815A2 (en) * 2008-10-09 2010-04-15 Duke University Vhh antibody fragments for use in the detection and treatment of cancer
JP5731394B2 (ja) 2008-12-10 2015-06-10 ザ ジェネラル ホスピタル コーポレイション 光サブサンプリングを通じて、光コヒーレンストモグラヒィーのイメージング深度範囲を伸ばすためのシステム、装置及び方法
JP2012515930A (ja) * 2009-01-26 2012-07-12 ザ ジェネラル ホスピタル コーポレーション 広視野の超解像顕微鏡を提供するためのシステム、方法及びコンピューターがアクセス可能な媒体
US9178330B2 (en) 2009-02-04 2015-11-03 The General Hospital Corporation Apparatus and method for utilization of a high-speed optical wavelength tuning source
WO2010105197A2 (en) 2009-03-12 2010-09-16 The General Hospital Corporation Non-contact optical system, computer-accessible medium and method for measuring at least one mechanical property of tissue using coherent speckle techniques(s)
US10492671B2 (en) 2009-05-08 2019-12-03 Novadaq Technologies ULC Near infra red fluorescence imaging for visualization of blood vessels during endoscopic harvest
US9595028B2 (en) 2009-06-08 2017-03-14 Boku, Inc. Systems and methods to add funds to an account via a mobile communication device
EP2453791B1 (en) 2009-07-14 2023-09-06 The General Hospital Corporation Apparatus for measuring flow and pressure within a vessel
US20110071403A1 (en) * 2009-09-21 2011-03-24 Board Of Regents Of The University Of Texas System Functional near-infrared fluorescence lymphatic mapping for diagnosing, accessing, monitoring and directing therapy of lymphatic disorders
US20110137178A1 (en) * 2009-10-06 2011-06-09 The General Hospital Corporation Devices and methods for imaging particular cells including eosinophils
US8518405B2 (en) 2009-10-08 2013-08-27 The University Of North Carolina At Charlotte Tumor specific antibodies and uses therefor
CN102883658B (zh) 2009-11-19 2016-06-22 调节成像公司 用于使用结构化照明经由单元件检测来分析浑浊介质的方法和设备
WO2011072055A2 (en) * 2009-12-08 2011-06-16 The General Hospital Corporation Methods and arrangements for analysis, diagnosis, and treatment monitoring of vocal folds by optical coherence tomography
LU91641B1 (en) * 2010-01-21 2011-07-22 Ct De Rech Public Gabriel Lippmann Cancerous or pre-cancerous tissue visualization method and device
WO2011109818A2 (en) * 2010-03-05 2011-09-09 The General Hospital Corporation System, methods and computer- accessible medium which provide micoscopic images of at least one anatomical structure at a particular resolution
JP5566751B2 (ja) * 2010-03-31 2014-08-06 富士フイルム株式会社 光断層情報生成装置、光強度分布算出方法および光強度分布算出プログラム
US9069130B2 (en) 2010-05-03 2015-06-30 The General Hospital Corporation Apparatus, method and system for generating optical radiation from biological gain media
US8681247B1 (en) * 2010-05-12 2014-03-25 Li-Cor, Inc. Field flattening correction method for fluorescence imaging system
US9557154B2 (en) 2010-05-25 2017-01-31 The General Hospital Corporation Systems, devices, methods, apparatus and computer-accessible media for providing optical imaging of structures and compositions
EP2575598A2 (en) 2010-05-25 2013-04-10 The General Hospital Corporation Apparatus, systems, methods and computer-accessible medium for spectral analysis of optical coherence tomography images
WO2011153434A2 (en) 2010-06-03 2011-12-08 The General Hospital Corporation Apparatus and method for devices for imaging structures in or at one or more luminal organs
GB201011913D0 (en) * 2010-07-15 2010-09-01 Lux Innovate Ltd Detecting device
EP2612200A4 (en) 2010-09-01 2015-11-25 Spectral Instr Imaging Llc EXPLORATION OF A LIGHT SOURCE ARRANGEMENT
EP2612134B1 (en) 2010-09-01 2019-10-23 Spectral Instruments Imaging, LLC Methods and systems for producing visible light and x-ray image data
CN101975769A (zh) * 2010-09-17 2011-02-16 福建师范大学 一种基于不同波长光源激发的人体组织自体荧光检测系统
JP5883018B2 (ja) 2010-10-27 2016-03-09 ザ ジェネラル ホスピタル コーポレイション 少なくとも１つの血管内部の血圧を測定するための装置、システム、および方法
WO2012149175A1 (en) 2011-04-29 2012-11-01 The General Hospital Corporation Means for determining depth-resolved physical and/or optical properties of scattering media
JP2014523536A (ja) 2011-07-19 2014-09-11 ザ ジェネラル ホスピタル コーポレイション 光コヒーレンストモグラフィーにおいて偏波モード分散補償を提供するためのシステム、方法、装置およびコンピュータアクセス可能な媒体
EP2748587B1 (en) 2011-08-25 2021-01-13 The General Hospital Corporation Methods and arrangements for providing micro-optical coherence tomography procedures
JP2015502562A (ja) 2011-10-18 2015-01-22 ザ ジェネラル ホスピタル コーポレイション 再循環光学遅延を生成および／または提供するための装置および方法
JP5970785B2 (ja) * 2011-11-16 2016-08-17 ソニー株式会社 生体計測装置、生体計測方法、プログラムおよび記録媒体
WO2013148306A1 (en) 2012-03-30 2013-10-03 The General Hospital Corporation Imaging system, method and distal attachment for multidirectional field of view endoscopy
JP2015517387A (ja) 2012-05-21 2015-06-22 ザ ジェネラル ホスピタル コーポレイション カプセル顕微鏡検査のための装置、デバイスおよび方法
CA2914778A1 (en) 2012-06-21 2013-12-27 Novadaq Technologies Inc. Quantification and analysis of angiography and perfusion
EP2888616A4 (en) 2012-08-22 2016-04-27 Gen Hospital Corp SYSTEM, METHOD, AND COMPUTER ACCESSIBLE MEDIUM FOR PRODUCING A MINIATURE ENDOSCOPE WITH SOFT LITHOGRAPHY
ES2668320T3 (es) 2012-11-07 2018-05-17 Modulated Imaging Inc. Formación de imágenes modulada eficiente
WO2014120791A1 (en) 2013-01-29 2014-08-07 The General Hospital Corporation Apparatus, systems and methods for providing information regarding the aortic valve
US11179028B2 (en) 2013-02-01 2021-11-23 The General Hospital Corporation Objective lens arrangement for confocal endomicroscopy
EP2967491B1 (en) 2013-03-15 2022-05-11 The General Hospital Corporation A transesophageal endoscopic system for determining a mixed venous oxygen saturation of a pulmonary artery
DE102013008003B4 (de) 2013-05-08 2015-03-19 Freshdetect Gmbh Messgerät zum Messen eines Oberflächenbelags auf einem Messobjekt, insbesondere auf einem Lebensmittel, und dessen Verwendung
EP2997354A4 (en) 2013-05-13 2017-01-18 The General Hospital Corporation Detecting self-interefering fluorescence phase and amplitude
WO2015010133A1 (en) 2013-07-19 2015-01-22 The General Hospital Corporation Determining eye motion by imaging retina. with feedback
EP3692887B1 (en) 2013-07-19 2024-03-06 The General Hospital Corporation Imaging apparatus which utilizes multidirectional field of view endoscopy
EP3025173B1 (en) 2013-07-26 2021-07-07 The General Hospital Corporation Apparatus with a laser arrangement utilizing optical dispersion for applications in fourier-domain optical coherence tomography
US11096584B2 (en) * 2013-11-14 2021-08-24 The George Washington University Systems and methods for determining lesion depth using fluorescence imaging
WO2015105870A1 (en) 2014-01-08 2015-07-16 The General Hospital Corporation Method and apparatus for microscopic imaging
US10736494B2 (en) 2014-01-31 2020-08-11 The General Hospital Corporation System and method for facilitating manual and/or automatic volumetric imaging with real-time tension or force feedback using a tethered imaging device
US10228556B2 (en) 2014-04-04 2019-03-12 The General Hospital Corporation Apparatus and method for controlling propagation and/or transmission of electromagnetic radiation in flexible waveguide(s)
WO2016014839A2 (en) 2014-07-23 2016-01-28 Ohio State Innovation Foundation Methods and compositions related to antibody fragments that bind to tumor-associated glycoprotein 72 (tag-72)
CN115919256A (zh) 2014-07-24 2023-04-07 大学健康网络 用于诊断目的的数据的收集和分析
KR102513779B1 (ko) 2014-07-25 2023-03-24 더 제너럴 하스피탈 코포레이션 생체 내 이미징 및 진단을 위한 장치, 디바이스 및 방법
AU2015327665B2 (en) 2014-09-29 2018-09-27 Stryker European Operations Limited Imaging a target fluorophore in a biological material in the presence of autofluorescence
EP3915467A1 (en) 2014-10-09 2021-12-01 Novadaq Technologies ULC Quantification of absolute blood flow in tissue using fluorescence-mediated photoplethysmography
AU2015343258B2 (en) * 2014-11-03 2020-07-16 460Medical, Inc. Systems and methods for lesion assessment
US9626754B2 (en) * 2015-05-28 2017-04-18 Jabil Circuit, Inc. System, apparatus and method for dispensed adhesive material inspection
US10084365B1 (en) 2016-02-04 2018-09-25 Harivallabh Pandya Electromagnetic machinery systems, device, assemblies, methods, processes, uses, and apparatus operable as a motor or generator with one or more stator coils, at least one permanent magnet rotor, and associated circuitry
US11140305B2 (en) 2017-02-10 2021-10-05 Stryker European Operations Limited Open-field handheld fluorescence imaging systems and methods
US10378006B2 (en) 2017-04-19 2019-08-13 The Florida International University Board Of Trustees Near-infrared ray exposure system for biological studies
US11016179B2 (en) * 2017-12-03 2021-05-25 Munro Design & Technologies, Llc Digital image processing systems for three-dimensional imaging systems with image intensifiers and methods thereof
SG11202010675UA (en) * 2018-04-26 2020-11-27 Dartmouth College Device and method for determining depth and concentration of a subsurface fluorescent object
DE102018126183B4 (de) * 2018-10-22 2020-08-06 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Bestimmung der Konzentration eines fluoreszierenden und/oder fluoreszenzmarkierten Analyten und Kalibrierverfahren zur Vorbereitung dieser Bestimmung
JP7240995B2 (ja) * 2019-09-17 2023-03-16 株式会社アドバンテスト ファントムおよび蛍光検出装置

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4541438A (en) * 1983-06-02 1985-09-17 The Johns Hopkins University Localization of cancerous tissue by monitoring infrared fluorescence emitted by intravenously injected porphyrin tumor-specific markers excited by long wavelength light
US5353799A (en) * 1991-01-22 1994-10-11 Non Invasive Technology, Inc. Examination of subjects using photon migration with high directionality techniques
US5022757A (en) * 1989-01-23 1991-06-11 Modell Mark D Heterodyne system and method for sensing a target substance
JP2525894B2 (ja) * 1989-04-07 1996-08-21 浜松ホトニクス株式会社 半導体試料の螢光特性検査装置
US5421337A (en) * 1989-04-14 1995-06-06 Massachusetts Institute Of Technology Spectral diagnosis of diseased tissue
US5070455A (en) * 1989-11-22 1991-12-03 Singer Imaging, Inc. Imaging system and method using scattered and diffused radiation
US5142372A (en) * 1990-03-08 1992-08-25 Alfano Robert R Three-dimensional optical imaging of semi-transparent and opaque objects using ultrashort light pulses, a streak camera and a coherent fiber bundle
US5213105A (en) * 1990-12-04 1993-05-25 Research Corporation Technologies, Inc. Frequency domain optical imaging using diffusion of intensity modulated radiation
CA2042075C (en) * 1991-05-08 2001-01-23 Branko Palcic Endoscopic imaging system
US5413098A (en) * 1991-12-24 1995-05-09 Sextant Medical Corporation Path constrained spectrophotometer and method for determination of spatial distribution of light or other radiation scattering and absorbing substances in a radiation scattering medium
JP3107914B2 (ja) * 1992-07-20 2000-11-13 浜松ホトニクス株式会社 散乱吸収体内部の吸収情報計測装置及び方法
US5452723A (en) * 1992-07-24 1995-09-26 Massachusetts Institute Of Technology Calibrated spectrographic imaging
US5421339A (en) * 1993-05-12 1995-06-06 Board Of Regents, The University Of Texas System Diagnosis of dysplasia using laser induced fluoroescence
US5340991A (en) * 1993-05-21 1994-08-23 The Board Of Regents Of The University Of Oklahoma Fluorokinetic analysis of diffusion from a vessel
AU700802B2 (en) * 1993-10-29 1999-01-14 Trustees Of The University Of Pennsylvania, The Object imaging using diffuse light
US5590660A (en) * 1994-03-28 1997-01-07 Xillix Technologies Corp. Apparatus and method for imaging diseased tissue using integrated autofluorescence
US5579773A (en) * 1994-09-30 1996-12-03 Martin Marietta Energy Systems, Inc. Laser-induced differential normalized fluorescence method for cancer diagnosis
US5647368A (en) * 1996-02-28 1997-07-15 Xillix Technologies Corp. Imaging system for detecting diseased tissue using native fluorsecence in the gastrointestinal and respiratory tract

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