JP3693916B2 - 新規なジヒドロキシヘキサン酸誘導体 - Google Patents

新規なジヒドロキシヘキサン酸誘導体 Download PDF

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Publication number
JP3693916B2
JP3693916B2 JP2000530493A JP2000530493A JP3693916B2 JP 3693916 B2 JP3693916 B2 JP 3693916B2 JP 2000530493 A JP2000530493 A JP 2000530493A JP 2000530493 A JP2000530493 A JP 2000530493A JP 3693916 B2 JP3693916 B2 JP 3693916B2
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JP
Japan
Prior art keywords
methyl
amide
carboxylic acid
dihydroxy
octyl
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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JP2000530493A
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English (en)
Japanese (ja)
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JP2002502839A (ja
Inventor
キャス，ジョン・チャールズ
ブラウン，マシュー・フランク
ポス，クリストファー・スタンリー
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ファイザー・プロダクツ・インク
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/50—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to ring nitrogen atoms
    • C07D241/52—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • AIDS & HIV (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
JP2000530493A 1998-02-05 1999-01-18 新規なジヒドロキシヘキサン酸誘導体 Expired - Lifetime JP3693916B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7380198P 1998-02-05 1998-02-05
US60/073,801 1998-02-05
PCT/IB1999/000067 WO1999040061A2 (en) 1998-02-05 1999-01-18 Novel dihydroxyhexanoic acid derivatives

Publications (2)

Publication Number Publication Date
JP2002502839A JP2002502839A (ja) 2002-01-29
JP3693916B2 true JP3693916B2 (ja) 2005-09-14

Family

ID=22115885

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000530493A Expired - Lifetime JP3693916B2 (ja) 1998-02-05 1999-01-18 新規なジヒドロキシヘキサン酸誘導体

Country Status (36)

Country Link
EP (1) EP1051405B1 (OSRAM)
JP (1) JP3693916B2 (OSRAM)
KR (1) KR100385529B1 (OSRAM)
CN (1) CN1177834C (OSRAM)
AP (1) AP992A (OSRAM)
AR (1) AR016175A1 (OSRAM)
AT (1) ATE337307T1 (OSRAM)
AU (1) AU752407B2 (OSRAM)
BG (1) BG104726A (OSRAM)
BR (1) BR9907655A (OSRAM)
CA (1) CA2320388C (OSRAM)
DE (1) DE69932920T2 (OSRAM)
DZ (1) DZ2717A1 (OSRAM)
EA (1) EA003137B1 (OSRAM)
ES (1) ES2268847T3 (OSRAM)
GT (1) GT199900011A (OSRAM)
HR (1) HRP20000529B1 (OSRAM)
HU (1) HUP0100832A3 (OSRAM)
IL (1) IL137330A0 (OSRAM)
IS (1) IS5562A (OSRAM)
MA (1) MA26603A1 (OSRAM)
MY (1) MY133125A (OSRAM)
NO (1) NO20003965D0 (OSRAM)
NZ (1) NZ505724A (OSRAM)
OA (1) OA11448A (OSRAM)
PA (1) PA8467301A1 (OSRAM)
PE (1) PE20000243A1 (OSRAM)
PL (1) PL342817A1 (OSRAM)
SK (1) SK11262000A3 (OSRAM)
TN (1) TNSN99013A1 (OSRAM)
TR (1) TR200002248T2 (OSRAM)
TW (1) TW470744B (OSRAM)
UA (1) UA57824C2 (OSRAM)
WO (1) WO1999040061A2 (OSRAM)
YU (1) YU47100A (OSRAM)
ZA (1) ZA99873B (OSRAM)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000044365A1 (en) * 1999-01-29 2000-08-03 Millennium Pharmaceuticals, Inc. Methods for preventing graft rejection and ischemia-reperfusion injury
DE60039115D1 (de) * 1999-08-20 2008-07-17 Dow Agrosciences Llc Fungizide heterocyclische aromatische amide und deren zusammensetzungen, verfahren zu deren anwendung und herstellung
EP1498417A1 (en) * 2000-02-04 2005-01-19 Pfizer Products Inc. Heterocyclic amide derivatives
EE200200432A (et) 2000-02-04 2003-12-15 Pfizer Products Inc. Heterotsüklilised amiidderivaadid
US6740636B2 (en) * 2000-07-31 2004-05-25 Schering Aktiengesellschaft Non-peptide CCR1 receptor antagonists in combination with cyclosporin A for the treatment of heart transplant rejection
US6746856B2 (en) 2000-08-09 2004-06-08 Pfizer Inc. Microbial conversion of bicyclic heteroaromatic compounds
BR0210519A (pt) 2001-06-22 2004-06-22 Pfizer Prod Inc Composições farmacêuticas de adsorvatos de fármaco amorfo
EP1269994A3 (en) * 2001-06-22 2003-02-12 Pfizer Products Inc. Pharmaceutical compositions comprising drug and concentration-enhancing polymers
WO2003000235A1 (en) * 2001-06-22 2003-01-03 Pfizer Products Inc. Pharmaceutical compositions of dispersions of drugs and neutral polymers
DE10152351B4 (de) * 2001-10-18 2005-09-22 Schering Ag Feste Arzneimittelformulierung für ein Piperazinharnstoffderivat
WO2003063833A1 (en) 2002-02-01 2003-08-07 Pfizer Products Inc. Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming materials
AU2003223050A1 (en) * 2002-05-14 2003-11-11 Pfizer Products Inc. Methods for manufacture of dihydro-furan-2-one derivatives
CA2484860A1 (en) * 2002-05-14 2003-11-20 Pfizer Products Inc. Dihydroxyhexanoic acid derivatives, their intermediates, and methods of making
MXPA05001781A (es) * 2002-08-12 2005-04-25 Pfizer Prod Inc Formas cristalinas de [4-carbamoil -1-(3- fluorobencil)-2, 7-dihidroxi- 7-metil- octil]-amida del acido quinoxalina-2- carboxilico.
PT1530457E (pt) 2002-08-12 2009-11-06 Bend Res Inc Composições farmacêuticas de fármacos na forma semi-ordenada e de polímeros
US20040097554A1 (en) * 2002-10-30 2004-05-20 Pfizer Inc Heteroaryl-hexanoic acid amide derivatives as immonomodulatory agents
US20040087571A1 (en) * 2002-10-30 2004-05-06 Pfizer Inc Methods of using CCR1 antagonists as immunomodulatory agents
CA2532931A1 (en) 2003-08-04 2005-02-10 Pfizer Products Inc. Pharmaceutical compositions of adsorbates of amorphous drugs and lipophilic microphase-forming materials

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4923864A (en) * 1987-12-15 1990-05-08 Pfizer Inc. Certain heterocyclic-hexanamides useful for treating hypertension
ES2180600T3 (es) * 1994-10-19 2003-02-16 Novartis Ag Eteres de isosteros substrato de aspartato proteasa antivirales.
DE19708106A1 (de) * 1997-02-28 1998-09-03 Bosch Gmbh Robert Einrichtung und Verfahren zur Information über Verkehrsstörungen

Also Published As

Publication number Publication date
OA11448A (en) 2003-11-18
IL137330A0 (en) 2001-07-24
EA003137B1 (ru) 2003-02-27
BG104726A (en) 2001-04-30
EA200000741A1 (ru) 2001-02-26
ZA99873B (en) 2000-08-04
NO20003965L (OSRAM) 2000-10-03
TW470744B (en) 2002-01-01
AP9901457A0 (en) 1999-03-31
ES2268847T3 (es) 2007-03-16
BR9907655A (pt) 2000-10-24
MA26603A1 (fr) 2004-12-20
TNSN99013A1 (fr) 2005-11-10
AU752407B2 (en) 2002-09-19
EP1051405B1 (en) 2006-08-23
DE69932920T2 (de) 2007-02-08
JP2002502839A (ja) 2002-01-29
WO1999040061A3 (en) 1999-10-21
DZ2717A1 (fr) 2003-09-01
PL342817A1 (en) 2001-07-02
PE20000243A1 (es) 2000-04-07
MY133125A (en) 2007-10-31
AP992A (en) 2001-08-06
CA2320388A1 (en) 1999-08-12
CA2320388C (en) 2005-05-03
KR100385529B1 (ko) 2003-05-27
NO20003965D0 (no) 2000-08-04
IS5562A (is) 2000-07-14
AU1778999A (en) 1999-08-23
HUP0100832A2 (hu) 2002-02-28
WO1999040061A2 (en) 1999-08-12
YU47100A (sh) 2002-11-15
KR20010040684A (ko) 2001-05-15
HK1034969A1 (en) 2001-11-09
AR016175A1 (es) 2001-06-20
CN1290255A (zh) 2001-04-04
CN1177834C (zh) 2004-12-01
HUP0100832A3 (en) 2002-03-28
NZ505724A (en) 2003-02-28
ATE337307T1 (de) 2006-09-15
UA57824C2 (uk) 2003-07-15
PA8467301A1 (es) 2000-05-24
GT199900011A (es) 2000-07-20
EP1051405A2 (en) 2000-11-15
DE69932920D1 (de) 2006-10-05
HRP20000529B1 (en) 2004-12-31
HRP20000529A2 (en) 2001-08-31
SK11262000A3 (sk) 2001-01-18
TR200002248T2 (tr) 2000-12-21

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