JP3258330B2 - 食道における胃の逆流を防止するための医用プロテーゼ - Google Patents

食道における胃の逆流を防止するための医用プロテーゼ

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Publication number
JP3258330B2
JP3258330B2 JP52911496A JP52911496A JP3258330B2 JP 3258330 B2 JP3258330 B2 JP 3258330B2 JP 52911496 A JP52911496 A JP 52911496A JP 52911496 A JP52911496 A JP 52911496A JP 3258330 B2 JP3258330 B2 JP 3258330B2
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prosthesis
esophagus
prosthesis according
pct
tube
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JPH10507392A (ja
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ゴディン，ノーマン
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バイオメディックス ソシエテ アノニム
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2002/044—Oesophagi or esophagi or gullets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/3008—Properties of materials and coating materials radio-opaque, e.g. radio-opaque markers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/30205—Three-dimensional shapes conical
    • A61F2002/30214—Three-dimensional shapes conical having tapered sections of different conicities
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/30224—Three-dimensional shapes cylindrical
    • A61F2002/30235—Three-dimensional shapes cylindrical tubular, e.g. sleeves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2002/30459—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements stapled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2002/30461—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements sutured, ligatured or stitched
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0066—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements stapled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0075—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0067—Three-dimensional shapes conical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0069—Three-dimensional shapes cylindrical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0096—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers
    • A61F2250/0098—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers radio-opaque, e.g. radio-opaque markers

Description

【発明の詳細な説明】 本発明は、耐胃酸性の生体適合性ポリマー材料で作ら
れた管を包含する、胃の内容物を食道へ逆流させないよ
うにする医用プロテーゼに関する。１端は胃の上に取り
付けられ、他端は胃の中で遊離状態にされている。
この型のプロテーゼ（国際特許出願公開第91 01117号
明細書に記載されている）は弾性的に閉じられたままの
開口通路を有する弁の形状を記載している。通路の部分
は、管の下方の端を閉じるために次第に狭められ、最大
の開口状態ではその部分はほぼ食道の下方端に取り付け
られている上方端部と同じ大きさである。これは閉じた
ままにしておこうとする弾性力に打ちかつことができる
力によって開かれるバルブの記載である。上記構想は、
それを開けることができるいかなる力もない場合には、
それを閉鎖したままにする比較的に剛性のプロテーゼを
含み、この力は食道による食塊に加えられた蠕動圧によ
り生じるものである。
この解決策は、自然に起こるのと反対の状況を創造
し、蠕動圧がバルブを開けなくてはならないので不十分
である。
ある場合には、たとえば、十分に噛まなかった食物を
飲み込む時、食道を通る食塊を通過させるのに増加した
圧力が必要であり、そのバルブを開けるのにさらに力が
必要なら、食物を詰まらせる危険または痛みを生じさせ
る危険のいずれかまたは両方がある。
本発明の目的は上述の解決策の欠点を少なくとも部分
的に克服することである。我々は、一見したところ同様
であるけれども、過去のものとはかなり異なる、他の解
決策が、上述の欠点なしに同等の結果を可能にすること
に気がついた。この構想は胃の中に食道を延長させる単
純な軟質の管状要素の相当に一定の部分に基づく。胃は
食道の軸に関して非対称形であるので、胃の逆流の場合
には、加えられた圧力は食道の軸に関して斜めの方向を
有する。したがって、特定の長さに延長された軟質の管
で食道を胃の中に延長するなら、胃の逆流の場合には、
軟質の管は斜めの圧力のもとでつぶれて、胃酸の食道へ
の出口をふさぐ。
この目的のために、本発明の対象は請求項１に限定す
るように、食道への胃の逆流をふせぐための医用プロテ
ーゼである。
既に記載した利点の他に、本発明の目的である医用プ
ロテーゼはその増加した柔軟性のために内視鏡で食道中
に導入するのがより容易であり、そのプロテーゼは同じ
理由のために決まった場所に取りつけるのもより容易で
ある。前記管状のプロテーゼは、通常閉鎖している上述
のバルブとは反対に、通常開いているので、食道の壁ま
たは裂孔ヘルニアの壁にこのプロテーゼを埋め込むのに
用いられる手段に加えられる力は、プロテーゼに加えら
れる力はプロテーゼの壁上の食塊の低い摩擦力だけであ
るので、非常に減少する。
図１は、本発明の対象であるプロテーゼを備えた胃及
び食道の断面図である。
図２は、図１のプロテーゼの断面図である。
図３は、図２のプロテーゼの変形の断面図である。
図１及び２に図解されたプロテーゼは生体適合性ポリ
マーで作られた単純な軟質の管である。いくつかの異な
ったポリマー、たとえば医用に特に作られたシリコー
ン、医用に作られたポリウレタン、ポリスチレン−エチ
レン（PSE）または他のエラストマーが考えられるが、
このリストは限定的なものではない。
この管の寸法はたとえば直径25〜30mmで（これはプロ
テーゼが埋め込まれる裂孔ヘルニアまたは食道の直径に
依存して変えることができる）、長さは５〜10cmで、そ
のほとんどは胃の中にあるであろう。壁の厚さは、大部
分、柔軟性を決めるであろう用いられるポリマーの性質
に依存するが、一般にほぼ0.2〜0.6mmの間で変化する。
この管は柔軟でなければならないばかりでなく、逆流圧
力の下で、圧力の内側にひっくり返らないようにある程
度までの抵抗を示さねばならない。しかしながら、吐く
時のような高圧力では、管が内側にひっくり返ることが
好ましい。この場合、これはまれなことであるが、管の
柔軟性は、蠕動圧のおかげでそれを元の位置にもどすこ
とを可能とするか、または内視鏡の介在がプロテーゼを
正しく元の位置にもどすのに必要であろう。
図１に図解するように、胃５における圧力増大の場合
には、力は矢印Ｆにより記載されるように加えられ、す
なわち、力は管１の長軸に関して、その結果柔軟な壁
に、斜の方向を有しており、管状プロテーゼは胃壁に対
してつぶれて、胃酸が胃を離れ、食道の粘膜に達するの
を防ぐだろう。
図１では、胃の逆流を助長する主要な因子の１つであ
る裂孔ヘルニア３の基底に縫合糸または外科用かすがい
で取り付けられる、フランジ２を有する。プロテーゼは
食道４の基底に取り付けることもできる。金属またはナ
イロンの縫合糸またはかすがいを、適当な内視鏡縫合装
置を用いてプロテーゼを結合させるのに用いることがで
きる。
管状プロテーゼは、用いられる生体適合物質に依存し
て、特に生体適合物質の粘度及びプロテーゼの壁の厚さ
に依存して、いくつかの異なった技術を用いて製造する
ことができる。プロテーゼは射出成形、押出成形または
溶液流延（この方法は所望の厚さの壁が得られるまで、
プロテーゼを生物適合性物質の溶液中に浸す方法であ
る）により製造することができる。射出成形を用いるな
ら、型からの容易な取り出しを助長するために約１゜ま
たは２゜の円錐形様の形を設計するのが好ましい。
図３により図解されている変形は、装置の壁を固定点
で強固なものにするために１先端でより厚いフランジか
らなる、射出成形された管状プロテーゼ６を示す。
図１及び２では、射出成形により得られた管状プロテ
ーゼは、成形品の取り出しを容易にするために１゜のわ
ずかな円錐形である。
図３は代替例の場合に管状のプロテーゼ６は、２つの
部分から作られ、固定フランジに隣接する、上位の部分
6a（これはこの例では長さ25mm、３゜の円錐形及び厚さ
0.5mmである）及び下位の部分6b（これはこの例では、
長さ55mm、１゜の円錐形及び厚さ0.3mmである）から作
られている。胃腔５（図１）中に伸長し、胃の逆流圧力
が増加した場合につぶれるのはこの下位の部分6bであ
る。
この特許出願の対象であるプロテーゼは、国際特許出
願公開第9101117号明細書に記載されたバルブとして機
能するが、同時に前記バルブの欠点を回避する。そのよ
り大きな柔軟性は前記プロテーゼの導入と内視鏡埋め込
みを容易にする。

Claims (8)

    (57)【特許請求の範囲】
  1. 【請求項１】耐胃酸性の生体適合性ポリマーから作られ
    た管（1,6）を包含する食道における胃の逆流を妨げる
    プロテーゼであって、その１端は胃（５）の上方開口に
    埋め込まれると同時に、他端は胃腔の中に自由に垂れ下
    がっており、その管状の導管（1,6）は、１端から他端
    まで直径25〜30mmのほとんど一定の部分を有し、その長
    さは５〜10cmであって、この導管（1,6）の壁の厚さ
    を、用いられたポリマーの性質に依存して、0.2〜0.6mm
    の間で選択して、胃の逆流により生じる圧力のレベルに
    達した時に、その外壁に適用された横からの圧力の下に
    その管がつぶれるようにされていることを特徴とする、
    前記プロテーゼ。
  2. 【請求項２】埋め込みのためのその上方端部でのより厚
    い環状のフランジ（2,7）を特徴とする、請求項１記載
    のプロテーゼ。
  3. 【請求項３】医用級のポリウレタンで作られることを特
    徴とする、請求項１に記載のプロテーゼ。
  4. 【請求項４】医用級のシリコーンで作られることを特徴
    とする、請求項１に記載のプロテーゼ。
  5. 【請求項５】医用級のポリスチレン−エチレン（PSE）
    で作られることを特徴とする、請求項１に記載のプロテ
    ーゼ。
  6. 【請求項６】管状導管（1,6）が縦に２つの部分（6a,6
    b）に分割され、第１部分（6a）はプロテーゼの上方端
    部でほぼ３゜の円錐形を示し、下方の第２部分（6b）は
    ほぼ１゜の円錐形を有し、下方の第２の部分（6b）の厚
    さは第１の上方部分（6a）の厚さよりも薄いことを特徴
    とする、請求項１に記載のプロテーゼ。
  7. 【請求項７】第２部分（6b）が導管（６）の全長のほぼ
    2/3を示すことを特徴とする、請求項６に記載のプロテ
    ーゼ。
  8. 【請求項８】第２部分の厚さが第１部分のほぼ半分であ
    ることを特徴とする、請求項７に記載のプロテーゼ。
JP52911496A 1995-03-28 1996-02-28 食道における胃の逆流を防止するための医用プロテーゼ Expired - Fee Related JP3258330B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH00866/95A CH688174A5 (fr) 1995-03-28 1995-03-28 Prothèse pour s'opposer au reflux gastrique dans l'oesophage.
CH866/95-5 1995-03-28
PCT/IB1996/000149 WO1996029954A1 (fr) 1995-03-28 1996-02-28 Prothese pour s'opposer au reflux gastrique dans l'×sophage

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JPH10507392A JPH10507392A (ja) 1998-07-21
JP3258330B2 true JP3258330B2 (ja) 2002-02-18

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CA (1) CA2218417C (ja)
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ES (1) ES2135868T3 (ja)
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US5306300A (en) * 1992-09-22 1994-04-26 Berry H Lee Tubular digestive screen

Also Published As

Publication number Publication date
DK0817598T3 (da) 2000-01-24
JPH10507392A (ja) 1998-07-21
MX9707359A (es) 1997-11-29
BR9607908A (pt) 1998-01-13
CH688174A5 (fr) 1997-06-13
CA2218417C (fr) 2004-09-21
AU689369B2 (en) 1998-03-26
DE69603264D1 (de) 1999-08-19
DE69603264T2 (de) 2000-04-13
EP0817598B1 (fr) 1999-07-14
ES2135868T3 (es) 1999-11-01
AU4632296A (en) 1996-10-16
US5861036A (en) 1999-01-19
WO1996029954A1 (fr) 1996-10-03
CN1179707A (zh) 1998-04-22
CA2218417A1 (fr) 1996-10-03
EP0817598A1 (fr) 1998-01-14
ATE182064T1 (de) 1999-07-15
CN1146367C (zh) 2004-04-21

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