JP3538203B2 - ビールの製造方法 - Google Patents
ビールの製造方法Info
- Publication number
- JP3538203B2 JP3538203B2 JP54307698A JP54307698A JP3538203B2 JP 3538203 B2 JP3538203 B2 JP 3538203B2 JP 54307698 A JP54307698 A JP 54307698A JP 54307698 A JP54307698 A JP 54307698A JP 3538203 B2 JP3538203 B2 JP 3538203B2
- Authority
- JP
- Japan
- Prior art keywords
- porous membrane
- cellulase
- beer
- membrane
- amylase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 235000013405 beer Nutrition 0.000 title claims description 91
- 238000004519 manufacturing process Methods 0.000 title claims description 12
- 239000012528 membrane Substances 0.000 claims description 182
- 238000000034 method Methods 0.000 claims description 84
- 238000001914 filtration Methods 0.000 claims description 83
- 102000004190 Enzymes Human genes 0.000 claims description 53
- 108090000790 Enzymes Proteins 0.000 claims description 53
- 229940088598 enzyme Drugs 0.000 claims description 53
- 229940106157 cellulase Drugs 0.000 claims description 46
- 108010059892 Cellulase Proteins 0.000 claims description 42
- 229920002678 cellulose Polymers 0.000 claims description 39
- 239000001913 cellulose Substances 0.000 claims description 38
- 230000000694 effects Effects 0.000 claims description 20
- 239000007864 aqueous solution Substances 0.000 claims description 18
- 108010065511 Amylases Proteins 0.000 claims description 15
- 102000013142 Amylases Human genes 0.000 claims description 15
- 235000019418 amylase Nutrition 0.000 claims description 15
- 239000004382 Amylase Substances 0.000 claims description 14
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 12
- 108090000637 alpha-Amylases Proteins 0.000 claims description 8
- 102000004139 alpha-Amylases Human genes 0.000 claims description 8
- 241000499912 Trichoderma reesei Species 0.000 claims description 7
- 229940024171 alpha-amylase Drugs 0.000 claims description 7
- 241000203780 Thermobifida fusca Species 0.000 claims description 5
- 241000223259 Trichoderma Species 0.000 claims description 5
- 230000008569 process Effects 0.000 claims description 5
- 108091005804 Peptidases Proteins 0.000 claims description 4
- 239000004365 Protease Substances 0.000 claims description 4
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims description 4
- 241000203640 Thermomonospora Species 0.000 claims description 4
- 108010019077 beta-Amylase Proteins 0.000 claims description 4
- 241000223262 Trichoderma longibrachiatum Species 0.000 claims description 3
- 238000004140 cleaning Methods 0.000 description 35
- 235000010980 cellulose Nutrition 0.000 description 32
- 239000000243 solution Substances 0.000 description 22
- 239000000758 substrate Substances 0.000 description 19
- 238000012360 testing method Methods 0.000 description 15
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 10
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 10
- 238000005406 washing Methods 0.000 description 10
- 238000005259 measurement Methods 0.000 description 9
- 102000004169 proteins and genes Human genes 0.000 description 9
- 108090000623 proteins and genes Proteins 0.000 description 9
- 239000012085 test solution Substances 0.000 description 9
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 8
- 238000011156 evaluation Methods 0.000 description 8
- 239000008103 glucose Substances 0.000 description 8
- 239000000463 material Substances 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 239000000203 mixture Substances 0.000 description 7
- 239000007974 sodium acetate buffer Substances 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 244000063299 Bacillus subtilis Species 0.000 description 6
- 235000014469 Bacillus subtilis Nutrition 0.000 description 6
- 239000000706 filtrate Substances 0.000 description 6
- 239000012530 fluid Substances 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 239000011148 porous material Substances 0.000 description 6
- LWFUFLREGJMOIZ-UHFFFAOYSA-N 3,5-dinitrosalicylic acid Chemical compound OC(=O)C1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1O LWFUFLREGJMOIZ-UHFFFAOYSA-N 0.000 description 5
- 108010084185 Cellulases Proteins 0.000 description 5
- 102000005575 Cellulases Human genes 0.000 description 5
- 239000004952 Polyamide Substances 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- 239000002585 base Substances 0.000 description 5
- 229920002647 polyamide Polymers 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 239000004094 surface-active agent Substances 0.000 description 5
- 241000228245 Aspergillus niger Species 0.000 description 4
- 101710121765 Endo-1,4-beta-xylanase Proteins 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 230000001413 cellular effect Effects 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 239000013505 freshwater Substances 0.000 description 4
- 238000009928 pasteurization Methods 0.000 description 4
- -1 Use Rotase Proteins 0.000 description 3
- 239000003513 alkali Substances 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 239000012982 microporous membrane Substances 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000193830 Bacillus <bacterium> Species 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 101710130006 Beta-glucanase Proteins 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- DBPRUZCKPFOVDV-UHFFFAOYSA-N Clorprenaline hydrochloride Chemical compound O.Cl.CC(C)NCC(O)C1=CC=CC=C1Cl DBPRUZCKPFOVDV-UHFFFAOYSA-N 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
- 229920002302 Nylon 6,6 Polymers 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 229940098773 bovine serum albumin Drugs 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000003792 electrolyte Substances 0.000 description 2
- 238000005265 energy consumption Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000011045 prefiltration Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 241000228212 Aspergillus Species 0.000 description 1
- 241000255925 Diptera Species 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- 239000005909 Kieselgur Substances 0.000 description 1
- 239000004695 Polyether sulfone Substances 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 229910021607 Silver chloride Inorganic materials 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- FNYLWPVRPXGIIP-UHFFFAOYSA-N Triamterene Chemical compound NC1=NC2=NC(N)=NC(N)=C2N=C1C1=CC=CC=C1 FNYLWPVRPXGIIP-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 229940025131 amylases Drugs 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000008151 electrolyte solution Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007515 enzymatic degradation Effects 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 230000009229 glucose formation Effects 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000003262 industrial enzyme Substances 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229920000620 organic polymer Polymers 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 229920006393 polyether sulfone Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 239000008237 rinsing water Substances 0.000 description 1
- 235000015067 sauces Nutrition 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D65/00—Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
- B01D65/02—Membrane cleaning or sterilisation ; Membrane regeneration
- B01D65/06—Membrane cleaning or sterilisation ; Membrane regeneration with special washing compositions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D65/00—Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
- B01D65/02—Membrane cleaning or sterilisation ; Membrane regeneration
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12H—PASTEURISATION, STERILISATION, PRESERVATION, PURIFICATION, CLARIFICATION OR AGEING OF ALCOHOLIC BEVERAGES; METHODS FOR ALTERING THE ALCOHOL CONTENT OF FERMENTED SOLUTIONS OR ALCOHOLIC BEVERAGES
- C12H1/00—Pasteurisation, sterilisation, preservation, purification, clarification, or ageing of alcoholic beverages
- C12H1/02—Pasteurisation, sterilisation, preservation, purification, clarification, or ageing of alcoholic beverages combined with removal of precipitate or added materials, e.g. adsorption material
- C12H1/06—Precipitation by physical means, e.g. by irradiation, vibrations
- C12H1/063—Separation by filtration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
- B01D2321/16—Use of chemical agents
- B01D2321/166—Use of enzymatic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/60—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrostatic variables, e.g. electrographic flaw testing
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Food Science & Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT59797A AT407046B (de) | 1997-04-08 | 1997-04-08 | Verfahren zur herstellung von kaltfiltriertem bier |
AT59697A AT407396B (de) | 1997-04-08 | 1997-04-08 | Verfahren zur herstellung von kaltfiltriertem bier |
AT597/97 | 1997-04-08 | ||
AT596/97 | 1997-04-08 | ||
PCT/US1998/006969 WO1998045029A1 (en) | 1997-04-08 | 1998-04-07 | Method for producing beer |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2001519715A JP2001519715A (ja) | 2001-10-23 |
JP3538203B2 true JP3538203B2 (ja) | 2004-06-14 |
Family
ID=25593269
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP54307698A Expired - Fee Related JP3538203B2 (ja) | 1997-04-08 | 1998-04-07 | ビールの製造方法 |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0973603A1 (pt) |
JP (1) | JP3538203B2 (pt) |
KR (1) | KR100538790B1 (pt) |
CN (1) | CN1137765C (pt) |
AU (1) | AU724451B2 (pt) |
BR (1) | BR9814243A (pt) |
CA (1) | CA2286267A1 (pt) |
WO (1) | WO1998045029A1 (pt) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6472199B1 (en) * | 2001-04-04 | 2002-10-29 | West Agro, Inc. | Method of cleaning dairy pipelines using enzyme pretreatment |
JP2005537120A (ja) | 2002-06-28 | 2005-12-08 | ネーデルランドセ・オルガニザテイエ・フール・テゲパスト−ナトウールベテンシヤツペリーク・オンデルツエク・テイエヌオー | フィルター浄化方法 |
AT503235B1 (de) * | 2002-08-09 | 2008-02-15 | Volker Dr Ribitsch | Verfahren und vorrichtung zur bestimmung des strömungspotentials bzw. zeta-potentials |
FR2878451B1 (fr) * | 2004-11-29 | 2009-11-06 | Otv Sa | Procede electrocinetique de determination de l'etat de charge electrostatique d'une membrane poreuse en cours de filtration, et son utilisation |
JP2007181773A (ja) * | 2006-01-06 | 2007-07-19 | Daicen Membrane Systems Ltd | 濾過膜の性能回復方法 |
US8801867B2 (en) | 2007-07-31 | 2014-08-12 | X-Flow B.V. | Method for cleaning filter membranes |
JP5343655B2 (ja) * | 2009-03-27 | 2013-11-13 | 東レ株式会社 | 膜モジュールの運転方法 |
CN102078770B (zh) * | 2010-12-02 | 2012-06-27 | 华南农业大学 | 一种用于纯生啤酒过滤膜清洗的固体复合酶剂 |
DE102017000534A1 (de) * | 2017-01-20 | 2018-07-26 | Thomas Schulze | Filterhilfsmittelfreies Verfahren zur Abscheidung von Hefe aus hefehaltigen Flüssigkeiten, insbesondere Getränken |
CN109569298B (zh) * | 2017-09-28 | 2022-02-08 | 东丽先端材料研究开发(中国)有限公司 | 一种发酵液膜过滤方法 |
CN112678918A (zh) * | 2020-12-24 | 2021-04-20 | 湖北中泉环保技术有限公司 | 用于处理大豆加工废水后的超滤膜的清洗方法 |
CN113980944B (zh) * | 2021-12-27 | 2022-04-15 | 中知国创生物技术(山东)有限公司 | 一种高活性啤酒复合酶及其制备方法和应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4832864A (en) | 1987-09-15 | 1989-05-23 | Ecolab Inc. | Compositions and methods that introduce variations in color density into cellulosic fabrics, particularly indigo dyed denim |
JP2663141B2 (ja) * | 1988-05-31 | 1997-10-15 | ユーホーケミカル株式会社 | イオン交換膜用洗浄剤 |
FR2660211A1 (fr) * | 1990-03-27 | 1991-10-04 | Ceramiques Tech Soc D | Procede de nettoyage de membranes semi-permeables. |
JPH04267933A (ja) * | 1991-02-25 | 1992-09-24 | Fuji Photo Film Co Ltd | 分離膜洗浄方法 |
DE4119040C2 (de) | 1991-06-10 | 1997-01-02 | Pall Corp | Verfahren und Gerät zum Testen des Betriebszustands von Filterelementen |
DE4209519C3 (de) | 1992-03-24 | 2000-06-15 | Pall Corp | Verfahren und Gerät zum schnellen Testen der Unversehrtheit von Filterelementen |
JPH05317028A (ja) * | 1992-05-18 | 1993-12-03 | Nippon Millipore Kogyo Kk | ビール濾過用フィルターの再生方法 |
US5227819A (en) | 1992-06-26 | 1993-07-13 | Nelson Tyler | Film magazine for motion picture camera |
US5449465A (en) | 1994-01-18 | 1995-09-12 | Pall Corporation | Filtration method using a relative pressure drop to initiate backwash |
DE19503060A1 (de) * | 1995-02-01 | 1996-08-08 | Henkel Ecolab Gmbh & Co Ohg | Reinigungsverfahren für Membranfilter |
-
1998
- 1998-04-07 KR KR10-1999-7009286A patent/KR100538790B1/ko not_active IP Right Cessation
- 1998-04-07 CA CA002286267A patent/CA2286267A1/en not_active Abandoned
- 1998-04-07 CN CNB988059525A patent/CN1137765C/zh not_active Expired - Fee Related
- 1998-04-07 AU AU68916/98A patent/AU724451B2/en not_active Ceased
- 1998-04-07 EP EP98914598A patent/EP0973603A1/en not_active Withdrawn
- 1998-04-07 WO PCT/US1998/006969 patent/WO1998045029A1/en active IP Right Grant
- 1998-04-07 JP JP54307698A patent/JP3538203B2/ja not_active Expired - Fee Related
- 1998-04-07 BR BR9814243-7A patent/BR9814243A/pt not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU6891698A (en) | 1998-10-30 |
BR9814243A (pt) | 2001-11-06 |
AU724451B2 (en) | 2000-09-21 |
CN1259882A (zh) | 2000-07-12 |
JP2001519715A (ja) | 2001-10-23 |
EP0973603A1 (en) | 2000-01-26 |
KR20010006206A (ko) | 2001-01-26 |
CN1137765C (zh) | 2004-02-11 |
CA2286267A1 (en) | 1998-10-15 |
KR100538790B1 (ko) | 2005-12-23 |
WO1998045029A1 (en) | 1998-10-15 |
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