JP3800611B2 - 美白剤または色素沈着症改善剤 - Google Patents
美白剤または色素沈着症改善剤 Download PDFInfo
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- JP3800611B2 JP3800611B2 JP2003372432A JP2003372432A JP3800611B2 JP 3800611 B2 JP3800611 B2 JP 3800611B2 JP 2003372432 A JP2003372432 A JP 2003372432A JP 2003372432 A JP2003372432 A JP 2003372432A JP 3800611 B2 JP3800611 B2 JP 3800611B2
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- 230000019612 pigmentation Effects 0.000 title claims description 21
- 230000002087 whitening effect Effects 0.000 title claims description 19
- 235000020971 citrus fruits Nutrition 0.000 claims description 37
- 239000003795 chemical substances by application Substances 0.000 claims description 26
- 208000012641 Pigmentation disease Diseases 0.000 claims description 23
- 239000000284 extract Substances 0.000 claims description 22
- ARGKVCXINMKCAZ-UHFFFAOYSA-N neohesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(CO)O3)OC3C(C(O)C(O)C(C)O3)O)=CC(O)=C2C(=O)C1 ARGKVCXINMKCAZ-UHFFFAOYSA-N 0.000 claims description 22
- 239000001100 (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one Substances 0.000 claims description 21
- QUQPHWDTPGMPEX-UHFFFAOYSA-N Hesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(COC4C(C(O)C(O)C(C)O4)O)O3)O)=CC(O)=C2C(=O)C1 QUQPHWDTPGMPEX-UHFFFAOYSA-N 0.000 claims description 21
- QUQPHWDTPGMPEX-UTWYECKDSA-N aurantiamarin Natural products COc1ccc(cc1O)[C@H]1CC(=O)c2c(O)cc(O[C@@H]3O[C@H](CO[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)cc2O1 QUQPHWDTPGMPEX-UTWYECKDSA-N 0.000 claims description 21
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- 229940025878 hesperidin Drugs 0.000 claims description 21
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- SSXJHQZOHUYEGD-UHFFFAOYSA-N 3-Methoxynobiletin Chemical compound C1=C(OC)C(OC)=CC=C1C1=C(OC)C(=O)C2=C(OC)C(OC)=C(OC)C(OC)=C2O1 SSXJHQZOHUYEGD-UHFFFAOYSA-N 0.000 description 1
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- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 1
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- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 1
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Description
(Rutaceae)のウンシュウミカン(Citrus unshiu)あるいはCitrus reticulataの成熟した果皮]、枳実・枳殻[ミカン科(Rutaceae)のダイダイCitrus aurantium var.
daidai、Citrus aurantium又はナツミカンCitrus natsudaidaiの未熟果をそのまま或いはそれを半分に横切したもの]、橙皮[ミカン科(Rutaceae)のCitrus aurantium又はダイダイCitrus aurantium var. daidaiの成熟した果皮]が収載されている。
(naringin)、アルカロイドとしてシネフリン(synephrine)などが含まれている。
本発明に従えば、ウンシュウミカンは、メラニン色素の産生に対して、優れた抑制効果を示す。したがって、美白剤に好適である。
本発明に従えば、ヘスペリジンによってメラニン色素の産生に対して優れた抑制効果を示すので、美白剤に好適である。
本発明に従えば、ウンシュウミカンは、シミ、ソバカス、色黒等の色素沈着症の原因であるメラニン色素の産生に対して、優れた抑制効果を示す。
本発明に従えば、ヘスペリジンによって、シミ、ソバカス、色黒等の色素沈着症の原因であるメラニン色素の産生に対して、優れた抑制効果を示す。
検体1;2003年、7月5日、8月5日、9月5日、10月5日に近畿大学湯浅農場で栽培されているウンシュウミカン果実を採取、細切後乾燥し、粉砕、粉末とした。
チロシナーゼ活性抑制試験;Masonらの方法に従った。被検体をdimethyl
sulfoxide、phoshate buffer(PBS、pH6.8)の1:9溶液に溶解した。0.03%に調整した基質dopa溶液(PBSに溶解)0.5mlに被検液0.5mlを加え、25℃、10分間インキュベートした。135 U/mlに調整した酵素チロシナーゼ液(PBSに溶解)を0.5ml加え,5分間インキュベートした.反応後475nmにおける吸光度を測定(UV−2400PC、Shimadzu)した。
表1は、ウンシュウミカン果実エキスおよびヘスペリジンの抗チロシナーゼ活性を示す。
抑制率(%)=(検体無添加である対照の吸光度−被検体の吸光度)/(検体無添加である対照の吸光度)×100
外用剤の製造;未成熟なウンシュウミカン果実のエキスを含有するエモリエントクリームおよびエモリエントローションを常法により製造した。
(1)エモリエントクリーム
(組成)
ステアリン酸 2.0重量%
ステアリールアルコール 7.0重量%
還元ラノリン 7.0重量%
スクワレン 5.0重量%
オクチルデカノール 6.0重量%
ポリオキシエチレンセチルエーテル 3.0重量%
親油型モノオキシステアリン酸グリセリン 2.0重量%
香料 0.3重量%
防腐剤、酸化防止剤 適量
プロピレングリコール 5.0重量%
被検体(未成熟なウンシュウミカン果実エキス) 1.0重量%
精製水 全体で100となる量
(組成)
ステアリン酸 0.2重量%
セタノール 1.5重量%
ワセリン 3.0重量%
ラノリンアルコール 2.0重量%
流動パラフィン 10.0重量%
ポチオキシエチレンモノオレイン酸エステル 2.0重量%
香料 0.3重量%
グリセリン 3.0重量%
プロピレングリコール 5.0重量%
トリエタノールアミン 1.0重量%
被検体(未成熟なウンシュウミカン果実エキス) 2.0重量%
精製水 全体で100となる量
Claims (3)
- 着果後2ヶ月ないし3ヶ月を経過した横径が2.0cm以上〜4.5cm以下の未成熟な柑橘類果実からアルコール抽出されたヘスペリジンを含有するエキスを含むことを特徴とする美白剤。
- 着果後2ヶ月ないし3ヶ月を経過した横径が2.0cm以上〜4.5cm以下の未成熟な柑橘類果実からアルコール抽出されたヘスペリジンを含有するエキスを含むことを特徴とする色素沈着症改善剤。
- 前記色素沈着症改善剤がシミ又はソバカスの改善剤であることを特徴とする請求項2に記載の色素沈着症改善剤。
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JP2003372432A JP3800611B2 (ja) | 2003-10-31 | 2003-10-31 | 美白剤または色素沈着症改善剤 |
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JP2003372432A JP3800611B2 (ja) | 2003-10-31 | 2003-10-31 | 美白剤または色素沈着症改善剤 |
Publications (3)
Publication Number | Publication Date |
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JP2005132793A JP2005132793A (ja) | 2005-05-26 |
JP2005132793A5 JP2005132793A5 (ja) | 2005-09-08 |
JP3800611B2 true JP3800611B2 (ja) | 2006-07-26 |
Family
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Application Number | Title | Priority Date | Filing Date |
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JP2003372432A Expired - Lifetime JP3800611B2 (ja) | 2003-10-31 | 2003-10-31 | 美白剤または色素沈着症改善剤 |
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JP4654060B2 (ja) * | 2005-03-29 | 2011-03-16 | 株式会社 ア・ファーマ近大 | ネオヘスペリジンの抗酸化作用に基づく美白剤または色素沈着症改善剤 |
JP2007031315A (ja) * | 2005-07-25 | 2007-02-08 | Pias Arise Kk | 転写因子Nrf2活性化剤、並びにその転写因子Nrf2活性化剤を配合した皮膚外用剤、化粧料、及び飲食品 |
JP2007063191A (ja) * | 2005-08-31 | 2007-03-15 | Harima Kanpo Seiyaku:Kk | 新規美白剤 |
JP2009007336A (ja) * | 2007-05-25 | 2009-01-15 | Shiseido Co Ltd | α−グリコシルヘスペリジンを含有する経口投与・摂取用の、メラニン低下剤、皮膚明度低下抑制剤、皮膚粘弾性低下抑制剤、皮脂量低下抑制剤、SCF産生抑制剤、およびかゆみ抑制剤 |
SG173193A1 (en) | 2009-02-03 | 2011-09-29 | Sunstar Inc | Hesperidin-containing composition |
JP5735254B2 (ja) * | 2009-10-22 | 2015-06-17 | 花王株式会社 | 経口紫外線抵抗性向上剤 |
US9814659B2 (en) * | 2012-04-02 | 2017-11-14 | Johnson & Johnson Consumer Inc. | Methods of lightening the skin |
FR3001634B1 (fr) * | 2013-02-06 | 2015-02-27 | Oreal | Utilisation de l'huile essentielle d'orange pour traiter les troubles de la pigmentation cutanee |
CN106214603A (zh) * | 2016-08-17 | 2016-12-14 | 柳州市亿廷贸易有限责任公司 | 祛斑磨砂膏及其制备方法 |
US10966948B2 (en) | 2019-07-23 | 2021-04-06 | Johnson & Johnson Surgical Vision, Inc. | Compositions and methods for treating the eye |
US11197841B2 (en) | 2019-07-23 | 2021-12-14 | Johnson & Johnson Surgical Vision, Inc. | Compositions and methods for treating the eye |
BR112021000724A2 (pt) | 2018-07-27 | 2021-04-13 | Johnson & Johnson Surgical Vision, Inc. | Composições e métodos para tratar os olhos |
JP7316647B2 (ja) * | 2019-07-16 | 2023-07-28 | 日本メナード化粧品株式会社 | カテプシンv活性促進剤及びgata-3産生抑制剤 |
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JPS61291508A (ja) * | 1985-06-19 | 1986-12-22 | Yutaka Miyauchi | 化粧水 |
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