JP3406653B2 - セファロスポリン中間体の製造法 - Google Patents

セファロスポリン中間体の製造法

Info

Publication number
JP3406653B2
JP3406653B2 JP22041193A JP22041193A JP3406653B2 JP 3406653 B2 JP3406653 B2 JP 3406653B2 JP 22041193 A JP22041193 A JP 22041193A JP 22041193 A JP22041193 A JP 22041193A JP 3406653 B2 JP3406653 B2 JP 3406653B2
Authority
JP
Japan
Prior art keywords
compound
formula
added
mmol
minutes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP22041193A
Other languages
English (en)
Japanese (ja)
Other versions
JPH06184161A (ja
Inventor
エム エフ リム ガリー
エム ロウビー ジョン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of JPH06184161A publication Critical patent/JPH06184161A/ja
Application granted granted Critical
Publication of JP3406653B2 publication Critical patent/JP3406653B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cephalosporin Compounds (AREA)
JP22041193A 1992-07-24 1993-07-09 セファロスポリン中間体の製造法 Expired - Lifetime JP3406653B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92023292A 1992-07-24 1992-07-24
US920,232 1992-07-24

Publications (2)

Publication Number Publication Date
JPH06184161A JPH06184161A (ja) 1994-07-05
JP3406653B2 true JP3406653B2 (ja) 2003-05-12

Family

ID=25443394

Family Applications (1)

Application Number Title Priority Date Filing Date
JP22041193A Expired - Lifetime JP3406653B2 (ja) 1992-07-24 1993-07-09 セファロスポリン中間体の製造法

Country Status (14)

Country Link
US (1) US5594131A (OSRAM)
EP (1) EP0581220B1 (OSRAM)
JP (1) JP3406653B2 (OSRAM)
KR (1) KR100290519B1 (OSRAM)
AT (1) ATE184608T1 (OSRAM)
CA (1) CA2099692C (OSRAM)
DE (1) DE69326400T2 (OSRAM)
DK (1) DK0581220T3 (OSRAM)
ES (1) ES2137211T3 (OSRAM)
GR (1) GR3032045T3 (OSRAM)
HU (1) HU213399B (OSRAM)
IL (1) IL106388A (OSRAM)
MX (1) MX9304433A (OSRAM)
TW (1) TW232695B (OSRAM)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN184516B (OSRAM) * 1996-01-19 2000-09-02 Lupin Laoratories Ltd
AU2307297A (en) * 1996-04-12 1997-11-07 Takeda Chemical Industries Ltd. Production of 7-aminocephalosporanic acid derivative
JP4616844B2 (ja) * 2003-12-23 2011-01-19 サンド・ゲーエムベーハー セファロスポリン合成に使用するための中間体の生成プロセス
US20070111980A1 (en) 2004-07-16 2007-05-17 Bandi Parthasaradhi Reddy Process for preparing pure cephalosporine intermediates
WO2006075244A2 (en) * 2005-01-17 2006-07-20 Orchid Chemicals & Pharmaceuticals Ltd Improved process for the preparation of cephalosporin antibiotic intermediate
WO2008010042A2 (en) * 2006-07-18 2008-01-24 Orchid Chemicals & Pharmaceuticals Limited Improved process for the preparation of cefepime intermediate
WO2009004463A1 (en) * 2007-07-04 2009-01-08 Orchid Chemicals & Pharmaceuticals Limited Improved process for the preparation of cefepime intermediate
CN107201391B (zh) * 2017-07-04 2020-07-07 吉林省爱诺德生物工程有限公司 一种盐酸头孢吡肟的合成方法
EP4019118A1 (en) * 2020-12-28 2022-06-29 Sartorius Stedim Biotech GmbH Method and system for testing the integrity of filters

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987001116A1 (en) 1985-08-20 1987-02-26 Bristol-Myers Company Process for preparing cephalosporin intermediates
US4659812A (en) 1985-08-20 1987-04-21 Bristol-Myers Company Cephalosporin intermediates

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4406899A (en) * 1982-03-04 1983-09-27 Bristol-Myers Company Cephalosporins
US4574052A (en) * 1984-05-31 1986-03-04 Richardson-Vicks Inc. Crackling aerosol foam
US4910301A (en) * 1985-08-05 1990-03-20 Bristol-Myers Company Cefepime cephalosporin salts
US4868294A (en) * 1986-07-11 1989-09-19 Bristol-Myers Company Process for preparing cephalosporin intermediates

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987001116A1 (en) 1985-08-20 1987-02-26 Bristol-Myers Company Process for preparing cephalosporin intermediates
US4659812A (en) 1985-08-20 1987-04-21 Bristol-Myers Company Cephalosporin intermediates

Also Published As

Publication number Publication date
DE69326400D1 (de) 1999-10-21
IL106388A0 (en) 1993-11-15
CA2099692C (en) 2003-09-30
MX9304433A (es) 1994-02-28
KR100290519B1 (ko) 2001-09-17
KR940002257A (ko) 1994-02-17
CA2099692A1 (en) 1994-01-25
ATE184608T1 (de) 1999-10-15
EP0581220A3 (en) 1994-05-18
EP0581220B1 (en) 1999-09-15
DK0581220T3 (da) 1999-12-20
TW232695B (OSRAM) 1994-10-21
GR3032045T3 (en) 2000-03-31
DE69326400T2 (de) 2000-05-18
EP0581220A2 (en) 1994-02-02
ES2137211T3 (es) 1999-12-16
JPH06184161A (ja) 1994-07-05
HUT64963A (en) 1994-03-28
IL106388A (en) 1999-10-28
US5594131A (en) 1997-01-14
HU9302145D0 (en) 1993-10-28
HU213399B (en) 1997-06-30

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