US20050251205A1 - Apparatus and methods for positioning and securing anchors - Google Patents
Apparatus and methods for positioning and securing anchors Download PDFInfo
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- US20050251205A1 US20050251205A1 US10/840,951 US84095104A US2005251205A1 US 20050251205 A1 US20050251205 A1 US 20050251205A1 US 84095104 A US84095104 A US 84095104A US 2005251205 A1 US2005251205 A1 US 2005251205A1
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- anchor
- suture
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- tissue
- cinching
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Definitions
- the present invention relates to apparatus and methods for positioning and securing anchors within tissue. More particularly, the present invention relates to apparatus and methods for positioning and securing anchors within folds of tissue within a body.
- Morbid obesity is a serious medical condition pervasive in the United States and other countries. Its complications include hypertension, diabetes, coronary artery disease, stroke, congestive heart failure, multiple orthopedic problems and pulmonary insufficiency with markedly decreased life expectancy.
- a number of surgical techniques have been developed to treat morbid obesity, e.g., bypassing an absorptive surface of the small intestine, or reducing the stomach size.
- many conventional surgical procedures may present numerous life-threatening post-operative complications, and may cause atypical diarrhea, electrolytic imbalance, unpredictable weight loss and reflux of nutritious chyme proximal to the site of the anastomosis.
- the sutures or staples that are often used in these surgical procedures typically require extensive training by the clinician to achieve competent use, and may concentrate significant force over a small surface area of the tissue, thereby potentially causing the suture or staple to tear through the tissue.
- Many of the surgical procedures require regions of tissue within the body to be approximated towards one another and reliably secured.
- the gastrointestinal lumen includes four tissue layers, wherein the mucosa layer is the inner-most tissue layer followed by connective tissue, the muscularis layer and the serosa layer.
- the anchors should engage at least the muscularis tissue layer in order to provide a proper foundation.
- the mucosa and connective tissue layers typically are not strong enough to sustain the tensile loads imposed by normal movement of the stomach wall during ingestion and processing of food.
- these layers tend to stretch elastically rather than firmly hold the anchors (or staples) in position, and accordingly, the more rigid muscularis and/or serosa layer should ideally be engaged.
- One conventional method for securing anchors within a body lumen to the tissue is to utilize sewing devices to suture the stomach wall into folds. This procedure typically involves advancing a sewing instrument through the working channel of an endoscope and into the stomach and against the stomach wall tissue. The contacted tissue is then typically drawn into the sewing instrument where one or more sutures or tags are implanted to hold the suctioned tissue in a folded condition known as a plication. Another method involves manually creating sutures for securing the plication.
- Another problem with conventional methods involves ensuring that the staple, knotted suture, or clip is secured tightly against the tissue and that the newly created plication will not relax under any slack which may be created by slipping staples, knots, or clips.
- Other conventional tissue securement devices such as suture anchors, twist ties, crimps, etc. are also often used to prevent sutures from slipping through tissue.
- many of these types of devices are typically large and unsuitable for low-profile delivery through the body, e.g., transesophageally.
- sutures, staples, clips, etc. may of these devices are configured to be placed only after the tissue has been plicated and not during the actual plication procedure.
- securing plications which may be created within a body lumen of a patient
- various methods and devices may be implemented.
- any number of conventional methods may be utilized for initially creating the plication.
- One method in particular may involve creating a plication through which a tissue anchor may be disposed within or through.
- a distal tip of a tissue plication apparatus may engage or grasp the tissue and move the engaged tissue to a proximal position relative to the tip of the device, thereby providing a substantially uniform plication of predetermined size.
- tools and methods which are particularly suited for delivering the anchoring and securement devices may be seen in further detail in co-pending U.S. patent application Ser. No. 10/735,030 filed Dec. 12, 2003, which is incorporated herein by reference in its entirety.
- tissue anchors may be utilized for securing the plications in their configured folds.
- a plication (or plications) may be secured via a length or lengths of suture extending through the plication and between a distally-positioned tissue anchor located on a distal side of the plication and a proximally-positioned tissue anchor located on a proximal side of the plication.
- anchors which may be utilized are disclosed in co-pending U.S. patent application Ser. No. 10/612,170, filed Jul. 1, 2003, which is incorporated herein by reference in its entirety.
- a proximally and/or distally located tissue anchor is preferably configured to slide along the connecting suture in a uni-directional manner.
- the proximal anchor is to be slid along the suture, it is preferably configured to translate over the suture such that the tissue plication is cinched between the anchors.
- the proximal anchor is preferably configured to utilize a locking mechanism which allows for the free uni-directional translation of the suture therethrough while enabling the anchor to be locked onto the suture if the anchor is pulled, pushed, or otherwise urged in the opposite direction along the suture.
- This uni-directional anchor locking mechanism facilitates the cinching of the tissue plication between the anchors and it may be utilized in one or several of the anchors in cinching a tissue fold.
- anchors utilized for the securement of tissue plications are not intended to be limiting.
- many of the anchor locking or cinching mechanisms may be utilized with, e.g., “T”-type anchors as well as with reconfigurable “basket”-type anchors, which generally comprise a number of configurable struts or legs extending between at least two collars or support members.
- reconfigurable “basket”-type anchors which generally comprise a number of configurable struts or legs extending between at least two collars or support members.
- Other variations of these or other types of anchors are also contemplated for use in an anchor locking or cinching assembly.
- a single type of anchor may be used exclusively in an anchor locking or cinching assembly; alternatively, a combination of different anchor types each utilizing different anchor locking or cinching mechanisms may be used in a single assembly.
- the different types of cinching or locking mechanisms are not intended to be limited to any of the particular variations shown and described below but may be utilized in any combinations or varying types of anchors as practicable.
- the suture itself may be modified or altered to integrate features or protrusions along its length or a specified portion of its length. Such features may be defined uniformly at regular intervals along the length of suture or intermittently, depending upon the desired locking or cinching effects.
- the suture may be made from metals such as Nitinol, stainless steels, Titanium, etc., provided that they are formed suitably thin and flexible. Using metallic sutures with the anchoring mechanisms may decrease any possibilities of suture failure and it may also provide a suture better able to withstand the acidic and basic environment of the gastrointestinal system. Also, it may enhance imaging of the suture and anchor assembly if examined under imaging systems. Sutures incorporating the use of features or protrusions along its length as well as sutures fabricated from metallic materials or any other conventional suture type may be utilized with any of the locking or cinching mechanisms described below in various combinations, if so desired.
- One variation for utilizing a locking mechanism which allows for free uni-directional translation of the suture through the anchor may include blocks or members which are adapted to slide within or upon an anchor to lock the suture. These blocks or members may include tapered edges which act to cleat the suture depending upon the direction the anchor is translated relative to the suture. Moreover, these blocks may be biased or urged to restrict the movement of the suture using a variety of biasing elements, such as springs, etc. In addition to blocks, one or several locking tabs which are levered to allow unidirectional travel of the suture through an anchor may also be utilized.
- locking mechanisms may also utilize a variety of knotting techniques.
- Conventional knots which are typically tied by the practitioner either within the body or outside the body and advanced over the suture length, may be utilized for locking the anchor in place relative to the tissue fold and opposing anchor; however, self-locking knots which enable the uni-directional travel of an anchor body relative to the suture and tissue are desirable. Accordingly, many different types of self-locking knots may be advanced with the anchor over the suture such that translation along a distal direction is possible yet reverse translation of the anchor is inhibited.
- locking pins may be urged or pushed into a frictional interference fit with portions or areas of the suture against the anchor or portions of the anchor. The use of such pins may effectively wedge the suture and thereby prevent further movement of the anchor along the suture length.
- locking collars or collets may also be used to cinch or lock the suture.
- One cinching variation may utilize a pulley or pin contained within the anchor over which a portion of the suture may travel. The looped suture may then be routed proximally and secured with a slip knot. As tension is applied to the suture, the slip knot may prevent the further movement of the anchor relative to the suture.
- cinching collars may generally be formed into tubular structures having obstructions formed within the collar lumen where the obstructions are formed from portions of the cinching collar itself. These obstructions may be adapted to form upon releasing of a constraining force when the anchor is to be locked into position. These obstructions may be used to form a tortuous path through which the suture may be routed to lock the suture within.
- locking collars which form tortuous paths may be adapted to reconfigure itself from a constrained delivery configuration to a deployed locking configuration when the anchor is to be cinched or locked into position relative to the tissue and suture.
- the locking collars may be configured to take various configurations, such as a proximally extending “S”-type, or other types, configuration.
- cinching and locking mechanisms which utilize mechanical clamping or crimping to achieve locking of the suture within or through the anchors may also be used to facilitate uni-directional locking.
- a simple mechanical crimp may be fastened upon the suture proximally of the anchor to prevent the reverse motion of the anchor.
- the crimp may be a simple tubular member or it may be integrally formed onto a proximal portion of the anchor body itself.
- additional measures may be optionally implemented to facilitate the cinching or locking of an anchor.
- Other measures may also be taken to inhibit any damage from occurring to the suture routed through an anchor. For instance, to ensure that the integrity of the suture is maintained in the presence of metallic basket anchors and to ensure that the suture is not subjected to any nicks or cuts, the portion of the suture passing through basket anchor may be encased in a protective sleeve made, e.g., from polypropylene, PTFE, etc.
- cinching or locking mechanisms which take advantage of any cold-flow effects of an engaged portion of suture by the tissue anchor. For instance, if a portion of the suture is wedged against the collar of an anchor or cinching member to lock the anchor, the portion of the collar may have multiple holes defined over its surface to allow for portions of the engaged suture to cold-flow at least partially into or through the holes to enhance the locking effects.
- the collar may be formed with an electrically conductive inner sleeve surrounded by an outer sleeve capable of flowing at least partially when heated.
- the inner sleeve may have a number of holes defined over its surface such that when the outer sleeve is heated, either by inductive heating or any other method, the outer sleeve material may flow through the holes and into contact with the suture passing therethrough. This contact may also enhance the locking effects of the collar.
- FIG. 1A shows a side view of one variation of a tissue plication apparatus which may be used to create tissue plications and to deliver cinching or locking anchors into the tissue.
- FIGS. 1B and 1C show detail side and perspective views, respectively, of the tissue manipulation assembly of the device of FIG. 1A .
- FIGS. 2A to 2 D show an example of a tissue plication procedure for the delivery and placement of tissue anchors.
- FIGS. 3A to 3 G show detail cross-sectional views of an anchor delivery assembly in proximity to a tissue plication and an example of delivering the tissue anchors on distal and proximal sides of the plication.
- FIGS. 4A and 4B show side and end views, respectively, of one anchor variation which is illustrated in the form of a T-type anchor utilizing locking blocks or members for cinching and locking the suture.
- FIG. 5 shows a side view of another cinching anchor variation utilizing locking blocks or members.
- FIG. 6 shows yet another side view of a cinching anchor variation utilizing locking blocks or members.
- FIG. 7 shows a perspective view of another locking anchor variation in which the anchor body defines an opening having a tapered or grooved portion.
- FIGS. 8A and 8B show cross-sectional side and top views, respectively, of another locking anchor variation utilizing a through-hole passage or opening and uni-directional levers or pivots through which the suture may pass.
- FIG. 8C shows a cross-sectional side view of an anchor body in combination with a modified suture having integrated features or protrusions defined along its length.
- FIGS. 9A and 9B show cross-sectional views of locking anchor variations having biased locking members in combination with a knotted suture.
- FIG. 9C shows another modification of the suture which may be coated with a metallic covering or slid within a sleeve.
- FIG. 10 shows a cross-sectional side view of an anchor assembly which utilizes a choke-type loop for cinching the anchors uni-directionally towards one another.
- FIG. 11A shows; a perspective view of another anchor assembly utilizing a slip knot at the proximal anchor.
- FIGS. 11B and 11C show top and cross-sectional side views, respectively, of an anchor which may optionally define grooves or channels extending at least partially therein to facilitate the cinching or wedging of the sutures within the grooves.
- FIGS. 12A to 12 G show examples of anchor assemblies utilizing various slip knots and looped sections which provide uni-directional travel for the anchors over the sutures.
- FIG. 13A shows a cross-sectional side view of an anchor delivery system delivering a basket-type anchor into or through a tissue plication.
- FIG. 13B shows a cross-sectional side view of multiple tissue plications which may be cinched towards one another and basket anchors as being deliverable through one or both tissue plications.
- FIGS. 14A and 14B show cross-sectional side views of an anchor cinching assembly utilizing a cinching collar or collet which may be wedged into an anchor collar for clamping upon the suture.
- FIGS. 15A and 15C show cross-sectional side views of another anchor cinching assembly utilizing a pin for wedging against a portion of the suture.
- FIGS. 15B and 15D show end views of the assembly of FIGS. 15A and 15C , respectively.
- FIG. 15E shows a perspective view of another cinching variation utilizing one or more tapered pins or blocks slidably disposed within a tapered channel defined in a proximal collar of the anchor.
- FIG. 15F shows a perspective view of the tapered pins from FIG. 15E .
- FIGS. 15G and 15H show cross-sectional side views of an alternative cinching assembly having a retractable pin in an engaged and disengaged configuration, respectively.
- FIGS. 16A and 16B show cross-sectional side views of another variation of a cinching assembly having a rotatable cinching collar.
- FIGS. 17A and 17B show cross-sectional side views of another cinching assembly having a retaining tube for providing a counterforce to stabilize the assembly during cinching or locking.
- FIGS. 18A and 18B show cross-sectional side views of another cinching assembly having one or several biasing members or cinching tabs.
- FIGS. 18C and 18D show end and perspective views, respectively, of a suture release member which may be used with the assembly of FIGS. 18A and 18B .
- FIGS. 19A and 19B show cross-sectional side views of another variation of a cinching assembly utilizing a deformable cinching member positioned within the anchor and distally of the anchor collar.
- FIG. 20A shows a cross-sectional side view of another cinching assembly utilizing a pivoting cinching member configured to lock against the suture.
- FIGS. 20B, 20C , and 20 D show end and cross-sectional side views, respectively, of the pivoting member positioned within the anchor collar.
- FIGS. 20E and 20F show cross-sectional side and perspective views, respectively, of another cinching assembly having a pivoting cinching member positioned proximally of the anchor collar.
- FIGS. 21A and 21B show cross-sectional side views of another cinching assembly configured to cinch or lock the suture with a tapered collar.
- FIG. 22A shows a cross-sectional side view of another cinching assembly utilizing a looped suture and a slip knot for cinching the anchor over the suture.
- FIGS. 22B and 22C show cross-sectional side and detail views, respectively, of another cinching assembly which may be utilized with a portion of suture wrapped or looped about a pin which enables unidirectional travel of the anchor relative to the suture
- FIGS. 22D and 22E show cross-sectional side and detail views, respectively, of another cinching assembly utilizing looped suture wedged within the anchor collar.
- FIG. 23 shows a cross-sectional side view of a cinching assembly variation utilizing a number of pulleys to create the cinching effect.
- FIG. 24A shows a cross-sectional side view of another cinching assembly variation in which a cinching sleeve may be used to create a tortuous path for the suture.
- FIGS. 24B and 24C show cross-sectional side views of another cinching assembly variation having a tubular structure, with and without retaining arms, respectively, positioned within the anchor collar through which the suture may pass uni-directionally.
- FIG. 24D shows a perspective view of one variation of the tubular structure of FIG. 24C with retaining arms.
- FIGS. 25A and 25B show cross-sectional side views of another cinching assembly variation in which a cinching collar, which may be independent of the anchor or formed integrally with the anchor, respectively, may have a tortuous path formed within the collar.
- FIG. 25C shows a perspective view of the collar of FIG. 25A in its unobstructed configuration with a constraining sleeve which may be positioned within the collar.
- FIGS. 26A and 26B show cross-sectional side views of another cinching assembly variation utilizing one or several pivoting levers which allow uni-directional travel of the suture therethrough.
- FIGS. 26C and 26D show alternative end views of the assembly of FIG. 26A in which the lever may be configured to prevent over cinching onto the suture.
- FIGS. 26E to 26 G show cross-sectional side views of alternative cinching assemblies in which the levers may be variously configured to create the tortuous path.
- FIGS. 27A and 27B show side views of another cinching assembly variation in a delivery profile and a reconfigured profile, respectively, which utilizes a crimp which may be self-forming.
- FIGS. 28A and 28B show cross-sectional side views of another cinching assembly variation utilizing either two cinching collars or a single integral cinching collar, respectively.
- FIG. 28C shows a cross-sectional side view of the cinching collar of FIG. 28A in one configuration for cinching the suture.
- FIGS. 28D and 28E show perspective views of the cinching collar of FIG. 28A in a delivery profile and a reconfigured profile.
- FIG. 28F shows a cross-sectional side view of another variation for a cinching configuration of the cinching collar of FIG. 28B .
- FIGS. 28G and 28H show cross-sectional side views of another cinching assembly variation in a delivery profile and reconfigured profile, respectively, in which an elongate cinching member may reconfigure itself to create a tortuous path for the suture.
- FIGS. 29A and 29B show cross-sectional side views of another cinching assembly variation utilizing a mechanical crimp.
- FIGS. 30A and 30B show cross-sectional side views of another cinching assembly variation in which a mechanical crimp may be utilized on the proximal collar of the anchor body.
- FIG. 31A shows a cross-sectional side view of a variation of a tool assembly which may be adapted to apply a mechanical crimping force upon a crimping collar.
- FIGS. 31B to 31 D show side, end, and perspective views, respectively, of a variation on a crimping collar which may be utilized as a separate crimping sleeve or as part of the anchor collar.
- FIGS. 32A and 32B show cross-sectional side and perspective views, respectively, of an alternative crimping tool.
- FIGS. 33A and 33B show perspective and end views, respectively, of a representative basket anchor having a protective sleeve encasing the suture disposed within the anchor.
- FIGS. 34A and 34B show cross-sectional side and perspective views, respectively, of a cinching collar defining a plurality of holes through the surface of the collar for enhancing the locking effects with the suture.
- FIG. 35A shows a cross-sectional side view of a cinching assembly variation which may utilize inductive heating to partially melt a portion of an outer sleeve into contact with the suture to enhance the anchor locking effects.
- FIGS. 35B and 35C show perspective assembly and exploded views, respectively, of an electrically conductive inner sleeve contained within the outer sleeve.
- FIGS. 35D and 35E show perspective views of alternative inner sleeves which may be utilized with the assembly of FIG. 35A .
- the anchoring and securement devices may be delivered and positioned via an endoscopic apparatus that engages a tissue wall of the gastrointestinal lumen, creates one or more tissue folds, and disposes one or more of the anchors through the tissue fold(s).
- the tissue anchor(s) may be disposed through the muscularis and/or serosa layers of the gastrointestinal lumen.
- a distal tip of a tissue plication apparatus may engage or grasp the tissue and move the engaged tissue to a proximal position relative to the tip of the device, thereby providing a substantially uniform plication of predetermined size.
- Formation of a tissue fold may be accomplished using at least two tissue contact areas that are separated by a linear or curvilinear distance, wherein the separation distance between the tissue contact points affects the length and/or depth of the fold.
- a tissue grabbing assembly engages or grasps the tissue wall in its normal state (i.e., non-folded and substantially flat), thus providing a first tissue contact area.
- the first tissue contact area then is moved to a position proximal of a second tissue contact area to form the tissue fold.
- the tissue anchor assembly then may be extended across the tissue fold at the second tissue contact area.
- a third tissue contact point may be established such that, upon formation of the tissue fold, the second and third tissue contact areas are disposed on opposing sides of the tissue fold, thereby providing backside stabilization during extension of the anchor assembly across the tissue fold from the second tissue contact area.
- the first tissue contact area may be utilized to engage and then stretch or rotate the tissue wall over the second tissue contact area to form the tissue fold.
- the tissue fold may then be articulated to a position where a portion of the tissue fold overlies the second tissue contact area at an orientation that is substantially normal to the tissue fold.
- a tissue anchor may then be delivered across the tissue fold at or near the second tissue contact area.
- the plication assembly 10 generally comprises a catheter or tubular body 12 which may be configured to be sufficiently flexible for advancement into a body lumen, e.g., transorally, percutaneously, laparoscopically, etc.
- Tubular body 12 may be configured to be torqueable through various methods, e.g., utilizing a braided tubular construction, such that when handle 16 is manipulated and rotated by a practitioner from outside the body, the torquing force is transmitted along body 12 such that the distal end of body 12 is rotated in a corresponding manner.
- Tissue manipulation assembly 14 is located at the distal end of tubular body 12 and is generally used to contact and form the tissue plication, as mentioned above.
- FIG. 1B shows an illustrative detail side view of tissue manipulation assembly 14 which shows launch tube 18 extending from the distal end of body 12 and in-between the arms of upper extension member or bail 20 .
- Launch tube 18 may define launch tube opening 24 and may be pivotally connected near or at its distal end via hinge or pivot 22 to the distal end of upper bail 20 .
- Lower extension member or bail 26 may similarly extend from the distal end of body 12 in a longitudinal direction substantially parallel to upper bail 20 .
- Upper bail 20 and lower bail 26 need not be completely parallel so long as an open space between upper bail 20 and lower bail 26 is sufficiently large enough to accommodate the drawing of several layers of tissue between the two members.
- Tissue acquisition member 28 may be an elongate member, e.g., a wire, hypotube, etc., which terminates at a tissue grasper 30 , in this example a helically-shaped member, configured to be reversibly rotatable for advancement into the tissue for the purpose of grasping or acquiring a region of tissue to be formed into a plication.
- Tissue acquisition member 28 may extend distally from handle 16 through body 12 and distally between upper bail 20 and lower bail 26 .
- Acquisition member 28 may also be translatable and rotatable within body 12 such that tissue grasper 30 is able to translate longitudinally between upper bail 20 and lower bail 26 .
- an optional guide or sled 32 may be connected to upper 20 or lower bail 26 to freely slide thereon.
- Guide 32 may also be slidably connected to acquisition member 28 such that the longitudinal motion of acquisition member 28 is supported by guide 32 .
- Tissue manipulation assembly 14 may be advanced into a body lumen such as the stomach and positioned adjacent to a region of tissue wall 40 to be plicated.
- launch tube 18 may be configured in a delivery profile such that tube 18 is disposed within or between the arms of upper bail 20 to present a relatively small profile.
- tissue acquisition member 30 may be advanced distally such that tissue acquisition member 30 comes into contact with tissue wall 40 at acquisition location or point 42 .
- guide 32 if utilized, may slide distally along with member 30 to aid in stabilizing the grasper.
- a helically-shaped acquisition member 30 is utilized, as illustrated in FIG. 2B , it may be rotated from its proximal end at handle 16 and advanced distally until the tissue at point 42 has been firmly engaged by acquisition member 30 . This may require advancement of acquisition member 30 through the mucosal layer and at least into or through the underlying muscularis layer and preferably into or through the serosa layer.
- the grasped tissue may then be pulled proximally between upper 20 and lower bails 26 via acquisition member 30 such that the acquired tissue is drawn into a tissue fold 44 , as seen in FIG. 2C .
- acquisition member 30 is withdrawn proximally relative to body 12
- guide 32 may also slide proximally to aid in stabilizing the device especially when drawing the tissue fold 44 .
- launch tube 18 may be advanced from its proximal end at handle 16 such that a portion 46 of launch tube 18 , which extends distally from body 12 , is forced to rotate at hinge or pivot 22 and reconfigure itself such portion 46 forms a curved or arcuate shape that positions launch tube opening 24 perpendicularly relative to a longitudinal axis of body 12 and/or bail members 20 , 26 .
- Launch tube 18 , or at least portion 46 of launch tube 18 is preferably fabricated from a highly flexible material or it may be fabricated, e.g., from Nitinol tubing material which is adapted to flex, e.g., via circumferential slots, to permit bending.
- assembly 14 may be configured such that launch tube 18 is reconfigured simultaneously with the proximal withdrawal of acquisition member 30 and acquired tissue 44 .
- the tissue wall of a body lumen typically comprises an inner mucosal layer, connective tissue, the muscularis layer and the serosa layer.
- the staples or anchors used to achieve reduction of the body lumen are preferably engaged at least through or at the muscularis tissue layer, and more preferably, the serosa layer.
- stretching of tissue fold 44 between bail members 20 , 26 permits an anchor to be ejected through both the muscularis and serosa layers, thus enabling durable gastrointestinal tissue approximation.
- needle assembly 48 may be advanced through launch tube 18 via manipulation from its proximal end at handle 16 to pierce preferably through a dual serosa layer through tissue fold 44 .
- Needle assembly 48 is preferably a hollow tubular needle through which one or several tissue anchors may be delivered through and ejected from in securing the tissue fold 44 , as further described below.
- tissue fold F may comprise a plication of tissue created using the apparatus 10 described herein or any other tool configured to create such a tissue plication.
- Tissue fold F may be disposed within a gastrointestinal lumen, such as the stomach, where tissue wall W may define the outer or serosal layer of the stomach.
- Anchor delivery assembly may generally comprise launch tube 18 and needle assembly 48 slidingly disposed within launch tube lumen 52 .
- Needle assembly 48 is generally comprised of needle 54 , which is preferably a hollow needle having a tapered or sharpened distal end 66 to facilitate its travel into and/or through the tissue.
- Other parts of the assembly such as upper and lower bail members 20 , 26 , respectively, and tissue acquisition member 28 have been omitted from these figures only for clarity.
- needle 54 may be urged or pushed into or through tissue fold F via needle pushrod or member 56 from its proximal end preferably located within handle 16 .
- Needle 54 may define needle lumen 58 within which distal anchor 62 and/or proximal anchor 64 may be situated during deployment and positioning of the assembly.
- a single suture or flexible element 70 (or multiple suture elements) may connect proximal anchor 64 and distal anchor 62 to one another.
- element 70 may comprise various materials such as monofilament, multifilament, or any other conventional suture material, elastic or elastomeric materials, e.g., rubber, etc.
- sutures may be made from metals such as Nitinol, stainless steels, Titanium, etc., provided that they are formed suitably thin and flexible.
- metallic sutures with the anchoring mechanisms described herein may additionally provide several benefits. For example, use of metallic suture material may decrease any possibilities of suture failure due to inadvertent cutting or shearing of the suture, it may provide a suture better able to withstand the acidic and basic environment of the gastrointestinal system, and it may also enhance imaging of the suture and anchor assembly if examined under conventional imaging systems such as X-rays, fluoroscopes, MRI, etc.
- suture 70 may encompass any of these materials or any other suitable material which is also biocompatible.
- Needle 54 may optionally define needle slot 60 along its length to allow suture 70 to pass freely within and out of needle 54 when distal anchor 62 is ejected from needle lumen 58 .
- needle 54 may define a solid structure with suture 70 being passed into needle lumen 58 via the distal opening of needle 54 .
- the proximal end of suture 70 may pass slidingly through proximal anchor 64 to terminate in suture loop 74 via cinching knot 72 .
- Suture loop 74 may be omitted and the proximal end of suture 70 may terminate proximally of the apparatus 10 within control handle 16 , proximally of control handle 16 , or at some point distally of control handle 16 .
- suture loop 74 may be provided to allow for a grasping or hooking tool to temporarily hold suture loop 74 for facilitating the cinching of proximal 64 and distal 62 anchors towards one another for retaining a configuration of tissue fold F, as described in further detail below.
- Cinching knot 72 may also comprise a slidable knot which may be slid distally along suture 70 to lock or hold against proximal anchor 64 once the tissue fold F and anchors 62 , 64 have been desirably positioned and tensioned, as also described below in further detail.
- anchor pushrod or member 68 may be actuated also via its proximal end to eject distal anchor 62 , as shown in FIG. 3C .
- FIG. 3D shows how needle 54 may be retracted back through tissue fold F by either retracting needle 54 back within launch tube lumen 52 or by withdrawing the entire anchor delivery assembly 50 proximally relative to tissue fold F.
- FIG. 3E shows that once needle 54 has been retracted, proximal anchor 64 may then be ejected from launch tube 18 on a proximal side of tissue fold F. With both anchors 62 , 64 disposed externally of launch tube 18 and suture 70 connecting the two, proximal anchor 64 may be held against the distal end of launch tube 18 and urged into contact against tissue fold F, as shown in FIGS. 3F and 3G , respectively.
- proximal anchor 64 or a portion of suture 70 may be configured to provide any number of directionally translatable locking mechanisms which provide for movement of an anchor along suture 70 in a first direction and preferably locks, inhibits, or prevents the reverse movement of the anchor back along suture 70 .
- the anchors may simply be delivered through various elongate hollow tubular members, e.g., a catheter, trocars, etc.
- anchors shown and described are intended to be illustrative and are not limited to the variations shown.
- tissue anchor variations are shown as “T”-type anchors while other variations are shown as reconfigurable “basket”-type anchors, which may generally comprise a number of configurable struts or legs extending between at least two collars or support members.
- Other variations of these or other types of anchors are also contemplated for use in an anchor assembly. Examples of anchors which may be utilized are disclosed in co-pending U.S. patent application Ser. No. 10/612,170, filed Jul. 1, 2003, which is incorporated herein by reference in its entirety.
- a single type of anchor may be used exclusively in an anchor assembly; alternatively, a combination of different anchor types may be used in an anchor assembly.
- the different types of cinching or locking mechanisms are not intended to be limited to any of the particular variations shown and described but may be utilized in any of the combinations or varying types of anchors as practicable.
- FIGS. 4A and 4B show side and end views, respectively, of one anchor variation 80 which is illustrated in the form of a T-type anchor. Although a T-type anchor is shown, the methods and devices used to cinch the anchor may be utilized in other types of anchors, which will be described below.
- Variation 80 may generally comprise an anchor body 82 having a circular, rectangular, square, etc., cross-section which defines openings 84 and 86 on opposing sides of the anchor 80 .
- Locking block or member 88 may be slidably disposed within anchor body 82 and define a tapered face 90 on the side of block 88 which tapers to at least one of the openings, in this case opening 86 . Openings 84 , 86 are preferably aligned with one another although this is not necessary.
- Suture 94 may be routed through opening 84 , around locking block 88 , and back out through opening 86 such that when anchor body 82 is translated in the direction of arrow 96 , anchor body 82 may slide freely over suture 94 due to the manner of tapered face 90 contacting suture 84 within opening 84 .
- tension within suture 94 may pull locking block 88 via suture 94 placed over contact surface 92 such that when block 88 translates in the direction of arrow 98 , suture 94 at opening 86 is forced into groove 100 defined along the leading edge of block 88 , as shown in FIG. 4B .
- This cleating action may effectively inhibit or prevent any further movement of anchor body 82 over suture 94 .
- anchor body 82 may be moved uni-directionally relative to suture 94 and a distally located anchor to effectively cinch tissue therebetween.
- FIG. 5 illustrates another cinching anchor in the side view of anchor variation 110 .
- anchor body 112 similarly defines openings 114 and 116 through which suture 96 may be routed.
- Locking block or member 118 which may similarly also define tapered face 120 may be slidably disposed within anchor body 112 .
- Locking block 118 may be urged via a biasing member, for instance spring 122 , to maintain a biasing force against suture 94 passing through anchor body 112 .
- biasing member 122 may force locking block 118 to exert a force at its leading edge against suture 94 , thereby preventing its movement and allowing only uni-directional movement.
- anchor body 132 also defines openings 134 , 136 through which suture 94 may pass.
- multiple locking blocks or members 138 , 140 may be configured to become biased in opposing directions via biasing members or springs 142 , 144 , respectively.
- Each of locking blocks 138 , 140 may define an opening through which suture 94 may pass.
- the biasing members 142 , 144 may urge their respective locking blocks 138 , 140 in directions 146 , 148 to create a tortuous path through the blocks and inhibit or prevent the reverse movement of anchor body 132 relative to suture 94 .
- FIG. 7 shows a perspective view of another locking anchor variation 150 in which anchor body 152 defines an opening 154 having a tapered or grooved portion 156 .
- Opening 154 may be sized to allow suture 94 to pass through opening 154 such that anchor body 152 may be translated freely relative to suture 94 .
- suture 94 may be manipulated to slide into tapered or grooved portion 156 , which preferably defines a diameter which is less than a diameter of suture 94 . Sliding suture 94 into tapered or grooved portion 156 may lock a position of anchor body 152 relative to suture 94 due to the cleating effect of grooved portion 156 on suture 94 .
- FIGS. 8A and 8B show cross-sectional side and top views, respectively, of another locking anchor variation 160 in which anchor body 162 may define a through-hole passage or opening 164 through which suture 94 may pass.
- Anchor body 162 may have one or several levered, flapped, or biased locking members 166 which may be integrally formed with anchor body 162 . These locking members 166 may be formed radially about opening 164 such that when suture 94 is absent, the resting configuration of locking members 166 define an opening 164 having a diameter less than that of the suture 94 passed through. Locking members 166 may be biased to protrude in a single direction, as shown in FIG.
- FIG. 8C shows a cross-sectional side view of anchor body 162 in combination with a modified suture 168 having integrated features or protrusions 170 defined along its length.
- Features or protrusions 170 may be defined uniformly at regular intervals along the length of suture 168 or intermittently, depending upon the desired effects, to enhance the locking ability of the anchor body onto the suture.
- the features or protrusions 170 may be integrally formed protrusions or they may simply comprise knotted sections of suture. Sutures which are modified or knotted may be optionally utilized in any of the locking anchor variations as described herein in place of conventional sutures, depending upon the desired degree of locking and locking effects.
- anchor body 182 may also comprise biased locking members 184 , contained within the anchor body 182 .
- the number and configuration of locking members 184 may be varied as desired and may optionally be apposed, as shown in FIG. 9A , or utilize a single member 184 , as shown in anchor variation 188 in FIG. 9B .
- the figures show knotted suture 186 used with anchor variation 180 ; however, conventional sutures may also be utilized.
- FIG. 9C shows another modification of suture 94 which may be utilized with any of the anchor locking variations shown herein.
- the portions of suture 94 which come into contact with the anchor locking mechanisms may be coated with a material having a relatively higher frictional coefficient, i.e., a coefficient of friction that is higher than the underlying suture material.
- the portion of suture 94 may be coated with a metallic covering or slid within sleeve 181 , which may be made of a metallic material such as Titanium, Nitinol, stainless steel, etc. to enhance the locking force between suture 94 and the anchor.
- sleeve 181 As shown in the figure, if sleeve 181 is utilized, the ends 183 , 185 of sleeve 181 may be crimped onto suture 94 . One or several openings 187 may also be defined along sleeve 181 to further enhance the locking capability between suture 94 and the locking mechanism.
- locking mechanisms may also utilize a variety of knotting techniques.
- Conventional knots which are typically tied by the practitioner either within the body or outside the body and advanced over the suture length, may be utilized for locking the anchor in place relative to the tissue fold and opposing anchor; however, self-locking knots which enable the uni-directional travel of an anchor body relative to the suture and tissue are desirable.
- FIG. 10 shows locking anchor assembly 190 with distal anchor 192 , which may be positioned distally of a tissue fold, and proximal anchor 194 , which may be positioned proximally of a tissue fold or folds.
- suture 94 may be routed through proximal anchor 194 via openings 196 , 198 and extended to distal anchor 192 .
- distal anchor 192 suture 94 may be routed through opening 200 and over pin 202 positioned within distal anchor 192 .
- Pin 202 may function as a pulley over which suture 94 may travel during anchor locking adjustments.
- Suture 94 may then be routed back towards proximal anchor 194 through opening 204 and define loop 206 through which the proximal portion of suture 94 passes to thereby create a choke-type loop.
- the terminal end of suture 94 may then be anchored at fixed end 208 within the body of proximal anchor 194 .
- proximal anchor 194 and distal anchor 192 may be freely drawn towards one another to secure any tissue fold or folds (not shown for clarity) disposed therebetween.
- loop 206 would “choke” suture 94 and prevent any reverse movement of proximal anchor 194 .
- FIG. 11A shows a perspective view of locking anchor assembly 210 having distal anchor 212 and proximal anchor 214 with suture 94 extending between the two anchors.
- Terminal end 230 of suture 94 may be knotted or otherwise retained by proximal anchor 214 and routed through opening 216 and back through opening 218 to create looped portion 228 , both openings 216 , 218 being defined in proximal anchor 214 .
- Suture 94 may be routed from opening 218 and through distal anchor 212 via openings 222 , 224 . Suture 94 may then be routed back to proximal anchor 214 through an opening 220 and wrapped 226 about looped portion 228 to continue on proximally.
- This knotted configuration facilitates advancement of proximal anchor 214 towards distal anchor 212 but chokes suture 94 when proximal anchor 214 is moved in an opposing direction.
- FIGS. 11B and 11C show top and cross-sectional side views of an alternative variation on proximal anchor 214 (and distal anchor 212 , if desired).
- anchor 214 may optionally define grooves or channels 232 which extend-at least partially between openings 216 , 218 , and 220 .
- These grooves or channels 232 may be sized such that any of the overlying suture 94 are cinched or wedged into grooves 232 to facilitate the cinching action of anchor 214 with respect to suture 94 .
- FIG. 12A Another locking anchor assembly 240 is shown in the perspective view of FIG. 12A , which shows distal anchor 242 and proximal anchor 244 with suture 94 extending between the two anchors.
- Suture 94 may be routed through opening 246 defined through proximal anchor 244 and passed through distal anchor 242 via openings 250 , 252 .
- Suture 94 may then be routed back towards proximal anchor 244 and passed through opening 248 to create at least two adjacent loops (half hitch knots) 254 , 256 with looped section 258 .
- the knotted suture may be slid distally with proximal anchor 244 .
- proximal anchor 244 Once proximal anchor 244 has been desirably positioned along suture 94 , the terminal end of suture 94 may be pulled, as shown by arrow 260 , to alter the knot configuration, commonly called changing the dressing of the knot, such that the knot becomes locked onto suture 94 and prevents any reverse movement of proximal anchor 244 .
- FIG. 12B also shows a perspective view of another locking anchor variation similar to that shown in FIG. 12A .
- suture 94 may be wrapped into two intertwined loops 264 , 266 and further wrapped again into adjacent intertwined loops 262 , 268 .
- Distal advancement of the knotted configuration along with proximal anchor 244 may be accomplished until the terminal end of suture 94 is placed under tension, as shown by arrow 260 .
- Tension may be applied once proximal anchor 244 has been desirably positioned along suture 94 to lock the knot into position and prevent any reverse movement of proximal anchor 244 along suture 94 .
- FIG. 12C shows a perspective view of another anchor locking assembly similar to the variations above.
- the knot may be modified by wrapping suture 94 into a first set of several loops, shown as three loops 270 , 272 , 274 , although in other variations, any number of loops may be utilized depending upon the desired locking effects.
- Suture 94 may then be wrapped in a second set of several additional loops in a proximally adjacent position about suture 94 , shown as loops 278 , 280 , 282 joined by looped section 276 .
- any number of loops in the second set may be utilized either independent of the number of loops in the first set or to mirror the first set of loops.
- a knotted configuration as shown in FIG. 12D , is formed which may be freely slid along suture 94 provided the knotted configuration itself is pushed along suture 94 , e.g., via a pusher tube, knot pusher, etc.
- the knot locks against suture 94 and prevents reverse movement of proximal anchor 244 along suture 94 .
- FIG. 12E shows a perspective view of another locking anchor variation similar to the variation shown in FIG. 12D yet having a single suture traverse between anchors 242 , 244 .
- suture 94 may have terminal end 286 anchored or retained by distal anchor 242 at opening 252 and have a single suture traverse to proximal anchor 244 .
- a second terminal end 288 may also be anchored or retained by proximal anchor 244 at opening 246 .
- the portions of suture 94 extending between proximal anchor 244 and the knot may have a biasing member, e.g., spring 290 , disposed over one or both lengths of suture to maintain proximal anchor 244 and the knot under a constant force to ensure that the knot is maintained under a locking force to prevent the reverse travel of proximal anchor 244 .
- a biasing member e.g., spring 290
- the locking and cinching mechanisms described herein may be utilized with a variety of different anchor types.
- the cinching mechanisms described above may be used not only with T-type anchors but also with reconfigurable basket-type anchors. Described hereinafter are basket-type anchors configured for implantation or placement against tissue in a similar manner as described previously and examples of how cinching mechanisms may be utilized in securing tissue plications.
- additional cinching mechanisms which are preferably utilizable with basket-type anchors are also described below.
- FIG. 13A shows anchor delivery system 300 in proximity to tissue fold F.
- tissue fold F may be disposed within a gastrointestinal lumen, such as the stomach, where tissue wall W may define the outer or serosal layer of the stomach.
- Delivery push tube or catheter 302 may be disposed within launch tube 18 proximally of basket anchor 306 , which is shown in a compressed delivery configuration with a relatively low profile when disposed within needle lumen 58 of needle 54 .
- a single basket anchor 306 is shown disposed within needle 54 only for illustrative purposes and is not intended to be limited by the number of basket anchors; rather, any number of basket anchors may be disposed within needle lumen 58 as practicable depending upon the desired procedure and anchoring results.
- Suture 94 may be routed through or externally of push tube lumen 304 and further routed within and/or through proximal collar 310 of anchor 306 .
- the terminal end of suture 94 may be routed within anchor 306 and affixed to distal collar 308 in one variation.
- suture 94 may be affixed or anchored within anchor 306 or at proximal collar 310 depending upon the desired effect and procedure being performed.
- suture 94 may be routed through anchor 306 such that the anchor 306 may freely slide along or over suture 94 .
- the basket anchors may comprise various configurations suitable for implantation within a body lumen. Basket anchors are preferably reconfigurable from a low profile delivery configuration to a radially expanded deployment configuration in which a number of struts, arms, or mesh elements may radially extend once released from launch tube 18 or needle 54 . Materials having shape memory or superelastic characteristics or which are biased to reconfigure when unconstrained are preferably used, e.g., spring stainless steels, Ni—Ti alloys such as Nitinol, etc.
- the basket anchor 306 is illustrated as having a number of reconfigurable struts or arm members 312 extending between distal collar 306 and proximal collar 310 ; however, this is intended only to be illustrative and suitable basket anchors are not intended to be limited to baskets only having struts or arms. Examples of suitable anchors are further described in detail in U.S. patent application Ser. No. 10/612,170, which has already been incorporated herein above.
- FIG. 13A shows basket anchor 306 delivered through tissue fold F via needle 54 and launch tube 18 .
- the other parts of the plication assembly such as upper and lower bail members 20 , 26 , respectively, and tissue acquisition member 28 have been omitted from these figures only for clarity.
- Proximal anchor 318 is also shown in a radially expanded profile contacting tissue fold F along tissue contact region 314 . Locking or cinching of suture 94 proximally of proximal anchor 318 enables the adequate securement of tissue fold F.
- distal basket anchor 306 may be disposed distally of at least one additional tissue fold F′, as shown in FIG. 13B , while proximal anchor 318 may be disposed proximally of tissue fold F.
- suture 94 may be similarly affixed within distal anchor 306 and routed through proximal anchor 318 , where suture 94 may be cinched or locked via proximal anchor 318 , as necessary. If tissue folds F and F′ are to be positioned into apposition with one another, distal basket anchor 306 and proximal anchor 318 may be approximated towards one another.
- proximal anchor 318 is preferably configured to allow suture 94 to pass freely therethrough during the anchor approximation. However, proximal anchor 318 is also preferably configured to prevent or inhibit the reverse translation of suture 94 through proximal anchor 318 by enabling uni-directional travel of anchor 318 over suture 94 . This cinching feature thereby allows for the automated locking of anchors 306 , 318 relative to one another during anchor approximation.
- delivery push tube 302 may be advanced distally to urge cinching collet 326 into anchor collar 322 such that clamping arms or teeth 328 are clamped onto suture 94 and cinching collet 326 is friction-fitted within anchor collar 322 .
- Anchor collar 322 may then be urged out of launch tube 18 and the anchor left against the tissue surface.
- FIG. 15C shows a cross-sectional side view of locking pin 388 having been urged into anchor collar 344 in a frictional engagement with suture 94 .
- FIG. 15D shows a cross-sectional end view of collar 344 with locking pin 388 and suture 94 positioned within.
- FIG. 15E shows a perspective view of another cinching variation 331 which is 20 similar to the variation described above.
- One or more tapered pins or blocks 339 may be slidably disposed within tapered channel 335 defined in proximal collar 333 .
- the figure shows two tapered pins 339 , although a single pin may be utilized or more than two pins may also be used. If two or more pins 339 are utilized, suture 94 may be passed between the pins 339 .
- Pins 339 may be free to slide along inner surface 337 of channel 335 in the direction of arrows 345 depending upon the direction of travel of suture 94 through channel 335 .
- pins 339 may be tapered distally from a larger diameter to a smaller diameter and although pins 339 are shown as semi-circularly shaped members, contact surface 341 may be curved or arcuate to better contact suture 94 . Moreover, contact surface 341 , which contacts suture 94 passing through channel 335 , may define a roughened surface or it may alternatively define a plurality of serrations, teeth, projections, etc., to facilitate contact against suture 94 .
- FIGS. 15G and 15H show a cinching anchor having a retractable pin.
- FIG. 15G shows proximal collar 347 with one or more retracting arms 349 extending proximally from collar 347 .
- Retracting arms 349 may be configured to pivot at bend 353 when urged via a compression force applied at bend 353 in the direction of arrows 355 .
- the application of this compression force may urge pin support collar 357 which is defined at a proximal portion of arms 349 , to move in the direction of arrow 359 .
- retracting arms 349 may be biased to retain pin 351 within proximal collar 347 unless a compression force is applied at bend 353 .
- FIGS. 16A and 16B show cross-sectional side views of another variation of cinching assembly 350 .
- Cinching assembly 350 may generally comprise outer tubing 352 and inner tubing 358 rotatingly positioned within outer tubing lumen 354 .
- Cinching member 362 may be positioned distally of outer tubing 352 and may generally comprise a collar base 364 and cinching collar 374 projecting proximally from collar base 364 .
- Cinching collar 374 is preferably tapered and threaded and may also be longitudinally slotted such that rotatable collar 368 may be rotatingly disposed upon slotted cinching collar 374 .
- suture 94 may pass freely through assembly 350 .
- engaging members 356 on outer tubing 352 may be correspondingly engaged against interface 366 and engaging members 363 on inner tubing 358 may be engaged against interface 372 .
- outer tubing 352 may be held stationary while inner tubing 358 is rotated to torque rotatable collar 368 about threaded cinching collar 374 .
- the tapered shape may urge the slotted members to cinch upon suture 94 passing therethrough.
- Stand-offs 370 which may protrude from rotatable collar 368 , may be adjusted in height to control how far rotatable collar 368 may be torqued onto collar base 364 such that the degree to which rotatable collar 368 is torqued about cinching collar 374 may be desirably adjusted.
- proximal anchor collar 310 may be ejected from launch tube 18 along with the cinching assembly, as shown in FIG. 16B .
- collar engaging arms 386 may be positioned within launch tube 18 or within retractable sleeve 382 . After locking pin 338 has been inserted within anchor collar 388 , engaging arms 386 may be advanced distally out of launch tube 18 or retractable sleeve 382 may be withdrawn proximally to expose engaging arms 386 . Once free of any constraining forces, engaging arms 386 may be biased to spring or open radially to then release proximal anchor collar 388 in a cinched configuration.
- proximal anchor collar 406 may comprise one or several biasing members or cinching tabs 408 within collar 406 .
- Each of the tabs 406 may be biased to project inwardly such that suture 94 passing through is automatically cinched and locked in position, as shown in FIG. 18A .
- a suture release member 404 which may generally comprise a cylindrically shaped tube or member having a tapered surface 410 and a suture lumen 412 defined therethrough, may be positioned within anchor collar 406 during anchor positioning to allow free passage of suture 94 through the anchor, as shown in FIG. 18B .
- FIG. 18C shows an end view of release member 404 defining suture lumen 412 extending therethrough.
- FIG. 18D shows a perspective view of release member 404 to show tapered surface 410 and suture lumen 412 in better detail. Tapered surface 410 may be omitted but is preferably to facilitate the insertion and removal of release member 404 from anchor collar 406 .
- tubular member 402 may engage suture release member 404 for withdrawal from anchor collar 406 .
- the removal of release member 404 may cause cinching tabs 408 to lock upon suture 94 and prevent the further movement of the anchor relative to suture 94 .
- FIGS. 19A and 19B show another variation of cinching assembly 420 in which a deformable cinching member 424 may be positioned within the anchor distally of anchor collar 422 .
- Cinching member 424 may define a tapered outer surface such that when the anchor is ready to be secured to suture 94 , the insertion of cinching member 424 into collar 422 may compress cinching member 424 about suture 94 such that any further movement of the anchor is prevented.
- Cinching member 424 may be pulled into anchor collar 422 via pull wire 426 , which may be manipulated at its proximal end by the surgeon or user when desired.
- FIGS. 20A to 20 D show cross-sectional views of another variation in cinching assembly 430 .
- proximal anchor collar 432 may comprise a pivotable locking member 434 contained either within anchor collar 432 or proximally of collar 432 .
- This example illustrates locking member 434 contained within collar 432 .
- Suture 94 may pass through locking member 434 , which is shown in the end view of collar 432 in FIG. 20B , as having two pivots 436 .
- locking member 434 and pivots 436 may be integrally formed from proximal collar 432 .
- Pivoting locking member 434 may be biased to rotate about pivot 436 such that a resting position of locking member 434 is against an inner surface of collar 432 .
- tension as represented by arrow 438 on suture 94 may force pivot 434 into an open position where suture 94 may pass freely through.
- locking member 436 may be biased to pivot in direction 440 to lock suture 94 against the inner surface of collar 432 .
- Opposite movement of the anchor relative to suture 94 may act to further cinch locking member 434 against suture 94 and thereby further inhibit the movement of the anchor in the reverse direction.
- locking member 434 ′ may extend proximally of proximal collar 432 at an angle relative to collar 432 .
- Locking member 434 ′ may be pivotable via pivot 436 ′ such that locking member 434 ′ may pivot in the direction of the arrows shown depending upon the direction which the tissue anchor is translated relative to suture 94 . If proximal collar 432 is translated distally over suture 94 , it may travel freely; however, if proximal collar 432 is translated proximally in the opposite direction, suture 94 may become wedged in a tapered portion of opening 442 through which suture 94 passes. Once suture 94 is wedged in tapered opening 442 , locking member 434 ′ may pivot towards proximal collar 432 , where it is stopped from further motion, thereby locking the tissue anchor onto suture 94 and preventing its reverse motion.
- FIGS. 21A and 21B show another cinching assembly variation 450 as seen in the cross-sectional side views.
- delivery push tube 452 may be disposed proximally of locking collar 454 and proximal tapered anchor collar 458 .
- locking collar 454 may be urged distally via push tube 452 such that locking collar 454 slides over proximal anchor collar 458 .
- locking collar 454 may be tapered and anchor collar 458 may also be tapered in a correspondingly opposed manner such that when locking collar 454 is mated with anchor collar 458 , anchor collar 458 may cinch locking collar 454 upon suture 94 to thereby prevent any further movement of the anchor over suture 94 .
- Both collars may be made from any of the same or similar materials, as described above.
- suture 94 may be routed through anchor proximal collar 462 and looped over pulley or pin 466 contained within distal collar 464 . Suture 94 may then be routed back through and looped 468 about suture 94 and tied with slip knot 470 . As tension is applied to suture 94 , slip knot 470 may prevent further movement of the anchor relative to suture 94 .
- FIGS. 22B and 22C show a variation which may be used in combination with cinching anchor variation 460 or alone.
- Pin 474 may optionally be positioned within proximal collar 462 and suture 94 may be wrapped or looped about itself around pin 474 in a manner as shown in the detail view of FIG. 22C .
- the configuration of loop 472 may allow for the uninhibited translation of the anchor in the direction of the arrow as shown; however, when the anchor is moved in the opposite direction, loop 472 may effectively cinch upon itself to thus prevent or inhibit the reverse motion of the anchor relative to suture 94 .
- FIGS. 22D and 22E Another cinching variation is shown FIGS. 22D and 22E .
- Suture 94 may be routed through proximal collar 462 with an additional length of cinching suture 476 .
- the distal end of cinching suture 476 may form loop 478 which is wrapped about suture 94 and free to slide over suture 94 .
- cinching suture 476 may be pulled proximally such that loop 478 is pulled into proximal collar 462 and becomes wedged against suture 94 .
- the multiple lengths of suturing material utilized for loop 478 and suture 94 preferably form a cross-sectional area which is larger than an inner diameter of proximal collar 462 such that positioning loop 478 and suture 94 within collar 462 ensures a frictional lock which prevents further movement of the suture 94 relative to the anchor.
- Suture 94 and cinching suture 476 are preferably made from the same or similar materials although differing suture materials may also be used.
- FIG. 23 shows a cross-sectional view of cinching assembly variation 480 in which proximal collar 482 may comprise pulley or pin 484 about which suture 94 may be looped once or several times 490 .
- Distal collar 486 may also comprise pulley or pin 488 about which suture 94 may also be looped once or several times before being wrapped or looped 492 back about suture 94 .
- the terminal end of loop 492 may be secured about suture 94 via slip knot 494 .
- This configuration of looping allows for the anchor to be advanced uni-directionally relative to the suture and tissue, yet prevents or inhibits the reverse movement of the anchor and thus effectively enables the tissue to be cinched via the anchors.
- Cinching sleeve 506 may generally comprise a tubular structure having sleeve lumen 510 defined therethrough and a number of openings 508 defined along the length of sleeve 506 . Openings 508 may be uniformly patterned along sleeve 506 or they may be randomly positioned. Moreover, any number of openings 508 may be utilized as practicable.
- suture 94 may be routed in various patterns throughout openings 508 and through sleeve lumen 510 before being routed through proximal collar 504 .
- cinching sleeve 506 may be urged distally via delivery push tube 502 . When urged or pushed distally, this may be done slowly so as to allow suture 94 to pass through the tortuous path created by suture 94 passing through openings 508 . However, once cinching sleeve 506 has been advanced proximally adjacent to proximal collar 504 , cinching sleeve 506 may become locked with proximal collar 504 pressing against sleeve 506 .
- FIG. 24B shows another variation of a cinching mechanism which utilizes a tortuous path.
- Cinching sleeve 512 may comprise a tubular structure having an opening 514 defined along a surface of sleeve 512 through which suture 94 may pass. Cinching sleeve 512 may be disposed within proximal collar 504 with suture 94 routed from outside of sleeve 512 and passing to within sleeve 512 through opening 514 . In operation, because of the manner in which suture 94 is routed through sleeve 512 and into the anchor, distal translation of the anchor relative to the tissue and suture 94 is uninhibited.
- an outer diameter of cinching sleeve 512 is preferably sized to be slightly less than an inner diameter of proximal collar 504 such that when suture 94 is passed through opening 514 , cinching sleeve 512 becomes wedged against collar 504 .
- Cinching sleeve 512 may be made from any of the same or similar materials as the anchors, as described above.
- FIGS. 24C and 24D show another variation similar to cinching sleeve 512 described above.
- Cinching sleeve variation 516 may be similarly sized as sleeve 512 and may also similarly define an opening 514 ; however, sleeve 516 includes one or several retaining arms 518 defined on a distal end of sleeve 516 . Any number of retaining arms 518 may be utilized provided that they extend radially and reside distally of proximal collar 504 such that they prevent sleeve 516 from sliding proximally out of collar 504 .
- Cinching sleeve 516 may also be made from the same or similar material as the anchor; for example, sleeve 516 may be fabricated from a material having superelastic characteristics, such as Nitinol. Accordingly, when cinching sleeve 516 is initially inserted through collar 504 and/or during anchor delivery through launch tube 18 into or through the tissue, retaining arm or arms 518 may be configured into a low profile with arm or arms 518 constrained into a tubular shape. Upon anchor release or upon being inserted through collar 504 , retaining arms 518 may be released to extend radially.
- assembly variation 520 may comprise cinching collar 522 located proximally of anchor proximal collar 524 .
- Cinching collar 522 may be a tubular structure having superelastic material characteristics, such as those found in Nitinol.
- Obstructing members 526 which may be formed from portions of cinching collar 522 , may be pressed or formed to extend into a lumen of cinching collar 522 such that a tortuous path is created for the passage of suture 94 . Although three obstructing members 526 are shown in the figure, any number of obstructions as practicable may be created depending upon the desired tortuous path to be created.
- Assembly 520 shows cinching collar 522 as a separate collar located proximally of anchor collar 524 ; however, the cinching collar may be integrated with the anchor collar such that a singular integral structure is formed, as shown in anchor variation 530 in the cross-sectional view of FIG. 25B .
- retaining sleeve 534 may be inserted within cinching collar 522 to maintain obstructing members 526 in an open position for allowing suture 94 to pass freely through sleeve 534 .
- retaining sleeve 534 may be withdrawn, as shown in the perspective view of FIG. 25C , using any number of methods. Removal of retaining sleeve 534 will allow for obstructing members 526 to reconfigure inwardly in the direction of arrows 532 to thus reconfigure cinching collar 522 into a tortuous path.
- Cinching assembly 540 may also utilize a single or any number of tabs or levers to aid in capturing suture 94 and/or creating a tortuous path for suture 94 to traverse.
- proximal collar 542 may have a pivoting lever 544 formed integrally from a side wall of proximal collar 542 .
- lever 544 may be included in a cinching collar separate from proximal collar 542 .
- Lever 544 may be biased to spring inwardly into proximal collar 542 upon suture 94 passing therethrough.
- suture 94 may be allowed to freely pass through proximal collar 542 and past lever 544 due to its pivoting motion.
- lever 544 may act to cinch down upon suture 54 against an inner surface of proximal collar 542 , as shown in the figure.
- FIG. 26B Another variation 546 of assembly 540 is shown in the cross-sectional view of FIG. 26B in which proximal collar 548 is shown as having at least two levers 550 , 552 both biased in opposing directions to create a tortuous path for suture 94 to traverse.
- the cinching levers may be configured to prevent or inhibit the over-cinching or cutting of suture 94 .
- FIGS. 26C and 26D show alternative end views of FIG. 26A . Uni-directional lever 544 , as seen in FIG.
- 26C may be formed from the side wall of proximal collar 542 such that when lever 544 cinches down upon suture 94 , the corners or ends of lever 544 contact an inner surface of proximal collar 542 at contact points 554 . The contact which occurs may ensure that an open space 556 is preserved and that lever 544 is prevented from over cinching onto suture 94 within space 556 and cutting suture 94 .
- FIG. 26D shows an alternative uni-directional lever 544 ′ which defines a curved or arcuate edge 558 which contacts suture 94 . The arcuate edge 558 may prevent the over cinching onto suture 94 and cutting of suture 94 .
- FIGS. 26E, 26F , and 26 G show alternative variations of cinching assembly 546 with uni-directional levers having various configurations.
- FIG. 26E shows a cross-sectional side view of cinching assembly 560 in which-proximal collar 562 may have levers 564 , 566 directed and biased in opposing directions to create a tortuous path. Each of the levers 564 , 566 in this variation may be curved inwardly towards proximal collar 562 .
- FIG. 26F shows a cross-sectional side view of cinching assembly 568 in which proximal collar 570 has uni-directional levers 572 , 574 angled towards on another when biased inwardly.
- FIG. 26G shows a cross-sectional side view of cinching assembly 576 in which proximal collar 578 has uni-directional levers 580 , 582 curved outwardly relative to one another when the levers are biased within collar 578 .
- FIGS. 27A and 27B shows yet another variation of cinching assembly 590 which utilizes a reconfigurable hollow member for cinching suture 94 .
- hollow member 594 may be constrained within tubular delivery member 592 to retain an elongate shape with suture 94 passing uninhibited therethrough.
- hollow member 594 may be advanced distally from tubular member 592 and when hollow member 594 has been ejected, it may adapted to reconfigure itself into a crimped configuration 594 ′ having a non-linear passageway.
- Suture 94 passing through the crimped configuration 594 ′ may be inhibited from passing freely therethrough by crimp 596 created within the hollow member.
- Hollow member 594 may have a variety of cross-sectional shapes, e.g., circular, rectangular, square, hexagonal, etc., and it is preferably made from a material having shape memory characteristics, e.g., Nitinol, such that when hollow member 594 is unconstrained, it may automatically reconfigure into its crimped configuration 594 ′.
- cinching assembly 600 which is configured to reconfigure itself upon being unconstrained is shown in the cross-sectional views of FIGS. 28A to 28 C.
- cinching collar 602 may comprise at least two circular members, first collar 606 and second collar 608 , connected by an elongate bridging member 604 .
- Cinching collar 602 may be positioned within launch tube 18 proximally adjacent to proximal collar 610 and adapted to reconfigure itself once released from launch tube 18 such that a tortuous path is created for suture 94 .
- FIGS. 28D and 28E show perspective views of cinching collar 602 in a constrained delivery configuration and an unconstrained cinching configuration.
- FIG. 28F shows a cross-sectional side view of another cinching assembly which is similar to the variation shown in FIG. 28B .
- first collar 606 may reconfigure itself to maintain its orientation relative to the anchor while joining member 612 may be formed to curve appropriately or approximately in an “S”-type configuration.
- the reconfigured cinching member may act to lock suture 94 relative to the anchor when the anchor is moved in a reverse direction.
- Cinching member 616 may be fabricated from a variety of materials, e.g., Nitinol, spring stainless steel, etc., which exhibit shape memory or superelastic characteristics, or aspects thereof. In use, cinching member 616 may be configured into an elongate delivery configuration.
- cinching member 616 When the tissue anchor is to be cinched or locked relative to the tissue, cinching member 616 may be released from a constraining force such that cinching member 616 reconfigures itself into an expanded or extended configuration which creates a tortuous path for suture 94 which sufficiently locks suture 94 within cinching member 616 .
- Cinching member 616 maybe comprised generally of an elongate bar, ribbon, cylinder, etc., or any elongate member having a diameter or cross-sectional area in its delivery configuration which is sufficiently small to be disposed and/or translated within launch tube 18 .
- Cinching member 616 may define a plurality of openings 618 along the length of cinching member 616 such that when cinching member 616 is in its elongate delivery configuration, as shown in FIG. 28G , suture 94 may be interwoven through openings 618 along a relatively straightened path. Openings 618 may be located along cinching member 616 at uniform locations or they may be randomly positioned along the length of cinching member 616 .
- cinching member 616 When released, cinching member 616 may reconfigure itself into an expanded suture-locking configuration 616 ′ which is sufficiently large to prohibit its passage into or through proximal collar 614 , as shown in FIG. 28H .
- Expanded configuration 616 ′ may comprise any reconfigured shape so long as the expanded shape is adapted to create the tortuous path for suture 94 and is large enough so that passage through proximal collar 614 is not possible.
- cinching and locking mechanisms which utilize mechanical clamping or crimping to achieve locking of the suture within or through the anchors may also be used to facilitate uni-directional locking.
- FIG. 29A shows delivery tube member 622 having crimping collar 624 disposed therewithin proximally of anchor proximal collar 626 .
- Suture 94 may be passed through both crimping collar 624 and proximal collar 626 .
- crimping collar 624 may be advanced distally adjacent to proximal collar 624 and mechanically crimped 624 ′ down upon suture 94 to create a lock and prevent the reverse movement of the anchor over suture 94 , as shown in FIG. 29B .
- FIG. 30A shows cinching assembly 630 in which the crimping collar 632 may be integral with the anchor rather than being a separate member.
- FIG. 30B shows a mechanically crimped collar 632 ′ which eliminates the need for a separate collar.
- FIG. 31A shows one variation of a tool assembly 640 which may be adapted to apply a mechanical crimping force upon a crimping collar.
- launch tube 18 may have delivery push tube 642 located therewithin and positioned proximally of proximal collar 652 of the tissue anchor.
- Push tube 642 may be used to hold and/or eject proximal collar 652 from launch tube 18 .
- Crimping device 644 may be advanced within launch tube 18 via crimping control member 646 , which may be manipulated from its proximal end.
- a collar retaining channel 650 maybe defined in a distal end of crimping device 644 and adapted to receive and securely hold proximal collar 652 within during a clamping or crimping process.
- Crimping members or arms 648 may be positioned within crimping device 644 on either side of retaining channel 650 .
- crimping members or arms 648 may be driven into contact with proximal collar 652 to crimp the collar.
- crimping arms 648 may be actuated through a variety of methods, e.g., hydraulically, pneumatically, via mechanical leverage, etc.
- Crimping assembly 660 is shown in the cross-sectional view of FIG. 32A .
- Crimping device 662 may be seen within launch tube 18 extending from crimping control member 664 .
- Collar retaining channel 672 may be likewise defined within crimping device 662 for retaining proximal collar 670 during a crimping procedure.
- This variation may utilize a separate elongate crimping member 666 having actuatable crimping arms 668 positioned at a distal end of elongate member 666 .
- elongate member 666 may be advanced distally until crimping arms 668 are positioned over proximal collar 670 and crimped down.
- FIG. 32B shows an exploded perspective view of the crimping assembly.
- FIGS. 31B to 31 D show side, end, and perspective views, respectively, of one variation of an anchor proximal collar 652 which is adapted for crimping upon a suture passing therethrough.
- a circumferential slot 656 may be defined through collar 652 partially around its circumference.
- Another longitudinal slot 658 may be defined through collar 652 extending longitudinally from a proximal edge of collar 652 to circumferential slot 656 .
- These slots 656 , 658 may define at least two crimping arms 654 which may be crimped down upon a length of suture passing through collar 652 .
- additional measures may be optionally implemented to facilitate the cinching or locking of an anchor.
- Other measures may also be taken to inhibit any damage from occurring to the suture routed through an anchor.
- the portion of suture 94 passing through basket anchor 682 may be encased in a protective sleeve 690 , as shown in the perspective view of FIG. 33A of anchor-sleeve assembly 680 .
- the basket anchor 682 is shown in this variation as having anchor struts or arms 688 in a partially deployed configuration.
- Sleeve 690 may extend between distal collar 684 and proximal collar 686 to prevent excessive contact between suture 94 and elements of basket anchor 682 .
- Sleeve 690 may be made from a variety of polymeric materials, e.g., polypropylene, PTFE, etc., provided that the material is suitably soft.
- FIG. 34A shows a cross-sectional view of cinching assembly 700 which may be implemented with any of the cinching and locking mechanisms described above.
- This particular variation utilizes the partial cold-flowing of the engaged suture 94 to enhance the locking or cinching effect of the tissue anchor.
- the cinching collar, or in this variation proximal collar 702 , against which suture 94 is wedged may have multiple through-holes 704 defined over the surface of collar 702 .
- the cross-sectional side view shows suture 94 wedged within collar 702 against locking pin 338 .
- the portion of suture 94 which is adjacent to through-holes 704 may have regions which cold-flow partially into through-holes 704 , as shown by cold-flowed suture material 706 .
- FIG. 34B shows a perspective view of collar 702 with multiple through-holes 704 defined over the body of collar 702 .
- Through-holes 704 may be defined in a uniform pattern; alternatively, they may be randomly defined over collar 702 or only over portions of collar 702 .
- FIGS. 35A to 35 E show an alternative variation 710 for locking a tissue anchor relative to suture 94 .
- An outer sleeve 720 which is preferably comprised of a polymeric material capable of at least partially flowing when heated, e.g., PTFE, may be disposed circumferentially about an electrically conductive inner sleeve 722 .
- inner sleeve 722 may be disposed within lumen 726 of outer sleeve 720 .
- Inner sleeve 722 may randomly or uniformly define a plurality of openings or through-holes 724 over the surface of inner sleeve 722 .
- outer and inner sleeves 720 , 722 may be positioned within delivery push tube 716 proximally of proximal collar 718 with suture 94 passing therethrough.
- an induction unit 712 having one or more induction coils 714 therewithin may be positioned circumferentially (or at least partially circumferentially) about outer and inner sleeves 720 , 722 .
- Induction unit 712 may be configured to be disposed within the launch tube 18 or it may be configured to be advanced over or positioned upon launch tube 18 .
- Thermal energy or electrical energy in various forms may be delivered to induction coils 714 such that the energy heats inner sleeve 722 , which may be positioned within induction coils 714 , as shown in FIG. 35A .
- inner sleeve 722 is heated via induction, the inner surface of outer sleeve 720 may be partially melted or deformed such that the material flows at least partially through or within through-hole 724 and contacts suture 94 positioned within inner sleeve 722 .
- the flowed material may cool and act to lock outer and inner sleeves 720 , 722 onto suture 94 .
- Induction unit 712 may then be removed from the area leaving outer and inner sleeves 720 , 722 locked relative to the tissue anchor.
- inner sleeve 722 shows through-holes 724 as circularly defined openings
- FIG. 35D shows a perspective view of one inner sleeve variation 728 having longitudinally defined slots 730 .
- FIG. 35E shows a perspective view of another inner sleeve variation 732 having circumferentially defined slots 734 .
- Any variety of opening shapes may be utilized so long as the opening or openings allow for material from the outer sleeve 720 to flow through into contact with the suture positioned within.
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Abstract
Description
- The subject matter of the present application is related to that of the following applications each of which is being filed on the same day as the present application: Ser. No. 10/______, entitled “Apparatus and Methods for Positioning and Securing Anchors” (Attorney Docket No. 021496-000900US); Ser. No. 10/______, entitled “Apparatus and Methods for Positioning and Securing Anchors” (Attorney Docket No. 021496-0001000US); Ser. No. 10/______, entitled “Apparatus and Methods for Positioning and Securing Anchors” (Attorney Docket No. 021496-0001200US); the full disclosure of each of these applications are incorporated herein by reference.
- 1. Field of the Invention
- The present invention relates to apparatus and methods for positioning and securing anchors within tissue. More particularly, the present invention relates to apparatus and methods for positioning and securing anchors within folds of tissue within a body.
- 2. Background of the Invention
- Morbid obesity is a serious medical condition pervasive in the United States and other countries. Its complications include hypertension, diabetes, coronary artery disease, stroke, congestive heart failure, multiple orthopedic problems and pulmonary insufficiency with markedly decreased life expectancy.
- A number of surgical techniques have been developed to treat morbid obesity, e.g., bypassing an absorptive surface of the small intestine, or reducing the stomach size. However, many conventional surgical procedures may present numerous life-threatening post-operative complications, and may cause atypical diarrhea, electrolytic imbalance, unpredictable weight loss and reflux of nutritious chyme proximal to the site of the anastomosis.
- Furthermore, the sutures or staples that are often used in these surgical procedures typically require extensive training by the clinician to achieve competent use, and may concentrate significant force over a small surface area of the tissue, thereby potentially causing the suture or staple to tear through the tissue. Many of the surgical procedures require regions of tissue within the body to be approximated towards one another and reliably secured. The gastrointestinal lumen includes four tissue layers, wherein the mucosa layer is the inner-most tissue layer followed by connective tissue, the muscularis layer and the serosa layer.
- One problem with conventional gastrointestinal reduction systems is that the anchors (or staples) should engage at least the muscularis tissue layer in order to provide a proper foundation. In other words, the mucosa and connective tissue layers typically are not strong enough to sustain the tensile loads imposed by normal movement of the stomach wall during ingestion and processing of food. In particular, these layers tend to stretch elastically rather than firmly hold the anchors (or staples) in position, and accordingly, the more rigid muscularis and/or serosa layer should ideally be engaged. This problem of capturing the muscularis or serosa layers becomes particularly acute where it is desired to place an anchor or other apparatus transesophageally rather than intraoperatively, since care must be taken in piercing the tough stomach wall not to inadvertently puncture adjacent tissue or organs.
- One conventional method for securing anchors within a body lumen to the tissue is to utilize sewing devices to suture the stomach wall into folds. This procedure typically involves advancing a sewing instrument through the working channel of an endoscope and into the stomach and against the stomach wall tissue. The contacted tissue is then typically drawn into the sewing instrument where one or more sutures or tags are implanted to hold the suctioned tissue in a folded condition known as a plication. Another method involves manually creating sutures for securing the plication.
- One of the problems associated with these types of procedures is the time and number of intubations needed to perform the various procedures endoscopically. Another problem is the time required to complete a plication from the surrounding tissue with the body lumen. In the period of time that a patient is anesthetized, procedures such as for the treatment of morbid obesity or for GERD must be performed to completion. Accordingly, the placement and securement of the tissue plication should ideally be relatively quick and performed with a minimal level of confidence.
- Another problem with conventional methods involves ensuring that the staple, knotted suture, or clip is secured tightly against the tissue and that the newly created plication will not relax under any slack which may be created by slipping staples, knots, or clips. Other conventional tissue securement devices such as suture anchors, twist ties, crimps, etc. are also often used to prevent sutures from slipping through tissue. However, many of these types of devices are typically large and unsuitable for low-profile delivery through the body, e.g., transesophageally.
- Moreover, when grasping or clamping onto or upon the layers of tissue with conventional anchors, sutures, staples, clips, etc., may of these devices are configured to be placed only after the tissue has been plicated and not during the actual plication procedure.
- In securing plications which may be created within a body lumen of a patient, various methods and devices may be implemented. Generally, any number of conventional methods may be utilized for initially creating the plication. One method in particular may involve creating a plication through which a tissue anchor may be disposed within or through. A distal tip of a tissue plication apparatus may engage or grasp the tissue and move the engaged tissue to a proximal position relative to the tip of the device, thereby providing a substantially uniform plication of predetermined size. Examples of tools and methods which are particularly suited for delivering the anchoring and securement devices may be seen in further detail in co-pending U.S. patent application Ser. No. 10/735,030 filed Dec. 12, 2003, which is incorporated herein by reference in its entirety.
- In securing these plications, various tissue anchors may be utilized for securing the plications in their configured folds. For example, a plication (or plications) may be secured via a length or lengths of suture extending through the plication and between a distally-positioned tissue anchor located on a distal side of the plication and a proximally-positioned tissue anchor located on a proximal side of the plication. Examples of anchors which may be utilized are disclosed in co-pending U.S. patent application Ser. No. 10/612,170, filed Jul. 1, 2003, which is incorporated herein by reference in its entirety.
- Generally, in securing a tissue plication, a proximally and/or distally located tissue anchor is preferably configured to slide along the connecting suture in a uni-directional manner. For instance, if the proximal anchor is to be slid along the suture, it is preferably configured to translate over the suture such that the tissue plication is cinched between the anchors. In this example, the proximal anchor is preferably configured to utilize a locking mechanism which allows for the free uni-directional translation of the suture therethrough while enabling the anchor to be locked onto the suture if the anchor is pulled, pushed, or otherwise urged in the opposite direction along the suture. This uni-directional anchor locking mechanism facilitates the cinching of the tissue plication between the anchors and it may be utilized in one or several of the anchors in cinching a tissue fold.
- Moreover, the types of anchors utilized for the securement of tissue plications are not intended to be limiting. For instance, many of the anchor locking or cinching mechanisms may be utilized with, e.g., “T”-type anchors as well as with reconfigurable “basket”-type anchors, which generally comprise a number of configurable struts or legs extending between at least two collars or support members. Other variations of these or other types of anchors are also contemplated for use in an anchor locking or cinching assembly.
- Furthermore, a single type of anchor may be used exclusively in an anchor locking or cinching assembly; alternatively, a combination of different anchor types each utilizing different anchor locking or cinching mechanisms may be used in a single assembly. Furthermore, the different types of cinching or locking mechanisms are not intended to be limited to any of the particular variations shown and described below but may be utilized in any combinations or varying types of anchors as practicable.
- The suture itself may be modified or altered to integrate features or protrusions along its length or a specified portion of its length. Such features may be defined uniformly at regular intervals along the length of suture or intermittently, depending upon the desired locking or cinching effects. Furthermore, the suture may be made from metals such as Nitinol, stainless steels, Titanium, etc., provided that they are formed suitably thin and flexible. Using metallic sutures with the anchoring mechanisms may decrease any possibilities of suture failure and it may also provide a suture better able to withstand the acidic and basic environment of the gastrointestinal system. Also, it may enhance imaging of the suture and anchor assembly if examined under imaging systems. Sutures incorporating the use of features or protrusions along its length as well as sutures fabricated from metallic materials or any other conventional suture type may be utilized with any of the locking or cinching mechanisms described below in various combinations, if so desired.
- One variation for utilizing a locking mechanism which allows for free uni-directional translation of the suture through the anchor may include blocks or members which are adapted to slide within or upon an anchor to lock the suture. These blocks or members may include tapered edges which act to cleat the suture depending upon the direction the anchor is translated relative to the suture. Moreover, these blocks may be biased or urged to restrict the movement of the suture using a variety of biasing elements, such as springs, etc. In addition to blocks, one or several locking tabs which are levered to allow unidirectional travel of the suture through an anchor may also be utilized.
- Aside from the use of mechanical locking features integrated within or with the anchor bodies, locking mechanisms may also utilize a variety of knotting techniques. Conventional knots, which are typically tied by the practitioner either within the body or outside the body and advanced over the suture length, may be utilized for locking the anchor in place relative to the tissue fold and opposing anchor; however, self-locking knots which enable the uni-directional travel of an anchor body relative to the suture and tissue are desirable. Accordingly, many different types of self-locking knots may be advanced with the anchor over the suture such that translation along a distal direction is possible yet reverse translation of the anchor is inhibited.
- Various anchor cinching or locking mechanisms utilizing friction as a primary source for locking may also be implemented. For instance, locking pins may be urged or pushed into a frictional interference fit with portions or areas of the suture against the anchor or portions of the anchor. The use of such pins may effectively wedge the suture and thereby prevent further movement of the anchor along the suture length. In addition to pins, locking collars or collets may also be used to cinch or lock the suture.
- In addition to friction-based locking and cinching mechanisms utilizable in tissue anchors, other mechanisms which create tortuous paths for the suture within or through the anchors may also be utilized for creating uni-directional locking. One cinching variation may utilize a pulley or pin contained within the anchor over which a portion of the suture may travel. The looped suture may then be routed proximally and secured with a slip knot. As tension is applied to the suture, the slip knot may prevent the further movement of the anchor relative to the suture.
- Another variation on utilizing tortuous paths may comprise collars which are independent from or integrally formed with the anchors. Such cinching collars may generally be formed into tubular structures having obstructions formed within the collar lumen where the obstructions are formed from portions of the cinching collar itself. These obstructions may be adapted to form upon releasing of a constraining force when the anchor is to be locked into position. These obstructions may be used to form a tortuous path through which the suture may be routed to lock the suture within.
- Moreover, locking collars which form tortuous paths may be adapted to reconfigure itself from a constrained delivery configuration to a deployed locking configuration when the anchor is to be cinched or locked into position relative to the tissue and suture. The locking collars may be configured to take various configurations, such as a proximally extending “S”-type, or other types, configuration.
- Other cinching and locking mechanisms which utilize mechanical clamping or crimping to achieve locking of the suture within or through the anchors may also be used to facilitate uni-directional locking. For instance, a simple mechanical crimp may be fastened upon the suture proximally of the anchor to prevent the reverse motion of the anchor. The crimp may be a simple tubular member or it may be integrally formed onto a proximal portion of the anchor body itself.
- Aside from the crimping mechanisms described above, additional measures may be optionally implemented to facilitate the cinching or locking of an anchor. Other measures may also be taken to inhibit any damage from occurring to the suture routed through an anchor. For instance, to ensure that the integrity of the suture is maintained in the presence of metallic basket anchors and to ensure that the suture is not subjected to any nicks or cuts, the portion of the suture passing through basket anchor may be encased in a protective sleeve made, e.g., from polypropylene, PTFE, etc.
- Another measure which may optionally be implemented are cinching or locking mechanisms which take advantage of any cold-flow effects of an engaged portion of suture by the tissue anchor. For instance, if a portion of the suture is wedged against the collar of an anchor or cinching member to lock the anchor, the portion of the collar may have multiple holes defined over its surface to allow for portions of the engaged suture to cold-flow at least partially into or through the holes to enhance the locking effects.
- Alternatively, the collar may be formed with an electrically conductive inner sleeve surrounded by an outer sleeve capable of flowing at least partially when heated. The inner sleeve may have a number of holes defined over its surface such that when the outer sleeve is heated, either by inductive heating or any other method, the outer sleeve material may flow through the holes and into contact with the suture passing therethrough. This contact may also enhance the locking effects of the collar.
-
FIG. 1A shows a side view of one variation of a tissue plication apparatus which may be used to create tissue plications and to deliver cinching or locking anchors into the tissue. -
FIGS. 1B and 1C show detail side and perspective views, respectively, of the tissue manipulation assembly of the device ofFIG. 1A . -
FIGS. 2A to 2D show an example of a tissue plication procedure for the delivery and placement of tissue anchors. -
FIGS. 3A to 3G show detail cross-sectional views of an anchor delivery assembly in proximity to a tissue plication and an example of delivering the tissue anchors on distal and proximal sides of the plication. -
FIGS. 4A and 4B show side and end views, respectively, of one anchor variation which is illustrated in the form of a T-type anchor utilizing locking blocks or members for cinching and locking the suture. -
FIG. 5 shows a side view of another cinching anchor variation utilizing locking blocks or members. -
FIG. 6 shows yet another side view of a cinching anchor variation utilizing locking blocks or members. -
FIG. 7 shows a perspective view of another locking anchor variation in which the anchor body defines an opening having a tapered or grooved portion. -
FIGS. 8A and 8B show cross-sectional side and top views, respectively, of another locking anchor variation utilizing a through-hole passage or opening and uni-directional levers or pivots through which the suture may pass. -
FIG. 8C shows a cross-sectional side view of an anchor body in combination with a modified suture having integrated features or protrusions defined along its length. -
FIGS. 9A and 9B show cross-sectional views of locking anchor variations having biased locking members in combination with a knotted suture. -
FIG. 9C shows another modification of the suture which may be coated with a metallic covering or slid within a sleeve. -
FIG. 10 shows a cross-sectional side view of an anchor assembly which utilizes a choke-type loop for cinching the anchors uni-directionally towards one another. -
FIG. 11A shows; a perspective view of another anchor assembly utilizing a slip knot at the proximal anchor. -
FIGS. 11B and 11C show top and cross-sectional side views, respectively, of an anchor which may optionally define grooves or channels extending at least partially therein to facilitate the cinching or wedging of the sutures within the grooves. -
FIGS. 12A to 12G show examples of anchor assemblies utilizing various slip knots and looped sections which provide uni-directional travel for the anchors over the sutures. -
FIG. 13A shows a cross-sectional side view of an anchor delivery system delivering a basket-type anchor into or through a tissue plication. -
FIG. 13B shows a cross-sectional side view of multiple tissue plications which may be cinched towards one another and basket anchors as being deliverable through one or both tissue plications. -
FIGS. 14A and 14B show cross-sectional side views of an anchor cinching assembly utilizing a cinching collar or collet which may be wedged into an anchor collar for clamping upon the suture. -
FIGS. 15A and 15C show cross-sectional side views of another anchor cinching assembly utilizing a pin for wedging against a portion of the suture. -
FIGS. 15B and 15D show end views of the assembly ofFIGS. 15A and 15C , respectively. -
FIG. 15E shows a perspective view of another cinching variation utilizing one or more tapered pins or blocks slidably disposed within a tapered channel defined in a proximal collar of the anchor. -
FIG. 15F shows a perspective view of the tapered pins fromFIG. 15E . -
FIGS. 15G and 15H show cross-sectional side views of an alternative cinching assembly having a retractable pin in an engaged and disengaged configuration, respectively. -
FIGS. 16A and 16B show cross-sectional side views of another variation of a cinching assembly having a rotatable cinching collar. -
FIGS. 17A and 17B show cross-sectional side views of another cinching assembly having a retaining tube for providing a counterforce to stabilize the assembly during cinching or locking. -
FIGS. 18A and 18B show cross-sectional side views of another cinching assembly having one or several biasing members or cinching tabs. -
FIGS. 18C and 18D show end and perspective views, respectively, of a suture release member which may be used with the assembly ofFIGS. 18A and 18B . -
FIGS. 19A and 19B show cross-sectional side views of another variation of a cinching assembly utilizing a deformable cinching member positioned within the anchor and distally of the anchor collar. -
FIG. 20A shows a cross-sectional side view of another cinching assembly utilizing a pivoting cinching member configured to lock against the suture. -
FIGS. 20B, 20C , and 20D show end and cross-sectional side views, respectively, of the pivoting member positioned within the anchor collar. -
FIGS. 20E and 20F show cross-sectional side and perspective views, respectively, of another cinching assembly having a pivoting cinching member positioned proximally of the anchor collar. -
FIGS. 21A and 21B show cross-sectional side views of another cinching assembly configured to cinch or lock the suture with a tapered collar. -
FIG. 22A shows a cross-sectional side view of another cinching assembly utilizing a looped suture and a slip knot for cinching the anchor over the suture. -
FIGS. 22B and 22C show cross-sectional side and detail views, respectively, of another cinching assembly which may be utilized with a portion of suture wrapped or looped about a pin which enables unidirectional travel of the anchor relative to the suture -
FIGS. 22D and 22E show cross-sectional side and detail views, respectively, of another cinching assembly utilizing looped suture wedged within the anchor collar. -
FIG. 23 shows a cross-sectional side view of a cinching assembly variation utilizing a number of pulleys to create the cinching effect. -
FIG. 24A shows a cross-sectional side view of another cinching assembly variation in which a cinching sleeve may be used to create a tortuous path for the suture. -
FIGS. 24B and 24C show cross-sectional side views of another cinching assembly variation having a tubular structure, with and without retaining arms, respectively, positioned within the anchor collar through which the suture may pass uni-directionally. -
FIG. 24D shows a perspective view of one variation of the tubular structure ofFIG. 24C with retaining arms. -
FIGS. 25A and 25B show cross-sectional side views of another cinching assembly variation in which a cinching collar, which may be independent of the anchor or formed integrally with the anchor, respectively, may have a tortuous path formed within the collar. -
FIG. 25C shows a perspective view of the collar ofFIG. 25A in its unobstructed configuration with a constraining sleeve which may be positioned within the collar. -
FIGS. 26A and 26B show cross-sectional side views of another cinching assembly variation utilizing one or several pivoting levers which allow uni-directional travel of the suture therethrough. -
FIGS. 26C and 26D show alternative end views of the assembly ofFIG. 26A in which the lever may be configured to prevent over cinching onto the suture. -
FIGS. 26E to 26G show cross-sectional side views of alternative cinching assemblies in which the levers may be variously configured to create the tortuous path. -
FIGS. 27A and 27B show side views of another cinching assembly variation in a delivery profile and a reconfigured profile, respectively, which utilizes a crimp which may be self-forming. -
FIGS. 28A and 28B show cross-sectional side views of another cinching assembly variation utilizing either two cinching collars or a single integral cinching collar, respectively. -
FIG. 28C shows a cross-sectional side view of the cinching collar ofFIG. 28A in one configuration for cinching the suture. -
FIGS. 28D and 28E show perspective views of the cinching collar ofFIG. 28A in a delivery profile and a reconfigured profile. -
FIG. 28F shows a cross-sectional side view of another variation for a cinching configuration of the cinching collar ofFIG. 28B . -
FIGS. 28G and 28H show cross-sectional side views of another cinching assembly variation in a delivery profile and reconfigured profile, respectively, in which an elongate cinching member may reconfigure itself to create a tortuous path for the suture. -
FIGS. 29A and 29B show cross-sectional side views of another cinching assembly variation utilizing a mechanical crimp. -
FIGS. 30A and 30B show cross-sectional side views of another cinching assembly variation in which a mechanical crimp may be utilized on the proximal collar of the anchor body. -
FIG. 31A shows a cross-sectional side view of a variation of a tool assembly which may be adapted to apply a mechanical crimping force upon a crimping collar. -
FIGS. 31B to 31D show side, end, and perspective views, respectively, of a variation on a crimping collar which may be utilized as a separate crimping sleeve or as part of the anchor collar. -
FIGS. 32A and 32B show cross-sectional side and perspective views, respectively, of an alternative crimping tool. -
FIGS. 33A and 33B show perspective and end views, respectively, of a representative basket anchor having a protective sleeve encasing the suture disposed within the anchor. -
FIGS. 34A and 34B show cross-sectional side and perspective views, respectively, of a cinching collar defining a plurality of holes through the surface of the collar for enhancing the locking effects with the suture. -
FIG. 35A shows a cross-sectional side view of a cinching assembly variation which may utilize inductive heating to partially melt a portion of an outer sleeve into contact with the suture to enhance the anchor locking effects. -
FIGS. 35B and 35C show perspective assembly and exploded views, respectively, of an electrically conductive inner sleeve contained within the outer sleeve. -
FIGS. 35D and 35E show perspective views of alternative inner sleeves which may be utilized with the assembly ofFIG. 35A . - In order to first create the plication within a body lumen of a patient, various methods and devices may be implemented. The anchoring and securement devices may be delivered and positioned via an endoscopic apparatus that engages a tissue wall of the gastrointestinal lumen, creates one or more tissue folds, and disposes one or more of the anchors through the tissue fold(s). The tissue anchor(s) may be disposed through the muscularis and/or serosa layers of the gastrointestinal lumen.
- Generally, in creating a plication through which a tissue anchor may be disposed within or through, a distal tip of a tissue plication apparatus may engage or grasp the tissue and move the engaged tissue to a proximal position relative to the tip of the device, thereby providing a substantially uniform plication of predetermined size.
- Formation of a tissue fold may be accomplished using at least two tissue contact areas that are separated by a linear or curvilinear distance, wherein the separation distance between the tissue contact points affects the length and/or depth of the fold. In operation, a tissue grabbing assembly engages or grasps the tissue wall in its normal state (i.e., non-folded and substantially flat), thus providing a first tissue contact area. The first tissue contact area then is moved to a position proximal of a second tissue contact area to form the tissue fold. The tissue anchor assembly then may be extended across the tissue fold at the second tissue contact area. Optionally, a third tissue contact point may be established such that, upon formation of the tissue fold, the second and third tissue contact areas are disposed on opposing sides of the tissue fold, thereby providing backside stabilization during extension of the anchor assembly across the tissue fold from the second tissue contact area.
- The first tissue contact area may be utilized to engage and then stretch or rotate the tissue wall over the second tissue contact area to form the tissue fold. The tissue fold may then be articulated to a position where a portion of the tissue fold overlies the second tissue contact area at an orientation that is substantially normal to the tissue fold. A tissue anchor may then be delivered across the tissue fold at or near the second tissue contact area. An apparatus in particular which is particularly suited to deliver the anchoring and securement devices described herein may be seen in further detail in co-pending U.S. patent application Ser. No. 10/735,030 filed Dec. 12, 2003 and entitled “Apparatus And Methods For Forming And Securing Gastrointestinal Tissue Folds”, which is incorporated herein by reference in its entirety.
- An illustrative side view of a
tissue plication assembly 10 which may be utilized with the tissue anchors described herein is shown inFIG. 1A . Theplication assembly 10 generally comprises a catheter ortubular body 12 which may be configured to be sufficiently flexible for advancement into a body lumen, e.g., transorally, percutaneously, laparoscopically, etc.Tubular body 12 may be configured to be torqueable through various methods, e.g., utilizing a braided tubular construction, such that when handle 16 is manipulated and rotated by a practitioner from outside the body, the torquing force is transmitted alongbody 12 such that the distal end ofbody 12 is rotated in a corresponding manner. -
Tissue manipulation assembly 14 is located at the distal end oftubular body 12 and is generally used to contact and form the tissue plication, as mentioned above.FIG. 1B shows an illustrative detail side view oftissue manipulation assembly 14 which showslaunch tube 18 extending from the distal end ofbody 12 and in-between the arms of upper extension member orbail 20.Launch tube 18 may definelaunch tube opening 24 and may be pivotally connected near or at its distal end via hinge or pivot 22 to the distal end ofupper bail 20. Lower extension member orbail 26 may similarly extend from the distal end ofbody 12 in a longitudinal direction substantially parallel toupper bail 20.Upper bail 20 andlower bail 26 need not be completely parallel so long as an open space betweenupper bail 20 andlower bail 26 is sufficiently large enough to accommodate the drawing of several layers of tissue between the two members. -
Upper bail 20 is shown in the figure as an open looped member andlower bail 26 is shown as a solid member; however, this is intended to be merely illustrative and either or both members may be configured as looped or solid members.Tissue acquisition member 28 may be an elongate member, e.g., a wire, hypotube, etc., which terminates at atissue grasper 30, in this example a helically-shaped member, configured to be reversibly rotatable for advancement into the tissue for the purpose of grasping or acquiring a region of tissue to be formed into a plication.Tissue acquisition member 28 may extend distally fromhandle 16 throughbody 12 and distally betweenupper bail 20 andlower bail 26.Acquisition member 28 may also be translatable and rotatable withinbody 12 such thattissue grasper 30 is able to translate longitudinally betweenupper bail 20 andlower bail 26. To support the longitudinal and rotational movement ofacquisition member 28, an optional guide orsled 32 may be connected to upper 20 orlower bail 26 to freely slide thereon.Guide 32 may also be slidably connected toacquisition member 28 such that the longitudinal motion ofacquisition member 28 is supported byguide 32. - An example of a tissue plication procedure is seen in
FIGS. 2A to 2D for delivering and placing a tissue anchor and is disclosed in further detail in co-pending U.S. patent application Ser. No. 10/735,030 filed Dec. 12, 2003, which has been incorporated by reference above.Tissue manipulation assembly 14, as seen inFIG. 2A , may be advanced into a body lumen such as the stomach and positioned adjacent to a region oftissue wall 40 to be plicated. During advancement,launch tube 18 may be configured in a delivery profile such thattube 18 is disposed within or between the arms ofupper bail 20 to present a relatively small profile. - Once
tissue manipulation assembly 14 has been desirably positioned relative totissue wall 40,tissue acquisition member 30 may be advanced distally such thattissue acquisition member 30 comes into contact withtissue wall 40 at acquisition location orpoint 42. Asacquisition member 30 is distally advanced relative tobody 12, guide 32, if utilized, may slide distally along withmember 30 to aid in stabilizing the grasper. If a helically-shapedacquisition member 30 is utilized, as illustrated inFIG. 2B , it may be rotated from its proximal end athandle 16 and advanced distally until the tissue atpoint 42 has been firmly engaged byacquisition member 30. This may require advancement ofacquisition member 30 through the mucosal layer and at least into or through the underlying muscularis layer and preferably into or through the serosa layer. - The grasped tissue may then be pulled proximally between upper 20 and
lower bails 26 viaacquisition member 30 such that the acquired tissue is drawn into atissue fold 44, as seen inFIG. 2C . Asacquisition member 30 is withdrawn proximally relative tobody 12, guide 32 may also slide proximally to aid in stabilizing the device especially when drawing thetissue fold 44. - Once the
tissue fold 44 has been formed,launch tube 18 may be advanced from its proximal end athandle 16 such that aportion 46 oflaunch tube 18, which extends distally frombody 12, is forced to rotate at hinge orpivot 22 and reconfigure itselfsuch portion 46 forms a curved or arcuate shape that positionslaunch tube opening 24 perpendicularly relative to a longitudinal axis ofbody 12 and/orbail members Launch tube 18, or atleast portion 46 oflaunch tube 18, is preferably fabricated from a highly flexible material or it may be fabricated, e.g., from Nitinol tubing material which is adapted to flex, e.g., via circumferential slots, to permit bending. Alternatively,assembly 14 may be configured such thatlaunch tube 18 is reconfigured simultaneously with the proximal withdrawal ofacquisition member 30 and acquiredtissue 44. - As discussed above, the tissue wall of a body lumen, such as the stomach, typically comprises an inner mucosal layer, connective tissue, the muscularis layer and the serosa layer. To obtain a durable purchase, e.g., in performing a stomach reduction procedure, the staples or anchors used to achieve reduction of the body lumen are preferably engaged at least through or at the muscularis tissue layer, and more preferably, the serosa layer. Advantageously, stretching of tissue fold 44 between
bail members - As shown in
FIG. 2D , oncelaunch tube opening 24 has been desirably positioned relative to thetissue fold 44,needle assembly 48 may be advanced throughlaunch tube 18 via manipulation from its proximal end athandle 16 to pierce preferably through a dual serosa layer throughtissue fold 44.Needle assembly 48 is preferably a hollow tubular needle through which one or several tissue anchors may be delivered through and ejected from in securing thetissue fold 44, as further described below. - Because
needle assembly 48 penetrates the tissue wall twice, it exits within the body lumen, thus reducing the potential for injury to surrounding organs. A detail cross-sectional view is shown inFIG. 3A ofanchor delivery assembly 50 in proximity to tissue fold F. In this example, tissue fold F may comprise a plication of tissue created using theapparatus 10 described herein or any other tool configured to create such a tissue plication. Tissue fold F may be disposed within a gastrointestinal lumen, such as the stomach, where tissue wall W may define the outer or serosal layer of the stomach. Anchor delivery assembly may generally compriselaunch tube 18 andneedle assembly 48 slidingly disposed withinlaunch tube lumen 52.Needle assembly 48 is generally comprised ofneedle 54, which is preferably a hollow needle having a tapered or sharpeneddistal end 66 to facilitate its travel into and/or through the tissue. Other parts of the assembly, such as upper andlower bail members tissue acquisition member 28 have been omitted from these figures only for clarity. - Once
launch tube 18 has been desirably positioned with respect to tissue fold F,needle 54 may be urged or pushed into or through tissue fold F via needle pushrod ormember 56 from its proximal end preferably located withinhandle 16.Needle 54 may defineneedle lumen 58 within whichdistal anchor 62 and/orproximal anchor 64 may be situated during deployment and positioning of the assembly. A single suture or flexible element 70 (or multiple suture elements) may connectproximal anchor 64 anddistal anchor 62 to one another. For instance,element 70 may comprise various materials such as monofilament, multifilament, or any other conventional suture material, elastic or elastomeric materials, e.g., rubber, etc. - Alternatively, metals which are biocompatible may also be utilized for suture materials. For instance, sutures may be made from metals such as Nitinol, stainless steels, Titanium, etc., provided that they are formed suitably thin and flexible. Using metallic sutures with the anchoring mechanisms described herein may additionally provide several benefits. For example, use of metallic suture material may decrease any possibilities of suture failure due to inadvertent cutting or shearing of the suture, it may provide a suture better able to withstand the acidic and basic environment of the gastrointestinal system, and it may also enhance imaging of the suture and anchor assembly if examined under conventional imaging systems such as X-rays, fluoroscopes, MRI, etc. As used herein,
suture 70 may encompass any of these materials or any other suitable material which is also biocompatible. -
Needle 54 may optionally defineneedle slot 60 along its length to allowsuture 70 to pass freely within and out ofneedle 54 whendistal anchor 62 is ejected fromneedle lumen 58. Alternatively, rather than utilizingneedle slot 60,needle 54 may define a solid structure withsuture 70 being passed intoneedle lumen 58 via the distal opening ofneedle 54. - The proximal end of
suture 70 may pass slidingly throughproximal anchor 64 to terminate insuture loop 74 via cinchingknot 72.Suture loop 74 may be omitted and the proximal end ofsuture 70 may terminate proximally of theapparatus 10 within control handle 16, proximally of control handle 16, or at some point distally of control handle 16. In this variation,suture loop 74 may be provided to allow for a grasping or hooking tool to temporarily holdsuture loop 74 for facilitating the cinching of proximal 64 and distal 62 anchors towards one another for retaining a configuration of tissue fold F, as described in further detail below. Cinchingknot 72 may also comprise a slidable knot which may be slid distally alongsuture 70 to lock or hold againstproximal anchor 64 once the tissue fold F and anchors 62, 64 have been desirably positioned and tensioned, as also described below in further detail. - After
needle assembly 48 has been pushed distally out throughlaunch tube opening 24 and penetrated into and/or through tissue fold F, as shown inFIG. 3B , anchor pushrod ormember 68 may be actuated also via its proximal end to ejectdistal anchor 62, as shown inFIG. 3C . Oncedistal anchor 62 has been ejected distally of tissue fold F,FIG. 3D shows howneedle 54 may be retracted back through tissue fold F by either retractingneedle 54 back withinlaunch tube lumen 52 or by withdrawing the entireanchor delivery assembly 50 proximally relative to tissue fold F. -
FIG. 3E shows that once needle 54 has been retracted,proximal anchor 64 may then be ejected fromlaunch tube 18 on a proximal side of tissue fold F. With bothanchors launch tube 18 andsuture 70 connecting the two,proximal anchor 64 may be held against the distal end oflaunch tube 18 and urged into contact against tissue fold F, as shown inFIGS. 3F and 3G , respectively. Asproximal anchor 64 is urged against tissue fold F,proximal anchor 64 or a portion ofsuture 70 may be configured to provide any number of directionally translatable locking mechanisms which provide for movement of an anchor alongsuture 70 in a first direction and preferably locks, inhibits, or prevents the reverse movement of the anchor back alongsuture 70. In other alternatives, the anchors may simply be delivered through various elongate hollow tubular members, e.g., a catheter, trocars, etc. - With respect to the anchor assemblies described herein, the types of anchors shown and described are intended to be illustrative and are not limited to the variations shown. For instance, several of the tissue anchor variations are shown as “T”-type anchors while other variations are shown as reconfigurable “basket”-type anchors, which may generally comprise a number of configurable struts or legs extending between at least two collars or support members. Other variations of these or other types of anchors are also contemplated for use in an anchor assembly. Examples of anchors which may be utilized are disclosed in co-pending U.S. patent application Ser. No. 10/612,170, filed Jul. 1, 2003, which is incorporated herein by reference in its entirety. Moreover, a single type of anchor may be used exclusively in an anchor assembly; alternatively, a combination of different anchor types may be used in an anchor assembly. Furthermore, the different types of cinching or locking mechanisms are not intended to be limited to any of the particular variations shown and described but may be utilized in any of the combinations or varying types of anchors as practicable.
- To accomplish the secure placement of anchors having uni-directional anchor movement over the suture in a self-locking manner, various devices and methods may be utilized.
FIGS. 4A and 4B show side and end views, respectively, of oneanchor variation 80 which is illustrated in the form of a T-type anchor. Although a T-type anchor is shown, the methods and devices used to cinch the anchor may be utilized in other types of anchors, which will be described below.Variation 80 may generally comprise ananchor body 82 having a circular, rectangular, square, etc., cross-section which definesopenings anchor 80. Locking block ormember 88 may be slidably disposed withinanchor body 82 and define a taperedface 90 on the side ofblock 88 which tapers to at least one of the openings, in this case opening 86.Openings -
Suture 94 may be routed throughopening 84, around lockingblock 88, and back out through opening 86 such that whenanchor body 82 is translated in the direction ofarrow 96,anchor body 82 may slide freely oversuture 94 due to the manner of taperedface 90 contactingsuture 84 withinopening 84. However, ifanchor body 82 were translated in the opposite direction, tension withinsuture 94 may pull lockingblock 88 viasuture 94 placed overcontact surface 92 such that whenblock 88 translates in the direction ofarrow 98,suture 94 at opening 86 is forced intogroove 100 defined along the leading edge ofblock 88, as shown inFIG. 4B . This cleating action may effectively inhibit or prevent any further movement ofanchor body 82 oversuture 94. Accordingly,anchor body 82 may be moved uni-directionally relative to suture 94 and a distally located anchor to effectively cinch tissue therebetween. -
FIG. 5 illustrates another cinching anchor in the side view ofanchor variation 110. In this variation,anchor body 112 similarly definesopenings member 118, which may similarly also define taperedface 120 may be slidably disposed withinanchor body 112. Lockingblock 118 may be urged via a biasing member, forinstance spring 122, to maintain a biasing force againstsuture 94 passing throughanchor body 112. Asanchor body 112 is translated oversuture 94 in the direction ofarrow 96, taperedface 120 may allowsuture 94 to pass freely betweenopenings anchor body 112 were to be moved in the opposite direction, biasingmember 122 may force lockingblock 118 to exert a force at its leading edge againstsuture 94, thereby preventing its movement and allowing only uni-directional movement. - Yet another locking
anchor variation 130 is shown in the side view inFIG. 6 . In this variation,anchor body 132 also definesopenings anchor body 132, multiple locking blocks ormembers blocks anchor body 132 is slowly moved oversuture 94 in a first direction, the anchor may translate freely. However, when moved quickly in the opposite direction, the biasingmembers directions anchor body 132 relative to suture 94. -
FIG. 7 shows a perspective view of another lockinganchor variation 150 in which anchorbody 152 defines anopening 154 having a tapered orgrooved portion 156. Opening 154 may be sized to allowsuture 94 to pass through opening 154 such thatanchor body 152 may be translated freely relative tosuture 94. Onceanchor body 152 has been desirably positioned relative to the tissue fold or to the opposing anchor,suture 94 may be manipulated to slide into tapered orgrooved portion 156, which preferably defines a diameter which is less than a diameter ofsuture 94. Slidingsuture 94 into tapered orgrooved portion 156 may lock a position ofanchor body 152 relative to suture 94 due to the cleating effect ofgrooved portion 156 onsuture 94. -
FIGS. 8A and 8B show cross-sectional side and top views, respectively, of another lockinganchor variation 160 in which anchorbody 162 may define a through-hole passage oropening 164 through which suture 94 may pass.Anchor body 162 may have one or several levered, flapped, or biased lockingmembers 166 which may be integrally formed withanchor body 162. These lockingmembers 166 may be formed radially about opening 164 such that whensuture 94 is absent, the resting configuration of lockingmembers 166 define anopening 164 having a diameter less than that of thesuture 94 passed through. Lockingmembers 166 may be biased to protrude in a single direction, as shown inFIG. 8A , such that whenanchor body 162 is moved in a first direction oversuture 94, theanchor 162 passes freely. However, whenanchor body 162 is moved in the opposing direction oversuture 94, lockingmembers 166 engage ontosuture 94 and prevent any reverse translation, thereby enabling uni-directional movement and locking ofanchor body 162. Although fivelocking members 166 are shown, any number of members may be utilized as practicable and as desired to effect a desired degree to locking. -
FIG. 8C shows a cross-sectional side view ofanchor body 162 in combination with a modifiedsuture 168 having integrated features orprotrusions 170 defined along its length. Features orprotrusions 170 may be defined uniformly at regular intervals along the length ofsuture 168 or intermittently, depending upon the desired effects, to enhance the locking ability of the anchor body onto the suture. Moreover, the features orprotrusions 170 may be integrally formed protrusions or they may simply comprise knotted sections of suture. Sutures which are modified or knotted may be optionally utilized in any of the locking anchor variations as described herein in place of conventional sutures, depending upon the desired degree of locking and locking effects. - As shown in the cross-sectional views of
FIGS. 9A and 9B of lockinganchor variations anchor body 182 may also comprise biased lockingmembers 184, contained within theanchor body 182. The number and configuration of lockingmembers 184 may be varied as desired and may optionally be apposed, as shown inFIG. 9A , or utilize asingle member 184, as shown inanchor variation 188 inFIG. 9B . The figures show knottedsuture 186 used withanchor variation 180; however, conventional sutures may also be utilized. -
FIG. 9C shows another modification ofsuture 94 which may be utilized with any of the anchor locking variations shown herein. The portions ofsuture 94 which come into contact with the anchor locking mechanisms may be coated with a material having a relatively higher frictional coefficient, i.e., a coefficient of friction that is higher than the underlying suture material. For example, the portion ofsuture 94 may be coated with a metallic covering or slid withinsleeve 181, which may be made of a metallic material such as Titanium, Nitinol, stainless steel, etc. to enhance the locking force betweensuture 94 and the anchor. As shown in the figure, ifsleeve 181 is utilized, theends sleeve 181 may be crimped ontosuture 94. One orseveral openings 187 may also be defined alongsleeve 181 to further enhance the locking capability betweensuture 94 and the locking mechanism. - Aside from the use of mechanical locking features integrated within or with the anchor bodies, locking mechanisms may also utilize a variety of knotting techniques. Conventional knots, which are typically tied by the practitioner either within the body or outside the body and advanced over the suture length, may be utilized for locking the anchor in place relative to the tissue fold and opposing anchor; however, self-locking knots which enable the uni-directional travel of an anchor body relative to the suture and tissue are desirable.
-
FIG. 10 shows lockinganchor assembly 190 withdistal anchor 192, which may be positioned distally of a tissue fold, andproximal anchor 194, which may be positioned proximally of a tissue fold or folds. In this variation,suture 94 may be routed throughproximal anchor 194 viaopenings distal anchor 192. Atdistal anchor 192,suture 94 may be routed throughopening 200 and overpin 202 positioned withindistal anchor 192.Pin 202 may function as a pulley over which suture 94 may travel during anchor locking adjustments.Suture 94 may then be routed back towardsproximal anchor 194 throughopening 204 and defineloop 206 through which the proximal portion ofsuture 94 passes to thereby create a choke-type loop. The terminal end ofsuture 94 may then be anchored atfixed end 208 within the body ofproximal anchor 194. - In operation, when tension is applied to suture 94 or when
proximal anchor 94 is advanced distally,proximal anchor 194 anddistal anchor 192 may be freely drawn towards one another to secure any tissue fold or folds (not shown for clarity) disposed therebetween. However, ifproximal anchor 194 were pulled or urged in the opposite direction away from the tissue or fromdistal anchor 192,loop 206 would “choke”suture 94 and prevent any reverse movement ofproximal anchor 194. -
FIG. 11A shows a perspective view of lockinganchor assembly 210 havingdistal anchor 212 andproximal anchor 214 withsuture 94 extending between the two anchors.Terminal end 230 ofsuture 94 may be knotted or otherwise retained byproximal anchor 214 and routed throughopening 216 and back throughopening 218 to create loopedportion 228, bothopenings proximal anchor 214.Suture 94 may be routed from opening 218 and throughdistal anchor 212 viaopenings Suture 94 may then be routed back toproximal anchor 214 through anopening 220 and wrapped 226 about loopedportion 228 to continue on proximally. This knotted configuration facilitates advancement ofproximal anchor 214 towardsdistal anchor 212 but chokessuture 94 whenproximal anchor 214 is moved in an opposing direction. -
FIGS. 11B and 11C show top and cross-sectional side views of an alternative variation on proximal anchor 214 (anddistal anchor 212, if desired). As shown,anchor 214 may optionally define grooves orchannels 232 which extend-at least partially betweenopenings channels 232, as seen inFIG. 11C , may be sized such that any of the overlyingsuture 94 are cinched or wedged intogrooves 232 to facilitate the cinching action ofanchor 214 with respect tosuture 94. - Another locking
anchor assembly 240 is shown in the perspective view ofFIG. 12A , which showsdistal anchor 242 andproximal anchor 244 withsuture 94 extending between the two anchors.Suture 94 may be routed throughopening 246 defined throughproximal anchor 244 and passed throughdistal anchor 242 viaopenings Suture 94 may then be routed back towardsproximal anchor 244 and passed throughopening 248 to create at least two adjacent loops (half hitch knots) 254, 256 with loopedsection 258. During cinching ofproximal anchor 244 against the tissue, the knotted suture may be slid distally withproximal anchor 244. Onceproximal anchor 244 has been desirably positioned alongsuture 94, the terminal end ofsuture 94 may be pulled, as shown byarrow 260, to alter the knot configuration, commonly called changing the dressing of the knot, such that the knot becomes locked ontosuture 94 and prevents any reverse movement ofproximal anchor 244. -
FIG. 12B also shows a perspective view of another locking anchor variation similar to that shown inFIG. 12A . In this variation,suture 94 may be wrapped into two intertwinedloops loops proximal anchor 244 may be accomplished until the terminal end ofsuture 94 is placed under tension, as shown byarrow 260. Tension may be applied onceproximal anchor 244 has been desirably positioned alongsuture 94 to lock the knot into position and prevent any reverse movement ofproximal anchor 244 alongsuture 94. -
FIG. 12C shows a perspective view of another anchor locking assembly similar to the variations above. The knot may be modified by wrappingsuture 94 into a first set of several loops, shown as threeloops Suture 94 may then be wrapped in a second set of several additional loops in a proximally adjacent position aboutsuture 94, shown asloops section 276. Likewise, any number of loops in the second set may be utilized either independent of the number of loops in the first set or to mirror the first set of loops. In either situation, once sutureterminal end 284 is tightened, a knotted configuration, as shown inFIG. 12D , is formed which may be freely slid alongsuture 94 provided the knotted configuration itself is pushed alongsuture 94, e.g., via a pusher tube, knot pusher, etc. However, once tension is applied alongsuture 94 byproximal anchor 244 pushing against the knot and by the tension created in the suture extending betweenanchors suture 94 and prevents reverse movement ofproximal anchor 244 alongsuture 94. -
FIG. 12E shows a perspective view of another locking anchor variation similar to the variation shown inFIG. 12D yet having a single suture traverse betweenanchors suture 94 may haveterminal end 286 anchored or retained bydistal anchor 242 at opening 252 and have a single suture traverse toproximal anchor 244. A secondterminal end 288 may also be anchored or retained byproximal anchor 244 atopening 246. The portions ofsuture 94 extending betweenproximal anchor 244 and the knot may have a biasing member, e.g.,spring 290, disposed over one or both lengths of suture to maintainproximal anchor 244 and the knot under a constant force to ensure that the knot is maintained under a locking force to prevent the reverse travel ofproximal anchor 244. - Yet another variation of a locking anchor variation having a single suture traversing the anchors is shown in the perspective view of
FIG. 12F . Aterminal end 252 ofsuture 94 may be anchored or retained atdistal anchor 242 and routed toproximal anchor 214 throughopening 218. The length ofsuture 94 may formloop 292 on a first side ofproximal anchor 214 and asecond loop 296 on the opposite side ofproximal anchor 214 betweenopenings Suture 94 may then be wrapped aboutloop 292 vialoop 294 on the first side to form an interlocking suture loop. This variation is also effective in allowingproximal anchor 214 to translate oversuture 94 towards the tissue anddistal anchor 242 yet prevent reverse movement ofproximal anchor 214 due to a choking action by the intertwined suture loops on the proximal side ofproximal anchor 214. -
FIG. 12G shows a perspective view of another locking anchor variation similar to that shown inFIG. 12F . Here,suture 94 may be routed throughopening 220 inproximal anchor 214 to formloop 292 before being passed throughopenings loop 294 throughloop 292. Likewise, this variation is also effective in allowingproximal anchor 214 to translate oversuture 94 towards the tissue anddistal anchor 242 yet prevent reverse movement ofproximal anchor 214. - As mentioned above, the locking and cinching mechanisms described herein may be utilized with a variety of different anchor types. For instance, the cinching mechanisms described above may be used not only with T-type anchors but also with reconfigurable basket-type anchors. Described hereinafter are basket-type anchors configured for implantation or placement against tissue in a similar manner as described previously and examples of how cinching mechanisms may be utilized in securing tissue plications. Moreover, additional cinching mechanisms which are preferably utilizable with basket-type anchors are also described below.
- When cinching or locking basket-type anchors, the baskets may be delivered into or through the tissue in the same or similar manner as described above, particularly as shown in
FIGS. 3A-3G . For example,FIG. 13A showsanchor delivery system 300 in proximity to tissue fold F. Again, tissue fold F may be disposed within a gastrointestinal lumen, such as the stomach, where tissue wall W may define the outer or serosal layer of the stomach. Delivery push tube orcatheter 302 may be disposed withinlaunch tube 18 proximally ofbasket anchor 306, which is shown in a compressed delivery configuration with a relatively low profile when disposed withinneedle lumen 58 ofneedle 54. Asingle basket anchor 306 is shown disposed withinneedle 54 only for illustrative purposes and is not intended to be limited by the number of basket anchors; rather, any number of basket anchors may be disposed withinneedle lumen 58 as practicable depending upon the desired procedure and anchoring results. -
Suture 94 may be routed through or externally ofpush tube lumen 304 and further routed within and/or throughproximal collar 310 ofanchor 306. The terminal end ofsuture 94 may be routed withinanchor 306 and affixed todistal collar 308 in one variation. Alternatively,suture 94 may be affixed or anchored withinanchor 306 or atproximal collar 310 depending upon the desired effect and procedure being performed. Moreover, if multiple anchors are utilized in a tissue plication procedure,suture 94 may be routed throughanchor 306 such that theanchor 306 may freely slide along or oversuture 94. - The basket anchors may comprise various configurations suitable for implantation within a body lumen. Basket anchors are preferably reconfigurable from a low profile delivery configuration to a radially expanded deployment configuration in which a number of struts, arms, or mesh elements may radially extend once released from
launch tube 18 orneedle 54. Materials having shape memory or superelastic characteristics or which are biased to reconfigure when unconstrained are preferably used, e.g., spring stainless steels, Ni—Ti alloys such as Nitinol, etc. Thebasket anchor 306 is illustrated as having a number of reconfigurable struts orarm members 312 extending betweendistal collar 306 andproximal collar 310; however, this is intended only to be illustrative and suitable basket anchors are not intended to be limited to baskets only having struts or arms. Examples of suitable anchors are further described in detail in U.S. patent application Ser. No. 10/612,170, which has already been incorporated herein above. -
FIG. 13A showsbasket anchor 306 delivered through tissue fold F vianeedle 54 andlaunch tube 18. As above, the other parts of the plication assembly, such as upper andlower bail members tissue acquisition member 28 have been omitted from these figures only for clarity. -
FIG. 13B shows one variation where a single fold F may be secured usingbasket anchor 306′. As seen,basket anchor 306′ has been urged or ejected fromneedle 54 and is shown in its radially expanded profile for placement against the tissue surface. In such a case, a terminal end ofsuture 94 may be anchored within the distal collar ofanchor 306′ and routed through tissue fold F and through, or at least partially through,proximal anchor 318, wheresuture 94 may be cinched or locked proximally of, within, or atproximal anchor 318 via any number of cinchingmechanisms 316 described herein.Proximal anchor 318 is also shown in a radially expanded profile contacting tissue fold F alongtissue contact region 314. Locking or cinching ofsuture 94 proximally ofproximal anchor 318 enables the adequate securement of tissue fold F. - If additional tissue folds are plicated for securement,
distal basket anchor 306 may be disposed distally of at least one additional tissue fold F′, as shown inFIG. 13B , whileproximal anchor 318 may be disposed proximally of tissue fold F. As above,suture 94 may be similarly affixed withindistal anchor 306 and routed throughproximal anchor 318, wheresuture 94 may be cinched or locked viaproximal anchor 318, as necessary. If tissue folds F and F′ are to be positioned into apposition with one another,distal basket anchor 306 andproximal anchor 318 may be approximated towards one another. As described above,proximal anchor 318 is preferably configured to allowsuture 94 to pass freely therethrough during the anchor approximation. However,proximal anchor 318 is also preferably configured to prevent or inhibit the reverse translation ofsuture 94 throughproximal anchor 318 by enabling uni-directional travel ofanchor 318 oversuture 94. This cinching feature thereby allows for the automated locking ofanchors - Aside from the anchor cinching or locking mechanisms utilizing looped and knotted sutures for facilitating uni-directional locking, various mechanisms utilizing friction may also be implemented.
FIGS. 14A and 14B show cross-sectional side views of one variation in cinchingassembly 320.Proximal collar 322, proximal portions ofstruts 312, and distal portions oflaunch tube 18 are shown and other features of the assembly and tissue fold F have been omitted from the figure only for clarity. - A locking or cinching collar or
collet 326 may be positioned withinlaunch tube 18 proximally ofanchor collar 322.Cinching collet 326 may comprise a cylindrically shaped member defining a lumen therethrough for passage ofsuture 94. A distal end of cinchingcollet 326 may have at least one and preferably several clamping arms orteeth 328 which are configured to cinch or clamp down uponsuture 94 passing through.Proximal anchor collar 322 may be sized to correspondingly receive cinchingcollet 326 therewithin to create an interference fit. relative to an outer diameter of cinchingcollet 326. A distal portion ofanchor collar 322 may also define a tapered orangled portion 324 such that when cinchingcollet 326 is advanced withinanchor collar 322,angled portion 324 may effectively force clamping arms orteeth 328 to cinch radially inward uponsuture 94. - In operation, once
proximal anchor 318 has been desirably positioned relative to tissue fold F and/or the distal anchor and withproximal collar 322 positioned withinlaunch tube 18,delivery push tube 302 may be advanced distally to urge cinchingcollet 326 intoanchor collar 322 such that clamping arms orteeth 328 are clamped ontosuture 94 and cinchingcollet 326 is friction-fitted withinanchor collar 322.Anchor collar 322 may then be urged out oflaunch tube 18 and the anchor left against the tissue surface. - Another cinching
assembly variation 330 is shown in the cross-section view ofFIGS. 15A and 15C .Launch tube 18 has been omitted from these figures for clarity only.Delivery push tube 332 is shown as definingsuture lumen 334 and locking member orpin lumen 336 therethrough. Although two separate lumens are shown, a single common lumen may be utilized in alternative variations. Withproximal anchor collar 344 positioned distally ofpush tube 332,suture 94 may be routed throughsuture lumen 334 and throughcollar lumen 346. Locking member or pin 338 may be positioned withinlumen 336 proximally ofcollar lumen 326.FIG. 15B shows an end view ofpush tube 332 with lockingpin 338 andsuture 94 positioned within prior to cinching of the anchor. - Once the anchor has been desirably positioned relative to the tissue,
suture 94 may be pulled proximally such thatanchor collar 344 rests against the distal end ofpush tube 332. Lockingpin 338, which may define a tapered orradiused end 340 to facilitate its insertion intocollar lumen 346, may be urged distally viapush rod 342 to force lockingpin 338 intoanchor collar 344 such that the portion ofsuture 94 withinanchor collar 344 becomes effectively wedged and thereby prevents further movement of the anchor alongsuture 94.FIG. 15C shows a cross-sectional side view of lockingpin 388 having been urged intoanchor collar 344 in a frictional engagement withsuture 94.FIG. 15D shows a cross-sectional end view ofcollar 344 with lockingpin 388 andsuture 94 positioned within. -
FIG. 15E shows a perspective view of another cinchingvariation 331 which is 20 similar to the variation described above. One or more tapered pins orblocks 339 may be slidably disposed within taperedchannel 335 defined inproximal collar 333. The figure shows twotapered pins 339, although a single pin may be utilized or more than two pins may also be used. If two ormore pins 339 are utilized,suture 94 may be passed between thepins 339.Pins 339 may be free to slide alonginner surface 337 ofchannel 335 in the direction ofarrows 345 depending upon the direction of travel ofsuture 94 throughchannel 335.FIG. 15F shows a perspective view of only pins 339 for clarity; as seen, pins 339 may be tapered distally from a larger diameter to a smaller diameter and althoughpins 339 are shown as semi-circularly shaped members,contact surface 341 may be curved or arcuate tobetter contact suture 94. Moreover,contact surface 341, which contacts suture 94 passing throughchannel 335, may define a roughened surface or it may alternatively define a plurality of serrations, teeth, projections, etc., to facilitate contact againstsuture 94. - In use, as
proximal collar 333 is translated in the direction ofarrow 343, pins 339 may be forced proximally such thatsuture 94 may pass freely throughchannel 335. However, ifproximal collar 333 were to be translated in the opposing direction, pins 339 may be forced in the opposite direction to cinch down uponsuture 94 withinchannel 335 and thereby inhibit any further motion. - An alternative variation of the assembly is shown in the cross-sectional views of
FIGS. 15G and 15H , which show a cinching anchor having a retractable pin.FIG. 15G showsproximal collar 347 with one or more retractingarms 349 extending proximally fromcollar 347. Retractingarms 349 may be configured to pivot atbend 353 when urged via a compression force applied atbend 353 in the direction ofarrows 355. The application of this compression force may urgepin support collar 357 which is defined at a proximal portion ofarms 349, to move in the direction ofarrow 359. This in turn may movepin 351, which extends frompin support collar 357, proximally out ofproximal collar 347 to thereby releasesuture 94 from its locked position. In one variation, retractingarms 349 may be biased to retainpin 351 withinproximal collar 347 unless a compression force is applied atbend 353. -
FIGS. 16A and 16B show cross-sectional side views of another variation of cinchingassembly 350.Cinching assembly 350 may generally compriseouter tubing 352 andinner tubing 358 rotatingly positioned withinouter tubing lumen 354. Cinchingmember 362 may be positioned distally ofouter tubing 352 and may generally comprise acollar base 364 and cinchingcollar 374 projecting proximally fromcollar base 364.Cinching collar 374 is preferably tapered and threaded and may also be longitudinally slotted such thatrotatable collar 368 may be rotatingly disposed upon slotted cinchingcollar 374. A distal end ofouter tubing 352 may define one or several engagingmembers 356 which are adapted to engagingly contact detents or keyedengagement interfaces 366 located oncollar base 364.Inner tubing 358 may also define one or several engagingmembers 363 which are also adapted to engagingly contact detents or keyedengagement interfaces 372 located on therotatable cinching collar 374.Suture 94 may be routed throughinner tubing lumen 360, through cinchingcollar 374, and throughproximal anchor collar 310. - In operation,
suture 94 may pass freely throughassembly 350. Once the anchor has been desirably positioned, engagingmembers 356 onouter tubing 352 may be correspondingly engaged againstinterface 366 and engagingmembers 363 oninner tubing 358 may be engaged againstinterface 372. Withsuture 94 tensioned appropriately,outer tubing 352 may be held stationary whileinner tubing 358 is rotated totorque rotatable collar 368 about threadedcinching collar 374. Asrotatable collar 368 is torqued onto cinchingcollar 374, the tapered shape may urge the slotted members to cinch uponsuture 94 passing therethrough. Stand-offs 370, which may protrude fromrotatable collar 368, may be adjusted in height to control how farrotatable collar 368 may be torqued ontocollar base 364 such that the degree to whichrotatable collar 368 is torqued about cinchingcollar 374 may be desirably adjusted. Once the cinchingcollar 374 has been desirably cinched ontosuture 94,proximal anchor collar 310 may be ejected fromlaunch tube 18 along with the cinching assembly, as shown inFIG. 16B . - Another variation on cinching
assembly 380 may be seen in the cross-sectional views ofFIGS. 17A and 17B .Assembly 380 is similar to cinchingassembly 330 shown above inFIGS. 15A to 15D.Delivery push tube 332 and pushrod 342 have been omitted from these figures only for clarity. In this variation, when lockingpin 338 is pushed distally intoproximal collar 388, a retainingtube member 384 may be utilized to provide a counterforce to stabilizeproximal collar 388 during cinching. Retainingtube member 384 may generally comprise one or severalcollar engaging arms 386 for engagingproximal anchor collar 388 atcollar detents 390 defined alonganchor collar 388. During the insertion of lockingpin 338 intocollar 388,collar engaging arms 386 may be positioned withinlaunch tube 18 or withinretractable sleeve 382. After lockingpin 338 has been inserted withinanchor collar 388, engagingarms 386 may be advanced distally out oflaunch tube 18 orretractable sleeve 382 may be withdrawn proximally to expose engagingarms 386. Once free of any constraining forces, engagingarms 386 may be biased to spring or open radially to then releaseproximal anchor collar 388 in a cinched configuration. - Another variation on cinching
assembly 400 is shown inFIGS. 18A to 18D, in whichproximal anchor collar 406 may comprise one or several biasing members or cinchingtabs 408 withincollar 406. Each of thetabs 406 may be biased to project inwardly such thatsuture 94 passing through is automatically cinched and locked in position, as shown inFIG. 18A . Asuture release member 404, which may generally comprise a cylindrically shaped tube or member having a taperedsurface 410 and asuture lumen 412 defined therethrough, may be positioned withinanchor collar 406 during anchor positioning to allow free passage ofsuture 94 through the anchor, as shown inFIG. 18B .FIG. 18C shows an end view ofrelease member 404 definingsuture lumen 412 extending therethrough.FIG. 18D shows a perspective view ofrelease member 404 to show taperedsurface 410 andsuture lumen 412 in better detail.Tapered surface 410 may be omitted but is preferably to facilitate the insertion and removal ofrelease member 404 fromanchor collar 406. When the anchor has been desirably positioned and is ready to be locked in place oversuture 94,tubular member 402 may engagesuture release member 404 for withdrawal fromanchor collar 406. The removal ofrelease member 404 may cause cinchingtabs 408 to lock uponsuture 94 and prevent the further movement of the anchor relative to suture 94. -
FIGS. 19A and 19B show another variation of cinchingassembly 420 in which adeformable cinching member 424 may be positioned within the anchor distally ofanchor collar 422. Cinchingmember 424 may define a tapered outer surface such that when the anchor is ready to be secured to suture 94, the insertion of cinchingmember 424 intocollar 422 may compress cinchingmember 424 aboutsuture 94 such that any further movement of the anchor is prevented. Cinchingmember 424 may be pulled intoanchor collar 422 viapull wire 426, which may be manipulated at its proximal end by the surgeon or user when desired. -
FIGS. 20A to 20D show cross-sectional views of another variation in cinchingassembly 430. As shown inFIG. 20A ,proximal anchor collar 432 may comprise apivotable locking member 434 contained either withinanchor collar 432 or proximally ofcollar 432. This example illustrates lockingmember 434 contained withincollar 432.Suture 94 may pass through lockingmember 434, which is shown in the end view ofcollar 432 inFIG. 20B , as having twopivots 436. Moreover, lockingmember 434 and pivots 436 may be integrally formed fromproximal collar 432. Pivoting lockingmember 434 may be biased to rotate aboutpivot 436 such that a resting position of lockingmember 434 is against an inner surface ofcollar 432. During distal anchor translation oversuture 94, tension as represented byarrow 438, onsuture 94 may forcepivot 434 into an open position wheresuture 94 may pass freely through. Upon having desirably positioned the anchor against tissue, lockingmember 436 may be biased to pivot indirection 440 to locksuture 94 against the inner surface ofcollar 432. Opposite movement of the anchor relative to suture 94 may act to furthercinch locking member 434 againstsuture 94 and thereby further inhibit the movement of the anchor in the reverse direction. - A similar variation is shown in the cross-sectional side and perspective views of
FIGS. 20E and 20F , respectively. In this variation, lockingmember 434′ may extend proximally ofproximal collar 432 at an angle relative tocollar 432. Lockingmember 434′ may be pivotable viapivot 436′ such that lockingmember 434′ may pivot in the direction of the arrows shown depending upon the direction which the tissue anchor is translated relative tosuture 94. Ifproximal collar 432 is translated distally oversuture 94, it may travel freely; however, ifproximal collar 432 is translated proximally in the opposite direction,suture 94 may become wedged in a tapered portion ofopening 442 through which suture 94 passes. Oncesuture 94 is wedged in taperedopening 442, lockingmember 434′ may pivot towardsproximal collar 432, where it is stopped from further motion, thereby locking the tissue anchor ontosuture 94 and preventing its reverse motion. -
FIGS. 21A and 21B show another cinchingassembly variation 450 as seen in the cross-sectional side views. In this variation,delivery push tube 452 may be disposed proximally of lockingcollar 454 and proximaltapered anchor collar 458. Once the anchor has been desirably positioned relative to the tissue fold F, withsuture 94 under tension, lockingcollar 454 may be urged distally viapush tube 452 such that lockingcollar 454 slides overproximal anchor collar 458. An inner surface of lockingcollar 454 may be tapered andanchor collar 458 may also be tapered in a correspondingly opposed manner such that when lockingcollar 454 is mated withanchor collar 458,anchor collar 458 may cinch lockingcollar 454 uponsuture 94 to thereby prevent any further movement of the anchor oversuture 94. Both collars may be made from any of the same or similar materials, as described above. - In addition to friction-based locking and cinching mechanisms utilizable in tissue anchors, other mechanisms which create tortuous paths for the suture within or through the anchors may also be utilized for creating uni-directional locking.
- One
cinching anchor variation 460 is shown in the cross-sectional side view inFIG. 22A . As shown,suture 94 may be routed through anchorproximal collar 462 and looped over pulley or pin 466 contained withindistal collar 464.Suture 94 may then be routed back through and looped 468 aboutsuture 94 and tied withslip knot 470. As tension is applied to suture 94,slip knot 470 may prevent further movement of the anchor relative to suture 94. -
FIGS. 22B and 22C show a variation which may be used in combination with cinchinganchor variation 460 or alone.Pin 474 may optionally be positioned withinproximal collar 462 andsuture 94 may be wrapped or looped about itself aroundpin 474 in a manner as shown in the detail view ofFIG. 22C . The configuration ofloop 472 may allow for the uninhibited translation of the anchor in the direction of the arrow as shown; however, when the anchor is moved in the opposite direction,loop 472 may effectively cinch upon itself to thus prevent or inhibit the reverse motion of the anchor relative to suture 94. - Another cinching variation is shown
FIGS. 22D and 22E .Suture 94 may be routed throughproximal collar 462 with an additional length of cinchingsuture 476. The distal end of cinchingsuture 476 may formloop 478 which is wrapped aboutsuture 94 and free to slide oversuture 94. After the anchor has been desirably positioned relative to the tissue and withsuture 94 preferably under tension, cinchingsuture 476 may be pulled proximally such thatloop 478 is pulled intoproximal collar 462 and becomes wedged againstsuture 94. The multiple lengths of suturing material utilized forloop 478 andsuture 94 preferably form a cross-sectional area which is larger than an inner diameter ofproximal collar 462 such thatpositioning loop 478 andsuture 94 withincollar 462 ensures a frictional lock which prevents further movement of thesuture 94 relative to the anchor.Suture 94 and cinchingsuture 476 are preferably made from the same or similar materials although differing suture materials may also be used. -
FIG. 23 shows a cross-sectional view of cinchingassembly variation 480 in whichproximal collar 482 may comprise pulley or pin 484 about which suture 94 may be looped once orseveral times 490.Distal collar 486 may also comprise pulley or pin 488 about which suture 94 may also be looped once or several times before being wrapped or looped 492 back aboutsuture 94. The terminal end ofloop 492 may be secured aboutsuture 94 viaslip knot 494. This configuration of looping allows for the anchor to be advanced uni-directionally relative to the suture and tissue, yet prevents or inhibits the reverse movement of the anchor and thus effectively enables the tissue to be cinched via the anchors. - Another cinching or locking
anchor variation 500 is shown in the cross-sectional view ofFIG. 24A . In creating a tortuous path forsuture 94, cinchingsleeve 506 may be positioned proximally ofproximal collar 504 within or distally ofdelivery push tube 502. Cinchingsleeve 506 may generally comprise a tubular structure havingsleeve lumen 510 defined therethrough and a number ofopenings 508 defined along the length ofsleeve 506.Openings 508 may be uniformly patterned alongsleeve 506 or they may be randomly positioned. Moreover, any number ofopenings 508 may be utilized as practicable. In either case,suture 94 may be routed in various patterns throughoutopenings 508 and throughsleeve lumen 510 before being routed throughproximal collar 504. Once the anchor is to be locked, cinchingsleeve 506 may be urged distally viadelivery push tube 502. When urged or pushed distally, this may be done slowly so as to allowsuture 94 to pass through the tortuous path created bysuture 94 passing throughopenings 508. However, once cinchingsleeve 506 has been advanced proximally adjacent toproximal collar 504, cinchingsleeve 506 may become locked withproximal collar 504 pressing againstsleeve 506. -
FIG. 24B shows another variation of a cinching mechanism which utilizes a tortuous path. Cinchingsleeve 512 may comprise a tubular structure having anopening 514 defined along a surface ofsleeve 512 through which suture 94 may pass. Cinchingsleeve 512 may be disposed withinproximal collar 504 withsuture 94 routed from outside ofsleeve 512 and passing to withinsleeve 512 throughopening 514. In operation, because of the manner in which suture 94 is routed throughsleeve 512 and into the anchor, distal translation of the anchor relative to the tissue andsuture 94 is uninhibited. But when the anchor is reversed in direction relative to suture 94,suture 94 and cinchingsleeve 512 may be drawn into the anchor and become locked due to the interference betweensuture 94, cinchingsleeve 512, andproximal collar 504. Accordingly, an outer diameter of cinchingsleeve 512 is preferably sized to be slightly less than an inner diameter ofproximal collar 504 such that whensuture 94 is passed throughopening 514, cinchingsleeve 512 becomes wedged againstcollar 504. Cinchingsleeve 512 may be made from any of the same or similar materials as the anchors, as described above. -
FIGS. 24C and 24D show another variation similar to cinchingsleeve 512 described above.Cinching sleeve variation 516 may be similarly sized assleeve 512 and may also similarly define anopening 514; however,sleeve 516 includes one or several retainingarms 518 defined on a distal end ofsleeve 516. Any number of retainingarms 518 may be utilized provided that they extend radially and reside distally ofproximal collar 504 such that they preventsleeve 516 from sliding proximally out ofcollar 504.FIG. 24D shows a perspective view of cinchingsleeve 516 with retainingarms 518 radially extended from the body ofsleeve 516. Cinchingsleeve 516 may also be made from the same or similar material as the anchor; for example,sleeve 516 may be fabricated from a material having superelastic characteristics, such as Nitinol. Accordingly, when cinchingsleeve 516 is initially inserted throughcollar 504 and/or during anchor delivery throughlaunch tube 18 into or through the tissue, retaining arm orarms 518 may be configured into a low profile with arm orarms 518 constrained into a tubular shape. Upon anchor release or upon being inserted throughcollar 504, retainingarms 518 may be released to extend radially. - Yet another
variation 520 on cinching assembly is shown inFIG. 25A . Generally,assembly variation 520 may comprise cinchingcollar 522 located proximally of anchorproximal collar 524.Cinching collar 522 may be a tubular structure having superelastic material characteristics, such as those found in Nitinol. Obstructingmembers 526, which may be formed from portions of cinchingcollar 522, may be pressed or formed to extend into a lumen of cinchingcollar 522 such that a tortuous path is created for the passage ofsuture 94. Although three obstructingmembers 526 are shown in the figure, any number of obstructions as practicable may be created depending upon the desired tortuous path to be created. -
Assembly 520 shows cinchingcollar 522 as a separate collar located proximally ofanchor collar 524; however, the cinching collar may be integrated with the anchor collar such that a singular integral structure is formed, as shown inanchor variation 530 in the cross-sectional view ofFIG. 25B . In either alternative during anchor placement relative to the tissue fold, retainingsleeve 534 may be inserted within cinchingcollar 522 to maintain obstructingmembers 526 in an open position for allowingsuture 94 to pass freely throughsleeve 534. Once the anchor has been desirably positioned, retainingsleeve 534 may be withdrawn, as shown in the perspective view ofFIG. 25C , using any number of methods. Removal of retainingsleeve 534 will allow for obstructingmembers 526 to reconfigure inwardly in the direction ofarrows 532 to thus reconfigure cinchingcollar 522 into a tortuous path. -
Cinching assembly 540 may also utilize a single or any number of tabs or levers to aid in capturingsuture 94 and/or creating a tortuous path forsuture 94 to traverse. As shown in the cross-sectional view ofFIG. 26A ,proximal collar 542 may have a pivotinglever 544 formed integrally from a side wall ofproximal collar 542. Alternatively,lever 544 may be included in a cinching collar separate fromproximal collar 542.Lever 544 may be biased to spring inwardly intoproximal collar 542 uponsuture 94 passing therethrough. During translation of the anchor in a first direction,suture 94 may be allowed to freely pass throughproximal collar 542 andpast lever 544 due to its pivoting motion. When the anchor is moved or urged in the reverse direction,lever 544 may act to cinch down uponsuture 54 against an inner surface ofproximal collar 542, as shown in the figure. - Another
variation 546 ofassembly 540 is shown in the cross-sectional view ofFIG. 26B in whichproximal collar 548 is shown as having at least twolevers suture 94 to traverse. In either variation, the cinching levers may be configured to prevent or inhibit the over-cinching or cutting ofsuture 94.FIGS. 26C and 26D show alternative end views ofFIG. 26A .Uni-directional lever 544, as seen inFIG. 26C , may be formed from the side wall ofproximal collar 542 such that whenlever 544 cinches down uponsuture 94, the corners or ends oflever 544 contact an inner surface ofproximal collar 542 at contact points 554. The contact which occurs may ensure that anopen space 556 is preserved and thatlever 544 is prevented from over cinching ontosuture 94 withinspace 556 and cuttingsuture 94.FIG. 26D shows an alternativeuni-directional lever 544′ which defines a curved orarcuate edge 558 which contacts suture 94. Thearcuate edge 558 may prevent the over cinching ontosuture 94 and cutting ofsuture 94. -
FIGS. 26E, 26F , and 26G show alternative variations of cinchingassembly 546 with uni-directional levers having various configurations.FIG. 26E shows a cross-sectional side view of cinchingassembly 560 in which-proximal collar 562 may havelevers levers proximal collar 562.FIG. 26F shows a cross-sectional side view of cinchingassembly 568 in whichproximal collar 570 hasuni-directional levers FIG. 26G shows a cross-sectional side view of cinchingassembly 576 in whichproximal collar 578 hasuni-directional levers collar 578. -
FIGS. 27A and 27B shows yet another variation of cinchingassembly 590 which utilizes a reconfigurable hollow member for cinchingsuture 94. As shown inFIG. 27A ,hollow member 594 may be constrained withintubular delivery member 592 to retain an elongate shape withsuture 94 passing uninhibited therethrough. When the anchor is to be cinched,hollow member 594 may be advanced distally fromtubular member 592 and whenhollow member 594 has been ejected, it may adapted to reconfigure itself into acrimped configuration 594′ having a non-linear passageway.Suture 94 passing through the crimpedconfiguration 594′ may be inhibited from passing freely therethrough bycrimp 596 created within the hollow member.Hollow member 594 may have a variety of cross-sectional shapes, e.g., circular, rectangular, square, hexagonal, etc., and it is preferably made from a material having shape memory characteristics, e.g., Nitinol, such that whenhollow member 594 is unconstrained, it may automatically reconfigure into itscrimped configuration 594′. - Another variation of cinching
assembly 600 which is configured to reconfigure itself upon being unconstrained is shown in the cross-sectional views ofFIGS. 28A to 28C. In this variation shown inFIG. 28A , cinchingcollar 602 may comprise at least two circular members,first collar 606 andsecond collar 608, connected by anelongate bridging member 604.Cinching collar 602 may be positioned withinlaunch tube 18 proximally adjacent toproximal collar 610 and adapted to reconfigure itself once released fromlaunch tube 18 such that a tortuous path is created forsuture 94.FIG. 28B shows an alternative variation in the cinching collar which may be an integrated variation with the proximal collar such thatfirst collar 606 is connected directly to the anchor via joiningmember 612. In either variation, once the cinching collar has been ejected fromlaunch tube 18, the collar may configure itself such thatfirst collar 606 andsecond collar 608 are biased towards one another to form, e.g., a “C”-shape as shown inFIG. 28C . The tortuous path which is created by cinchingcollar 602 forsuture 94 to follow may be sufficient to prevent the further translation of the anchor relative to suture 94.FIGS. 28D and 28E , respectively, show perspective views of cinchingcollar 602 in a constrained delivery configuration and an unconstrained cinching configuration. -
FIG. 28F shows a cross-sectional side view of another cinching assembly which is similar to the variation shown inFIG. 28B . Rather than havingfirst collar 606 and joiningmember 612 reconfigure itself into a semi-circular shape relative to the anchor,first collar 606 may reconfigure itself to maintain its orientation relative to the anchor while joiningmember 612 may be formed to curve appropriately or approximately in an “S”-type configuration. The reconfigured cinching member may act to locksuture 94 relative to the anchor when the anchor is moved in a reverse direction. - Another configuration for a cinching assembly is shown in the side view of
FIG. 28G , which shows cinchingmember 616 located proximally ofproximal collar 614. Cinchingmember 616 may be fabricated from a variety of materials, e.g., Nitinol, spring stainless steel, etc., which exhibit shape memory or superelastic characteristics, or aspects thereof. In use, cinchingmember 616 may be configured into an elongate delivery configuration. When the tissue anchor is to be cinched or locked relative to the tissue, cinchingmember 616 may be released from a constraining force such that cinchingmember 616 reconfigures itself into an expanded or extended configuration which creates a tortuous path forsuture 94 which sufficiently lockssuture 94 within cinchingmember 616. - Cinching
member 616 maybe comprised generally of an elongate bar, ribbon, cylinder, etc., or any elongate member having a diameter or cross-sectional area in its delivery configuration which is sufficiently small to be disposed and/or translated withinlaunch tube 18. Cinchingmember 616 may define a plurality ofopenings 618 along the length of cinchingmember 616 such that when cinchingmember 616 is in its elongate delivery configuration, as shown inFIG. 28G ,suture 94 may be interwoven throughopenings 618 along a relatively straightened path.Openings 618 may be located along cinchingmember 616 at uniform locations or they may be randomly positioned along the length of cinchingmember 616. When released, cinchingmember 616 may reconfigure itself into an expanded suture-lockingconfiguration 616′ which is sufficiently large to prohibit its passage into or throughproximal collar 614, as shown inFIG. 28H .Expanded configuration 616′ may comprise any reconfigured shape so long as the expanded shape is adapted to create the tortuous path forsuture 94 and is large enough so that passage throughproximal collar 614 is not possible. - Other cinching and locking mechanisms which utilize mechanical clamping or crimping to achieve locking of the suture within or through the anchors may also be used to facilitate uni-directional locking.
- For instance, cinching
assembly 620 may be seen in the cross-sectional view ofFIGS. 29A and 29B .FIG. 29A showsdelivery tube member 622 having crimpingcollar 624 disposed therewithin proximally of anchorproximal collar 626.Suture 94 may be passed through both crimpingcollar 624 andproximal collar 626. Once the anchor has been desirably positioned, crimpingcollar 624 may be advanced distally adjacent toproximal collar 624 and mechanically crimped 624′ down uponsuture 94 to create a lock and prevent the reverse movement of the anchor oversuture 94, as shown inFIG. 29B . The crimping may be accomplished via mechanical graspers or pinchers configured to clamp down uponcollar 624. Similarly,FIG. 30A shows cinchingassembly 630 in which the crimpingcollar 632 may be integral with the anchor rather than being a separate member.FIG. 30B shows a mechanically crimpedcollar 632′ which eliminates the need for a separate collar. - To accomplish mechanical crimping upon a cinching collar, various methods may be utilized.
FIG. 31A shows one variation of atool assembly 640 which may be adapted to apply a mechanical crimping force upon a crimping collar. As seen, launchtube 18 may havedelivery push tube 642 located therewithin and positioned proximally ofproximal collar 652 of the tissue anchor. Pushtube 642 may be used to hold and/or ejectproximal collar 652 fromlaunch tube 18. Crimpingdevice 644 may be advanced withinlaunch tube 18 via crimpingcontrol member 646, which may be manipulated from its proximal end. - A
collar retaining channel 650 maybe defined in a distal end of crimpingdevice 644 and adapted to receive and securely holdproximal collar 652 within during a clamping or crimping process. Crimping members orarms 648 may be positioned within crimpingdevice 644 on either side of retainingchannel 650. Whenproximal collar 652 or crimping sleeve is to be clamped or crimped, crimping members orarms 648 may be driven into contact withproximal collar 652 to crimp the collar. Moreover, crimpingarms 648 may be actuated through a variety of methods, e.g., hydraulically, pneumatically, via mechanical leverage, etc. - An alternative crimping
assembly 660 is shown in the cross-sectional view ofFIG. 32A . Crimpingdevice 662 may be seen withinlaunch tube 18 extending from crimpingcontrol member 664.Collar retaining channel 672 may be likewise defined within crimpingdevice 662 for retainingproximal collar 670 during a crimping procedure. This variation may utilize a separateelongate crimping member 666 havingactuatable crimping arms 668 positioned at a distal end ofelongate member 666. In use, withproximal anchor collar 670 positioned within retainingchannel 672,elongate member 666 may be advanced distally until crimpingarms 668 are positioned overproximal collar 670 and crimped down.FIG. 32B shows an exploded perspective view of the crimping assembly. -
FIGS. 31B to 31D show side, end, and perspective views, respectively, of one variation of an anchorproximal collar 652 which is adapted for crimping upon a suture passing therethrough. To facilitate crimping of thecollar 652, acircumferential slot 656 may be defined throughcollar 652 partially around its circumference. Anotherlongitudinal slot 658 may be defined throughcollar 652 extending longitudinally from a proximal edge ofcollar 652 tocircumferential slot 656. Theseslots arms 654 which may be crimped down upon a length of suture passing throughcollar 652. - Aside from the crimping mechanisms described above, additional measures may be optionally implemented to facilitate the cinching or locking of an anchor. Other measures may also be taken to inhibit any damage from occurring to the suture routed through an anchor.
- To ensure that the integrity of
suture 94 is maintained in the presence of metallic basket anchors 682 and to ensure thatsuture 94 is not subjected to any nicks or cuts, the portion ofsuture 94 passing throughbasket anchor 682 may be encased in aprotective sleeve 690, as shown in the perspective view ofFIG. 33A of anchor-sleeve assembly 680. Thebasket anchor 682 is shown in this variation as having anchor struts orarms 688 in a partially deployed configuration.Sleeve 690 may extend betweendistal collar 684 andproximal collar 686 to prevent excessive contact betweensuture 94 and elements ofbasket anchor 682.FIG. 33B shows an end view of the anchor-sleeve assembly 680 showing the relative positioning ofsleeve 690 relative to suture 94 andanchor collar 686.Sleeve 690 may be made from a variety of polymeric materials, e.g., polypropylene, PTFE, etc., provided that the material is suitably soft. -
FIG. 34A shows a cross-sectional view of cinchingassembly 700 which may be implemented with any of the cinching and locking mechanisms described above. This particular variation utilizes the partial cold-flowing of the engagedsuture 94 to enhance the locking or cinching effect of the tissue anchor. The cinching collar, or in this variationproximal collar 702, against which suture 94 is wedged may have multiple through-holes 704 defined over the surface ofcollar 702. The cross-sectional side view showssuture 94 wedged withincollar 702 against lockingpin 338. The portion ofsuture 94 which is adjacent to through-holes 704 may have regions which cold-flow partially into through-holes 704, as shown by cold-flowedsuture material 706. These portions ofsuture material 706 may enhance the locking aspects ofsuture 94 againstcollar 702.FIG. 34B shows a perspective view ofcollar 702 with multiple through-holes 704 defined over the body ofcollar 702. Through-holes 704 may be defined in a uniform pattern; alternatively, they may be randomly defined overcollar 702 or only over portions ofcollar 702. -
FIGS. 35A to 35E show analternative variation 710 for locking a tissue anchor relative to suture 94. Anouter sleeve 720 which is preferably comprised of a polymeric material capable of at least partially flowing when heated, e.g., PTFE, may be disposed circumferentially about an electrically conductiveinner sleeve 722. As shown in the perspective views ofFIGS. 35B and 35C ,inner sleeve 722 may be disposed withinlumen 726 ofouter sleeve 720.Inner sleeve 722 may randomly or uniformly define a plurality of openings or through-holes 724 over the surface ofinner sleeve 722. - In operation, outer and
inner sleeves delivery push tube 716 proximally ofproximal collar 718 withsuture 94 passing therethrough. When the tissue anchor has been desirably positioned andsuture 94 has also been desirably tensioned, aninduction unit 712 having one ormore induction coils 714 therewithin may be positioned circumferentially (or at least partially circumferentially) about outer andinner sleeves Induction unit 712 may be configured to be disposed within thelaunch tube 18 or it may be configured to be advanced over or positioned uponlaunch tube 18. Thermal energy or electrical energy in various forms, e.g., RF, microwave, etc., may be delivered toinduction coils 714 such that the energy heatsinner sleeve 722, which may be positioned withininduction coils 714, as shown inFIG. 35A . Asinner sleeve 722 is heated via induction, the inner surface ofouter sleeve 720 may be partially melted or deformed such that the material flows at least partially through or within through-hole 724 and contacts suture 94 positioned withininner sleeve 722. The flowed material may cool and act to lock outer andinner sleeves suture 94.Induction unit 712 may then be removed from the area leaving outer andinner sleeves - Although
inner sleeve 722 shows through-holes 724 as circularly defined openings, other shapes may be utilized. For example,FIG. 35D shows a perspective view of oneinner sleeve variation 728 having longitudinally definedslots 730. Alternatively,FIG. 35E shows a perspective view of anotherinner sleeve variation 732 having circumferentially definedslots 734. Any variety of opening shapes may be utilized so long as the opening or openings allow for material from theouter sleeve 720 to flow through into contact with the suture positioned within. - Although a number of illustrative variations are described above, it will be apparent to those skilled in the art that various changes and modifications may be made thereto without departing from the scope of the invention. Moreover, although specific locking or cinching configurations may be shown with various types of anchors, it is intended that the various locking or cinching configurations be utilized with the various types of anchors in various combinations as practicable. It is intended in the appended claims to cover all such changes and modifications that fall within the true spirit and scope of the invention.
Claims (25)
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
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US10/841,411 US8057511B2 (en) | 2004-05-07 | 2004-05-07 | Apparatus and methods for positioning and securing anchors |
US10/840,950 US8308765B2 (en) | 2004-05-07 | 2004-05-07 | Apparatus and methods for positioning and securing anchors |
US10/841,245 US7736378B2 (en) | 2004-05-07 | 2004-05-07 | Apparatus and methods for positioning and securing anchors |
US10/840,951 US20050251205A1 (en) | 2004-05-07 | 2004-05-07 | Apparatus and methods for positioning and securing anchors |
US10/869,472 US20050251208A1 (en) | 2004-05-07 | 2004-06-15 | Linear anchors for anchoring to tissue |
US10/954,665 US20050251159A1 (en) | 2004-05-07 | 2004-09-29 | Methods and apparatus for grasping and cinching tissue anchors |
US11/036,946 US7390329B2 (en) | 2004-05-07 | 2005-01-14 | Methods for grasping and cinching tissue anchors |
JP2007511613A JP4901724B2 (en) | 2004-05-07 | 2005-05-06 | Apparatus and method for placing and securing an anchor |
PCT/US2005/015765 WO2005110244A1 (en) | 2004-05-07 | 2005-05-06 | Apparatus and methods for positioning and securing anchors |
ES05746261T ES2864169T3 (en) | 2004-05-07 | 2005-05-06 | Anchor for implantation in a body |
EP05746261.6A EP1750591B1 (en) | 2004-05-07 | 2005-05-06 | Anchor for implantation in a body |
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US10/840,950 US8308765B2 (en) | 2004-05-07 | 2004-05-07 | Apparatus and methods for positioning and securing anchors |
US10/840,951 US20050251205A1 (en) | 2004-05-07 | 2004-05-07 | Apparatus and methods for positioning and securing anchors |
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US10/869,472 Continuation-In-Part US20050251208A1 (en) | 2004-05-07 | 2004-06-15 | Linear anchors for anchoring to tissue |
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US10/841,245 Active 2026-08-22 US7736378B2 (en) | 2004-05-07 | 2004-05-07 | Apparatus and methods for positioning and securing anchors |
US10/840,950 Active 2028-02-11 US8308765B2 (en) | 2003-08-11 | 2004-05-07 | Apparatus and methods for positioning and securing anchors |
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US10/841,245 Active 2026-08-22 US7736378B2 (en) | 2004-05-07 | 2004-05-07 | Apparatus and methods for positioning and securing anchors |
US10/840,950 Active 2028-02-11 US8308765B2 (en) | 2003-08-11 | 2004-05-07 | Apparatus and methods for positioning and securing anchors |
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US20050251159A1 (en) * | 2004-05-07 | 2005-11-10 | Usgi Medical Inc. | Methods and apparatus for grasping and cinching tissue anchors |
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WO2008006084A2 (en) | 2006-07-07 | 2008-01-10 | Usgi Medical, Inc. | Low profile tissue anchors, tissue anchor systems, and methods for their delivery and use |
WO2007136631A3 (en) * | 2006-05-18 | 2008-03-27 | Bard Inc C R | Suture lock fastening device |
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Also Published As
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US20050251157A1 (en) | 2005-11-10 |
US20050251206A1 (en) | 2005-11-10 |
US8308765B2 (en) | 2012-11-13 |
US7736378B2 (en) | 2010-06-15 |
US8057511B2 (en) | 2011-11-15 |
US20050251207A1 (en) | 2005-11-10 |
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