US20060167481A1 - Slitted tissue fixation devices and assemblies for deploying the same - Google Patents

Slitted tissue fixation devices and assemblies for deploying the same Download PDF

Info

Publication number
US20060167481A1
US20060167481A1 US11043903 US4390305A US2006167481A1 US 20060167481 A1 US20060167481 A1 US 20060167481A1 US 11043903 US11043903 US 11043903 US 4390305 A US4390305 A US 4390305A US 2006167481 A1 US2006167481 A1 US 2006167481A1
Authority
US
Grant status
Application
Patent type
Prior art keywords
fastener
members
assembly
member
deployment wire
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11043903
Inventor
Steve Baker
Stefan Kraemer
Raymond Wolniewicz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EndoGastric Solutions Inc
Original Assignee
EsophyX Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/064Surgical staples, i.e. penetrating the tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/068Surgical staplers, e.g. containing multiple staples or clamps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/08Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/10Surgical instruments, devices or methods, e.g. tourniquets for applying or removing wound clamps, e.g. containing only one clamp or staple; Wound clamp magazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00526Methods of manufacturing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743Type of operation; Specification of treatment sites
    • A61B2017/00818Treatment of the gastro-intestinal system
    • A61B2017/00827Treatment of gastro-esophageal reflux
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00831Material properties
    • A61B2017/00862Material properties elastic or resilient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00831Material properties
    • A61B2017/00955Material properties thermoplastic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/064Surgical staples, i.e. penetrating the tissue
    • A61B2017/0645Surgical staples, i.e. penetrating the tissue being elastically deformed for insertion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/064Surgical staples, i.e. penetrating the tissue
    • A61B2017/0647Surgical staples, i.e. penetrating the tissue having one single leg, e.g. tacks
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22038Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with a guide wire
    • A61B2017/22042Details of the tip of the guide wire
    • A61B2017/22044Details of the tip of the guide wire with a pointed tip
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/03Automatic limiting or abutting means, e.g. for safety
    • A61B2090/037Automatic limiting or abutting means, e.g. for safety with a frangible part, e.g. by reduced diameter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3937Visible markers

Abstract

Tissue fasteners carried on a tissue piercing deployment wire fasten tissue layers of a mammalian body together include a first member, a second member, and a connecting member extending between the first and second members. One of the first and second members has a configuration alterable by a deployment wire to permit release of the fastener from the deployment wire after deployment and without causing excessive tissue trauma.

Description

    FIELD OF THE INVENTION
  • The present invention generally relates to tissue fixation devices, and more particularly to devices for treating gastroesophageal reflux disease using the same. The present invention more particularly relates to such tissue fixation devices which may be used in surgical environments and which are self-deploying.
  • BACKGROUND
  • Gastroesophageal reflux disease (GERD) is a chronic condition caused by the failure of the anti-reflux barrier located at the gastroesophageal junction to keep the contents of the stomach from splashing into the esophagus. The splashing is known as gastroesophageal reflux. The stomach acid is designed to digest meat, and will digest esophageal tissue when persistently splashed into the esophagus.
  • A principal reason for regurgitation associated with GERD is the mechanical failure of a deteriorated gastroesophageal flap to close and seal against high pressure in the stomach. Due to reasons including lifestyle, a Grade I normal gastroesophageal flap may deteriorate into a malfunctioning Grade III or absent valve Grade IV gastroesophageal flap. With a deteriorated gastroesophageal flap, the stomach contents are more likely to be regurgitated into the esophagus, the mouth, and even the lungs. The regurgitation is referred to as “heartburn” because the most common symptom is a burning discomfort in the chest under the breastbone. Burning discomfort in the chest and regurgitation (burping up) of sour-tasting gastric juice into the mouth are classic symptoms of gastroesophageal reflux disease (GERD). When stomach acid is regurgitated into the esophagus, it is usually cleared quickly by esophageal contractions. Heartburn (backwashing of stomach acid and bile onto the esophagus) results when stomach acid is frequently regurgitated into the esophagus and the esophageal wall is inflamed.
  • Complications develop for some people who have GERD. Esophagitis (inflammation of the esophagus) with erosions and ulcerations (breaks in the lining of the esophagus) can occur from repeated and prolonged acid exposure. If these breaks are deep, bleeding or scarring of the esophagus with formation of a stricture (narrowing of the esophagus) can occur. If the esophagus narrows significantly, then food sticks in the esophagus and the symptom is known as dysphagia. GERD has been shown to be one of the most important risk factors for the development of esophageal adenocarcinoma. In a subset of people who have severe GERD, if acid exposure continues, the injured squamous lining is replaced by a precancerous lining (called Barrett's Esophagus) in which a cancerous esophageal adenocarcinoma can develop.
  • Other complications of GERD may not appear to be related to esophageal disease at all. Some people with GERD may develop recurrent pneumonia (lung infection), asthma (wheezing), or a chronic cough from acid backing up into the esophagus and all the way up through the upper esophageal sphincter into the lungs. In many instances, this occurs at night, while the person is in a supine position and sleeping. Occasionally, a person with severe GERD will be awakened from sleep with a choking sensation. Hoarseness can also occur due to acid reaching the vocal cords, causing a chronic inflammation or injury.
  • GERD never improves without intervention. Life style changes combined with both medical and surgical treatments exist for GERD. Medical therapies include antacids and proton pump inhibitors. However, the medical therapies only mask the reflux. Patients still get reflux and perhaps emphysema because of particles refluxed into the lungs. Barrett's esophagus results in about 10% of the GERD cases. The esophageal epithelium changes into tissue that tends to become cancerous from repeated acid washing despite the medication.
  • Several open laparotomy and laproscopic surgical procedures are available for treating GERD. One surgical approach is the Nissen fundoplication. The Nissen approach typically involves a 360-degree wrap of the fundus around the gastroesophageal junction. The procedure has a high incidence of postoperative complications. The Nissen approach creates a 360-degree moveable flap without a fixed portion. Hence, Nissen does not restore the normal movable flap. The patient cannot burp because the fundus was used to make the repair, and may frequently experience dysphagia. Another surgical approach to treating GERD is the Belsey Mark IV (Belsey) fundoplication. The Belsey procedure involves creating a valve by suturing a portion of the stomach to an anterior surface of the esophagus. It reduces some of the postoperative complications encountered with the Nissen fundoplication, but still does not restore the normal movable flap. None of these procedures fully restores the normal anatomical anatomy or produces a normally functioning gastroesophageal junction. Another surgical approach is the Hill repair. In the Hill repair, the gastroesophageal junction is anchored to the posterior abdominal areas, and a 180-degree valve is created by a system of sutures. The Hill procedure restores the moveable flap, the cardiac notch and the Angle of His. However, all of these surgical procedures are very invasive, regardless of whether done as a laproscopic or an open procedure.
  • New, less surgically invasive approaches to treating GERD involve transoral endoscopic procedures. One procedure contemplates a machine device with robotic arms that is inserted transorally into the stomach. While observing through an endoscope, an endoscopist guides the machine within the stomach to engage a portion of the fundus with a corkscrew-like device on one arm. The arm then pulls on the engaged portion to create a fold of tissue or radial plication at the gastroesophageal junction. Another arm of the machine pinches the excess tissue together and fastens the excess tissue with one pre-tied implant. This procedure does not restore normal anatomy. The fold created does not have anything in common with a valve. In fact, the direction of the radial fold prevents the fold or plication from acting as a flap of a valve.
  • Another transoral procedure contemplates making a fold of fundus tissue near the deteriorated gastroesophageal flap to recreate the lower esophageal sphincter (LES). The procedure requires placing multiple U-shaped tissue clips around the folded fundus to hold it in shape and in place.
  • This and the previously discussed procedure are both highly dependent on the skill, experience, aggressiveness, and courage of the endoscopist. In addition, these and other procedures may involve esophageal tissue in the repair. Esophageal tissue is fragile and weak, in part due to the fact, that the esophagus is not covered by serosa, a layer of very sturdy, yet very thin tissue, covering and stabilizing all intraabdominal organs, similar like a fascia covering and stabilizing muscle. Involvement of esophageal tissue in the repair of a gastroesophageal flap valve poses unnecessary risks to the patient, such as an increased risk of fistulas between the esophagus and the stomach.
  • A new and improved apparatus and method for restoration of a gastroesophageal flap valve is fully disclosed in copending U.S. application Ser. No. 10/150,740, filed May 17, 2002, for TRANSORAL ENDOSCOPIC GASTROESOPHAGEAL FLAP VALVE RESTORATION DEVICE, ASSEMBLY, SYSTEM AND METHOD, is assigned to the assignee of this invention, and is incorporated herein by reference. That apparatus and method provides a transoral endoscopic gastroesophageal flap valve restoration. A longitudinal member arranged for transoral placement into a stomach carries a tissue shaper that non-invasively grips and shapes stomach tissue. A tissue fixation device is then deployed to maintain the shaped stomach tissue in a shape approximating a gastroesophageal flap.
  • Whenever tissue is to be maintained in a shape as, for example, in the improved assembly last mentioned above, it is necessary to fasten at least two layers of tissue together. In applications such as gastroesophageal flap valve restoration, there is very limited room to maneuver a fastener deployment device. For example, this and other medical fastening applications provide confined working channels and spaces and often must be fed through an endoscope to permit visualization or other small lumen guide catheters to the place where the fasteners are to be deployed. To make matters worse, multiple fasteners may also be required. Hence, with current fasteners and deployment arrangements, it is often difficult to direct a single fastener to its intended location, let alone a number of such fasteners.
  • Once the fastening site is located, the fasteners employed must be truly able to securely maintain the tissue. Still further, the fastener must be readily deployable. Also, quite obviously, the fasteners are preferably deployable in the tissue in a manner which does not unduly traumatize the tissue.
  • SUMMARY
  • The invention provides a fastener for use in a mammalian body. The fastener comprises a first member and a second member, wherein the first and second members have first and second ends. The fastener further comprises a connecting member fixed to each of the first and second members intermediate the first and second ends and extending between the first and second members. The first and second members are separated by the connecting member and one of the first and second members has a through channel along the axis arranged to be slidingly received on a tissue piercing deployment wire, and a slit extending between the first and second ends and communicating with the through channel.
  • The slit is substantially parallel to the through channel. The slit may include an elongated slot portion dimensioned to receive the tissue piercing deployment wire. The slit further has a width less than the diameter of the through channel.
  • The invention further provides a fastener assembly for use in a mammalian body, comprising a fastener including a first member and a second member. The first and second members have first and second ends. The fastener further comprises a connecting member fixed to each of the first and second members intermediate the first and second ends and extending between the first and second members. The first and second members are separated by the connecting member, and one of the first and second members has a longitudinal axis, a through channel along the axis, and a slit between the first and second ends and communicating with the through channel. The assembly further comprises a deployment wire arranged to be slidingly received by the through channel of the one of the first and second members and to pierce into the tissue. The deployment wire is arranged to be received by the slit to enable early deployment of the one of the first and second members and reduced tissue compression. The assembly further comprises a pusher that pushes the one of first and second members into the tissue while on the deployment wire.
  • The invention further comprises a fastener assembly for use in a mammalian body compromising a fastener including a first member, and a second member, wherein the first and second members have first and second ends. The fastener further comprises a connecting member fixed to each of the first and second members intermediate the first and second ends and extends between and separates the first and second members. The one of the first and second members has a longitudinal axis, a through channel along the axis, and a slit extending between the first and second ends and communicating with the through channel. The assembly further comprises a deployment wire arranged to be slidingly received by the through channel of the one of the first and second members and has a pointed tip to pierce into tissue, the pointed tip having a cross-sectional dimension equal to or greater than the cross-sectional dimension of the through channel. The assembly further comprises a pusher that pushes the one of first and second members into the tissue while on the deployment wire.
  • The invention still further provides a fastener assembly for use in a mammalian body, comprising a deployment wire having an end arranged to pierce into tissue to be fastened, a fastener including a member having a through channel dimensioned to be slidingly received on the deployment wire, and a pusher that pushes the fastener into the tissue while on the deployment wire. The pusher is tubular having a distal end, a sidewall, a lumen, and an opening in the sidewall communicating with the lumen. The pusher is carried on the deployment wire with the deployment wire extending through the sidewall opening, into the lumen, and beyond the distal end of the pusher. The fastener member is carried on the deployment wire between the deployment wire end and the distal end of the pusher arranged to pierce into the tissue upon being pushed by the pusher.
  • The invention further provides a fastener for use in a mammalian body comprising a first member, a second member, the first and second members having first and second ends, and a connecting member fixed to each of the first and second members intermediate the first and second ends and extending between the first and second members. The first and second members are separated by the connecting member and one of the first and second members has a through channel arranged to be slidingly received on a tissue piercing deployment wire and a configuration alterable by the tissue piercing deployment wire that permits release of the fastener from the tissue piercing deployment wire.
  • The configuration of the one of the first and second members is alterable by being tearable by the tissue piercing deployment wire. The member may have a sidewall that is tearable by the tissue piercing deployment wire. The sidewall may have a varying thickness, such as by a scoring line, to assist in the sidewall tearing.
  • Alternatively, the configuration of the one of the first and second members may be alterable by being deformable by the tissue piercing deployment wire. The member may have a sidewall that is deformable by the tissue piercing deployment wire. The sidewall may include a lengthwise slit. The lengthwise slit may be continuous from the first end to the second end. The slit may include a slot portion.
  • The invention still further provides a fastener assembly for use in a mammalian body, comprising a fastener including a first member, a second member, the first and second members having first and second ends, and a connecting member fixed to each of the first and second members intermediate the first and second ends and extending between the first and second members. The first and second members are separated by the connecting member and one of the first and second members has a longitudinal axis and a through channel along the axis. The assembly further includes a deployment wire arranged to be slidingly received by the through channel of the one of the first and second members and to pierce into the tissue and a pusher that pushes the one of first and second members into the tissue while on the deployment wire. The one of the first and second members has a configuration that is alterable by the tissue piercing deployment wire that permits release of the fastener from the tissue piercing deployment wire upon relative movement of the one of the first and second members and the tissue piercing deployment wire.
  • The pusher is tubular having a distal end, a sidewall, a lumen, and an opening in the sidewall communicating with the lumen. The pusher is carried on the tissue piercing deployment wire which extends through the sidewall opening, into the lumen, and beyond the distal end of the pusher. The one of the first and second members is carried on the deployment wire between the deployment wire end and the distal end of the pusher to be arranged to pierce into the tissue upon being pushed by the pusher.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • The features of the present invention which are believed to be novel are set forth with particularity in the appended claims. The invention, together with further objects and advantages thereof, may best be understood by making reference to the following description taken in conjunction with the accompanying drawings, in the several figures of which like reference numerals identify like elements, and wherein:
  • FIG. 1 is a front cross-sectional view of the esophageal-gastro-intestinal tract from a lower portion of the esophagus to the duodenum;
  • FIG. 2 is a front cross-sectional view of the esophageal-gastro-intestinal tract illustrating a Grade I normal appearance movable flap of the gastroesophageal flap valve (in dashed lines) and a Grade III reflux appearance gastroesophageal flap of the gastroesophageal flap valve (in solid lines);
  • FIG. 3 is a perspective view of a fastener embodying the invention;
  • FIG. 4 is a side view of the fastener of FIG. 3;
  • FIG. 5 is a perspective view with portions cut away of a fastener assembly according to a first embodiment of the invention in an early stage of deploying the fastener of FIGS. 3 and 4;
  • FIG. 6 is a perspective view of the assembly of FIG. 5 shown with the fastener being driven in the tissue layers to be fastened;
  • FIG. 7 is a perspective view of the assembly of FIG. 5 shown with the fastener in an intermediate stage of deployment;
  • FIG. 8 is a perspective view of the assembly of FIG. 5 shown with the fastener almost completely deployed;
  • FIG. 9 is a perspective view showing the fastener of the assembly of FIG. 5 fully deployed and securely fastening a pair of tissue layers together;
  • FIG. 10 is an exploded side view of a deployment wire and pusher arrangement according to an embodiment of the invention;
  • FIG. 11 is a perspective view with portions cut away of a fastener assembly according to a second embodiment of the invention in an early stage of deploying a further fastener embodiment of the invention;
  • FIG. 12 is a perspective view of the assembly of FIG. 11 shown with the fastener being driven in the tissue layers to be fastened;
  • FIG. 13 is a perspective view of the assembly of FIG. 11 shown with the fastener in an intermediate stage of deployment;
  • FIG. 14 is a perspective view of the assembly of FIG. 11 shown with the fastener almost completely deployed;
  • FIG. 15 is a perspective view showing the fastener of the assembly of FIG. 11 fully deployed and securely fastening a pair of tissue layers together;
  • FIG. 16 is a perspective view with portions cut away of a fastener assembly according to a still further embodiment of the invention in an early stage of deploying a still further fastener embodiment of the invention;
  • FIG. 17 is a perspective view of the assembly of FIG. 16 shown with the fastener being driven in the tissue layers to be fastened;
  • FIG. 18 is a perspective view of the assembly of FIG. 16 shown with the fastener in an intermediate stage of deployment;
  • FIG. 19 is a perspective view of the assembly of FIG. 16 shown with the fastener almost completely deployed; and
  • FIG. 20 is a perspective view showing the fastener of the assembly of FIG. 16 fully deployed and securely fastening a pair of tissue layers together.
  • DETAILED DESCRIPTION
  • FIG. 1 is a front cross-sectional view of the esophageal-gastro-intestinal tract 40 from a lower portion of the esophagus 41 to the duodenum 42. The stomach 43 is characterized by the greater curvature 44 on the anatomical left side and the lesser curvature 45 on the anatomical right side. The tissue of the outer surfaces of those curvatures is referred to in the art as serosa tissue. As will be seen subsequently, the nature of the serosa tissue is used to advantage for its ability to bond to like serosa tissue. The fundus 46 of the greater curvature 44 forms the superior portion of the stomach 43, and traps gas and air bubbles for burping. The esophageal tract 41 enters the stomach 43 at an esophageal orifice below the superior portion of the fundus 46, forming a cardiac notch 47 and an acute angle with respect to the fundus 46 known as the Angle of His 57. The lower esophageal sphincter (LES) 48 is a discriminating sphincter able to distinguish between burping gas, liquids, and solids, and works in conjunction with the fundus 46 to burp. The gastroesophageal flap valve (GEFV) 49 includes a moveable portion and an opposing more stationary portion. The moveable portion of the GEFV 49 is an approximately 180 degree, semicircular, gastroesophageal flap 50 (alternatively referred to as a “normal moveable flap” or “moveable flap”) formed of tissue at the intersection between the esophagus 41 and the stomach 43. The opposing more stationary portion of the GEFV 49 comprises a portion of the lesser curvature 45 of the stomach 43 adjacent to its junction with the esophagus 41. The gastroesophageal flap 50 of the GEFV 49 principally comprises tissue adjacent to the fundus 46 portion of the stomach 43, is about 4 to 5 cm long (51) at it longest portion, and the length may taper at its anterior and posterior ends. The gastroesophageal flap 50 is partially held against the lesser curvature 45 portion of the stomach 43 by the pressure differential between the stomach 43 and the thorax, and partially by the resiliency and the anatomical structure of the GEFV 49, thus providing the valving function. The GEFV 49 is similar to a flutter valve, with the gastroesophageal flap 50 being flexible and closeable against the other more stationary side.
  • The esophageal tract is controlled by an upper esophageal sphincter (UES) in the neck near the mouth for swallowing, and by the LES 48 and the GEFV 49 at the stomach. The normal anti-reflux barrier is primarily formed by the LES 48 and the GEFV 49 acting in concert to allow food and liquid to enter the stomach, and to considerably resist reflux of stomach contents into the esophagus 41 past the gastroesophageal tissue junction 52. Tissue aboral of the gastroesophageal tissue junction 52 is generally considered part of the stomach because the tissue protected from stomach acid by its own protective mechanisms. Tissue oral of the gastroesophageal junction 52 is generally considered part of the esophagus and it is not protected from injury by prolonged exposure to stomach acid. At the gastroesophageal junction 52, the juncture of the stomach and esophageal tissues form a zigzag line, which is sometimes referred to as the “Z-line.” For the purposes of these specifications, including the claims, “stomach” means the tissue aboral of the gastroesophageal junction 52.
  • FIG. 2 is a front cross-sectional view of an esophageal-gastro-intestinal tract illustrating a Grade I normal appearance movable flap 50 of the GEFV 49 (shown in dashed lines) and a deteriorated Grade III gastroesophageal flap 55 of the GEFV 49 (shown in solid lines). As previously mentioned, a principal reason for regurgitation associated with GERD is the mechanical failure of the deteriorated (or reflux appearance) gastroesophageal flap 55 of the GEFV 49 to close and seal against the higher pressure in the stomach. Due to reasons including lifestyle, a Grade I normal gastroesophageal flap 50 of the GEFV 49 may deteriorate into a Grade III deteriorated gastroesophageal flap 55. The anatomical results of the deterioration include moving a portion of the esophagus 41 that includes the gastroesophageal junction 52 and LES 48 toward the mouth, straightening of the cardiac notch 47, and increasing the Angle of His 57. This effectively reshapes the anatomy aboral of the gastroesophageal junction 52 and forms a flattened fundus 56. The deteriorated gastroesophageal flap 55 illustrates a gastroesophageal flap valve 49 and cardiac notch 47 that have both significantly degraded. Dr. Hill and colleagues developed a grading system to describe the appearance of the GEFV and the likelihood that a patient will experience chronic acid reflux. L. D. Hill, et al., The gastroesophageal flap valve: in vitro and in vivo observations, Gastrointestinal Endoscopy 1996:44:541-547. Under Dr. Hill's grading system, the normal movable flap 50 of the GEFV 49 illustrates a Grade I flap valve that is the least likely to experience reflux. The deteriorated gastroesophageal flap 55 of the GEFV 49 illustrates a Grade III (almost Grade IV) flap valve. A Grade IV flap valve is the most likely to experience reflux. Grades II and III reflect intermediate grades of deterioration and, as in the case of III, a high likelihood of experiencing reflux. With the deteriorated GEFV represented by deteriorated gastroesophageal flap 55 and the fundus 46 moved inferior, the stomach contents are presented a funnel-like opening directing the contents into the esophagus 41 and the greatest likelihood of experiencing reflux. Disclosed subsequently is a fastener and assembly which may be employed to advantage in restoring the normal gastroesophageal flap valve anatomy.
  • FIG. 3 is a perspective view and FIG. 4 is a side view of a fastener 100 embodying the present invention. The fastener 100 generally includes a first member 102, a second member 104, and a connecting member 106. As may be noted in FIG. 3, the first member 102 and second member 104 are substantially parallel to each other and substantially perpendicular to the connecting member 106 which connects the first member 102 to the second member 104.
  • The first member 102 is generally cylindrical or can have any other shape. It has a longitudinal axis 108 and a through channel 112 along the longitudinal axis 108. The through channel 112 is formed by a through bore which is dimensioned to be slidingly received on a tissue piercing deployment wire to be described.
  • The first member 102 also includes a first end 116 and a second end 118. Similarly, the second member 104 includes a first end 120 and a second end 122. The first end 116 of member 102 forms a pointed dilation tip 124. The dilation tip 124 may be conical and more particularly takes the shape of a truncated cone. The tip can also be shaped to have a cutting edge in order to reduce tissue resistance.
  • The first and second members 102 and 104 and the connecting member 106 may be formed of different materials and have different textures. These materials may include, for example, plastic materials such as polypropylene, polyethylene, polyglycolic acid, polyurethane, or a thermoplastic elastomer. The plastic materials may include a pigment contrasting with body tissue color to enable better visualization of the fastener during its deployment. Alternatively, the fastener may be formed of a metal, such as stainless steel or a shape memory metal, such as Nitinol.
  • As may be further noted in FIG. 3, the connecting member 106 has a vertical dimension 128 and a horizontal dimension 130 which is transverse to the vertical dimension. The horizontal dimension is substantially less than the vertical dimension to render the connecting member 106 readily bendable in a horizontal plane. The connecting member is further rendered bendable by the nature of the material from which the fastener 100 is formed. The connecting member may be formed from either an elastic plastic or a permanently deformable plastic. An elastic material would prevent compression necrosis in some applications.
  • It may be noted in FIGS. 3 and 4, that the first member 102 has a continuous lengthwise slit 125 extending between the first and second ends 116 and 118. The slit 125 includes an optional slot portion 126 that communications with the through channel 112. The slot 126 has a transverse dimension for more readily enabling receipt of a tissue piercing deployment wire during deployment of the fastener 100. Also, because the fastener number 102 is formed of flexible material, the slit 125 may be made larger through separation to allow the deployment wire to be snapped into and released from the through channel 112 as will be seen subsequently. This permits early release of the first member during deployment 102 and decreases compression on the tissue layers. The slit 125 extends substantially parallel to the through channel 112 and the center axis 108 of the first member 102. It may also be noted that the slit 125 has a width dimension that is smaller or less than the diameter D of the through channel 112. This assures that the fastener 100 will remain on a tissue piercing deployment wire as it is pushed towards and into the tissue as will be seen subsequently.
  • Referring now to FIG. 5, it is a perspective view with portions cut away of a fastener assembly 200 embodying the present invention for deploying the fastener 100. The tissue layer portions above the fastener 100 have been shown cut away in FIGS. 5-9 to enable the deployment procedure to be seen more clearly. The assembly 200 generally includes the fastener 100, a deployment wire 164, a pusher 166, and a guide tube 168.
  • The first member 102 of the fastener 100 is slidingly received on the deployment wire 164. The deployment wire 164 has a pointed tip 178 for piercing the tissue layers 180 and 182 to be fastened together. The tip 178 is enlarged with respect to the diameter of the deployment wire 164 and preferably has a cross-sectional dimension greater than that of the through channel and preferably the first member 102. This permits the tip 178 to cut sufficient tissue to enable the fastener member 102 to readily pass through the tissue layers 180 and 182. It may also serve as a guide to guide the wire 164 off of the member 102 at the end of the deployment. The tissue piercing wire 164, fastener 100, and the pusher 166 are all within the guide tube 168. The guide tube 168 may take the form of a catheter, for example, as previously mentioned, or a guide channel within a block of material.
  • As will be further noted in FIG. 5, the second member 104 is disposed along side the first member 102. This is rendered possible by the flexibility of the connecting member 106.
  • With the first member 102 of the fastener 100 slidingly received on the tissue piercing wire 164 and with the pusher 166 just touching the first member 102 on the tissue piercing wire 164, the tip 178 of the tissue piercing wire 164 pierces the tissue layers 180 and 182. The subassembly of the tissue piercing wire 164, fastener 100, and pusher 166 may be guided to its intended location relative to the tissue layers 180 and 182 by the guide tube 168.
  • As shown in FIG. 6, the tissue piercing wire 164 has pierced the tissue layers 180 and 182 and the pusher 166 has pushed the first member 102 of the fastener 100 through the tissue layers 180 and 182 on the tissue piercing wire 164. This may be accomplished by moving the wire 164 and the pusher 166 together.
  • As may be seen in FIG. 7, wire 164 has been pushed further forward and independently from the first member 102. The first member 102 has also been pushed forward by the pusher 166 to cause the second member 104 to engage the tissue layer 180. Continued pushing of the first member 102 causes the first member to pivot in a counter clockwise direction because the second member 104 is held by the tissue layer 180. The counter clockwise movement of the first member 102 causes the wire 164 to spread the slit 125 open, to pass down the slit to enter slot portion 126 and to eventually pass through the slit 125 at end 118. The fastener 100 is then released from the wire 164.
  • In FIG. 8, it will now be seen that the second end 118 of the first member 102 has cleared the wire 164 and tissue layer 182. The tissue piercing wire 164 may now be retracted into the pusher 166 and the tissue piercing wire 164 and pusher 166 may be withdrawn.
  • FIG. 9 illustrates the fastener 100 in its fully deployed position. It will be noted that the fastener has returned to its original shape. The tissue layers 180 and 182 are fastened together between the first member 102 of the fastener 100 and the second member 104 of the fastener 100. The connecting member 106 extends through the tissue layers 180 and 182.
  • The release of the fastener 100 from the wire 164 with minimal damage to the tissue layers 180 and 182 is made possible because the first member 102 has a configuration alterable by the wire 164. The slit 125 in member 102 assists in the configuration change and release.
  • Referring now to FIG. 10, it shows a deployment wire/pusher arrangement 160 which may be employed in the assembly 200 of FIGS. 5-9. The arrangement 160 includes the deployment piercing wire 164 and the pusher 166. The wire 164 includes the tissue piercing tip 178. The pusher 166 is tubular and has a distal end 165, a lumen 162, and an opening 167 through the pusher sidewall 161 and communicating with the lumen 162. The lumen 162 is configured to permit the pusher 166 to slidingly be carried on the wire 164. To that end, the wire extends within the lumen 162 from the distal end 165 and through the opening 167. A fastener 100, of the type previously described, has been snapped onto the deployment wire 164 between the deployment wire tip 178 and the distal end 165 of the pusher 166. An optional stiffener 169 may also be provided for the pusher 166.
  • After a fastener is deployed, the pusher 166 may be retracted from the patient while the pusher is still on the deployment wire 164, a further fastener may then be snapped onto the wire through the slit 125. The pusher may then be advanced down the deployment wire to deploy the fastener as previously described.
  • FIGS. 11-15 show a deployment sequence of another fastener assembly 210 embodying the invention. As shown in FIG. 11, the assembly 210 includes the deployment wire 164, the pusher 166, the guide tube 168, and a fastener 300. The fastener 300 includes a first member 302, a second member 304, and a connecting member 306. The fastener 300 is similar to the fastener 100 previously described except that to render the configuration of the first member 302 alterable by the deployment wire 164 as the first member 102 is so alterable, the first member 302 is stretchable to obviate the need for a slit. More specifically, the first member 302 may be formed of rubber, for example, to permit the wire 164 to be separated from the member 302 by simply pulling the wire tip 178 back through through the member. Deformation of the member 302 occurs to permit this separation.
  • FIG. 11 shows the fastener 300 on the wire with the wire tip 178 just piercing the tissue layer. The first member 302 is carried on the wire 164 which extends through the through channel of the first member 302.
  • As seen in FIG. 12, the pusher 166 and wire 164 are moved forward together to cause the wire 164 and member 302 to extend through the tissue layers 180 and 186. From this point, as may be seen in FIG. 13, the pusher pushes the member 302 forward. The second member 304 first engages tissue layer 180 and once so engaged, the first member 302 is caused to rotate (counter clockwise in FIG. 13). The elasticity of the member 302 causes the wire tip to stretch the sidewall of the first member 302. As the member 302 is continued to be pushed, and with optional retraction of the deployment wire 114, it continues to rotate. Eventually, the end 318 of the member 302 pops free of the wire tip. This may be seen in FIG. 14. The end 318 of the member is now free of the wire 164.
  • The pusher 166 and deployment wire 164 may now be extracted. As shown in FIG. 15, the tissue layers 180 and 182 are now fixed together between the first and second members 302 and 304 with the connecting member 306 extending therebetween.
  • FIGS. 16-20 show a deployment sequence of another fastener assembly 220 embodying the invention. As shown in FIG. 16, the assembly 220 includes the deployment wire 164, the pusher 166, the guide tube 168, and a fastener 400. The fastener 400 includes a first member 402, a second member 404, and a connecting member 406. The fastener 400 is similar to the fasteners 100 and 300 previously described except that, to render the configuration of the first member 402 alterable by the deployment wire 164, the first member 402 is tearable by tip 178 of the wire 164. More specifically, the first member 402 may be formed, for example, to permit the wire 164 to tear the member 402 lengthwise as the wire tip 178 is pulled back through through the member 402. To assist the tearing, the member sidewall may have a varying thickness, such as a tearing or score line 403.
  • FIG. 16 shows the fastener 400 on the wire with the wire tip 178 just piercing the tissue layer. The first member 402 is carried on the wire 164 which extends through the through channel of the first member 402.
  • As seen in FIG. 17, the pusher 166 and wire 164 are moved forward together to cause the wire 164 and member 402 to extend through the tissue layers 180 and 186. From this point, the pusher 166 pushes the member 402 to cause the tip 178 to begin tearing the member 402 along the score line 402. As may be seen in FIG. 18, the pusher pushes the member 402 forward. The second member 404 first engages tissue layer 180 and once so engaged, the first member 402 is caused to rotate (counter clockwise in FIG. 18). The turning of the member 402 causes the wire tip 178 to tear through the sidewall of the first member 402. As the member 402 is continued to be pushed, it continues to be turned lengthwise. Eventually, the end 418 of the member 402 releases from the wire tip. This may be seen in FIG. 19. The end 418 of the member is now free of the wire 164.
  • The pusher 166 and deployment wire 164 may now be extracted. As shown in FIG. 20, the tissue layers 180 and 182 are now fixed together between the first and second members 402 and 404 with the connecting member 406 extending therebetween.
  • While the invention has been described by means of specific embodiments and applications thereof, it is understood that numerous modifications and variations may be made thereto by those skilled in the art without departing from the spirit and scope of the invention. It is therefore to be understood that within the scope of the claims, the invention may be practiced otherwise than as specifically described herein.

Claims (73)

  1. 1. A fastener for use in a mammalian body, comprising:
    a first member;
    a second member,
    the first and second members having first and second ends; and
    a connecting member fixed to each of the first and second members intermediate the first and second ends and extending between the first and second members,
    the first and second members being separated by the connecting member, and
    one of the first and second members having a through channel along the axis arranged to be slidingly received on a tissue piercing deployment wire, and a slit extending between the first and second ends and communicating with the through channel.
  2. 2. The fastener of claim 1 wherein the slit includes an elongated slot portion dimensional to receive the tissue piercing deployment wire.
  3. 3. The fastener of claim 1 wherein the slit is substantially parallel to the through channel.
  4. 4. The fastener of claim 1 wherein the connecting member is flexible permitting another one of the first and second members to be next to the one of the first and second members when the one of the first and second members is on the tissue piercing deployment wire.
  5. 5. The fastener of claim 1 wherein one end of the one of the first and second members further includes a pointed tip.
  6. 6. The fastener of claim 1 wherein the through channel comprises a through bore.
  7. 7. The fastener of claim 1 wherein the first member, the second member, and the connecting member are all formed of plastic material.
  8. 8. The fastener of claim 7 wherein the first member, the second member, and the connecting member are all formed in one piece.
  9. 9. The fastener of claim 7 wherein the connecting member is formed of plastic elastic material.
  10. 10. The fastener of claim 7 wherein the plastic material includes a color pigment contrasting with body tissue color to enable visualization of the fastener with an endoscope.
  11. 11. The fastener of claim 1 wherein the through channel has a diameter, wherein the slit has a width, and wherein the width of the slit is less than the diameter of the through channel.
  12. 12. A fastener assembly for use in a mammalian body, comprising:
    a fastener including a first member, a second member, wherein the first and second members have first and second ends, and a connecting member fixed to each of the first and second members intermediate the first and second ends and extending between the first and second members, wherein the first and second members are separated by the connecting member, and wherein one of the first and second members has a longitudinal axis, a through channel along the axis, and a slit extending between the first and second ends and communicating with the through channel;
    a deployment wire arranged to be slidingly received by the through channel of the one of the first and second members and to pierce into the tissue and arranged to be received by the slit to enable early deployment of the one of the first and second members and reduced tissue compression; and
    a pusher that pushes the one of first and second members into the tissue while on the deployment wire.
  13. 13. The assembly of claim 12 wherein the slit includes a slotted portion dimensioned to receive the deployment wire.
  14. 14. The assembly of claim 12 wherein the slit is substantially parallel to the through channel.
  15. 15. The assembly of claim 12 wherein the pusher is also arranged to be slidingly received on the deployment wire.
  16. 16. The assembly of claim 12 wherein the connecting member of the fastener is flexible, and wherein the assembly further comprises a guide tube extending over the deployment wire and the fastener, the other one of the first and second members being disposed next to the one of the first and second members within the guide tube.
  17. 17. The assembly of claim 12 wherein the first and second members are arranged to be side by side when the one of the first and second members is slidingly received on the deployment wire.
  18. 18. The assembly of claim 12 wherein one end of the one of the first and second members of the fastener further includes a pointed tip.
  19. 19. The assembly of claim 12 further comprising a guide tube extending over the deployment wire and the fastener.
  20. 20. The assembly of claim 12 wherein the first member, the second member, and the connecting member of the fastener are all formed of plastic material.
  21. 21. The assembly of claim 12 wherein the one of the first and second members of the fastener is self-deployable when the tissue piercing deployment wire is received by the slit.
  22. 22. The assembly of claim 12 wherein the through channel has a diameter, wherein the slit has a width, and wherein the width of the slit is less than the diameter of the through channel.
  23. 23. A fastener assembly for use in a mammalian body, comprising:
    a fastener including a first member, a second member, wherein the first and second members have first and second ends, and a connecting member fixed to each of the first and second members intermediate the first and second ends and extending between the first and second members, wherein the first and second members are separated by the connecting member, and wherein one of the first and second members has a cross-sectional dimension and a slit extending between the first and second ends and communicating with the through channel;
    a deployment wire arranged to be slidingly received by the through channel of the one of the first and second members and having a pointed tip to pierce into tissue, the pointed tip having a cross-sectional dimension equal to or greater than the cross-sectional dimension of the through channel; and
    a pusher that pushes the one of first and second members into the tissue while on the deployment wire.
  24. 24. The assembly of claim 23 wherein the slit includes a slot portion dimension to receive the deployment wire.
  25. 25. The assembly of claim 23 wherein the pusher is also arranged to be slidingly received on the deployment wire.
  26. 26. The assembly of claim 23 wherein the connecting member of the fastener is flexible, and wherein the assembly further comprises a guide tube extending over the deployment wire and fastener, the other one of the first and second members being disposed next to the one of the first and second members within the guide tube.
  27. 27. The assembly of claim 23 wherein the first and second members are arranged to be side by side when the one of the first and second members is slidingly received on the deployment wire.
  28. 28. The assembly of claim 25 wherein one end of the one of the first and second members of the fastener further includes a pointed tip.
  29. 29. The assembly of claim 28 wherein the pointed tip comprises a truncated cone.
  30. 30. The assembly of claim 23 further comprising a guide tube extending over the deployment wire and the fastener.
  31. 31. The assembly of claim 23 wherein the one of the first and second members is formed of a flexible material to permit the deployment wire to be received within the through channel through the slit.
  32. 32. The assembly of claim 31 wherein the first member, the second member, and the connecting member of the fastener are all formed of plastic material.
  33. 33. The assembly of claim 31 wherein the first member, the second member, and the connecting member of the fastener are all formed in one piece.
  34. 34. The assembly of claim 31 wherein the fastener is formed of one of polyurethane, thermoplastic elastomer, and polypropylene.
  35. 35. The assembly of claim 31 wherein the fastener is formed of metal.
  36. 36. The assembly of claim 23 wherein the one of the first and second members of the fastener is self-deployable when the tissue piercing deployment wire is received by the slit during retraction.
  37. 37. The assembly of claim 23 wherein the through channel has a diameter, wherein the slit has a width, and wherein the width of the slit is less than the diameter of the through channel.
  38. 38. A fastener assembly for use in a mammalian body, comprising:
    a deployment wire having an end arranged to pierce into tissue to be fastened;
    a fastener including a member having a through channel dimensioned to be slidingly received on the deployment wire; and
    a pusher that pushes the fastener into the tissue while on the deployment wire,
    the pusher being tubular having a distal end, a sidewall, a lumen, and an opening in the sidewall communicating with the lumen,
    wherein the pusher is carried on the deployment wire, the deployment wire extending through the sidewall opening, into the lumen, and beyond the distal end of the pusher, and
    wherein the fastener member is carried on the deployment wire between the deployment wire end and the distal end of the pusher arranged to pierce into the tissue upon being pushed by the pusher.
  39. 39. The assembly of claim 38 wherein the fastener member includes first and second ends and a slit extending between the first and second ends and communicating with the through channel.
  40. 40. The assembly of claim 39 wherein the through channel has a diameter, wherein the slit has a width, and wherein the width of the slit is less than the diameter of the through channel.
  41. 41. The fastener assembly of claim 38 wherein the fastener member is a first member, and wherein the fastener includes the first member, a second member and a connecting member extending between the first and second members.
  42. 42. The assembly of claim 41 wherein the first member, the second member, and the connecting member of the fastener are all formed of plastic material.
  43. 43. The assembly of claim 41 wherein the first member includes first and second ends and a slit extending between the first and second ends and communicating with the through channel.
  44. 44. The assembly of claim 43 wherein the slit includes an elongated slot.
  45. 45. The assembly of claim 44 wherein the first member of the fastener is self-deployable when the tissue piercing deployment wire is received by the elongated slot.
  46. 46. The assembly of claim 41 wherein the connecting member of the fastener is flexible, and wherein the assembly further comprises a guide tube extending over the deployment wire and the fastener, the second member being disposed next to the first member within the guide tube.
  47. 47. The assembly of claim 41 wherein the first and second members are arranged to be side by side when the first member is a slidingly received on the deployment wire.
  48. 48. The assembly of claim 41 wherein one end of the first member of the fastener further includes a pointed tip.
  49. 49. The assembly of claim 47 wherein the first member, the second member, and the connecting member of the fastener are all formed in one piece.
  50. 50. The assembly of claim 41 wherein the fastener is formed of a shape memory material.
  51. 51. The assembly of claim 41 further comprising a guide tube extending over the deployment wire and the fastener.
  52. 52. The assembly of claim 28 wherein the fastener member has a slit communicating with the through channel to enable the through channel to be received by the deployment wire and wherein the deployment wire includes a piercing tip, the piercing tip having a cross-sectional dimension and the fastener member having a cross-sectional dimension and wherein the cross-sectional dimension of the piercing tip is greater than the cross-sectional area of the fastener member.
  53. 53. A fastener for use in a mammalian body, comprising:
    a first member;
    a second member,
    the first and second members having first and second ends; and
    a connecting member fixed to each of the first and second members intermediate the first and second ends and extending between the first and second members,
    the first and second members being separated by the connecting member, and
    one of the first and second members having a through channel arranged to be slidingly received on a tissue piercing deployment wire, and a configuration alterable by the tissue piercing deployment wire that permits release of the fastener from the tissue piercing deployment wire.
  54. 54. The fastener of claim 53, wherein the configuration of the one of the first and second members is tearable by the tissue piercing deployment wire.
  55. 55. The fastener of claim 54, wherein the one of the first and second members has a sidewall, and wherein the sidewall is tearable by the tissue piercing deployment wire.
  56. 56. The fastener of claim 55, wherein the sidewall has a varying thickness.
  57. 57. The fastener of claim 53, wherein the configuration of the one of the first and second members is deformable by the tissue piercing deployment wire.
  58. 58. The fastener of claim 57, wherein the one of the first and second members has a sidewall, and wherein the sidewall is deformable by the tissue piercing deployment wire.
  59. 59. The fastener of claim 58, wherein the sidewall includes a lengthwise slit.
  60. 60. The fastener of claim 59, wherein the lengthwise slit is continuous from the first end to the second end.
  61. 61. The fastener of claim 60, wherein the slit includes a slot portion.
  62. 62. A fastener assembly for use in a mammalian body, comprising:
    a fastener including a first member, a second member, wherein the first and second members have first and second ends, and a connecting member fixed to each of the first and second members intermediate the first and second ends and extending between the first and second members, wherein the first and second members are separated by the connecting member, and wherein one of the first and second members has a longitudinal axis and a through channel along the axis;
    a deployment wire arranged to be slidingly received by the through channel of the one of the first and second members and to pierce into the tissue; and
    a pusher that pushes the one of first and second members into the tissue while on the deployment wire,
    the one of the first and second members having a configuration that is alterable by the tissue piercing deployment wire that permits release of the fastener from the tissue piercing deployment wire upon relative movement of the one of the first and second members and the tissue piercing deployment wire.
  63. 63. The fastener assembly of claim 62, wherein the configuration of the one of the first and second members is tearable by the tissue piercing deployment wire.
  64. 64. The fastener assembly of claim 63, wherein the one of the first and second members has a cross-sectional dimension and wherein the tissue piercing deployment wire has a tip end having a cross-sectional dimension that is greater than or equal to the cross-sectional dimension of the through channel.
  65. 65. The fastener assembly of claim 63, wherein the one of the first and second members has a sidewall, and wherein the sidewall is tearable by the tissue piercing deployment wire.
  66. 66. The fastener assembly of claim 65, wherein the sidewall has a varying thickness.
  67. 67. The fastener assembly of claim 62, wherein the configuration of the one of the first and second members is deformable by the tissue piercing deployment wire.
  68. 68. The fastener assembly of claim 67, wherein the one of the first and second members has a cross-sectional dimension and wherein the tissue piercing deployment wire has a tip end having a cross-sectional dimension that is greater than or equal to the cross-sectional dimension of the through channel.
  69. 69. The fastener assembly of claim 67, wherein the one of the first and second members has a sidewall, and wherein the sidewall is deformable by the tissue piercing deployment wire.
  70. 70. The fastener assembly of claim 69, wherein the sidewall includes a lengthwise slit.
  71. 71. The fastener assembly of claim 70, wherein the lengthwise slit is continuous from the first end to the second end.
  72. 72. The fastener assembly of claim 71, wherein the slit includes a slot portion.
  73. 73. The fastener assembly of claim 62, wherein the pusher is tubular having a distal end, a sidewall, a lumen, and an opening in the sidewall communicating with the lumen, wherein the pusher is carried on the tissue piercing deployment wire, the tissue piercing deployment wire extending through the sidewall opening, into the lumen, and beyond the distal end of the pusher, and wherein the one of the first and second members is carried on the deployment wire between the deployment wire end and the distal end of the pusher arranged to pierce into the tissue upon being pushed by the pusher.
US11043903 2005-01-25 2005-01-25 Slitted tissue fixation devices and assemblies for deploying the same Abandoned US20060167481A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11043903 US20060167481A1 (en) 2005-01-25 2005-01-25 Slitted tissue fixation devices and assemblies for deploying the same

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US11043903 US20060167481A1 (en) 2005-01-25 2005-01-25 Slitted tissue fixation devices and assemblies for deploying the same
PCT/US2006/002815 WO2006081368A3 (en) 2005-01-25 2006-01-25 Slitted tissue fixation devices and assemblies for deploying the same
ES06719606T ES2573849T3 (en) 2005-01-25 2006-01-25 cloven tissue fixation devices and assemblies for deployment thereof
JP2007552411A JP2008528132A (en) 2005-01-25 2006-01-25 Slits biological tissue anchor and structures to take advantage of the device
EP20060719606 EP1848347B1 (en) 2005-01-25 2006-01-25 Slitted tissue fixation devices and assemblies for deploying the same
US12803077 US8337514B2 (en) 2005-01-25 2010-06-17 Slitted tissue fixation devices and assemblies for deploying the same
US13680944 US9358007B2 (en) 2005-01-25 2012-11-19 Slitted tissue fixation devices and assemblies for deploying the same
US15152337 US9572578B2 (en) 2005-01-25 2016-05-11 Slitted tissue fixation devices and assemblies for deploying the same
US15400693 US20170112494A1 (en) 2005-01-25 2017-01-06 Slitted tissue fixation devices and assemblies for deploying the same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12803077 Continuation US8337514B2 (en) 2005-01-25 2010-06-17 Slitted tissue fixation devices and assemblies for deploying the same

Publications (1)

Publication Number Publication Date
US20060167481A1 true true US20060167481A1 (en) 2006-07-27

Family

ID=36697906

Family Applications (5)

Application Number Title Priority Date Filing Date
US11043903 Abandoned US20060167481A1 (en) 2005-01-25 2005-01-25 Slitted tissue fixation devices and assemblies for deploying the same
US12803077 Active 2025-03-11 US8337514B2 (en) 2005-01-25 2010-06-17 Slitted tissue fixation devices and assemblies for deploying the same
US13680944 Active 2026-09-21 US9358007B2 (en) 2005-01-25 2012-11-19 Slitted tissue fixation devices and assemblies for deploying the same
US15152337 Active US9572578B2 (en) 2005-01-25 2016-05-11 Slitted tissue fixation devices and assemblies for deploying the same
US15400693 Pending US20170112494A1 (en) 2005-01-25 2017-01-06 Slitted tissue fixation devices and assemblies for deploying the same

Family Applications After (4)

Application Number Title Priority Date Filing Date
US12803077 Active 2025-03-11 US8337514B2 (en) 2005-01-25 2010-06-17 Slitted tissue fixation devices and assemblies for deploying the same
US13680944 Active 2026-09-21 US9358007B2 (en) 2005-01-25 2012-11-19 Slitted tissue fixation devices and assemblies for deploying the same
US15152337 Active US9572578B2 (en) 2005-01-25 2016-05-11 Slitted tissue fixation devices and assemblies for deploying the same
US15400693 Pending US20170112494A1 (en) 2005-01-25 2017-01-06 Slitted tissue fixation devices and assemblies for deploying the same

Country Status (5)

Country Link
US (5) US20060167481A1 (en)
EP (1) EP1848347B1 (en)
JP (1) JP2008528132A (en)
ES (1) ES2573849T3 (en)
WO (1) WO2006081368A3 (en)

Cited By (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007047873A2 (en) 2005-10-18 2007-04-26 Endogastric Solutions, Inc. Invaginator for gastroesophageal flap valve restoration device
WO2007064713A2 (en) 2005-12-01 2007-06-07 Endogastric Solutions, Inc. Apparatus and method for concurrently forming a gastroesophageal valve and tightening the lower esophageal sphincter
US20090312776A1 (en) * 2006-02-03 2009-12-17 Biomet Sports Medicine, Llc Method and Apparatus for Coupling Soft Tissue to a Bone
US20100145368A1 (en) * 2008-12-05 2010-06-10 Chu Michael S H Insertion Device and Method for Delivery of a Mesh Carrier
US7909851B2 (en) * 2006-02-03 2011-03-22 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US7959650B2 (en) 2006-09-29 2011-06-14 Biomet Sports Medicine, Llc Adjustable knotless loops
US8118836B2 (en) 2004-11-05 2012-02-21 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8128658B2 (en) 2004-11-05 2012-03-06 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to bone
US8137382B2 (en) 2004-11-05 2012-03-20 Biomet Sports Medicine, Llc Method and apparatus for coupling anatomical features
US8221454B2 (en) 2004-02-20 2012-07-17 Biomet Sports Medicine, Llc Apparatus for performing meniscus repair
US8251998B2 (en) 2006-08-16 2012-08-28 Biomet Sports Medicine, Llc Chondral defect repair
US8273106B2 (en) 2006-02-03 2012-09-25 Biomet Sports Medicine, Llc Soft tissue repair and conduit device
US8298262B2 (en) 2006-02-03 2012-10-30 Biomet Sports Medicine, Llc Method for tissue fixation
US8303604B2 (en) 2004-11-05 2012-11-06 Biomet Sports Medicine, Llc Soft tissue repair device and method
US8317825B2 (en) 2004-11-09 2012-11-27 Biomet Sports Medicine, Llc Soft tissue conduit device and method
US8337525B2 (en) 2006-02-03 2012-12-25 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US8343227B2 (en) 2009-05-28 2013-01-01 Biomet Manufacturing Corp. Knee prosthesis assembly with ligament link
US8361113B2 (en) 2006-02-03 2013-01-29 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8409253B2 (en) 2006-02-03 2013-04-02 Biomet Sports Medicine, Llc Soft tissue repair assembly and associated method
US8500818B2 (en) 2006-09-29 2013-08-06 Biomet Manufacturing, Llc Knee prosthesis assembly with ligament link
US8506597B2 (en) 2011-10-25 2013-08-13 Biomet Sports Medicine, Llc Method and apparatus for interosseous membrane reconstruction
US8562645B2 (en) 2006-09-29 2013-10-22 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US8562647B2 (en) 2006-09-29 2013-10-22 Biomet Sports Medicine, Llc Method and apparatus for securing soft tissue to bone
US8574235B2 (en) 2006-02-03 2013-11-05 Biomet Sports Medicine, Llc Method for trochanteric reattachment
US20130303856A1 (en) * 2010-10-29 2013-11-14 Vectec S.A. Single Use, Disposable, Tissue Suspender Device
US8597327B2 (en) 2006-02-03 2013-12-03 Biomet Manufacturing, Llc Method and apparatus for sternal closure
US8652171B2 (en) 2006-02-03 2014-02-18 Biomet Sports Medicine, Llc Method and apparatus for soft tissue fixation
US8652172B2 (en) 2006-02-03 2014-02-18 Biomet Sports Medicine, Llc Flexible anchors for tissue fixation
US8672969B2 (en) 2006-09-29 2014-03-18 Biomet Sports Medicine, Llc Fracture fixation device
US8672968B2 (en) 2006-09-29 2014-03-18 Biomet Sports Medicine, Llc Method for implanting soft tissue
US8771352B2 (en) 2011-05-17 2014-07-08 Biomet Sports Medicine, Llc Method and apparatus for tibial fixation of an ACL graft
US8801783B2 (en) 2006-09-29 2014-08-12 Biomet Sports Medicine, Llc Prosthetic ligament system for knee joint
US8936621B2 (en) 2006-02-03 2015-01-20 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US8968364B2 (en) 2006-02-03 2015-03-03 Biomet Sports Medicine, Llc Method and apparatus for fixation of an ACL graft
US8998949B2 (en) 2004-11-09 2015-04-07 Biomet Sports Medicine, Llc Soft tissue conduit device
US9017381B2 (en) 2007-04-10 2015-04-28 Biomet Sports Medicine, Llc Adjustable knotless loops
US9078644B2 (en) 2006-09-29 2015-07-14 Biomet Sports Medicine, Llc Fracture fixation device
US9149267B2 (en) 2006-02-03 2015-10-06 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US9259217B2 (en) 2012-01-03 2016-02-16 Biomet Manufacturing, Llc Suture Button
US9271713B2 (en) 2006-02-03 2016-03-01 Biomet Sports Medicine, Llc Method and apparatus for tensioning a suture
US9314241B2 (en) 2011-11-10 2016-04-19 Biomet Sports Medicine, Llc Apparatus for coupling soft tissue to a bone
US9357991B2 (en) 2011-11-03 2016-06-07 Biomet Sports Medicine, Llc Method and apparatus for stitching tendons
US9370350B2 (en) 2011-11-10 2016-06-21 Biomet Sports Medicine, Llc Apparatus for coupling soft tissue to a bone
US9381013B2 (en) 2011-11-10 2016-07-05 Biomet Sports Medicine, Llc Method for coupling soft tissue to a bone
US9538998B2 (en) 2006-02-03 2017-01-10 Biomet Sports Medicine, Llc Method and apparatus for fracture fixation
US9615822B2 (en) 2014-05-30 2017-04-11 Biomet Sports Medicine, Llc Insertion tools and method for soft anchor
US9700291B2 (en) 2014-06-03 2017-07-11 Biomet Sports Medicine, Llc Capsule retractor
US9757119B2 (en) 2013-03-08 2017-09-12 Biomet Sports Medicine, Llc Visual aid for identifying suture limbs arthroscopically
US9918826B2 (en) 2006-09-29 2018-03-20 Biomet Sports Medicine, Llc Scaffold for spring ligament repair
US9918827B2 (en) 2013-03-14 2018-03-20 Biomet Sports Medicine, Llc Scaffold for spring ligament repair
US9955980B2 (en) 2015-02-24 2018-05-01 Biomet Sports Medicine, Llc Anatomic soft tissue repair

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7632287B2 (en) 2004-02-20 2009-12-15 Endogastric Solutions, Inc. Tissue fixation devices and assemblies for deploying the same
US20060116697A1 (en) 2004-11-30 2006-06-01 Esophyx, Inc. Flexible transoral endoscopic gastroesophageal flap valve restoration device and method
US20060167481A1 (en) 2005-01-25 2006-07-27 Esophyx, Inc. Slitted tissue fixation devices and assemblies for deploying the same
US20070038232A1 (en) 2005-08-12 2007-02-15 Kraemer Stefan J M Apparatus and method for securing the stomach to the diaphragm for use, for example, in treating hiatal hernias and gastroesophageal reflux disease
WO2008085994A3 (en) 2007-01-08 2008-09-18 Endogastric Solutions Connected fasteners, delivery device and method
US9955957B2 (en) 2011-09-09 2018-05-01 Endogastric Solutions, Inc. Methods and devices for manipulating and fastening tissue
US20130066338A1 (en) 2011-09-09 2013-03-14 Richard Romley Methods and devices for manipulating and fastening tissue
US9572571B2 (en) 2011-09-09 2017-02-21 Endogastric Solutions, Inc. Methods and devices for manipulating and fastening tissue
US9161754B2 (en) 2012-12-14 2015-10-20 Endogastric Solutions, Inc. Apparatus and method for concurrently forming a gastroesophageal valve and tightening the lower esophageal sphincter
JP6087040B1 (en) * 2015-09-17 2017-03-01 オリンパス株式会社 Endoscopic treatment tool
EP3351189A1 (en) 2015-09-17 2018-07-25 Olympus Corporation Endoscope treatment instrument

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5549631A (en) * 1993-05-14 1996-08-27 Bonutti; Peter M. Method of closing discontinuity in tissue
US5626614A (en) * 1995-12-22 1997-05-06 Applied Medical Resources Corporation T-anchor suturing device and method for using same
US6007567A (en) * 1996-08-19 1999-12-28 Bonutti; Peter M. Suture anchor
US6315789B1 (en) * 1999-02-08 2001-11-13 Andrew H. Cragg Medical device anchoring system and method
US20020183765A1 (en) * 1998-05-26 2002-12-05 Scimed Life Systems, Inc. Implantable tissue fastener and system for treating gastroesophageal reflux disease
US6790214B2 (en) * 2002-05-17 2004-09-14 Esophyx, Inc. Transoral endoscopic gastroesophageal flap valve restoration device, assembly, system and method
US20050004575A1 (en) * 2000-11-24 2005-01-06 Jean-Claude Sgro Fastener for fixing a prosthesis, and device for delivering this fastener
US20050187567A1 (en) * 2004-02-20 2005-08-25 Esophyx, Inc. Tissue fixation devices and assemblies for deploying the same

Family Cites Families (140)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2753870A (en) 1955-03-15 1956-07-10 James A Muffly Instrument for probing the reticulum
US3875928A (en) 1973-08-16 1975-04-08 Angelchik Jean P Method for maintaining the reduction of a sliding esophageal hiatal hernia
US4006747A (en) 1975-04-23 1977-02-08 Ethicon, Inc. Surgical method
US4271828A (en) 1979-09-13 1981-06-09 Angelchik Jean P Method for maintaining the reduction of a sliding esophageal hiatal hernia
US4823794A (en) * 1982-07-12 1989-04-25 Pierce William S Surgical pledget
US4595007A (en) 1983-03-14 1986-06-17 Ethicon, Inc. Split ring type tissue fastener
US4576772A (en) 1984-07-20 1986-03-18 Warner-Lambert Technologies, Inc. Catheter with optimum resistance to bending and method of manufacture
US4696300A (en) * 1985-04-11 1987-09-29 Dennison Manufacturing Company Fastener for joining materials
US4669473A (en) 1985-09-06 1987-06-02 Acufex Microsurgical, Inc. Surgical fastener
US4895148A (en) * 1986-05-20 1990-01-23 Concept, Inc. Method of joining torn parts of bodily tissue in vivo with a biodegradable tack member
DE3619197C2 (en) 1986-06-07 1988-03-31 Ethicon Gmbh & Co Kg, 2000 Norderstedt, De
US4921479A (en) 1987-10-02 1990-05-01 Joseph Grayzel Catheter sheath with longitudinal seam
JPH0377050B2 (en) * 1987-12-04 1991-12-09 Sumitomo Heavy Industries
US4846836A (en) 1988-10-03 1989-07-11 Reich Jonathan D Artificial lower gastrointestinal valve
US5314473A (en) 1989-07-20 1994-05-24 Godin Norman J Prosthesis for preventing gastric reflux into the esophagus
US5080543A (en) * 1990-01-08 1992-01-14 Engineered Construction Components (America) Inc. Fastening sleeves and fastening systems employing same
US5041129A (en) * 1990-07-02 1991-08-20 Acufex Microsurgical, Inc. Slotted suture anchor and method of anchoring a suture
US5006106A (en) 1990-10-09 1991-04-09 Angelchik Jean P Apparatus and method for laparoscopic implantation of anti-reflux prosthesis
US5088979A (en) 1990-10-11 1992-02-18 Wilson-Cook Medical Inc. Method for esophageal invagination and devices useful therein
CA2063159C (en) * 1991-03-22 1999-06-15 Thomas W. Sander Orthopedic fastener
US5289963A (en) 1991-10-18 1994-03-01 United States Surgical Corporation Apparatus and method for applying surgical staples to attach an object to body tissue
US5197649A (en) * 1991-10-29 1993-03-30 The Trustees Of Columbia University In The City Of New York Gastrointestinal endoscoptic stapler
US5411520A (en) 1991-11-08 1995-05-02 Kensey Nash Corporation Hemostatic vessel puncture closure system utilizing a plug located within the puncture tract spaced from the vessel, and method of use
US5254126A (en) * 1992-06-24 1993-10-19 Ethicon, Inc. Endoscopic suture punch
WO1994003142A1 (en) 1992-07-30 1994-02-17 Temple University - Of The Commonwealth System Of Higher Education Direct manual cardiac compression device and method of use thereof
US5403326A (en) * 1993-02-01 1995-04-04 The Regents Of The University Of California Method for performing a gastric wrap of the esophagus for use in the treatment of esophageal reflux
US5549621A (en) 1993-05-14 1996-08-27 Byron C. Sutherland Apparatus and method for performing vertical banded gastroplasty
US5540718A (en) 1993-09-20 1996-07-30 Bartlett; Edwin C. Apparatus and method for anchoring sutures
WO1995008945A3 (en) 1993-09-20 1995-04-20 Boston Scient Corp Multiple biopsy sampling device
US5582616A (en) 1994-08-05 1996-12-10 Origin Medsystems, Inc. Surgical helical fastener with applicator
US5571116A (en) * 1994-10-02 1996-11-05 United States Surgical Corporation Non-invasive treatment of gastroesophageal reflux disease
US5938668A (en) 1994-10-07 1999-08-17 United States Surgical Surgical suturing apparatus
EP0817598B1 (en) 1995-03-28 1999-07-14 Biomedix SA Prosthesis for preventing gastro-oesophageal reflux
US5759151A (en) 1995-06-07 1998-06-02 Carnegie Mellon University Flexible steerable device for conducting exploratory procedures
US6119913A (en) * 1996-06-14 2000-09-19 Boston Scientific Corporation Endoscopic stapler
US5718717A (en) * 1996-08-19 1998-02-17 Bonutti; Peter M. Suture anchor
US5814054A (en) 1996-09-23 1998-09-29 Symbiosis Corporation Automatic needle-passer suturing instrument
US6071292A (en) * 1997-06-28 2000-06-06 Transvascular, Inc. Transluminal methods and devices for closing, forming attachments to, and/or forming anastomotic junctions in, luminal anatomical structures
US5887594A (en) * 1997-09-22 1999-03-30 Beth Israel Deaconess Medical Center Inc. Methods and devices for gastroesophageal reflux reduction
US6086600A (en) 1997-11-03 2000-07-11 Symbiosis Corporation Flexible endoscopic surgical instrument for invagination and fundoplication
US6254642B1 (en) 1997-12-09 2001-07-03 Thomas V. Taylor Perorally insertable gastroesophageal anti-reflux valve prosthesis and tool for implantation thereof
US6295990B1 (en) 1998-02-03 2001-10-02 Salient Interventional Systems, Inc. Methods and systems for treating ischemia
US6740098B2 (en) 1998-05-11 2004-05-25 Surgical Connections, Inc. Surgical stabilizer devices and methods
US6113611A (en) * 1998-05-28 2000-09-05 Advanced Vascular Technologies, Llc Surgical fastener and delivery system
US6264700B1 (en) 1998-08-27 2001-07-24 Endonetics, Inc. Prosthetic gastroesophageal valve
JP2002531169A (en) 1998-08-31 2002-09-24 ウイルソンークック メディカル インク. Anti-reflux esophageal prosthesis
US6113612A (en) 1998-11-06 2000-09-05 St. Jude Medical Cardiovascular Group, Inc. Medical anastomosis apparatus
DE69931018D1 (en) * 1998-12-30 2006-06-01 Ethicon Inc Thread belay device
US6159146A (en) 1999-03-12 2000-12-12 El Gazayerli; Mohamed Mounir Method and apparatus for minimally-invasive fundoplication
US6098629A (en) 1999-04-07 2000-08-08 Endonetics, Inc. Submucosal esophageal bulking device
US6375668B1 (en) 1999-06-02 2002-04-23 Hanson S. Gifford Devices and methods for treating vascular malformations
US6821285B2 (en) * 1999-06-22 2004-11-23 Ndo Surgical, Inc. Tissue reconfiguration
US6663639B1 (en) * 1999-06-22 2003-12-16 Ndo Surgical, Inc. Methods and devices for tissue reconfiguration
US6494888B1 (en) 1999-06-22 2002-12-17 Ndo Surgical, Inc. Tissue reconfiguration
US6835200B2 (en) * 1999-06-22 2004-12-28 Ndo Surgical. Inc. Method and devices for tissue reconfiguration
US7955340B2 (en) 1999-06-25 2011-06-07 Usgi Medical, Inc. Apparatus and methods for forming and securing gastrointestinal tissue folds
US8574243B2 (en) 1999-06-25 2013-11-05 Usgi Medical, Inc. Apparatus and methods for forming and securing gastrointestinal tissue folds
US7744613B2 (en) 1999-06-25 2010-06-29 Usgi Medical, Inc. Apparatus and methods for forming and securing gastrointestinal tissue folds
US7160312B2 (en) 1999-06-25 2007-01-09 Usgi Medical, Inc. Implantable artificial partition and methods of use
US6231561B1 (en) 1999-09-20 2001-05-15 Appriva Medical, Inc. Method and apparatus for closing a body lumen
EP1095622A1 (en) 1999-10-29 2001-05-02 Biomedix S.A. Endoscopic suturing instrument
US6387104B1 (en) 1999-11-12 2002-05-14 Scimed Life Systems, Inc. Method and apparatus for endoscopic repair of the lower esophageal sphincter
US6428548B1 (en) 1999-11-18 2002-08-06 Russell F. Durgin Apparatus and method for compressing body tissue
CA2397333A1 (en) 2000-01-21 2001-07-26 Miravant Medical Technologies Local drug delivery using photosensitizer-mediated and electromagnetic radiation-enhanced vascular permeability
JP5073905B2 (en) 2000-02-29 2012-11-14 ゼネラル・エレクトリック・カンパニイ Turbine component made from nickel base superalloys and superalloy
ES2435094T3 (en) 2000-05-19 2013-12-18 C.R. Bard, Inc. Device and method for capturing and suture tissue
DE60110761T2 (en) 2000-03-16 2006-05-04 Medigus Ltd. Device for fundoplication
US6592596B1 (en) 2000-05-10 2003-07-15 Scimed Life Systems, Inc. Devices and related methods for securing a tissue fold
US6443944B1 (en) 2000-05-19 2002-09-03 Rajiv Doshi Surgical devices comprising articulated members and methods for using the same
US6743239B1 (en) 2000-05-25 2004-06-01 St. Jude Medical, Inc. Devices with a bendable tip for medical procedures
US6676698B2 (en) 2000-06-26 2004-01-13 Rex Medicol, L.P. Vascular device with valve for approximating vessel wall
US6921361B2 (en) 2000-07-24 2005-07-26 Olympus Corporation Endoscopic instrument for forming an artificial valve
US20040093024A1 (en) * 2000-09-01 2004-05-13 James Lousararian Advanced wound site management systems and methods
DE60133113T2 (en) 2000-09-21 2009-05-20 Medigus Ltd. ENDOSCOPES WITH MULTIPLE VIEWS DIRECTIONS AND A clip device
US20020082621A1 (en) * 2000-09-22 2002-06-27 Schurr Marc O. Methods and devices for folding and securing tissue
US6736828B1 (en) 2000-09-29 2004-05-18 Scimed Life Systems, Inc. Method for performing endoluminal fundoplication and apparatus for use in the method
US6551333B2 (en) * 2000-10-19 2003-04-22 Ethicon Endo-Surgery, Inc. Method for attaching hernia mesh
US6447524B1 (en) * 2000-10-19 2002-09-10 Ethicon Endo-Surgery, Inc. Fastener for hernia mesh fixation
US7727246B2 (en) * 2000-12-06 2010-06-01 Ethicon Endo-Surgery, Inc. Methods for endoluminal treatment
US20020139606A1 (en) 2001-04-03 2002-10-03 Williams Donald J. Electric power steering system including a segmented stator switched reluctance motor
US6916332B2 (en) * 2001-05-23 2005-07-12 Scimed Life Systems, Inc. Endoluminal fundoplication device and related method for installing tissue fastener
US7083629B2 (en) 2001-05-30 2006-08-01 Satiety, Inc. Overtube apparatus for insertion into a body
US7115136B2 (en) 2001-06-20 2006-10-03 Park Medical Llc Anastomotic device
FR2826253B1 (en) * 2001-06-21 2004-03-12 Sofradim Production An assembly comprising a fastener for fixing a medical use and in place of this fastener delivery device
US6716226B2 (en) * 2001-06-25 2004-04-06 Inscope Development, Llc Surgical clip
JP4768154B2 (en) 2001-06-29 2011-09-07 テルモ株式会社 Medical energy irradiation apparatus
WO2003005915A1 (en) * 2001-07-10 2003-01-23 Australian Surgical Design And Manufacturing Pty Limited Surgical fixation device
EP2272436B1 (en) 2001-10-20 2012-12-05 Applied Medical Resources Corporation Wound retraction apparatus
US7318833B2 (en) 2001-12-19 2008-01-15 Nmt Medical, Inc. PFO closure device with flexible thrombogenic joint and improved dislodgement resistance
US7261722B2 (en) 2001-12-20 2007-08-28 Rex Medical, L.P. Apparatus and method for treating gastroesophageal reflux disease
FR2836816B1 (en) * 2002-03-08 2005-01-28 Sofradim Production An apparatus for storing, distributing and placing of surgical fasteners in "i" layer
US7527590B2 (en) * 2002-03-19 2009-05-05 Olympus Corporation Anastomosis system
US6699263B2 (en) 2002-04-05 2004-03-02 Cook Incorporated Sliding suture anchor
US7077850B2 (en) 2002-05-01 2006-07-18 Scimed Life Systems, Inc. Tissue fastening devices and related insertion tools and methods
US20050085829A1 (en) 2002-05-17 2005-04-21 Esophyx, Inc. Transoral endoscopic gastroesophageal flap valve restoration device, assembly, system and method
US6773440B2 (en) 2002-07-02 2004-08-10 Satiety, Inc. Method and device for use in tissue approximation and fixation
US7083630B2 (en) * 2002-08-29 2006-08-01 Scimed Life Systems, Inc. Devices and methods for fastening tissue layers
US20040044364A1 (en) * 2002-08-29 2004-03-04 Devries Robert Tissue fasteners and related deployment systems and methods
WO2004021872A3 (en) 2002-09-06 2004-12-02 Bard Inc C R Tissue capturing devices
EP1545332B1 (en) 2002-10-04 2007-08-22 Tyco Healthcare Group Lp Tool assembly for surgical stapling device
US20090149871A9 (en) 2002-11-01 2009-06-11 Jonathan Kagan Devices and methods for treating morbid obesity
US7037344B2 (en) 2002-11-01 2006-05-02 Valentx, Inc. Apparatus and methods for treatment of morbid obesity
CA2512203C (en) 2002-12-02 2012-10-23 Gi Dynamics, Inc. Bariatric sleeve
US7618426B2 (en) * 2002-12-11 2009-11-17 Usgi Medical, Inc. Apparatus and methods for forming gastrointestinal tissue approximations
US7416554B2 (en) * 2002-12-11 2008-08-26 Usgi Medical Inc Apparatus and methods for forming and securing gastrointestinal tissue folds
US7637905B2 (en) 2003-01-15 2009-12-29 Usgi Medical, Inc. Endoluminal tool deployment system
EP1596723A2 (en) * 2003-02-04 2005-11-23 ev3 Sunnyvale, Inc. Patent foramen ovale closure system
ES2428967T3 (en) 2003-07-14 2013-11-12 W.L. Gore & Associates, Inc. tubular closure device patent foramen ovale (PFO) retention system
JP3833199B2 (en) 2003-07-24 2006-10-11 沖電気工業株式会社 Complementary signal generating circuit
US20050247320A1 (en) 2003-10-10 2005-11-10 Stack Richard S Devices and methods for retaining a gastro-esophageal implant
US20050177176A1 (en) 2004-02-05 2005-08-11 Craig Gerbi Single-fold system for tissue approximation and fixation
US20050187565A1 (en) * 2004-02-20 2005-08-25 Baker Steve G. Tissue fixation devices and a transoral endoscopic gastroesophageal flap valve restoration device and assembly using same
US20060009792A1 (en) 2004-02-20 2006-01-12 Esophyx, Inc. Tissue fixation assembly having prepositioned fasteners and method
US8628547B2 (en) 2004-03-09 2014-01-14 Ethicon Endo-Surgery, Inc. Devices and methods for placement of partitions within a hollow body organ
US8252009B2 (en) 2004-03-09 2012-08-28 Ethicon Endo-Surgery, Inc. Devices and methods for placement of partitions within a hollow body organ
US7255675B2 (en) 2004-03-23 2007-08-14 Michael Gertner Devices and methods to treat a patient
US20050228413A1 (en) * 2004-04-12 2005-10-13 Binmoeller Kenneth F Automated transluminal tissue targeting and anchoring devices and methods
US8308765B2 (en) 2004-05-07 2012-11-13 Usgi Medical, Inc. Apparatus and methods for positioning and securing anchors
US20050251176A1 (en) 2004-05-07 2005-11-10 Usgi Medical Inc. System for treating gastroesophageal reflux disease
US7347863B2 (en) 2004-05-07 2008-03-25 Usgi Medical, Inc. Apparatus and methods for manipulating and securing tissue
US7390329B2 (en) * 2004-05-07 2008-06-24 Usgi Medical, Inc. Methods for grasping and cinching tissue anchors
US7850704B2 (en) 2004-09-27 2010-12-14 Theranova, Llc Method and apparatus for anchoring implants
US20060167481A1 (en) 2005-01-25 2006-07-27 Esophyx, Inc. Slitted tissue fixation devices and assemblies for deploying the same
US20060190018A1 (en) 2005-02-18 2006-08-24 Esophyx, Inc. Transoral endoscopic gastroesophageal flap valve restoration device having a guided tissue gripper
US20060253130A1 (en) 2005-05-03 2006-11-09 Esophyx, Inc. Tissue fixation assemblies having a plurality of fasteners ready for serial deployment
US7674271B2 (en) 2005-05-04 2010-03-09 InTailor Surgical, Inc. Endoluminal gastric ring and method
US20070021760A1 (en) 2005-07-19 2007-01-25 Brian Kelleher Methods and apparatus for securing an anchor to soft tissue
US20070112363A1 (en) 2005-11-15 2007-05-17 Endogastric Solutions, Inc. Apparatus including multiple invaginators for restoring a gastroesophageal flap valve and method
US20070129738A1 (en) 2005-12-01 2007-06-07 Endogastric Solutions, Inc. Apparatus and method for concurrently forming a gastroesophageal valve and tightening the lower esophageal sphincter
US20070191870A1 (en) 2006-02-10 2007-08-16 Endogastric Solutions, Inc. Transesophageal gastric reduction method and device for practicing same
US20070191871A1 (en) 2006-02-10 2007-08-16 Endogastric Solutions, Inc. Transesophageal gastric reduction method and device for reducing the size of a previously formed gastric reduction pouch
US20070276409A1 (en) 2006-05-25 2007-11-29 Ethicon Endo-Surgery, Inc. Endoscopic gastric restriction methods and devices
US7841503B2 (en) 2006-07-16 2010-11-30 Medigus Ltd. Endoscopic device comprising linear staplers and a video camera on its distal end
US20080294179A1 (en) 2007-05-12 2008-11-27 Balbierz Daniel J Devices and methods for stomach partitioning
US7954687B2 (en) 2007-11-06 2011-06-07 Tyco Healthcare Group Lp Coated surgical staples and an illuminated staple cartridge for a surgical stapling instrument
WO2010087756A1 (en) 2009-01-29 2010-08-05 Milux Holding S.A. Stomach instrument and method
EP3072480A1 (en) 2008-01-29 2016-09-28 Kirk Promotion LTD. Apparatus for treating gerd comprising a stimulation device
US8020741B2 (en) 2008-03-18 2011-09-20 Barosense, Inc. Endoscopic stapling devices and methods
EP2273927A4 (en) * 2008-04-02 2015-04-01 Linvatec Corp Method and apparatus for meniscal repair
US8906037B2 (en) 2009-03-18 2014-12-09 Endogastric Solutions, Inc. Methods and devices for forming a tissue fold

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5549631A (en) * 1993-05-14 1996-08-27 Bonutti; Peter M. Method of closing discontinuity in tissue
US5626614A (en) * 1995-12-22 1997-05-06 Applied Medical Resources Corporation T-anchor suturing device and method for using same
US6007567A (en) * 1996-08-19 1999-12-28 Bonutti; Peter M. Suture anchor
US20020183765A1 (en) * 1998-05-26 2002-12-05 Scimed Life Systems, Inc. Implantable tissue fastener and system for treating gastroesophageal reflux disease
US6315789B1 (en) * 1999-02-08 2001-11-13 Andrew H. Cragg Medical device anchoring system and method
US20050004575A1 (en) * 2000-11-24 2005-01-06 Jean-Claude Sgro Fastener for fixing a prosthesis, and device for delivering this fastener
US6790214B2 (en) * 2002-05-17 2004-09-14 Esophyx, Inc. Transoral endoscopic gastroesophageal flap valve restoration device, assembly, system and method
US20050187567A1 (en) * 2004-02-20 2005-08-25 Esophyx, Inc. Tissue fixation devices and assemblies for deploying the same

Cited By (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8221454B2 (en) 2004-02-20 2012-07-17 Biomet Sports Medicine, Llc Apparatus for performing meniscus repair
US8551140B2 (en) 2004-11-05 2013-10-08 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to bone
US9801708B2 (en) 2004-11-05 2017-10-31 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US9504460B2 (en) 2004-11-05 2016-11-29 Biomet Sports Medicine, LLC. Soft tissue repair device and method
US9572655B2 (en) 2004-11-05 2017-02-21 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8840645B2 (en) 2004-11-05 2014-09-23 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8118836B2 (en) 2004-11-05 2012-02-21 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8128658B2 (en) 2004-11-05 2012-03-06 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to bone
US8137382B2 (en) 2004-11-05 2012-03-20 Biomet Sports Medicine, Llc Method and apparatus for coupling anatomical features
US8303604B2 (en) 2004-11-05 2012-11-06 Biomet Sports Medicine, Llc Soft tissue repair device and method
US8317825B2 (en) 2004-11-09 2012-11-27 Biomet Sports Medicine, Llc Soft tissue conduit device and method
US8998949B2 (en) 2004-11-09 2015-04-07 Biomet Sports Medicine, Llc Soft tissue conduit device
WO2007047873A2 (en) 2005-10-18 2007-04-26 Endogastric Solutions, Inc. Invaginator for gastroesophageal flap valve restoration device
WO2007064713A2 (en) 2005-12-01 2007-06-07 Endogastric Solutions, Inc. Apparatus and method for concurrently forming a gastroesophageal valve and tightening the lower esophageal sphincter
US9492158B2 (en) 2006-02-03 2016-11-15 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8298262B2 (en) 2006-02-03 2012-10-30 Biomet Sports Medicine, Llc Method for tissue fixation
US10004489B2 (en) 2006-02-03 2018-06-26 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8088130B2 (en) 2006-02-03 2012-01-03 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8337525B2 (en) 2006-02-03 2012-12-25 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US10004588B2 (en) 2006-02-03 2018-06-26 Biomet Sports Medicine, Llc Method and apparatus for fixation of an ACL graft
US8361113B2 (en) 2006-02-03 2013-01-29 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8409253B2 (en) 2006-02-03 2013-04-02 Biomet Sports Medicine, Llc Soft tissue repair assembly and associated method
US9993241B2 (en) 2006-02-03 2018-06-12 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US9801620B2 (en) 2006-02-03 2017-10-31 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to bone
US8273106B2 (en) 2006-02-03 2012-09-25 Biomet Sports Medicine, Llc Soft tissue repair and conduit device
US8292921B2 (en) 2006-02-03 2012-10-23 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US9763656B2 (en) 2006-02-03 2017-09-19 Biomet Sports Medicine, Llc Method and apparatus for soft tissue fixation
US8574235B2 (en) 2006-02-03 2013-11-05 Biomet Sports Medicine, Llc Method for trochanteric reattachment
US9642661B2 (en) 2006-02-03 2017-05-09 Biomet Sports Medicine, Llc Method and Apparatus for Sternal Closure
US8597327B2 (en) 2006-02-03 2013-12-03 Biomet Manufacturing, Llc Method and apparatus for sternal closure
US8608777B2 (en) 2006-02-03 2013-12-17 Biomet Sports Medicine Method and apparatus for coupling soft tissue to a bone
US8632569B2 (en) 2006-02-03 2014-01-21 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US8652171B2 (en) 2006-02-03 2014-02-18 Biomet Sports Medicine, Llc Method and apparatus for soft tissue fixation
US8652172B2 (en) 2006-02-03 2014-02-18 Biomet Sports Medicine, Llc Flexible anchors for tissue fixation
US9622736B2 (en) 2006-02-03 2017-04-18 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US9603591B2 (en) 2006-02-03 2017-03-28 Biomet Sports Medicine, Llc Flexible anchors for tissue fixation
US8721684B2 (en) 2006-02-03 2014-05-13 Biomet Sports Medicine, Llc Method and apparatus for coupling anatomical features
US10022118B2 (en) 2006-02-03 2018-07-17 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8771316B2 (en) 2006-02-03 2014-07-08 Biomet Sports Medicine, Llc Method and apparatus for coupling anatomical features
US9149267B2 (en) 2006-02-03 2015-10-06 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US9561025B2 (en) 2006-02-03 2017-02-07 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US9538998B2 (en) 2006-02-03 2017-01-10 Biomet Sports Medicine, Llc Method and apparatus for fracture fixation
US9532777B2 (en) 2006-02-03 2017-01-03 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8932331B2 (en) 2006-02-03 2015-01-13 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to bone
US8936621B2 (en) 2006-02-03 2015-01-20 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US8968364B2 (en) 2006-02-03 2015-03-03 Biomet Sports Medicine, Llc Method and apparatus for fixation of an ACL graft
US7909851B2 (en) * 2006-02-03 2011-03-22 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US9005287B2 (en) 2006-02-03 2015-04-14 Biomet Sports Medicine, Llc Method for bone reattachment
US9510821B2 (en) 2006-02-03 2016-12-06 Biomet Sports Medicine, Llc Method and apparatus for coupling anatomical features
US9510819B2 (en) 2006-02-03 2016-12-06 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US20090312776A1 (en) * 2006-02-03 2009-12-17 Biomet Sports Medicine, Llc Method and Apparatus for Coupling Soft Tissue to a Bone
US9498204B2 (en) 2006-02-03 2016-11-22 Biomet Sports Medicine, Llc Method and apparatus for coupling anatomical features
US9173651B2 (en) 2006-02-03 2015-11-03 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US9468433B2 (en) 2006-02-03 2016-10-18 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US9414833B2 (en) 2006-02-03 2016-08-16 Biomet Sports Medicine, Llc Soft tissue repair assembly and associated method
US9271713B2 (en) 2006-02-03 2016-03-01 Biomet Sports Medicine, Llc Method and apparatus for tensioning a suture
US9402621B2 (en) 2006-02-03 2016-08-02 Biomet Sports Medicine, LLC. Method for tissue fixation
US8251998B2 (en) 2006-08-16 2012-08-28 Biomet Sports Medicine, Llc Chondral defect repair
US8777956B2 (en) 2006-08-16 2014-07-15 Biomet Sports Medicine, Llc Chondral defect repair
US8801783B2 (en) 2006-09-29 2014-08-12 Biomet Sports Medicine, Llc Prosthetic ligament system for knee joint
US8231654B2 (en) 2006-09-29 2012-07-31 Biomet Sports Medicine, Llc Adjustable knotless loops
US8500818B2 (en) 2006-09-29 2013-08-06 Biomet Manufacturing, Llc Knee prosthesis assembly with ligament link
US10004493B2 (en) 2006-09-29 2018-06-26 Biomet Sports Medicine, Llc Method for implanting soft tissue
US9414925B2 (en) 2006-09-29 2016-08-16 Biomet Manufacturing, Llc Method of implanting a knee prosthesis assembly with a ligament link
US9918826B2 (en) 2006-09-29 2018-03-20 Biomet Sports Medicine, Llc Scaffold for spring ligament repair
US8562645B2 (en) 2006-09-29 2013-10-22 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US9788876B2 (en) 2006-09-29 2017-10-17 Biomet Sports Medicine, Llc Fracture fixation device
US9486211B2 (en) 2006-09-29 2016-11-08 Biomet Sports Medicine, Llc Method for implanting soft tissue
US8562647B2 (en) 2006-09-29 2013-10-22 Biomet Sports Medicine, Llc Method and apparatus for securing soft tissue to bone
US9724090B2 (en) 2006-09-29 2017-08-08 Biomet Manufacturing, Llc Method and apparatus for attaching soft tissue to bone
US9078644B2 (en) 2006-09-29 2015-07-14 Biomet Sports Medicine, Llc Fracture fixation device
US9681940B2 (en) 2006-09-29 2017-06-20 Biomet Sports Medicine, Llc Ligament system for knee joint
US8672969B2 (en) 2006-09-29 2014-03-18 Biomet Sports Medicine, Llc Fracture fixation device
US8672968B2 (en) 2006-09-29 2014-03-18 Biomet Sports Medicine, Llc Method for implanting soft tissue
US9539003B2 (en) 2006-09-29 2017-01-10 Biomet Sports Medicine, LLC. Method and apparatus for forming a self-locking adjustable loop
US7959650B2 (en) 2006-09-29 2011-06-14 Biomet Sports Medicine, Llc Adjustable knotless loops
US9833230B2 (en) 2006-09-29 2017-12-05 Biomet Sports Medicine, Llc Fracture fixation device
US9861351B2 (en) 2007-04-10 2018-01-09 Biomet Sports Medicine, Llc Adjustable knotless loops
US9017381B2 (en) 2007-04-10 2015-04-28 Biomet Sports Medicine, Llc Adjustable knotless loops
US20100145368A1 (en) * 2008-12-05 2010-06-10 Chu Michael S H Insertion Device and Method for Delivery of a Mesh Carrier
US9028509B2 (en) * 2008-12-05 2015-05-12 Boston Scientific Scimed, Inc. Insertion device for delivery of a mesh carrier
US9974637B2 (en) 2008-12-05 2018-05-22 Boston Scientific Scimed, Inc. Insertion device for delivery of a mesh carrier
US8343227B2 (en) 2009-05-28 2013-01-01 Biomet Manufacturing Corp. Knee prosthesis assembly with ligament link
US8900314B2 (en) 2009-05-28 2014-12-02 Biomet Manufacturing, Llc Method of implanting a prosthetic knee joint assembly
US20130303856A1 (en) * 2010-10-29 2013-11-14 Vectec S.A. Single Use, Disposable, Tissue Suspender Device
US9737289B2 (en) * 2010-10-29 2017-08-22 Vectec S.A. Single use, disposable, tissue suspender device
US8771352B2 (en) 2011-05-17 2014-07-08 Biomet Sports Medicine, Llc Method and apparatus for tibial fixation of an ACL graft
US9216078B2 (en) 2011-05-17 2015-12-22 Biomet Sports Medicine, Llc Method and apparatus for tibial fixation of an ACL graft
US8506597B2 (en) 2011-10-25 2013-08-13 Biomet Sports Medicine, Llc Method and apparatus for interosseous membrane reconstruction
US9445827B2 (en) 2011-10-25 2016-09-20 Biomet Sports Medicine, Llc Method and apparatus for intraosseous membrane reconstruction
US9357991B2 (en) 2011-11-03 2016-06-07 Biomet Sports Medicine, Llc Method and apparatus for stitching tendons
US9357992B2 (en) 2011-11-10 2016-06-07 Biomet Sports Medicine, Llc Method for coupling soft tissue to a bone
US9314241B2 (en) 2011-11-10 2016-04-19 Biomet Sports Medicine, Llc Apparatus for coupling soft tissue to a bone
US9381013B2 (en) 2011-11-10 2016-07-05 Biomet Sports Medicine, Llc Method for coupling soft tissue to a bone
US9370350B2 (en) 2011-11-10 2016-06-21 Biomet Sports Medicine, Llc Apparatus for coupling soft tissue to a bone
US9259217B2 (en) 2012-01-03 2016-02-16 Biomet Manufacturing, Llc Suture Button
US9433407B2 (en) 2012-01-03 2016-09-06 Biomet Manufacturing, Llc Method of implanting a bone fixation assembly
US9757119B2 (en) 2013-03-08 2017-09-12 Biomet Sports Medicine, Llc Visual aid for identifying suture limbs arthroscopically
US9918827B2 (en) 2013-03-14 2018-03-20 Biomet Sports Medicine, Llc Scaffold for spring ligament repair
US9615822B2 (en) 2014-05-30 2017-04-11 Biomet Sports Medicine, Llc Insertion tools and method for soft anchor
US9700291B2 (en) 2014-06-03 2017-07-11 Biomet Sports Medicine, Llc Capsule retractor
US9955980B2 (en) 2015-02-24 2018-05-01 Biomet Sports Medicine, Llc Anatomic soft tissue repair

Also Published As

Publication number Publication date Type
US20160270787A1 (en) 2016-09-22 application
US8337514B2 (en) 2012-12-25 grant
WO2006081368A2 (en) 2006-08-03 application
US20130274764A1 (en) 2013-10-17 application
ES2573849T3 (en) 2016-06-10 grant
US20170112494A1 (en) 2017-04-27 application
EP1848347A4 (en) 2013-02-20 application
JP2008528132A (en) 2008-07-31 application
US9572578B2 (en) 2017-02-21 grant
WO2006081368A3 (en) 2007-10-18 application
EP1848347A2 (en) 2007-10-31 application
US9358007B2 (en) 2016-06-07 grant
EP1848347B1 (en) 2016-04-06 grant
US20100262169A1 (en) 2010-10-14 application

Similar Documents

Publication Publication Date Title
US7530984B2 (en) Transgastric method for carrying out a partial fundoplication
US7892214B2 (en) Attachment system for transmural attachment at the gastroesophageal junction
US7503922B2 (en) Obesity treatment tools and methods
US6773440B2 (en) Method and device for use in tissue approximation and fixation
US8006701B2 (en) Device and method for the therapy of obesity
US7494496B2 (en) Device for transfixing and joining tissue
US6663639B1 (en) Methods and devices for tissue reconfiguration
US20080249566A1 (en) Methods and devices for reducing gastric volume
US20060106420A1 (en) Patch for treating a septal defect
US20090024144A1 (en) Hybrid endoscopic/laparoscopic device for forming serosa to serosa plications in a gastric cavity
US20090326561A1 (en) Surgical suture arrangement
US20070129735A1 (en) Systems and techniques for minimally invasive gastrointestinal procedures
US20050277957A1 (en) Devices and methods of locking and cutting a suture in a medical procedure
US7776057B2 (en) Methods and devices for tissue reconfiguration
US20080294179A1 (en) Devices and methods for stomach partitioning
US7736372B2 (en) Apparatus and methods for endoscopic suturing
US20090125040A1 (en) Tissue acquisition devices and methods
US6113609A (en) Implantable tissue fastener and system for treating gastroesophageal reflux disease
US20080009888A1 (en) Low profile tissue anchors, tissue anchor systems, and methods for their delivery and use
US6926722B2 (en) Devices and related methods for securing a tissue fold
US7618426B2 (en) Apparatus and methods for forming gastrointestinal tissue approximations
US6030364A (en) Apparatus and method for percutaneous placement of gastro-intestinal tubes
US20090276055A1 (en) Method for gastric volume reduction surgery
US7077850B2 (en) Tissue fastening devices and related insertion tools and methods
US5403326A (en) Method for performing a gastric wrap of the esophagus for use in the treatment of esophageal reflux

Legal Events

Date Code Title Description
AS Assignment

Owner name: ESOPHYX, INC., WASHINGTON

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:BAKER, STEVE G.;KRAEMER, STEFAN J.M.;WOLNIEWICZ III, RAYMOND MICHAEL;REEL/FRAME:016556/0940

Effective date: 20050228

AS Assignment

Owner name: ENDOGASTRIC SOLUTIONS, INC., WASHINGTON

Free format text: CHANGE OF NAME;ASSIGNOR:ENDO GASTRIC SOLUTIONS, INC.;REEL/FRAME:021901/0887

Effective date: 20050830

AS Assignment

Owner name: ENDO GASTRIC SOLUTIONS, INC., WASHINGTON

Free format text: CHANGE OF NAME;ASSIGNOR:ESOPHYX, INC.;REEL/FRAME:022137/0807

Effective date: 20050711

AS Assignment

Owner name: CHICAGO GROWTH PARTNERS, LP, ILLINOIS

Free format text: SECURITY AGREEMENT;ASSIGNOR:ENDOGASTRIC SOLUTIONS, INC.;REEL/FRAME:022529/0024

Effective date: 20090409

Owner name: FOUNDATION MEDICAL PARTNERS II, L.P, CONNECTICUT

Free format text: SECURITY AGREEMENT;ASSIGNOR:ENDOGASTRIC SOLUTIONS, INC.;REEL/FRAME:022529/0024

Effective date: 20090409

Owner name: ADVANCED TECHNOLOGY VENTURES VII, L.P., MASSACHUSE

Free format text: SECURITY AGREEMENT;ASSIGNOR:ENDOGASTRIC SOLUTIONS, INC.;REEL/FRAME:022529/0024

Effective date: 20090409

Owner name: ADVANCED TECHNOLOGY VENTURES VII (B), L.P., MASSAC

Free format text: SECURITY AGREEMENT;ASSIGNOR:ENDOGASTRIC SOLUTIONS, INC.;REEL/FRAME:022529/0024

Effective date: 20090409

Owner name: ADVANCED TECHNOLOGY VENTURES VII (C), L.P., MASSAC

Free format text: SECURITY AGREEMENT;ASSIGNOR:ENDOGASTRIC SOLUTIONS, INC.;REEL/FRAME:022529/0024

Effective date: 20090409

Owner name: ATV ENTREPRENEURS VII, L.P., MASSACHUSETTS

Free format text: SECURITY AGREEMENT;ASSIGNOR:ENDOGASTRIC SOLUTIONS, INC.;REEL/FRAME:022529/0024

Effective date: 20090409

Owner name: MPM BIOVENTURES III, L.P., MASSACHUSETTS

Free format text: SECURITY AGREEMENT;ASSIGNOR:ENDOGASTRIC SOLUTIONS, INC.;REEL/FRAME:022529/0024

Effective date: 20090409

Owner name: MPM BIOVENTURES III-QP, L.P., MASSACHUSETTS

Free format text: SECURITY AGREEMENT;ASSIGNOR:ENDOGASTRIC SOLUTIONS, INC.;REEL/FRAME:022529/0024

Effective date: 20090409

Owner name: MPM BIOVENTURES III GMBH & CO. BETEILIGUNGS KG, MA

Free format text: SECURITY AGREEMENT;ASSIGNOR:ENDOGASTRIC SOLUTIONS, INC.;REEL/FRAME:022529/0024

Effective date: 20090409

Owner name: MPM BIOVENTURES III PARALLEL FUND, L.P., MASSACHUS

Free format text: SECURITY AGREEMENT;ASSIGNOR:ENDOGASTRIC SOLUTIONS, INC.;REEL/FRAME:022529/0024

Effective date: 20090409

Owner name: MPM ASSET MANAGEMENT INVESTORS 2003 BVIII LLC, MAS

Free format text: SECURITY AGREEMENT;ASSIGNOR:ENDOGASTRIC SOLUTIONS, INC.;REEL/FRAME:022529/0024

Effective date: 20090409

Owner name: MPM BIOVENTURES II, L.P., MASSACHUSETTS

Free format text: SECURITY AGREEMENT;ASSIGNOR:ENDOGASTRIC SOLUTIONS, INC.;REEL/FRAME:022529/0024

Effective date: 20090409

Owner name: MPM BIOVENTURES II-QP, L.P., MASSACHUSETTS

Free format text: SECURITY AGREEMENT;ASSIGNOR:ENDOGASTRIC SOLUTIONS, INC.;REEL/FRAME:022529/0024

Effective date: 20090409

Owner name: MPM BIOVENTURES GMBH & CO. PARALLEL-BETEILIGUNGS K

Free format text: SECURITY AGREEMENT;ASSIGNOR:ENDOGASTRIC SOLUTIONS, INC.;REEL/FRAME:022529/0024

Effective date: 20090409

Owner name: MPM ASSET MANAGEMENT INVESTORS 2000 B LLC, MASSACH

Free format text: SECURITY AGREEMENT;ASSIGNOR:ENDOGASTRIC SOLUTIONS, INC.;REEL/FRAME:022529/0024

Effective date: 20090409

Owner name: DE NOVO VENTURES III, LP, CALIFORNIA

Free format text: SECURITY AGREEMENT;ASSIGNOR:ENDOGASTRIC SOLUTIONS, INC.;REEL/FRAME:022529/0024

Effective date: 20090409

Owner name: OAKWOOD MEDICAL INVESTORS IV (QP), L.L.C., MISSOUR

Free format text: SECURITY AGREEMENT;ASSIGNOR:ENDOGASTRIC SOLUTIONS, INC.;REEL/FRAME:022529/0024

Effective date: 20090409

Owner name: OAKWOOD MEDICAL INVESTORS IV, L.L.C., MISSOURI

Free format text: SECURITY AGREEMENT;ASSIGNOR:ENDOGASTRIC SOLUTIONS, INC.;REEL/FRAME:022529/0024

Effective date: 20090409

Owner name: CHICAGO GROWTH PARTNERS, LP,ILLINOIS

Free format text: SECURITY AGREEMENT;ASSIGNOR:ENDOGASTRIC SOLUTIONS, INC.;REEL/FRAME:022529/0024

Effective date: 20090409

Owner name: FOUNDATION MEDICAL PARTNERS II, L.P,CONNECTICUT

Free format text: SECURITY AGREEMENT;ASSIGNOR:ENDOGASTRIC SOLUTIONS, INC.;REEL/FRAME:022529/0024

Effective date: 20090409

Owner name: ADVANCED TECHNOLOGY VENTURES VII, L.P.,MASSACHUSET

Free format text: SECURITY AGREEMENT;ASSIGNOR:ENDOGASTRIC SOLUTIONS, INC.;REEL/FRAME:022529/0024

Effective date: 20090409

Owner name: ADVANCED TECHNOLOGY VENTURES VII (B), L.P.,MASSACH

Free format text: SECURITY AGREEMENT;ASSIGNOR:ENDOGASTRIC SOLUTIONS, INC.;REEL/FRAME:022529/0024

Effective date: 20090409

Owner name: ADVANCED TECHNOLOGY VENTURES VII (C), L.P.,MASSACH

Free format text: SECURITY AGREEMENT;ASSIGNOR:ENDOGASTRIC SOLUTIONS, INC.;REEL/FRAME:022529/0024

Effective date: 20090409

Owner name: ATV ENTREPRENEURS VII, L.P.,MASSACHUSETTS

Free format text: SECURITY AGREEMENT;ASSIGNOR:ENDOGASTRIC SOLUTIONS, INC.;REEL/FRAME:022529/0024

Effective date: 20090409

Owner name: MPM BIOVENTURES III, L.P.,MASSACHUSETTS

Free format text: SECURITY AGREEMENT;ASSIGNOR:ENDOGASTRIC SOLUTIONS, INC.;REEL/FRAME:022529/0024

Effective date: 20090409

Owner name: MPM BIOVENTURES III-QP, L.P.,MASSACHUSETTS

Free format text: SECURITY AGREEMENT;ASSIGNOR:ENDOGASTRIC SOLUTIONS, INC.;REEL/FRAME:022529/0024

Effective date: 20090409

Owner name: MPM BIOVENTURES III GMBH & CO. BETEILIGUNGS KG,MAS

Free format text: SECURITY AGREEMENT;ASSIGNOR:ENDOGASTRIC SOLUTIONS, INC.;REEL/FRAME:022529/0024

Effective date: 20090409

Owner name: MPM BIOVENTURES III PARALLEL FUND, L.P.,MASSACHUSE

Free format text: SECURITY AGREEMENT;ASSIGNOR:ENDOGASTRIC SOLUTIONS, INC.;REEL/FRAME:022529/0024

Effective date: 20090409

Owner name: MPM ASSET MANAGEMENT INVESTORS 2003 BVIII LLC,MASS

Free format text: SECURITY AGREEMENT;ASSIGNOR:ENDOGASTRIC SOLUTIONS, INC.;REEL/FRAME:022529/0024

Effective date: 20090409

Owner name: MPM BIOVENTURES II, L.P.,MASSACHUSETTS

Free format text: SECURITY AGREEMENT;ASSIGNOR:ENDOGASTRIC SOLUTIONS, INC.;REEL/FRAME:022529/0024

Effective date: 20090409

Owner name: MPM BIOVENTURES II-QP, L.P.,MASSACHUSETTS

Free format text: SECURITY AGREEMENT;ASSIGNOR:ENDOGASTRIC SOLUTIONS, INC.;REEL/FRAME:022529/0024

Effective date: 20090409

Owner name: MPM ASSET MANAGEMENT INVESTORS 2000 B LLC,MASSACHU

Free format text: SECURITY AGREEMENT;ASSIGNOR:ENDOGASTRIC SOLUTIONS, INC.;REEL/FRAME:022529/0024

Effective date: 20090409

Owner name: DE NOVO VENTURES III, LP,CALIFORNIA

Free format text: SECURITY AGREEMENT;ASSIGNOR:ENDOGASTRIC SOLUTIONS, INC.;REEL/FRAME:022529/0024

Effective date: 20090409

Owner name: OAKWOOD MEDICAL INVESTORS IV (QP), L.L.C.,MISSOURI

Free format text: SECURITY AGREEMENT;ASSIGNOR:ENDOGASTRIC SOLUTIONS, INC.;REEL/FRAME:022529/0024

Effective date: 20090409

Owner name: OAKWOOD MEDICAL INVESTORS IV, L.L.C.,MISSOURI

Free format text: SECURITY AGREEMENT;ASSIGNOR:ENDOGASTRIC SOLUTIONS, INC.;REEL/FRAME:022529/0024

Effective date: 20090409

AS Assignment

Owner name: ENDOGASTRIC SOLUTIONS, INC.,WASHINGTON

Free format text: RELEASE BY SECURED PARTY;ASSIGNORS:CHICAGO GROWTH PARTNERS, LP;DE NOVO VENTURES III, LP;MPM BIOVENTURES GMBH & CO. PARALLEL-BETEILIGUNGS KG;AND OTHERS;SIGNING DATES FROM 20100128 TO 20100210;REEL/FRAME:023915/0906

Owner name: ENDOGASTRIC SOLUTIONS, INC., WASHINGTON

Free format text: RELEASE BY SECURED PARTY;ASSIGNORS:CHICAGO GROWTH PARTNERS, LP;DE NOVO VENTURES III, LP;MPM BIOVENTURES GMBH & CO. PARALLEL-BETEILIGUNGS KG;AND OTHERS;SIGNING DATES FROM 20100128 TO 20100210;REEL/FRAME:023915/0906