JP3345082B2 - オキシアルキン、これを含有する薬剤並びにこの化合物及び薬剤の製造方法 - Google Patents

オキシアルキン、これを含有する薬剤並びにこの化合物及び薬剤の製造方法

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Publication number
JP3345082B2
JP3345082B2 JP07054093A JP7054093A JP3345082B2 JP 3345082 B2 JP3345082 B2 JP 3345082B2 JP 07054093 A JP07054093 A JP 07054093A JP 7054093 A JP7054093 A JP 7054093A JP 3345082 B2 JP3345082 B2 JP 3345082B2
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JP
Japan
Prior art keywords
general formula
oxyalkyne
hydroxy
group
prop
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP07054093A
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English (en)
Japanese (ja)
Other versions
JPH0625135A (ja
Inventor
ウルリッヒ・ザイプ
ウエルナー・フオーレンベルク
ウエルナー・エングルベルガー
コルネリア・ガイスト
ミッヒヤエル・ハウラント
Original Assignee
グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング
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Publication of JPH0625135A publication Critical patent/JPH0625135A/ja
Application granted granted Critical
Publication of JP3345082B2 publication Critical patent/JP3345082B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
JP07054093A 1992-03-30 1993-03-29 オキシアルキン、これを含有する薬剤並びにこの化合物及び薬剤の製造方法 Expired - Fee Related JP3345082B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4210332:0 1992-03-30
DE4210332A DE4210332C1 (enExample) 1992-03-30 1992-03-30

Publications (2)

Publication Number Publication Date
JPH0625135A JPH0625135A (ja) 1994-02-01
JP3345082B2 true JP3345082B2 (ja) 2002-11-18

Family

ID=6455388

Family Applications (1)

Application Number Title Priority Date Filing Date
JP07054093A Expired - Fee Related JP3345082B2 (ja) 1992-03-30 1993-03-29 オキシアルキン、これを含有する薬剤並びにこの化合物及び薬剤の製造方法

Country Status (3)

Country Link
US (1) US5326902A (enExample)
JP (1) JP3345082B2 (enExample)
DE (1) DE4210332C1 (enExample)

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US6103496A (en) 1998-05-29 2000-08-15 Vanderbilt University Isolated and purified 12R-lipoxygenase protein and nucleic acids
CA2425215C (en) * 2000-10-10 2009-12-29 University Of North Carolina At Chapel Hill Compositions and methods for enhancing paracellular permeability across epithelial and endothelial barriers
US20040086903A1 (en) * 2000-12-29 2004-05-06 Jean-Jacques Lareyre Epididymal lipocalin gene and uses thereof
WO2003068941A2 (en) 2002-02-13 2003-08-21 Duke University Modulation of immune response by non-peptide binding stress response polypeptides
US20050069918A1 (en) * 2003-05-29 2005-03-31 Francois Claret JAB1 as a prognostic marker and a therapeutic target for human cancer
MXPA06013236A (es) * 2004-05-14 2007-02-28 Univ North Carolina Prouroguanilina, y analogos sinteticos o productos de escision proteolitica derivados de la misma, como agentes terapeuticos y de diagnostico para enfermedades que comprenden hemeostasis de sales y/o fluidos.
CA2579574A1 (en) 2004-07-23 2007-01-04 The University Of North Carolina At Chapel Hill Methods and materials for determining pain sensitivity and predicting and treating related disorders
JP5274248B2 (ja) 2005-05-27 2013-08-28 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 酸化窒素治療及び医生物的応用のための酸化窒素放出粒子
WO2007011702A2 (en) * 2005-07-15 2007-01-25 The University Of North Carolina At Chapel Hill Use of egfr inhibitors to prevent or treat obesity
US20100292339A1 (en) * 2005-10-05 2010-11-18 Zeisel Steven H Genetic Polymorphisms Predictive of Nutritional Requirements for Choline in Subjects
CA2631675A1 (en) * 2005-11-30 2007-06-21 The University Of North Carolina At Chapel Hill Identification of genetic polymorphic variants associated with somatosensory disorders and methods of using the same
AU2008207735B2 (en) 2007-01-26 2013-10-03 University Of Louisville Research Foundation, Inc. Modification of exosomal components for use as a vaccine
WO2009014789A2 (en) * 2007-05-03 2009-01-29 Kotwal Girish J Enveloped virus neutralizing compounds
US20110014218A1 (en) * 2008-01-25 2011-01-20 University Of North Carolina At Chapel Hill Ixodes scapularis salivary proteins and methods of use for modulation of the alternative complement pathway
US8518405B2 (en) 2009-10-08 2013-08-27 The University Of North Carolina At Charlotte Tumor specific antibodies and uses therefor
EP3078374B1 (en) 2011-10-17 2019-06-19 Vanderbilt University Indomethacin analogs for the treatment of castrate-resistant prostate cancer
CN104755505B (zh) 2012-08-17 2017-03-01 北卡罗来纳大学查珀尔希尔分校 水溶性的释放一氧化氮的聚葡糖胺和其用途
WO2015051001A2 (en) 2013-10-01 2015-04-09 University Of Mississippi Medical Center Composition and method for therapeutic agent delivery during pregnancy
SG10201911414SA (en) 2015-06-18 2020-02-27 Nat Univ Singapore Novel thrombin inhibitors
US10758605B2 (en) 2015-06-29 2020-09-01 University Of Louisville Research Foundation, Inc. Compositions and methods for treating cancer and promoting wound healing
WO2017004526A1 (en) 2015-07-02 2017-01-05 University Of Louisville Research Foundation, Inc. EDIBLE PLANT-DERIVED MICROVESICLE COMPOSITIONS FOR DELIVERY OF miRNA AND METHODS FOR TREATMENT OF CANCER
CN108697772B (zh) 2015-12-30 2022-06-24 马歇尔大学科研协会 用于治疗视网膜病的组合物和方法
WO2018127819A1 (en) 2017-01-03 2018-07-12 The University Of North Carolina At Chapel Hill Nitric oxide-releasing alginates as biodegradable antibacterial scaffolds and methods pertaining thereto
WO2018178902A1 (en) 2017-03-28 2018-10-04 The University Of North Carolina At Chapel Hill Nitric oxide-releasing polyaminoglycosides as biodegradable antibacterial scaffolds and methods pertaining thereto
EP3592335A4 (en) 2017-04-10 2021-01-27 The University of North Carolina at Chapel Hill COMPOUNDS, COMPOSITIONS AND PROCEDURES FOR INHIBITING A Pathogen and / or Modifying Slime
US11220528B2 (en) 2017-05-11 2022-01-11 Marshall University Research Corporation Compositions and methods for treating pulmonary hypertension
US12460050B2 (en) 2017-11-15 2025-11-04 The University Of North Carolina At Chapel Hill Nitric oxide-releasing hyperbranched compounds as antibacterial scaffolds and methods pertaining thereto
AU2019231712B2 (en) 2018-03-06 2025-04-10 The University Of North Carolina At Chapel Hill Nitric oxide-releasing cyclodextrins as biodegradable antibacterial scaffolds and methods pertaining thereto
CA3124673A1 (en) 2018-12-28 2020-07-02 The University Of North Carolina At Chapel Hill Nitric oxide-releasing antibacterial polymers and scaffolds fabricated therefrom and methods pertaining thereto
CA3128500A1 (en) 2019-02-01 2020-08-06 Marshall University Research Corporation Transient receptor potential melastatin 8 (trpm8) antagonists and related methods
WO2020180705A1 (en) 2019-03-01 2020-09-10 The University Of North Carolina At Chapel Hill Extended nitric oxide-releasing polymers via functionalized mesoporous silica nanoparticles
WO2024107866A1 (en) 2022-11-15 2024-05-23 Celularity Inc. Compositions and methods for treating cancer
WO2024148248A1 (en) 2023-01-05 2024-07-11 Celularity Inc. Dermal rejuvenation composition comprising placenta derived biomaterial and uses thereof
WO2024167694A2 (en) 2023-02-06 2024-08-15 Celularity Inc. Placental extracellular matrices for ocular delivery of ophthalmic therapeutic agents

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* Cited by examiner, † Cited by third party
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US4652584A (en) * 1984-07-13 1987-03-24 Mcneilab, Inc. Acetylenic phenoxypropanol derivatives and pharmaceutical compositions for the treatment of hypertension
ZA863425B (en) * 1985-05-08 1988-01-27 Du Pont 2-substituted-1-naphthols as 5-lipoxygenase inhibitors
US4897422A (en) * 1987-02-10 1990-01-30 Abbott Laboratories Lipoxygenase inhibiting compounds
DE3888574T2 (de) * 1987-04-24 1994-06-30 Abbott Lab Harnstoff-Derivate mit lipoxygenasehemmender Wirkung.
US4937373A (en) * 1988-12-08 1990-06-26 Hoffmann-La Roche Inc. Substituted naphthalene carboxylic acids
US5220059A (en) * 1990-04-19 1993-06-15 Abbott Laboratories Lipoxygenase-inhibiting compounds derived from non-steroidal antiinflammatory carboxylic acids
DE4023742A1 (de) * 1990-07-26 1992-01-30 Gruenenthal Gmbh Substituierte phenylacetylene, diese enthaltende arzneimittel und verfahren zur herstellung dieser verbindungen und arzneimittel

Also Published As

Publication number Publication date
DE4210332C1 (enExample) 1993-07-15
US5326902A (en) 1994-07-05
JPH0625135A (ja) 1994-02-01

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Effective date: 20020723

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